ПОЛИВИНИЛПИРРОЛИДОН K90 (ПВП К90)POLYVINYLPYRROLIDONE K90 (PVP K90)

Поливинилпирролидон это белый или светло-желтый слоеный гигроскопичный порошок. Используется, главным образом, как связующее вещество для таблеток. Также применяется как вещество, способствующее растворению и препятствующее слёживанию и комкованию, как диспергирующий агент и стабилизатор для чувствительных к высокой температуре активных веществ.

ПВП К-90 — высокомолекулярный (70 000 — 90 000) - высокоэффективное связующее. Часто используют в качестве стабилизатора в суспензиях, в качестве загустителя и гидролизующего агента

ХИМИЧЕСКОЕ НАЗВАНИЕ

polyvinylpyrrilidone

CAS

9003-39-8

СФЕРЫ ПРИМЕНЕНИЯ

Газообразные лекарственные формы (ГЛФ) аэрозоли, Жидкие лекарственные формы (ЖЛФ), Мягкие лекарственные формы (МЛФ), Твердые лекарственные формы (ТЛФ)

POLYVINYLPYRROLIDONE K90 (PVP K90)

Polyvinylpyrrolidone is a white or light yellow layered hygroscopic powder. Mainly used as a binder for tablets. Also used as a dissolving and anti-caking agent, as a dispersing agent and stabilizer for high temperature sensitive active substances.

PVP K-90 - high molecular weight (70,000 - 90,000) - highly effective binder. Often used as a stabilizer in suspensions, as a thickener and as a hydrolyzing agent

CHEMICAL NAME

polyvinylpyrrilidone

CAS

9003-39-8

APPLICATIONS

Gaseous dosage forms (GDF) aerosols , Liquid dosage forms (LF) , Soft dosage forms (MLF) , Solid dosage forms (TLF)

DOCUMENTS

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone

Medical

PVP was used as a plasma volume expander for trauma victims after the 1950s. It is not preferred as volume expander due to its ability to provoke histamine release and also interfere with blood grouping.

It is used as a binder in many pharmaceutical tablets;it simply passes through the body when taken orally. (However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.

 The long-term effects of crospovidone or povidone within the lung are unknown).

PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties. This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine, among a plethora of others.

It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.

PVP is used in some contact lenses and their packaging solutions. It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology and Air Optix contact lens packaging solution (as an ingredient called "copolymer 845").

PVP is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.

Technical

PVP is also used in many technical applications:

as an adhesive in glue stick and hot-melt adhesives

as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process

as an emulsifier and disintegrant for solution polymerization

to increase resolution in photoresists for cathode ray tubes (CRT)

in aqueous metal quenching

for production of membranes, such as dialysis and water purification filters

as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating

as a thickening agent in tooth whitening gels

as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation

as an additive to Doro's RNA extraction buffer

as a liquid-phase dispersion enhancing agent in DOSY NMR 

as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly

as a stabilizing agent in all inorganic solar cells

Other uses

PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well 

as in inks for inkjet printers.

PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. 

It has also been used in contact lens solutions and in steel-quenching solutions.

PVP is the basis of the early formulas for hair sprays and hair gels, and still continues 

to be a component of some.

As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine and some beers.

In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols

 during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.

In microscopy, PVP is useful for making an aqueous mounting medium.

PVP can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.

Properties

PVP is soluble in water and other polar solvents. For example, it is soluble in various alcohols, such as methanol and ethanol,as well as in more exotic solvents like the deep 

eutectic solvent formed by choline chloride and urea (Relin).When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. 

In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.

A 2014 study found fluorescent properties of PVP and its oxidized hydrolyzate

1-ethenylpyrrolidin-2-one

Other names

PVP, Povidone

PVPP, Crospovidone, Polyvidone

PNVP

Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]

1-Ethenyl-2-pyrrolidon homopolymer

1-Vinyl-2-pyrrolidinon-Polymere