CMIT MIT

CAS NO :26172-55-4

SYNONYMS:Isothiazolinones (CMIT/MIT); 3(2H)-Isthiazolone,5-chloro-2-methyl; 2-Methyl-3(2H)-Isothiazolone; 5-chloro-2-methyl-3(2h)-isothiazolone; 5-chloro-2-methyl-4-isothiazolin-3-on; 5-chloro-2-methyl-isothiazolylthione-3; methylchloroisothiazoline; 5-Chloro-2-methyl-Isothiazolone Kathon (Isothiazolineone,CIT/MIT,CMIT/MIT)

Kathon (Isothiazolineone,CIT/MIT,CMIT/MIT)
Product Specifications 1. Chemically stable at pH 2.0-4.0 2. Broad spectrum efficacy for bacteria, fungi, and enzyme 3. Low use level, no VOC and odor 4. No APE surfactant 5. Compatible with many surfactants and other ingredients Typical use concentrations are in the range of 0.05-0.2% (w/w) in...
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Description
Product Specifications

1. Chemically stable at pH 2.0-4.0

2. Broad spectrum efficacy for bacteria, fungi, and enzyme

3. Low use level, no VOC and odor

4. No APE surfactant

5. Compatible with many surfactants and other ingredients

 

Industrial applications also are quite wide ranging, from preservative and sanitizing uses to antimicrobial agents, energy production, metalworking fluids, mining, paint manufacturing, and paper manufacturing, many of which increase potential exposure to it by humans as well as organisms, both terrestrial and marine. Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined.[1]
Applications
Methylisothiazolinone and other isothiazolinone-derived biocides are used for controlling microbial growth in water-containing solutions.[2] Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloromethylisothiazolinone or CMIT) and 2-methyl-4-isothiazolin-3-one (methylisothiazolinone or MIT), which are the active ingredients in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon. Kathon is supplied to manufacturers as a concentrated stock solution containing from 10-15% of CMIT/MIT. For applications the recommended use level is from 6 ppm to 75 ppm active isothiazolones. Biocidal applications range from industrial water storage tanks to cooling units, in processes as varied as mining, paper manufacturing, metalworking fluids and energy production.

Kathon also has been used to control slime in the manufacture of paper products that contact food. In addition, this product serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food.[3]

Other isothiazolinones
One isothiazolinone, Sea-Nine 211 (4,5-dichloro-2-n-octyl-4-isothiazolino-3-one, DCOI), has quickly replaced tributyltin as the antifouling agent of choice in ship hull paint. A recent study reported the presence of DCOI in both port water and sediment samples in Osaka, Japan, especially in weakly circulating mooring areas.[4] Of environmental concern, DCOI levels predicted in marinas now are considered a threat to various marine invertebrate species.[5] Isothiazolinones also are extremely toxic to fish.[1]

In industrial use, the greatest occupational inhalation exposure occurs during open pouring. Non-occupational exposure to isothiazolinones by the general population also occurs, albeit at much lower concentrations.[6] These compounds are present in a very large number of commonly used cosmetics.[7] "Leave-on" cosmetics (hand-creams, lotions, etc.) contain 15 parts per million (100 micromolar) of combined CMIT/MIT.

 

On December 13, 2013 the trade group, Cosmetics Europe,[19] following discussions with the European Society of Contact Dermatitis (ESCD),[20] recommended to its members "that the use of Methylisothiazolinone (MIT) in leave-on skin products including cosmetic wet wipes is discontinued. This action is recommended in the interests of consumer safety in relation to adverse skin reactions. It is recommended that companies do not wait for regulatory intervention under the Cosmetics Regulation but implement this recommendation as soon as feasible."[21]

On March 27, 2014, the European Commission's Scientific Committee on Consumer Safety issued an opinion on the safety of Methylisothiazolinone. This report only considered the issue of contact sensitization. The committee concluded:

"Current clinical data indicate that 100 ppm MI in cosmetic products is not safe for the consumer.

"For leave-on cosmetic products (including ‘wet wipes'), no safe concentrations of MI for induction of contact allergy or elicitation have been adequately demonstrated.

"For rinse-off cosmetic products, a concentration of 15 ppm (0.0015%) MI is considered safe for the consumer from the view of induction of contact allergy. However, no information is available on elicitation."[22]

CAS No. 26172-55-4, 2682-20-4 Molecular weight: 115.16

 

Isothiazolinones (CMIT/MIT)

2-methyl-4-thiazoline-3-ketone 5-chloro- methyl-4-thiazoline-3-ketone

Properties:
Isothiazolinones (CMIT/MIT) is composed of 5-chloro-2-methyl-4-thiazoline-3-ketone (CMI) and 2-methyl-4-thiazoline-3-ketone (MI). The bactericidal effect of Isothiazolinones (CMIT/MIT) is carried out through breaking the bond between bacteria and algae protein. When contacted with microbes, Isothiazolinones (CMIT/MIT) can quickly inhibit their growth, thus leading to death of these microbes. Isothiazolinones (CMIT/MIT) has strong inhibition and biocidal effects on ordinary bacteria, fungi and alga, and has many advantages such as high biocidal efficiency, good degradation, no residual, safety in operation, good compatibleness, good stabilization, low cost in operation.

Isothiazolinones (CMIT/MIT) can mix with chlorine and most cation, anion, and non-ionic surfactants. When used at high dosage, its biosludge stripping effect is excellent.

Isothiazolinones (CMIT/MIT) is a kind of fungicidal with properties of broad spectrum, high efficiency, low toxicity and non-oxidative, it is the ideal biocidal in industrial circulating cool water system and in wastewater treatment in oilfield, papermaking, pesticide, cutting oil, leather, detergent and cosmetics etc..

 

Chemical Name: Chloromethylisothiazolinone/ Methylisothiazolinone

For short named: CMIT/MIT

CAS No.: 26172-55-4/ 2682-20-4/ 55965-84-9

General:

CMIT/MIT-14 microbicide is formulation for latex emulsions developed following consultations with key customers in this market. Free of divalent salt. It is formulated specifically to meet the changing needs and pressures facing latex emulsion manufacturers.

The active ingredients of CMIT/MIT 14 are identified using the IUPAC nomenclature as 5-Chloro-2-methyl-4-isothiazolin-3-one and 2-Methl-4-isothiazolin-3-one.

The performance is similar to KATHON LX 1400.

 

Performance characteristics

1. As a broad-spectrum, long-lasting bactericide to kill many bacteria, fungi and yeasts, the using amount is small.

2. Suitable for use in the medium of the pH value in the range of 2 to 9; free of divalent salt, cross-link no emulsion.

3. Miscible with water; can be added in any production step; easy to use.

4. It has a low toxicity and an appropriate concentration of using, which will lead to no harm completely.

 

Usage and Cautions

1. In water treatment applications, dilute it into a 1.5% aqueous solution first. Add the solution at a quantity of 80 to 100 ppm for one or two times each week depending on the multiplication of microorganisms like bacteria and algae.

2. Avoid direct eyes' contact with it for a long period. Once the contact happens, rinse eyes with water without delay. No long-term contact with the skin is allowed.

3. Any contact with reducible metals is forbidden during storage, for example, iron and aluminum, so as to avoid decomposition.

4. Not suitable for use in the alkaline medium of pH> 9.0 due to its poor stability. Any combination of this chemical with highly nucleophilic chemicals, like S2- and R-NH2, will lead to declined quality or even complete failure of the product.

 

Isothiazolinones
1,2-Benzisothiazolin-3-One(BIT)
2-Methyl-4-Isothiazolin-3One(MIT)
2-N-Octyl-4-Isothiazolin-3-One(OIT)
Isothiazolinone(cmit mit)
Sterilization principle of Isothiazolinones
Isothiazolinone is mainly composed of 5-chloro-2-methyl-4-isothiazoline-3-ketone(CMIT) and 2-methyl-4-isothiazoline-3-ketone(MIT). Isothiazolinone kills bacteria by breaking the bonds of bacteria and algae proteins. Isothiazolinone can rapid irreversibly inhibit microorganisms growth after contact with them. That reaction results in the death of microorganisms cells. For this reason, isothiazolinone has strong inhibition and sterilization effect on common fungus and algae.

Methyl Isothiazolinone(MIT)
Methyl Isothiazolinone(MIT) usages

Methyl Isothiazolinone (MIT) is a high effective biocide and heat-resisting water-based preservatives. Methyl Isothiazolinone has good effect on inhibiting growth of mold, bacteria and fungus. It also can be directly put in personal care products, cosmetics, coatings, pulp and other fields.

Methyl isothiazolinone is used as preservative in some cleaning products, including some green cleaning products. Such as detergent, cleansing cream, universal quick cleanser, glass cleaner, floor cleaner, countertop panel spray Detergents, linen detergents, room sprays, air fresheners, carpet cleaners and wet wipes. Beyond that, it is important to note that Methyl Isothiazolinone is often used in combination with another synthetic preservative, benzisothiazolinone(BIT)

Isothiazolinones (CMIT/MIT);3(2H)-Isthiazolone,5-chloro-2-methyl;2-Methyl-3(2H)-Isothiazolone

Chloromethyl-methylisothiazolone (CMIT/MIT) is a broad spectrum biocide which has been used successfully for microbial control and preventing biofouling in industrial water treatment. This paper presents a review of the various reports over the past 20 years on the efficacy of CMIT/MIT biocide versus Legionella bacteria and the protozoa associated with their growth. These studies included a wide range of conditions, including single organisms in cooling water and complex model systems with bacteria, biofilms, and protozoa. Overall, low levels of CMIT/MIT (1-10 ppm active) provided significant reduction in viable counts of various strains and species of Legionella bacteria in planktonic and biofilm studies and also against the amoebae and ciliated protozoa associated with their growth
CAS No. 26172-55-4, 2682-20-4 EINECS No. 247-500-7

UN Number: 1760 RIDADR : UN 1760 8/PG 2

Molecular weight: 115.16

Structural Formula:

Properties:

CMIT/MIT is composed of 5-chloro-2-methyl-4-thiazoline-3-ketone (CMI) and 2-methyl-4-thiazoline-3-ketone (MI). The bactericidal effect of CMIT/MIT is carried out through breaking the bond between bacteria and algae protein. When contacted with microbes, CMIT/MIT can quickly inhibit their growth, then leading to death of these microbes.

CMIT/MIT is a kind of broad spectrum, high efficiency, low toxicity, non-oxidative biocide.

CMIT/MIT has strong inhibition and biocidal effects on ordinary bacteria, fungi and alga. It has many advantages such as high-efficiency, good degradation, no residual, safety in operation, great compatibleness, good stabilization, low cost and so on. It can mix with chlorine and most cation, anion, and non-ionic surfactants. When used at high dosage, its effect on biosludge stripping is excellent.

 

Specification:

Notes: 2%, 4% and 8% or any concentration can be supplied on demands.

 

CMIT/MIT is the ideal biocidal in industrial circulating cool water system and in wastewater treatment in oilfield, papermaking, pesticide, cutting oil, leather, detergent and cosmetics etc.

When used as sludge stripper for grade II, the dosage of 150-300mg/L is preferred, when used as boicide, the dosage of 80-100mg/L is preferred, and charges every 3-7 days. No used together with oxidative fungicidal such as chlorine, and no used in cooling water system containing sulfur.

When used together with quaternary amine, the effect will be better. When used as industrial fungicide, the dosage of 0.05-0.4% is preferred.

 

Synonyms:

Isothiazolinones (CMIT/MIT);

3(2H)-Isthiazolone,5-chloro-2-methyl;

2-Methyl-3(2H)-Isothiazolone;

5-chloro-2-methyl-3(2h)-isothiazolone;

5-chloro-2-methyl-4-isothiazolin-3-on;

5-chloro-2-methyl-isothiazolylthione-3;

kathoncg5243; methylchloroisothiazoline;

5-Chloro-2-methyl-Isothiazolone;

 

Biocide and Algicide

CMIT/MIT
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 5-chloro-2-methyl-2h-isothiazolin-3-one/2-methyl-2h-isothiazol-3-one

ISOTHIAZOLONE BIOCIDES IN WATER TREATMENT

Isothiazolone biocides are widely used for microbial control in industrial water treatment. 5 The most frequently used product is a 3:1 ratio of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl- 4-isothiazolin-3-one (MIT) at a final concentration of 1.5% total active ingredient. (1) CMIT/MIT has broad spectrum efficacy versus bacteria, algae, and fungi. The chemical structures of CMIT/MIT are shown in Figure 1. All biocide concentrations in this paper are reported on an active ingredient basis. The CMIT/MIT biocide described in this paper is manufactured by Rohm and Haas Company.

 

CMIT/MIT 14%
Raw material Name: 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE
Common Name: Kathon 886 (Kathon is a registered trade mark of Rohm & Hass
Chemical Name: 5-Chloro-2-Methyl-4-Isothiazole-3-One
CAS NO.: 26172-55-4/2682-20-4
Molecular Formula: C4H4ClNOS/C4H5NOS
Molecular weight: 149.59/115.14

Physical Form: Colorless to Amber liquid
Attribute Specification:
1. pH: 1.0 - 4.0
2. % Actives: 13.9 - 14.5
Attribute Specification:
3. Appearance: Colorless to Amber Liquid
4. Specific Gravity @ 77F: 1.260 - 1.300
5. Magnesium (%): 4.2 - 5.5
6. 5-Chloro-2-Methyl-4-Isothiazoline-one: 10.1 - 11.3
7. 2-Methyl-4-Isothiazoline-3-one: 3.0 - 4.1
Typical Properties :

APPLICATIONS: It is a liquid biocide, biodegradable, water-soluble and of low toxicity. It can be used to control the growth of bacteria, fungi and algae in industrial water treatment, paper mill, leather, coatings and household products.
Description:

kathon cg is consist of 5-Choro-2methyl-4-isothiazolin-3-one and 2-Methyl-4-isothiazolin-3-one(MI).By means of breaking the bonds of bacterium and Algal protein, kill the microorganisms.Once contact with microorganisms,can inhibit their growth of them rapidly and irreversibly, thereby results the death of microbial cell,With the function of inhibiting and killing towards Fungus, bacteria,yeast,algae.No residual, operation safety, good compatibility, strong stability,low usage cost.can be mixed with chlorine and anion and cation.Under high dose, it effects obviously towards biological slime stripping.

 

Application:

Broad-spectrum sterilization, high efficient,low toxicity,good degradability, Non oxidizing biocide.Widely used in oil field, paper making, pesticide,leather, ink,cosmetics, paints, water-based polymer, metal cutting fluids, adhesives, dyes, and paraffin liquid industry.Used for Industry disinfection and anti corrosion,coating anti corrosion,daily chemicals anti corrosion.can also be used as the water treatment applications in the industries of petrochemicals, electricity, central air conditioning and industrial cooling water for the sterilization and algae removal purposes.
Dosage:
After formulated,according to the actual conditions, directly blend into the industry cycled water,using dosage see to seasons,environment,water source,

 

 

Storage period: 12 Months.
Isothiazolinones CMIT/MIT description, its application areas and related patterns
Isothiazolinones CMIT/MIT market situation
Isothiazolinones CMIT/MIT manufacturers and distributors
Isothiazolinones CMIT/MIT prices (by region and provided by market players)
isothiazolinones CMIT/MIT end-uses breakdown
Isothiazolinones CMIT/MIT downstream industries trends
Key Topics Covered:

1. ISOTHIAZOLINONES CMIT/MIT GENERAL INFORMATION
1.1. General information, synonyms
1.2. Composition, chemical structure
1.3. Safety information
1.4. Hazards identification
1.5. Handling and storage
1.6. Transport information

2. ISOTHIAZOLINONES CMIT/MIT APPLICATION

3. ISOTHIAZOLINONES CMIT/MIT PATENTS

 

CMIT-MIT Usage

1. It is used as a bactericidal preservative for the treatment of industrial circulating water. It can effectively kill algae, bacteria and fungi.

2. The active single agent can be widely used in industrial cooling water, return water of oil field, paper making, rubber, cosmetics, photographic film and washing products.

3. Used as an invertase inhibitor for angiotensin and a prodrug for hypertension

 

Conclusion
These findings suggest that CMIT/MIT exposure induce the injury of alveolar epithelial cells with inflammatory response via the p38-JNK1/2-ERK1/2 signaling pathway.

sothiazolinones (CMIT/MIT)
CAS No. 26172-55-4, 2682-20-4 Molecular weight: 115.16

Structural Formula:
2-methyl-4-thiazoline-3-ketone 5-chloro- methyl-4-thiazoline-3-ketone

Properties:
Isothiazolinones (CMIT/MIT) is composed of 5-chloro-2-methyl-4-thiazoline-3-ketone (CMI) and 2-methyl-4-thiazoline-3-ketone (MI). The bactericidal effect of Isothiazolinones (CMIT/MIT) is carried out through breaking the bond between bacteria and algae protein. When contacted with microbes,Isothiazolinones (CMIT/MIT) can quickly inhibit their growth, thus leading to death of these microbes. Isothiazolinones (CMIT/MIT) has strong inhibition and biocidal effects on ordinary bacteria, fungi and alga, and has many advantages such as high biocidal efficiency, good degradation, no residual, safety in operation, good compatibleness, good stabilization, low cost in operation.

Isothiazolinones (CMIT/MIT) can mix with chlorine and most cation, anion, and non-ionic surfactants. When used at high dosage, its biosludge stripping effect is excellent.

Isothiazolinones (CMIT/MIT) is a kind of fungicidal with properties of broad spectrum, high efficiency, low toxicity and non-oxidative, it is the ideal biocidal in industrial circulating cool water system and in wastewater treatment in oilfield, papermaking, pesticide, cutting oil, leather, detergent and cosmetics etc..