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1,2-Benzisothiazolin 20%


2634-33-5; 1,2-Benzisothiazol-3(2H)-one; 1,2-Benzisothiazolin-3-one; 1,2-benzothiazol-3-one; benzisothiazolone; Benzo[d]isothiazol-3(2H)-one; Benzo[d]isothiazol-3-one; Proxel; 1,2-Benzisothiazoline-3-one; Proxel PL; Benzo[d]isothiazol-3-ol; 2,3-dihydro-1,2-benzothiazol-3-one; Nipacide BIT; Proxel AB; Proxel XL 2; 1,2-BENZISOTHIAZOL-3-ONE; benzoisothiazol-3-one; 1,2-benzoisothiazolin-3-one; 1,2-Benzisothiazolone; Caswell No. 079A; Caswell No. 513A; C7H5NOS; UNII-HRA0F1A4R3; CCRIS 6369; 3-Hydroxy-1,2-benzisothiazole; IPX; CHEBI:167099; EINECS 220-120-9; EPA Pesticide Chemical Code 098901; HRA0F1A4R3; 1,2-Benzoisothiazoline-3-one; 40991-37-5; DMSMPAJRVJJAGA-UHFFFAOYSA-N; 2,3-dihydro-3-oxo-1,2-benzisothiazole; MLS-0254244.0001; Benzo(d)isothiazol-3(2H)-one; Benzisothiazolin-3-one; Benzocil; Acticide BIT; Canguard BIT; Denicide BIT; Proxel BD; Proxel CF; Proxel TN; Proxel XL; Proxel BDN; Proxel GXL; Proxel Ultra 5; San-aibac AP; Proxel LV-S; Proxel Press Paste; Apizas AP-DS; Acticide BW 20; Bestcide 200K; Nipacide BIT 20; Parmetol B 70; Parmetol D 11; Proxel GXL(S); Proxel HL 2; Nuosept 485; Nuosept 491; Nuosept 495; Topcide 600; XBINX; Denicide BIT 20N; Koralone B 119; Nipacide BIT 10W; Preventol BIT 20D; Proxel BD 20; Proxel Press Paste D; Troysan 1050; Bioban BIT 20DPG; benzisothiazoline-3-one; Canguard BIT 20DPG; 1,2-benzisothiazolinone; SD 202 (bactericide); Canguard Ultra BIT 20LE; 1,2-Benzoisothiazol-3-one; BIT 10W; BIT 20; 2-Thiobenzimide; 2,3-Dihydrobenzisothiazol-3-one; 1,2-benzisothiazole-3(2h)-one; SD 202; 1,2-Benzothiazolinone; PubChem15685; Benzisothiazolone (BIT); ACMC-209u7v; Epitope ID:115004; Benzisothiazol-3(2H)-one; DSSTox_CID_12523; DSSTox_RID_78967; DSSTox_GSID_32523; SCHEMBL26078; cid_17520; KSC201Q7J; MLS000771034; REGID_for_CID_17520; CHEMBL297304; SCHEMBL5586024; DTXSID5032523; BDBM46658; CTK1A1874; HSDB 8271; 1,2-BIT; HMS1755P21; HMS2706H20; 1,2-Benzisothiazol-3-one (BIT); KS-00000E5U; ZINC2581983; Tox21_300489; ANW-43433; MFCD00127753; AKOS001062434; AKOS030227972; AC-2653; CS-W018117; FS-3163; MCULE-3257757873; NE11261; 1,2-BENZISOTHAZOL-3(2H)-ONE; 1,2-Benzisothiazol-3(2H)-one, 97%; NCGC00164206-01; NCGC00248077-01; NCGC00254467-01; BR-46705; LS-33607; SC-15324; SMR000344133; US9011882, Table 1, Compound 20; CAS-2634-33-5; AB0008332; AB1001358; DB-027306; AM20060449; B2430; FT-0606282; EN300-17679; 34B335; M-4954; 634B335; A818398; AE-562/40151878; Q411746; 1,2-Benzisothiazol-3(2H)-one, analytical standard; W-107178; Z56983154; F0288-0100; InChI=1/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9; bit20; BIT20%; BENZISOTHIAZOLE 20; benziso thiazole 20; benz-iso-thiazole; Bit %20



Benzisothiazolinone has a microbicide and a fungicide mode of action. It is widely used as a preservative, for example in: emulsion paints, caulks, varnishes, adhesives, inks, and photographic processing solutions home cleaning and car care products; laundry detergents, stain removers and fabric softeners; industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins agriculture in pesticide formulations gas and oil drilling in muds and packer fluids preservation.[2]:iv In paints, it is commonly used alone or as a mixture with methylisothiazolinone. Typical concentrations in products are 200-400 ppm depending on the application area and the combination with other biocides. According to a study in Switzerland, 19% of the paints, varnishes and coatings contained BIT in 2000. The fraction in adhesives, sealants, plasters and fillers was shown at that time as 25%.[3] A later study in 2014 shows a dramatic rise in usage, to 95.8% of house paints.[4]
Benzo[d]isothiazol-3-one is an organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion. It has a role as a disinfectant, a platelet aggregation inhibitor, an environmental contaminant, a xenobiotic, a drug allergen and a sensitiser. It is an organonitrogen heterocyclic compound and an organic heterobicyclic compound.
PubChem CID: 17520
Property Name Property Value 
XLogP3-AA 1.3 
Hydrogen Bond Donor Count 1 
Rotatable Bond Count 0 
Exact Mass 151.009185 g/mol 
Monoisotopic Mass 151.009185 g/mol 
Topological Polar Surface Area 54.4 Ų 
Heavy Atom Count 10 
Formal Charge 0 
Complexity 160
Color/Form : Off-white to yellowish solid -European Commission; Opinion on Benzisothiazolinone,
White to off-white fine, crystalline powder - Dow Chemical; Product Safety Assessment. 1,2-Benisothiazol-3(2H)-one (BIT)
Technical product (commercial) can be in the form of a solid paste that is off-white to brown in color - USEPA/OPPTS; Reregistration Eligibility Decisions (REDs) Database on 1,2-Benzisothiazolin-3-one (BIT) 
Boiling Point : 327.6 °C
Melting Point : 156.6 °C
Solubility :In water, 1.1 g/L at 20 °C; 0.938 g/L at 20 °C and pH 4.8; 1.288 g/L at 20 deg and pH 6.7; 1.651 g/L at 20 °C at pH 9.1; 1.198 g/L at 30 °C pH 4.8
Density :1.483 g/cu cm at 20 °C
Vapor Pressure:2.78X10-6 mm Hg at 25 °C
Stability/Shelf Life : Stable under recommended storage conditions - Sigma-Aldrich; Safety Data Sheet for 1,2-Benzisothiazol-3(2H)-one.
Function and uses
Benzisothiazolinone is listed in the EU Cosmetics Inventory, Section 1 with indicated function "antimicrobial". It is currently not regulated in the annexes of the Cosmetics Directive 76/768/EEC. The submitted dossier requests a maximum level of 100 ppm as preservative in cosmetic products. This is greater than the level proposed in the earlier submission, which the applicant justifies with the availability of more recent studies, demonstration of a greater margin of safety. Aside from its use in cosmetic products, there are also other uses: Under the Biocide review programme for existing substances (Commission Regulation (EC) No 1451/2007), Benzisothiazolinone is examined for use in the following product types: SCCS/1482/12 Opinion on benzisothiazolinone
Private area and public health area disinfectants and other biocidal products (2), In-can preservatives (6), Film preservatives (7), Fibre, leather, rubber and polymerised materials preservatives (9), Masonry preservatives (10), Preservatives for liquid-cooling and processing systems (11), Slimicides (12), Metalworking-fluid preservatives (13), Embalming and taxidermist fluids (22). Benzisothiazolinone is used as a slimicide in the manufacture of disposable powder-free polyvinyl chloride gloves. Benzisothiazolinone is widely used in industry as a preservative in water-based solutions such as pastes, paints and cutting oils.



BIT 20 1 2-Benzisothiazolin 3 one 20% solution CAS 2634-33-5
Appearance:Amber liquid
Package: 25kg,200kg,1.25mt drum
Product description: BIT-20 is a new generation Broad-spectrum preservatives benzisothiazolin. Widely used in Latex paint、Waterborne wood coatings、Waterborne polymers、adhesive、inks、Dyedispersion、Liquid paraffin etc.
BIT-20 biocide benzisothiazolinone ; In-Can Preservation for Paints, Adhesives and Related Products
BIT-20/ 1,2-Benzisothiazolin-3-one
Purity: 20% liquid
Solvent: DPG, or PG
BIT-20 biocide is a broad spectrum microbicide for the preservation of industrial water-based products against the attack of microorganisms. The Composition of BIT-20 is 20% solution of 1,2-Benzisothiazolin-3-one in dipropylene glycol and water.
BIT-20 is specifically recommended for the preservation of polymer emulsions, paints and coatings, adhesives, and printing inks.
Application field
Suitable for applications in the water-based polymer, leather, paint, textile, printing and dyeing, metal cutting fluids, adhesives, inks, dyes, dye dispersions industries to resist corrosion.
Performance characteristics
1. Serve as a broad-spectrum, long-lasting biocide to kill many bacteria, fungi and yeasts; the liquid with a lowest concentration of 0.1% will have a good antibacterial effect;
2. Good compatibility with all kinds of emulsifiers, surfactants and other agents; miscible in the solutions of alcohol and water at any ratio.
3. Wider applications that like products; suitable for use in the medium of the pH value in the range of 4.0-12.
4. Excellent inactivity, with the active ingredient able to withstand a high temperature of 150 ℃.
5. Low toxicity; contain no heavy metals and halogen compounds; inactive to amines; free of formaldehyde.
Usage and Cautions
1. For use in cosmetics, body care products, and other daily chemicals, the concentration of using is in the range of 0.05-0.40% (w/w) depending on the storage environment and whether the product is susceptible to the destroy of microorganisms. The specific formula and instructions for the concentration of using will be based on the company's microbial technology division
2. It can be added at any production step; but it's suggested to be added at the final step at less than 50 ℃; avoid adding at a temperature of higher than 50 ℃.
3. Wear protective clothing, rubber gloves and goggles and masks, avoid contact with skin, eyes and mucous membranes.
Safety: In an acute oral toxicity test, the LD50 in rats is 2500 mg/kg.
Packaging : 25kg, 200 kg per plastic drum; 1mt IBC drum; Or as your request;
Storage and Transportatio : With a shelf time of one year when stored at room temperature in a dark, air-tight, and moisture-proof place.
Product Description
Benzisothiazolinone (BIT) is a widely used biocide and belongs to the group of isothiazolinones.
Benzisothiazolinone has a microbicide and a fungicide mode of action. It is widely used as a preservative, for example in:
-Emulsion paints, caulks, varnishes, adhesives, inks, and photographic processing solutions;-Home cleaning and car care products; laundry detergents, stain removers and fabric softeners;-Industrial settings, for example in textile spin-finish solutions, leather processing solutions, preservation of fresh animal hides and skins;-Agriculture in pesticide formulations;-Gas and oil drilling in muds and packer fluids preservation.
Health hazards
Given sufficient dose and duration, dermal exposure can produce skin sensitization and allergic contact dermatitis,[5] and is classified as an irritant for skin and eyes.[1] Benzisothiazolinone has also been linked with Systemic Contact Dermatitis via airborne contact.[6] In 2012, the Scientific Committee on Consumer Safety in Europe found BIT's "sensitising potential is of concern...Sensitisation from related isothiazolinones is an important problem in consumers. This has occurred because there has been consumer exposure before safe levels of exposure relevant to sensitisation have been established. Benzisothiazolinone is a skin sensitiser in animal models with potency similar to methylisothiazolinone. Methylisothiazolinone, at 100 ppm (0.01%) in cosmetic products is causing contact allergy and allergic contact dermatitis in the consumer. Benzisothiazolinone is known to be a sensitiser in man and has induced sensitisation at circa 20 ppm in gloves."[7] The opinion further states: "There is no information on what may be safe levels of exposure to benzisothiazolinone in cosmetic products from the point of view of sensitisation. Until safe levels of exposure have been established, the use of benzisothiazolinone in cosmetic products as a preservative or for other functions cannot be considered safe in relation to sensitisation." Later, in 2013, researchers published a study that set out to derive the highest concentration of BIT in certain consumer products that would result in exposures below the No Expected Sensitization Induction Level (NESIL); that is, where normal use would yield a dose below the level at which skin sensitization might occur. The products under consideration were sunscreen, laundry detergent, dish soap, and spray cleaner; by way of calculation they derived BIT NESILs of 0.0075%, 0.035%, 0.035%, 0.021%, respectively. They then performed a pilot examination via bulk sample analysis of one representative product from each category labelled as containing BIT. Their findings showed all BIT concentrations well below the derived NESIL, with 0.0009% and 0.0027% for sunscreen and dish soap, respectively, and no detection in the laundry detergent and spray cleaner products, meaning the concentration was at or below the limit of detection of 0.0006%.[8]



BIT-20 biyosit, mikroorganizmaların saldırısına karşı endüstriyel su bazlı ürünlerin korunması için geniş spektrumlu bir mikrobisittir. Bileşimi BIT-20 20% çözüm 1,2-Benzisothiazolin-3-one çin'de dipropilen glikol ve su.
BIT-20, polimer emülsiyonlarının, boyaların ve kaplamaların, yapıştırıcıların ve baskı mürekkeplerinin korunması için özellikle tavsiye edilir.
Görünüm : Açık kehribar sıvı
Aktif Madde : 20%
PH (10% suda) : 11.0-13.0
Özgül ağırlık (g/ml) : 1.14 25 °C
Sıcaklık kararlılığı : 50 ° c'ye kadar sabit (matrise bağlı olarak 100 ° c'ye kadar kısa süreler için)
PH stabilite : PH 4-12 'de kararlı
Ürün Faydaları
1. yüksek pH sistemlerinde geniş spektrumlu aktivite, bakteri, mantar ve mayaları kontrol eder.
2. aminlerin varlığında kararlı.
3. spesifik olmayan etki modu, azaltılmış mikrobiyal direnç potansiyeline neden olur.
4. sıvı formu ve çoğu sulu kompozisyonlarda iyi uyumluluk nedeniyle kullanım kolaylığı.
5. performans geliştirmeleri ve maliyet azaltma sağlayan CMI/MI, bronopol veya formaldehit releasers gibi ko-biyositler ile mükemmel performans.
6. aktif madde uçucu değildir ve hala sıcak olan sıvılarda birleşme sağlayan nispeten yüksek bir ısı stabilitesine sahiptir.
7. açık açık renk ile belirgin yüksek saflıkta aktif madde.
Antimikrobiyal Özellikler
Önerilen doz seviyelerinde kullanılan BIT-20 biyosit aşağıdaki mikroorganizmalara karşı etkilidir:
Pseudomonas aeruginosa, Fusarium solani,Pseudomonas fluorescens,Aspergilus nijer,Pseudomonas putida Alternaria alternata,Escherichia coli Aureobasidium pullulans,Klebsiella pneumoniae Chaetomium globosum,Enterobacter cloacae,Citrobacter freundii,Proteus vulgaris,Staphylococcus aureus
Yönlü Kullanım için
Aşağıda bazı genel dozlama önerileri vardır, ancak en uygun doz seviyelerini belirlemek için son üründe özel test yapılması önerilir.
Ürün BIT-% 20 (Ürünün toplam ağırlığına göre)
Polimer Emülsiyonları:
Stiren 0.05-0.15% dayalı polimer emülsiyonları
Akrilik, akrilik, bütadien, PVA ve
Çeşitli uygulamalar için stiren.
Emülsiyonlar boyalar ve kaplamalar 0.05-0.25%
Su bazlı yapıştırıcılar 0.05-0.25%
Baskı mürekkepleri ve çeşme çözümleri 0.05-0.15%
Sıvalar 0.05-0.25%
Kazanlar gibi yapı malzemeleri, 0.08-0.25%
Sızdırmazlık maddeleri, grouts, aralıklı, hazır karışım çimentosu,wallboard bileşikleri ve bant eklemi bileşikleri.
Matkap çamurları gibi yağ geri kazanım malzemeleri,
Packer sıvıları ve tamamlama sıvıları, 0.05-0.15%
Polisakkarit sıvı kaybı kontrol maddeleri ve/veya kalınlaştırıcı içeren Gibi nişastası.
Katkı maddeleri içeren ikincil yağ geri kazanımı enjeksiyon suyu,
Kalınlaştırıcı kullanarak polimer veya micellar/polimer su taşkınları gibi 0.015-0.15%
Gibi ksantan sakızı.
Davul başına 25Kg, davul başına 200Kg veya IBC davul başına 1000Kg.




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