POLYHEXAMETHYLENE BIGUANIDE (POLİHEGZAMETİLEN BİGUANİD) |

Ürünler > Kozmetik- Deterjan (Dezenfektan) ve İlaç Kimyasalları > POLYHEXAMETHYLENE BIGUANIDE (POLİHEGZAMETİLEN BİGUANİD) >

POLYHEXAMETHYLENE BIGUANIDE (POLİHEGZAMETİLEN BİGUANİD)

Polyhexamethylene Biguanide

CAS NO: 32289-58-0

INCI name Polyaminopropyl Biguanide,

SYNONYM polyhexamethylene biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide; Poly(hexamethylenebiguanide hydrochloride); Poliheksametilen biguanid; Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Poliheksametilen biguanid; Poliheksametilen biguanid; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), hydrochloride; Poliheksametilen biguanid; Polihekzametilen biguanid; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride; Baquacil; Caswell No. 676; Cosmocil CQ; EPA Pesticide Chemical Code 111801; PHMB; Polihexanide ; Polihexanido; Poliheksametilen biguanid; Poliheksametilen biguanid; Polihexanidum; Polyhexanide; PP 073 UNII-322U039GMF; Vantocil IB; Vantocil TG; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Poliheksametilen biguanid; PHMB; 1-(diaminomethylidene)-2-hexylguanidine; C8H19N5; Polyhexanide; Baquacil; cosmocil; Lavasept; PHMB Polymer; polihexanide; polihexanide hydrochloride; poly (hexamethylene biguanide); poly(hexamethylenebiguanide) hydrochloride; poly (iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl); Poliheksametilen biguanid; hydrochloride polyhexamethylen-biguanide; polyhexamethylenbiguanid; polyhexamethylenbiguanide; polyhexamethylene biguanide; Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride; polyhexanide; Vantocil; Vantocil IB of Vantocil; Polyhexanide; PHMB; POLIHEXANIDE; 28757-47-3; polyhexamethylene biguanide; n-hexylbiguanide; 1-Hexylbiguanide; POLYXEDININE; SCHEMBL45011;Poliheksametilen biguanid; N-Hexylimidodicarbonimidic diamide; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N```-1,6-Hexanediylbis(N`-cyanoguanidine) hexamethylenediamine polymer hydrochloride; PHMB; Polihexanide; Poliheksametilen biguanid; Polihekzametilen biguanid;polyhexamethylene biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide; Poly(hexamethylenebiguanide hydrochloride); Poliheksametilen biguanid; Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Poliheksametilen biguanid; Poliheksametilen biguanid; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), hydrochloride; Poliheksametilen biguanid; Polihekzametilen biguanid; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride; Baquacil; Caswell No. 676; Cosmocil CQ; EPA Pesticide Chemical Code 111801; PHMB; Polihexanide ; Polihexanido; Poliheksametilen biguanid; Poliheksametilen biguanid; Polihexanidum; Polyhexanide; PP 073 UNII-322U039GMF; Vantocil IB; Vantocil TG; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Poliheksametilen biguanid; PHMB; 1-(diaminomethylidene)-2-hexylguanidine; C8H19N5; Polyhexanide; Baquacil; cosmocil; Lavasept; PHMB Polymer; polihexanide; polihexanide hydrochloride; poly (hexamethylene biguanide); poly(hexamethylenebiguanide) hydrochloride; poly (iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl); Poliheksametilen biguanid; hydrochloride polyhexamethylen-biguanide; polyhexamethylenbiguanid; polyhexamethylenbiguanide; polyhexamethylene biguanide; Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride; polyhexanide; Vantocil; Vantocil IB of Vantocil; Polyhexanide; PHMB; POLIHEXANIDE; 28757-47-3; polyhexamethylene biguanide; n-hexylbiguanide; 1-Hexylbiguanide; POLYXEDININE; SCHEMBL45011;Poliheksametilen biguanid; N-Hexylimidodicarbonimidic diamide; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N```-1,6-Hexanediylbis(N`-cyanoguanidine) hexamethylenediamine polymer hydrochloride; PHMB; Polihexanide; Poliheksametilen biguanid; Polihekzametilen biguanid;polyhexamethylene biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide; Poly(hexamethylenebiguanide hydrochloride); Poliheksametilen biguanid; Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Poliheksametilen biguanid; Poliheksametilen biguanid; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), hydrochloride; Poliheksametilen biguanid; Polihekzametilen biguanid; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride; Baquacil; Caswell No. 676; Cosmocil CQ; EPA Pesticide Chemical Code 111801; PHMB; Polihexanide ; Polihexanido; Poliheksametilen biguanid; Poliheksametilen biguanid; Polihexanidum; Polyhexanide; PP 073 UNII-322U039GMF; Vantocil IB; Vantocil TG; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Poliheksametilen biguanid; PHMB; 1-(diaminomethylidene)-2-hexylguanidine; C8H19N5; Polyhexanide; Baquacil; cosmocil; Lavasept; PHMB Polymer; polihexanide; polihexanide hydrochloride; poly (hexamethylene biguanide); poly(hexamethylenebiguanide) hydrochloride; poly (iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl); Poliheksametilen biguanid; hydrochloride polyhexamethylen-biguanide; polyhexamethylenbiguanid; polyhexamethylenbiguanide; polyhexamethylene biguanide; Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride; polyhexanide; Vantocil; Vantocil IB of Vantocil; Polyhexanide; PHMB; POLIHEXANIDE; 28757-47-3; polyhexamethylene biguanide; n-hexylbiguanide; 1-Hexylbiguanide; POLYXEDININE; SCHEMBL45011;Poliheksametilen biguanid; N-Hexylimidodicarbonimidic diamide; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N```-1,6-Hexanediylbis(N`-cyanoguanidine) hexamethylenediamine polymer hydrochloride; PHMB; Polihexanide; Poliheksametilen biguanid; Polihekzametilen biguanid; 1-(diaminomethylidene)-2-hexylguanidine; C8H19N5; Polyhexanide; Baquacil; cosmocil; Lavasept; PHMB Polymer; polihexanide; polihexanide hydrochloride; poly (hexamethylene biguanide); poly(hexamethylenebiguanide) hydrochloride; poly (iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl); hydrochloride polyhexamethylen-biguanide; polyhexamethylenbiguanid; polyhexamethylenbiguanide; polyhexamethylene biguanide; polyhexamethylene biguanide hydrochloride; polyhexanide; Vantocil; Vantocil IB of Vantocil; Polyhexanide; PHMB; POLIHEXANIDE; 28757-47-3; Polyhexamethylene biguanide; n-hexylbiguanide; 1-Hexylbiguanide; POLYXEDININE; SCHEMBL45011; N-Hexylimidodicarbonimidic diamide; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N```-1,6-Hexanediylbis(N`-cyanoguanidine) hexamethylenediamine polymer hydrochloride; PHMB; Polihexanide;

POLİHEKSAMETİLEN BİGUANİDE

Poliheksametilen biguanid (Poliheksanid, PHMB) tuvalet malzemeleri gibi kişisel bakım ürünlerinde ve Poliheksametilen biguanid (Poliheksanid, PHMB) yüzme havuzlarında dezenfektan olarak bir dezenfektan olarak yaygın olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) (PHMB) CAS 32289-58-0 Poliheksametilen biguanid (Poliheksanid, PHMB) katyonik polielektrolitlerin belirgin özelliklerini taşır. Ayrıca Poliheksametilen biguanid (Poliheksanid, PHMB) organik anyonlar ve polianyon ile iyon ilişkisini kullanarak Poliheksametilen biguanid (Poliheksanid, PHMB) için benzersiz belirleme yöntemleri vardır. Poliheksanid (Poliheksametilen biguanid (Poliheksanid), PHMB) bir dezenfektan ve anti-septik olarak uygulanan bir polimerdir.

Dermatolojik kullanımda Poliheksametilen biguanid (Poliheksanid, PHMB) , polihexanide olarak da adlandırılır. Poliheksametilen biguanid (Poliheksanid, PHMB) Pseudomonas aeruginosa, Staphylococcus aureus (aynı zamanda metisiline dirençli tip, MRSA), Escherichia coli, Candida albicans (maya), Aspergillus brasiliensis (küf), vankomisine dirençli enterokoklar ve Klebsiella pneumoniae (karbapenem-dirençli enterobacteriaceae) 'ye karşı çok etkilidir. ).

Poliheksametilen biguanid (Poliheksanid, PHMB) (PHMB) CAS 32289-58-0 Poliheksametilen biguanid (Poliheksanid, PHMB) içeren bazı ürünler, ameliyat öncesi irrigasyon için, Poliheksametilen biguanid (Poliheksanid, PHMB) hem cerrahi öncesi hem de sonra cilt ve Poliheksametilen biguanid (Poliheksanid, PHMB) mukoza zarı dezenfeksiyonu, Poliheksametilen biguanid (Poliheksanid, PHMB) ameliyat sonrası pansumanlar, Poliheksametilen biguanid (Poliheksanid, PHMB) cerrahi ve cerrahi olmayan yaralar için uygulanır. Poliheksametilen biguanid (Poliheksanid, PHMB) pansuman, cerrahi banyo / hidroterapi, Poliheksametilen biguanid (Poliheksanid, PHMB) diyabetik ayak ülseri gibi kronik yaralar ve Poliheksametilen biguanid (Poliheksanid, PHMB) yanık yara yönetimi, Poliheksametilen biguanid (Poliheksanid, PHMB) küçük insizyonlar sırasında rutin antiseps, kateterizasyon, skopi, ilk yardım, yüzey dezenfeksiyonu ve keten dezenfeksiyonu. Poliheksametilen biguanid (Poliheksanid, PHMB) PHMB) CAS 32289-58-0 Poli (heksametilenbiguanid) Hcl göz damlaları, Poliheksametilen biguanid (Poliheksanid, PHMB) etkilenen gözler için tedavi olarak kullanılmıştır.

Poliheksametilen biguanid (Poliheksanid, PHMB) CAS 32289-58-0 Poli (heksametilenbiguanid) Hcl çözeltisi, bazı farmasötik veya veterinerlik formülasyonlarında önemli bir bileşendir.Poliheksametilen biguanid (Poliheksanid, PHMB) (PHMB) CAS 32289-58-0 Poliheksametilen biguanid (Poliheksanid, PHMB) bakterileri öldürmek için bir dezenfektan veya koruyucu olarak uygulanır. Poliheksametilen biguanid (Poliheksanid, PHMB) Gram-pozitif bakteriyi, gram-negatif bakteriyi, mantarı ve mayayı vb. Kısıtlar.Koruyucu olarak, Poliheksametilen biguanid (Poliheksanid, PHMB) (PHMB) CAS 32289-58-0 Poli (heksametilenbiguanid) Poliheksametilen biguanid (Poliheksanid, PHMB) kozmetik ürünler, Poliheksametilen biguanid (Poliheksanid, PHMB) kişisel bakım ürünleri, Poliheksametilen biguanid (Poliheksanid, PHMB) yumuşatıcılar, Poliheksametilen biguanid (Poliheksanid, PHMB) temas çözeltileri, Poliheksametilen biguanid (Poliheksanid, PHMB) el yıkama ürünleri vb. Poliheksametilen biguanid (Poliheksanid, PHMB) Kimyasal ürünlerden kullanılır. Poliheksametilen biguanid (Poliheksanid, PHMB) aynı zamanda hastaneler, Poliheksametilen biguanid (Poliheksanid, PHMB) okullar, Poliheksametilen biguanid (Poliheksanid, PHMB) oteller ve Poliheksametilen biguanid (Poliheksanid, PHMB) diğer birçok kamu alanı gibi yaygın olarak bulunan dezenfeksiyon alanında da uygulanmaktadır.

Poliheksametilen biguanid (Poliheksanid, PHMB) Moleküler Formülü (C8H17N5) n

Poliheksametilen biguanid (Poliheksanid, PHMB) pH Seviyesi 4 ~ 5

Poliheksametilen biguanid (Poliheksanid, PHMB) Acısının Tadı

Poliheksametilen biguanid (Poliheksanid)in Saflığı% 20

Poliheksametilen biguanid (Poliheksanid, PHMB) PHMB Bileşenleri

Poliheksametilen biguanid (Poliheksanid)'in Özellikleri PHMB (Poliheksametilen biguanid (Poliheksanid)), geniş klinik, evsel ve endüstriyel uygulamalara sahip, suda çözünür bir katyonik dezenfektandır

Poliheksametilen biguanid (Poliheksanid)in Raf Ömrü 2 Yıl

Poliheksametilen biguanid (Poliheksanid, PHMB) Oda Sıcaklığının Saklanması

Poliheksametilen biguanid (Poliheksanid, PHMB) (C8H17N5) n Yapısal Formülü

Poliheksametilen biguanid (Poliheksanid)e Sınıfı TEKNİK

Ürün Tipi Poliheksametilen biguanid (Poliheksanid)e PHMB

Poliheksametilen biguanid (Poliheksanid)e İlaç Uygulaması

Poliheksametilen biguanid (Poliheksanid, PHMB) Sıvısının Fiziksel Şekli

Poliheksametilen biguanid (Poliheksanid)e SU BEYAZININ GÖRÜNÜMÜ

Poliheksametilen biguanid (Poliheksanid), renksiz ila soluk sarı formda mevcuttur, Poliheksametilen biguanid (Poliheksanid), PHMB sıvı formda erişilebilir. Poliheksametilen biguanid (Poliheksanid), acı bir tada sahiptir ve saflık derecesi% 20'dir. Poliheksametilen biguanid (Poliheksanid), 24 ay saklanabilir. Dezenfekte edici kimyasal olan Poliheksametilen biguanid (Poliheksanid, PHMB) suda çözünür ve doğası gereği katyoniktir. Poliheksametilen biguanid (Poliheksanid), evsel, endüstriyel ve klinik uygulama amaçlarına uygundur. Poliheksametilen biguanid (Poliheksanid)in Ph seviyesi, sıvı madde 4 ila 5 arasında değişir. Poliheksametilen biguanid (Poliheksanid), PHMB, Poliheksametilen biguanid (Poliheksanid)in anti bakteriyel özelliklerini korumak için kontrollü sıcaklık altında formüle edilmiştir. Poliheksametilen biguanid (Poliheksanid, PHMB) standardı, sıvı Poliheksametilen biguanid (Poliheksanid, PHMB) bileşimi, formülasyon yöntemi, etkililiği, raf ömrü, ph değeri, olası toksin içeriği, vb. Pearance: beyaz toz; renksiz sıvı; renksiz yarı saydam kristaller. Poliheksametilen biguanid (Poliheksanid, PHMB) tahlili:% 95;% 98;% 20; % 25;% 50Poliheksametilen biguanid (Poliheksanid), dezenfektan, antibakteriyel, bakterisit, küf önleyici, yosun önleyici, topaklaştırıcı vb. Poliheksametilen biguanid (Poliheksanid, PHMB) tuvalet malzemeleri gibi kişisel bakım ürünlerinde ve Poliheksametilen biguanid (Poliheksanid, PHMB) yüzme havuzlarında dezenfektan olarak bir dezenfektan olarak yaygın olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) (PHMB) CAS 32289-58-0 Poliheksametilen biguanid (Poliheksanid, PHMB) katyonik polielektrolitlerin belirgin özelliklerini taşır. Ayrıca Poliheksametilen biguanid (Poliheksanid, PHMB) organik anyonlar ve polianyon ile iyon ilişkisini kullanarak Poliheksametilen biguanid (Poliheksanid, PHMB) için benzersiz belirleme yöntemleri vardır. Poliheksanid (Poliheksametilen biguanid (Poliheksanid), PHMB) bir dezenfektan ve anti-septik olarak uygulanan bir polimerdir.Dermatolojik kullanımda Poliheksametilen biguanid (Poliheksanid, PHMB) , polihexanide olarak da adlandırılır. Poliheksametilen biguanid (Poliheksanid, PHMB) Pseudomonas aeruginosa, Staphylococcus aureus (aynı zamanda metisiline dirençli tip, MRSA), Escherichia coli, Candida albicans (maya), Aspergillus brasiliensis (küf), vankomisine dirençli enterokoklar ve Klebsiella pneumoniae (karbapenem-dirençli enterobacteriaceae) 'ye karşı çok etkilidir. ).

Poliheksametilen biguanid (Poliheksanid, PHMB) bir başka iyi uygulaması da klor veya brom bazlı ürünler yerine bir yüzme havuzu ve spa su dezenfektanı olarak kullanılmasıdır.Poliheksametilen biguanid (Poliheksanid, PHMB) CAS 32289-58-0 Poli (heksametilentebiguanid ayrıca bazı kontakt lens temizleme ürünlerinde, Poliheksametilen biguanid (Poliheksanid, PHMB) kozmetik ürünlerinde, Poliheksametilen biguanid (Poliheksanid, PHMB) kişisel deodorantlarda ve Poliheksametilen biguanid (Poliheksanid, PHMB) bazı veterinerlik ürünlerinde bir bileşen olarak kullanılır. Poliheksametilen biguanid (Poliheksanid, PHMB) sağlık hizmetlerinde yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) kimyasallarda yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) tekstilde yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) kağıtta yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) mendillerde yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) hayvancılıkta yaygın olarak kullanılmaktadır, su ürünleri yetiştiriciliği Poliheksametilen biguanid (Poliheksanid, PHMB) balıkçılıkta, plastiklerde yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) tarımda yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) su arıtımında yaygın olarak kullanılmaktadır ve Poliheksametilen biguanid (Poliheksanid, PHMB) diğer alanlarda yaygın olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid), saflaştırılmış suyla veya diğer katkı maddesi bileşiğiyle seyreltildikten hemen sonra kullanılabilir.Poliheksametilen biguanid (Poliheksanid)'in farklı uygulama alanlarında ürün dozajı oldukça farklı olduğu için profesyonel ve teknik kişilerimizin rehberliğinde Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılması tavsiye edilir.Poliheksanid (Poliheksametilen biguanid (Poliheksanid), PHMB), dezenfektan ve antiseptik olarak kullanılan bir polimerdir. Dermatolojik kullanımda Poliheksametilen biguanid (Poliheksanid), poliheksanid (INN) olarak yazılır ve Lavasept, Serasept, Prontosan ve Omnicide gibi isimler altında satılır. Poliheksametilen biguanid (Poliheksanid)in Pseudomonas aeruginosa, Staphylococcus aureus (ayrıca metisiline dirençli tip, MRSA), Escherichia coli, Candida albicans (maya), Aspergillus brasiliensis (küf), vankomisine dirençli enterokoklara (küf) karşı etkili olduğu gösterilmiştir. dirençli enterobacteriaceae). Poliheksametilen biguanid (Poliheksanid, PHMB) içeren Poliheksametilen biguanid (Poliheksanid), inter-operatif sulamada kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) ameliyat sonrası cilt için, Poliheksametilen biguanid (Poliheksanid), ameliyat sonrası cilt için, Poliheksametilen biguanid (Poliheksanid), dezenfeksiyon için Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılır. ameliyat sonrası pansumanlar, Poliheksametilen biguanid (Poliheksanid), cerrahi için, Poliheksametilen biguanid (Poliheksanid), cerrahi olmayan yara pansumanları için, Poliheksametilen biguanid (Poliheksanid), cerrahi banyo / hidroterapi için, Poliheksametilen biguanid (Poliheksanid), diyabetik ayak ülseri ve yanık yarası yönetimi gibi kronik yaralarda kullanılır, Poliheksametilen biguanid (Poliheksanid), küçük kesiler sırasında rutin antisepsi için kullanılır; Poliheksametilen biguanid (Poliheksanid), kateterizasyon, skopi, ilk yardım, yüzey dezenfeksiyonu ve keten dezenfeksiyonu için kullanılır. Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür tuzu (çözelti), formülasyonların çoğunda kullanılır. Poliheksametilen biguanid (Poliheksanid), ilgili bir biguanid dezenfektandır. Poliheksametilen biguanid (Poliheksanid, PHMB) (yara bakım pansumanları, kontakt lens temizleme solüsyonları, perioperatif temizlik ürünleri ve yüzme havuzu temizleyicileri gibi çeşitli ürünlerde kullanılan antiviral ve antibakteriyel özelliklere sahip bir antiseptiktir. Poliheksametilen biguanid (Poliheksanid), çeşitli şekillerde kullanılan antiviral ve antibakteriyel özelliklere sahip bir antiseptiktir. yara bakım pansumanları, kontakt lens temizleme solüsyonları, perioperatif temizlik ürünleri ve yüzme havuzu temizleyicileri dahil. Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca poliheksanid ve poliaminopropil biguanid olarak bilinir, polimerik biguanid hidroklorür; poliheksanid biguanid. Poliheksametilen biguanid (Poliheksanid, PHMB) yaygın olarak kullanılan bir antiseptiktir, Poliheksametilen biguanid (Poliheksanid, PHMB) kozmetikte bir koruyucu ve kişisel bakım ürünlerinde sıklıkla kullanılan Poliheksametilen biguanid (Poliheksanid, PHMB Poliheksametilen biguanid (Poliheksanid)in Pseudomonas aeruginosa, Staphylococcus aureus (ayrıca metisiline dirençli tip, MRSA), Escherichia coli, Candida albicans (maya), Aspergillus brasiliensis (küf), vankomisine dirençli enterokoklara (küf) karşı etkili olduğu gösterilmiştir. dirençli enterobacteriaceae). Poliheksametilen biguanid (Poliheksanid, PHMB) içeren Poliheksametilen biguanid (Poliheksanid), inter-operatif sulamada kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) ameliyat sonrası cilt için, Poliheksametilen biguanid (Poliheksanid), ameliyat sonrası cilt için, Poliheksametilen biguanid (Poliheksanid), dezenfeksiyon için Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılır. ameliyat sonrası pansumanlar, Poliheksametilen biguanid (Poliheksanid), cerrahi için, Poliheksametilen biguanid (Poliheksanid), cerrahi olmayan yara pansumanları için, Poliheksametilen biguanid (Poliheksanid), cerrahi banyo / hidroterapi için, Poliheksametilen biguanid (Poliheksanid), diyabetik ayak ülseri ve yanık yarası yönetimi gibi kronik yaralarda kullanılır, Poliheksametilen biguanid (Poliheksanid), küçük kesiler sırasında rutin antisepsi için kullanılır; Poliheksametilen biguanid (Poliheksanid), kateterizasyon, skopi, ilk yardım, yüzey dezenfeksiyonu ve keten dezenfeksiyonu için kullanılır. Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür tuzu (çözelti), formülasyonların çoğunda kullanılır. Poliheksametilen biguanid (Poliheksanid), ilgili bir biguanid dezenfektandır. Poliheksametilen biguanid (Poliheksanid, PHMB) (yara bakım pansumanları, kontakt lens temizleme solüsyonları, perioperatif temizlik ürünleri ve yüzme havuzu temizleyicileri gibi çeşitli ürünlerde kullanılan antiviral ve antibakteriyel özelliklere sahip bir antiseptiktir. Poliheksametilen biguanid (Poliheksanid), çeşitli şekillerde kullanılan antiviral ve antibakteriyel özelliklere sahip bir antiseptiktir. Yara bakım pansumanları, kontakt lens temizleme solüsyonları, perioperatif temizlik ürünleri ve yüzme havuzu temizleyicileri dahil. Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca poliheksanid ve poliaminopropil biguanid olarak bilinir, polimerik biguanid hidroklorür; poliheksanid biguanid. Poliheksametilen biguanid (Poliheksanid, PHMB) yaygın olarak kullanılan bir antiseptiktir olarak PHMB, kozmetikte, kişisel bakım ürünlerinde, kumaş yumuşatıcılarında, kontakt lens solüsyonlarında, el yıkamalarında ve daha fazlasında kullanılır. Kozmetikte, Poliheksametilen biguanid (Poliheksanid, PHMB) geniş spektrumlu bir koruyucu olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) suda serbestçe çözünür ve bu nedenle mikroorganizma büyümesine en duyarlı olan su bazlı ürünlerde yaygın olarak kullanılır. Poliheksametilen biguanid (Poliheksanid), çok çeşitli Gram pozitif ve Gram negatif bakterilere, mantarlara ve mayalara karşı mükemmel bir aktiviteye sahiptir ve özellikle kontrol edilmesi zor olan Pseudomanas türleri gibi mikroorganizmalara karşı etkilidir. Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca ıslak mendilleri korumak için kullanılır; tekstilde koku kontrolü; yara irigasyonunda ve steril pansumanlarda mikrobiyal kontaminasyonu önlemek için; tıbbi / dişçilik malzemesi ve SCCS / 1581/16 Poliheksametilen biguanid (Poliheksanid, PHMB) Sunum III 13 tepsileri, çiftlik ekipmanları, hayvan içme suyu ve gıda işleme kurumları ve hastaneler için sert yüzeyler hakkında Son Görüş; ve elektrikli süpürgelerin ve tuvaletlerin kokusunu gidermek için. Poliheksametilen biguanid (Poliheksanid, PHMB) antimikrobiyal el yıkamalarında, Poliheksametilen biguanid (Poliheksanid, PHMB) losyonlarda ve Poliheksametilen biguanid (Poliheksanid, PHMB) hava filtresi işlemlerinde ozona alternatif olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca rekreasyonel su arıtımı için aktif bir bileşen olarak, çok çeşitli mikroorganizmalara karşı etkili olan klorsuz polimerik bir dezenfektan olarak kullanılır. Poliheksametilen biguanid (Poliheksanid)in bildirilen diğer kullanımları, yüzme havuzu suyunun arıtılması, bira bardağı sterilizasyonu, bira fabrikalarında katı yüzey dezenfeksiyonu ve deri ve postların kısa süreli korunmasıdır. PHMB, poliheksanid veya poliheksanid olarak da bilinen Poliheksametilen biguanid (Poliheksanid), suda oldukça çözünür ve hidrolitik olarak stabil bir polimerik malzemedir. Poliheksametilen biguanid (Poliheksanid, PHMB) içinde çoklu hidrojen bağı ve kenetleme yerlerinin mevcudiyeti, Poliheksametilen biguanid (Poliheksanid)i, supramoleküler kimya alanında potansiyel ilgi alanı haline getirmektedir. Poliheksametilen biguanid (Poliheksanid), hem Gram-pozitif hem de Gram-negatif bakterilere karşı aktivite gösterir ve çeşitli dezenfektan solüsyonları ve antiseptiklerde, tipik olarak hidroklorür tuzu olarak çeşitli sektörlerde yaygın olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) de katı halde mevcuttur. Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür (PHMB), çok çeşitli antimikrobiyal uygulamalarda kullanılan bir polimer olan kimyasal bir biyosittir. Bu derleme, hem insanlara hem de çevreye yönelik sentez yöntemleri, etki modu, antimikrobiyal etkiler ve güvenlik hususlarından Poliheksametilen biguanid (Poliheksanid, PHMB) özelliklerinin kapsamlı bir literatürünü sağlar. Hücresel organizmalara karşı etkinlik, bir heksametilen grubu olan esnek bir aralayıcıya bağlı temel biguanid grubuna bağlıdır. Poliheksametilen biguanid (Poliheksanid), hücre zarı bütünlüğünü bozarak hücre ölümünü tetikleyen geniş spektrumlu bir dezenfektandır. Poliheksametilen biguanid (Poliheksanid, PHMB) çevre dostu bir üründür, aşındırıcı değildir ve hem insanlar hem de hayvanlar için toksik değildir. Poliheksametilen biguanid (Poliheksanid, PHMB) kozmetiklerde, kişisel bakım ürünlerinde, kumaş yumuşatıcılarda, kontakt lens solüsyonlarında, el yıkamalarında ve daha fazlasında koruyucu olarak kullanılır. Kozmetikte, Poliheksametilen biguanid (Poliheksanid)e meyve ve sebzelerin korunması. Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca ıslak mendilleri korumak için kullanılır; Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca tekstilde kokuyu kontrol etmek için kullanılır; Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca yara irrigasyonunda ve steril pansumanlarda mikrobiyal kontaminasyonu önlemek için kullanılır; Poliheksametilen biguanid (Poliheksanid)e ayrıca tıbbi / diş alet ve tepsilerini dezenfekte etmek için kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca çiftlik ekipmanı olarak kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca hayvan içme suyu ve gıda işleme kurumları ve hastaneler için sert yüzeyler kullanılır; ve Poliheksametilen biguanid (Poliheksanid)e de vakum ve tuvaletlerin kokusunu gidermek için kullanılır. Poliheksametilen biguanid (Poliheksanid), potansiyel çok amaçlı işlevsel kullanım için Poliheksametilen biguanid (Poliheksanid)in geniş kabulüne ve kullanımına ek olarak geniş bir etki spektrumuna sahip çok hızlı etki ile düşük konsantrasyonlarda çalışabilir. 20 ° C ve 101.3 kPa güçlü amonyak kokusu ile off-beyaz ila soluk sarı toz

KozmetikPoliheksametilen biguanid (Poliheksanid), geniş spektrumlu koruyucu olarak kullanılır. Serbestçe suda çözünür ve bu nedenle en hassas tomikroorganizma büyümesi olan su bazlı ürünlerde yaygın olarak kullanılmaktadır. Çok çeşitli Gram pozitif ve Gram negatif bakterilere, mantarlara ve mayalara karşı mükemmel bir aktiviteye sahiptir ve özellikle kontrol edilmesi zor Pseudomanas türleri gibi mikroorganizmalara karşı etkilidir.

Poliheksametilen biguanid (Poliheksanid, PHMB) da kullanılırKorumak ıslak mendiller; Tekstildeki kokuyu kontrol etmek; mikroorganizmayı önlemek içinYara sulamada kontaminasyon ve steril pansumanlar; tıbbi/dental gereçler dezenfekte etmekVe tepsiler, çiftlik ekipmanları, hayvan içme suyu ve gıda işleme için sert yüzeylerKurumlar ve hastaneler; ve vakumlar ve tuvaletler deodorize etmek. Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılırOzona alternatif olarak antimikrobiyal el yıkama ve ovalama ve hava filtresi tedavileri.

Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca, çok çeşitli mikroorganizmalara karşı etkili olan klorsuz bir polimerik dezenfektan olarak, eğlence suyu arıtımı için aktif bir bileşen olarak kullanılır.Poliheksametilen biguanid (Poliheksanid)`nin daha fazla bildirilen kullanımları yüzme havuzu suyunun arıtılmasıdır, bira bardağıSterilize etme, bira fabrikalarında katı yüzey dezenfeksiyonu ve gizler kısa süreli korunması veDerileri. Poliheksanid (Poliheksametilen biguanid (Poliheksanid), Poliheksametilen biguanid (Poliheksanid)), dezenfektan ve antiseptik olarak kullanılan bir polimerdir. Dermatolojik kullanımda [1] poliheksanid (INN) olarak yazılır . Poliheksametilen biguanid (Poliheksanid)in bildirilen diğer kullanımları, yüzme havuzu suyunun arıtılması, bira bardağı sterilizasyonu, bira fabrikalarında katı yüzey dezenfeksiyonu ve deri ve postların kısa süreli korunmasıdır. PHMB, poliheksanid veya poliheksanid olarak da bilinen Poliheksametilen biguanid (Poliheksanid), suda oldukça çözünür ve hidrolitik olarak stabil bir polimerik malzemedir. Poliheksametilen biguanid (Poliheksanid, PHMB) içinde çoklu hidrojen bağı ve kenetleme yerlerinin mevcudiyeti, Poliheksametilen biguanid (Poliheksanid)i, supramoleküler kimya alanında potansiyel ilgi alanı haline getirmektedir. Poliheksametilen biguanid (Poliheksanid), hem Gram-pozitif hem de Gram-negatif bakterilere karşı aktivite gösterir ve çeşitli dezenfektan solüsyonları ve antiseptiklerde, tipik olarak hidroklorür tuzu olarak çeşitli sektörlerde yaygın olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) de katı halde mevcuttur. Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür (PHMB), çok çeşitli antimikrobiyal uygulamalarda kullanılan bir polimer olan kimyasal bir biyosittir. Bu derleme, hem insanlara hem de çevreye yönelik sentez yöntemleri, etki modu, antimikrobiyal etkiler ve güvenlik hususlarından Poliheksametilen biguanid (Poliheksanid, PHMB) özelliklerinin kapsamlı bir literatürünü sağlar. Hücresel organizmalara karşı etkinlik, bir heksametilen grubu olan esnek bir aralayıcıya bağlı temel biguanid grubuna bağlıdır. Poliheksametilen biguanid (Poliheksanid), hücre zarı bütünlüğünü bozarak hücre ölümünü tetikleyen geniş spektrumlu bir dezenfektandır. Poliheksametilen biguanid (Poliheksanid, PHMB) çevre dostu bir üründür, aşındırıcı değildir ve hem insanlar hem de hayvanlar için toksik değildir. Poliheksametilen biguanid (Poliheksanid, PHMB) kozmetiklerde, kişisel bakım ürünlerinde, kumaş yumuşatıcılarda, kontakt lens solüsyonlarında, el yıkamalarında ve daha fazlasında koruyucu olarak kullanılır. Kozmetikte, Poliheksametilen biguanid (Poliheksanid)e meyve ve sebzelerin korunması. Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca ıslak mendilleri korumak için kullanılır; Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca tekstilde kokuyu kontrol etmek için kullanılır; Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca yara irrigasyonunda ve steril pansumanlarda mikrobiyal kontaminasyonu önlemek için kullanılır; Poliheksametilen biguanid (Poliheksanid)e ayrıca tıbbi / diş alet ve tepsilerini dezenfekte etmek için kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca çiftlik ekipmanı olarak kullanılır, ve Lavasept, Serasept, (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Prontosan ve Omnicide gibi isimler altında satılır. [2] Poliheksametilen biguanid (Poliheksanid)`nin Pseudomonas aeruginosa, Staphylococcus aureus (ayrıca metisiline dirençli tip, MRSA), Escherichia coli, Candida albicans (maya), Aspergillus brasiliensis (küf), vankomisine dirençli enterokok ve Klebsiella pneumoniae`ye karşı etkili olduğu gösterilmiştir. dirençli enterobacteriaceae). [Poliheksanid (Poliheksametilen biguanid (Poliheksanid), Poliheksametilen biguanid (Poliheksanid)), dezenfektan ve antiseptik olarak kullanılan bir polimerdir. Dermatolojik kullanımda [1] poliheksanid (INN) olarak yazılır Poliheksametilen biguanid (Poliheksanid, PHMB) sağlık hizmetlerinde yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) kimyasallarda yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) tekstilde yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) kağıtta yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) mendillerde yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) hayvancılıkta yaygın olarak kullanılmaktadır, su ürünleri yetiştiriciliği Poliheksametilen biguanid (Poliheksanid, PHMB) balıkçılıkta, plastiklerde yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) tarımda yaygın olarak kullanılmaktadır, Poliheksametilen biguanid (Poliheksanid, PHMB) su arıtımında yaygın olarak kullanılmaktadır ve Poliheksametilen biguanid (Poliheksanid, PHMB) diğer alanlarda yaygın olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid), saflaştırılmış suyla veya diğer katkı maddesi bileşiğiyle seyreltildikten hemen sonra kullanılabilir. Referans miktarı 1: 125 ~ 1: 1000 (w / w).

Poliheksametilen biguanid (Poliheksanid)'in farklı uygulama alanlarında ürün dozajı oldukça farklı olduğu için profesyonel ve teknik kişilerimizin rehberliğinde Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılması tavsiye edilir.Poliheksanid (Poliheksametilen biguanid (Poliheksanid), PHMB), dezenfektan ve antiseptik olarak kullanılan bir polimerdir. Dermatolojik kullanımda Poliheksametilen biguanid (Poliheksanid), poliheksanid (INN) olarak yazılır ve Lavasept, Serasept, Prontosan ve Omnicide gibi isimler altında satılır. Poliheksametilen biguanid (Poliheksanid)in Pseudomonas aeruginosa, Staphylococcus aureus (ayrıca metisiline dirençli tip, MRSA), Escherichia coli, Candida albicans (maya), Aspergillus brasiliensis (küf), vankomisine dirençli enterokoklara (küf) karşı etkili olduğu gösterilmiştir. dirençli enterobacteriaceae). Poliheksametilen biguanid (Poliheksanid, PHMB) içeren Poliheksametilen biguanid (Poliheksanid), inter-operatif sulamada kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) ameliyat sonrası cilt için, Poliheksametilen biguanid (Poliheksanid), ameliyat sonrası cilt için, Poliheksametilen biguanid (Poliheksanid), dezenfeksiyon için Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılır. ameliyat sonrası pansumanlar, Poliheksametilen biguanid (Poliheksanid), cerrahi için, Poliheksametilen biguanid (Poliheksanid), cerrahi olmayan yara pansumanları için, Poliheksametilen biguanid (Poliheksanid), cerrahi banyo / hidroterapi için, Poliheksametilen biguanid (Poliheksanid), diyabetik ayak ülseri ve yanık yarası yönetimi gibi kronik yaralarda kullanılır, Poliheksametilen biguanid (Poliheksanid), küçük kesiler sırasında rutin antisepsi için kullanılır; Poliheksametilen biguanid (Poliheksanid), kateterizasyon, skopi, ilk yardım, yüzey dezenfeksiyonu ve keten dezenfeksiyonu için kullanılır. Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür tuzu (çözelti), formülasyonların çoğunda kullanılır. Poliheksametilen biguanid (Poliheksanid), ilgili bir biguanid dezenfektandır. Poliheksametilen biguanid (Poliheksanid, PHMB) (yara bakım pansumanları, kontakt lens temizleme solüsyonları, perioperatif temizlik ürünleri ve yüzme havuzu temizleyicileri gibi çeşitli ürünlerde kullanılan antiviral ve antibakteriyel özelliklere sahip bir antiseptiktir. Poliheksametilen biguanid (Poliheksanid), çeşitli şekillerde kullanılan antiviral ve antibakteriyel özelliklere sahip bir antiseptiktir. ve Lavasept, Serasept, Prontosan ve Omnicide gibi isimler altında satılır. [2] Poliheksametilen biguanid (Poliheksanid)`nin Pseudomonas aeruginosa, Staphylococcus aureus (ayrıca metisiline dirençli tip, MRSA), Escherichia coli, Candida albicans (maya), Aspergillus brasiliensis (küf), vankomisine dirençli enterokok ve Klebsiella pneumoniae`ye karşı etkili olduğu gösterilmiştir. dirençli enterobacteriaceae). (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Poliheksametilen biguanid (Poliheksanid, PHMB) içeren bazı ürünler, inter-operatif irrigasyon, ameliyat öncesi ve sonrası cilt ve mukoz membran dezenfeksiyonu, ameliyat sonrası pansumanlar, cerrahi ve cerrahi olmayan yara pansumanları, cerrahi banyo / hidroterapi, diyabetik ayak ülseri ve yanık gibi kronik yaralar için kullanılır. yara yönetimi, küçük kesiler sırasında rutin antisepsi, kateterizasyon, skopi, ilk yardım, yüzey dezenfeksiyonu ve keten dezenfeksiyonu. [Acanthamoeba keratitinden etkilenen gözlerin tedavisi için Poliheksametilen biguanid (Poliheksanid, PHMB) göz damlaları kullanılmıştır.(Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Baquacil markalı, klor veya brom bazlı ürünler yerine yüzme havuzu ve spa suyu dezenfektanı olarak da bir uygulamaya sahiptir. Baqua-Spa 3 sanitize olarak, Poliheksametilen biguanid (Poliheksanid), renksiz ila soluk sarı formda mevcuttur, Poliheksametilen biguanid (Poliheksanid), PHMB sıvı formda erişilebilir. Poliheksametilen biguanid (Poliheksanid), acı bir tada sahiptir ve saflık derecesi% 20'dir. Poliheksametilen biguanid (Poliheksanid), 24 ay saklanabilir. Dezenfekte edici kimyasal olan Poliheksametilen biguanid (Poliheksanid, PHMB) suda çözünür ve doğası gereği katyoniktir. Poliheksametilen biguanid (Poliheksanid), evsel, endüstriyel ve klinik uygulama amaçlarına uygundur. Poliheksametilen biguanid (Poliheksanid)in Ph seviyesi, sıvı madde 4 ila 5 arasında değişir. Poliheksametilen biguanid (Poliheksanid), PHMB, Poliheksametilen biguanid (Poliheksanid)in anti bakteriyel özelliklerini korumak için kontrollü sıcaklık altında formüle edilmiştir. Poliheksametilen biguanid (Poliheksanid, PHMB) standardı, sıvı Poliheksametilen biguanid (Poliheksanid, PHMB) bileşimi, formülasyon yöntemi, etkililiği, raf ömrü, ph değeri, olası toksin içeriği, vb. Pearance: beyaz toz; renksiz sıvı; renksiz yarı saydam kristaller. Revacil Spa 3 dezenfektanı olarak ve Leisure Time Free sisteminde mevcuttur.(Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca bazı kontakt lens temizleme ürünlerinde, kozmetiklerde, kişisel deodorantlarda ve bazı veterinerlik ürünlerinde bir bileşen olarak kullanılır. Ayrıca, istenmeyen kokuların gelişmesini önlemek için olduğu iddia edilen kıyafetleri tedavi etmek için de kullanılır (Purista). (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür tuzu (çözelti), formülasyonların çoğunda kullanılır.Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür -% 20 sulu çözeltiPoliheksametilen biguanid (Poliheksanid), poliheksanid veya poliheksanid olarak da bilinen Poliheksametilen biguanid (Poliheksanid)in, suda oldukça çözünür ve hidrolitik olarak stabil bir polimerik malzemedir. Poliheksametilen biguanid (Poliheksanid, PHMB) içinde çoklu hidrojen bağı ve şelasyon yerlerinin varlığı, onu supramoleküler kimya alanında potansiyel ilgi alanı haline getirir. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide) Poliheksametilen biguanid (Poliheksanid), hem Gram-pozitif hem de Gram-negatif bakterilere karşı aktivite gösterir ve çeşitli dezenfektan solüsyonları ve antiseptiklerde, tipik olarak hidroklorür tuzu olarak çeşitli sektörlerde yaygın olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid), katı olarak da mevcuttur. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Aktif bileşen (ai) Poly Hexa Metilen Biguanide (Poliheksametilen biguanid (Poliheksanid)), iki monomerin (1,6-heksanmetilendiamin ve N, N `` `- 1,6-heksandiilbis [N`-siyanoguanidin] polikondensasyonuyla elde edilen küçük boyutlu bir polimerdir. (yani. HMBDA)). Poliheksametilen biguanid (Poliheksanid, PHMB) küçük boyutlu bir polimer olduğundan, imalat işlemi sırasında meydana gelen bazı yan reaksiyonlar, polimerin yapısını önemli ölçüde değiştirebilir. Birim guanidin elde etmek için yan reaksiyon, işlemde% 10`a kadar meydana geldi. Bu nedenle Poliheksametilen biguanid (Poliheksanid)`nin yapısının sadece tekrarlayan guanidin biriminden oluşmadığı, aynı zamanda tekrarlayan guanidin ve biguanid biriminden oluştuğu düşünülebilir. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Üretildiği haliyle aktif madde (TK3),% 20 a / a sulu Poliheksametilen biguanid (Poliheksanid, PHMB) çözeltisidir. "Saflık", polimerler ve ilgili maddelerin bir karışımı olan Poliheksametilen biguanid (Poliheksanid)`ye uygulanması zor bir kavramdır. Bunun yerine, başvuru sahibi, "toplam katıların yüzdesi" veya "kurutulmuş malzeme" olarak tanımlanan polimerin "gücüne" atıfta bulunmaktadır. Poliheksametilen biguanid (Poliheksanid), renksiz ila soluk sarı formda mevcuttur, Poliheksametilen biguanid (Poliheksanid), PHMB sıvı formda erişilebilir. Poliheksametilen biguanid (Poliheksanid), acı bir tada sahiptir ve saflık derecesi% 20'dir. Poliheksametilen biguanid (Poliheksanid), 24 ay saklanabilir. Dezenfekte edici kimyasal olan Poliheksametilen biguanid (Poliheksanid, PHMB) suda çözünür ve doğası gereği katyoniktir. Poliheksametilen biguanid (Poliheksanid), evsel, endüstriyel ve klinik uygulama amaçlarına uygundur. Poliheksametilen biguanid (Poliheksanid)in Ph seviyesi, sıvı madde 4 ila 5 arasında değişir. Poliheksametilen biguanid (Poliheksanid), PHMB, Poliheksametilen biguanid (Poliheksanid)in anti bakteriyel özelliklerini korumak için kontrollü sıcaklık altında formüle edilmiştir. Poliheksametilen biguanid (Poliheksanid, PHMB) standardı, sıvı Poliheksametilen biguanid (Poliheksanid, PHMB) bileşimi, formülasyon yöntemi, etkililiği, raf ömrü, ph değeri, olası toksin içeriği, vb. Pearance: beyaz toz; renksiz sıvı; renksiz yarı saydam kristaller. Poliheksametilen biguanid (Poliheksanid, PHMB) tahlili:% 95;% 98;% 20; % 25;% 50 Poliheksametilen biguanid (Poliheksanid), dezenfektan, antibakteriyel, bakterisit, küf önleyici, yosun önleyici, topaklaştırıcı vb. Poliheksametilen biguanid (Poliheksanid, PHMB) tuvalet malzemeleri gibi kişisel bakım ürünlerinde ve Poliheksametilen biguanid (Poliheksanid, PHMB) yüzme havuzlarında dezenfektan olarak bir dezenfektan olarak yaygın olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) (PHMB) CAS 32289-58-0 Poliheksametilen biguanid (Poliheksanid, PHMB) katyonik polielektrolitlerin belirgin özelliklerini taşır. Ayrıca Poliheksametilen biguanid (Poliheksanid, PHMB) organik anyonlar ve polianyon ile iyon ilişkisini kullanarak Poliheksametilen biguanid (Poliheksanid, PHMB) için benzersiz belirleme yöntemleri vardır. Poliheksanid (Poliheksametilen biguanid (Poliheksanid), PHMB) bir dezenfektan ve anti-septik olarak uygulanan bir polimerdir. Dermatolojik kullanımda Poliheksametilen biguanid (Poliheksanid, PHMB) , polihexanide olarak da adlandırılır. Poliheksametilen biguanid (Poliheksanid, PHMB) Pseudomonas aeruginosa, Staphylococcus aureus (aynı zamanda metisiline dirençli tip, MRSA), Escherichia coli, Candida albicans (maya), Aspergillus brasiliensis (küf), vankomisine dirençli enterokoklar ve Klebsiella pneumoniae (karbapenem-dirençli enterobacteriaceae) 'ye karşı çok etkilidir. ).

Poliheksametilen biguanid (Poliheksanid), gıda dezenfeksiyonu da dahil olmak üzere gelişmiş çevresel işlemler için umut verici olacak, Poliheksametilen biguanid (Poliheksanid, PHMB) su dezenfeksiyonu için umut verici olacak, Poliheksametilen biguanid (Poliheksanid, PHMB) yüzey dezenfeksiyonu için umut verici olacak ve ideal bir antimikrobiyal ajan için kriterleri karşılayacaktır. Dezenfekte edici ajan, cansız nesneler ve yüzeyler üzerindeki zararlı mikroorganizmaları (yani bakteriler, virüsler veya mantarlar) kontrol etmek, önlemek veya yok etmek için kullanılan bir maddedir. Poliheksametilen biguanid (Poliheksanid), çoğu patojenik mikroorganizmayı yok eder veya geri dönüşü olmayan bir şekilde inaktive eder (Ewart, 2001; EPA, 2004; Quinn ve Markey, 2001; Kennedy ve diğerleri, 2000). Kimyasal dezenfektanlar yaklaşık 150 yıl önce bilimsel olarak kullanılıyordu, ancak eski zamanlarda deneysel uygulamalar bulunabilir. O zamandan beri birkaç yeni biyosit piyasaya sürüldü ve mikroorganizmalara karşı aktiviteleri üzerine önemli miktarda araştırma yapıldı. Biguanidinler, birçok bilinen veya potansiyel uygulamaya sahip ilginç bir bileşik sınıfıdır. Daha düşük konsantrasyonlarda bakteriostatiktir, membran enzimlerini inhibe eder ve hücresel bileşenlerin sızmasını teşvik eder. Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür kimyasal bir biyosittir ve polimerik guanidin ailesinin bir üyesi, gıda endüstrisinde dezenfektan, antiseptik ve genel dezenfektan olarak ve yüzme havuzlarının dezenfeksiyonunda çok başarılı bir şekilde kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) kullanılan biyosit, ABD Çevre Koruma Ajansı (EPA) tarafından gözden geçirilmiş ve mesleki kullanıcılar haricinde, topluma veya çevreye olumsuz sağlık etkileri açısından çok düşük toplam riske sahip olduğu belirtilmiştir (EPA, 2005). Poliheksametilen biguanid (Poliheksanid), bakteri hücre duvarındaki negatif yüklü fosfolipidlerin fosfat baş gruplarına bağlanarak sertliğin artmasına neden olarak polar olmayan British Journal of Environmental Sciences Cilt 4, No. 1, s. 49-55, Şubat 2016 ___ Avrupa Araştırma Merkezi tarafından yayınlandı Training and Development UK (www.eajournals.org) 50 ISSN 2055-0219 (Baskı), ISSN 2055-0227 (çevrimiçi) segmentler hidrofobik alanlara bölünerek, hücre ölümüyle sonuçlanan sonraki sitoplazmik dökülme ile membranı bozar (Kaehn, 2010) . Poliheksametilen biguanid (Poliheksanid)e direnç kazanan bakteri vakaları bildirilmemiştir. Poliheksametilen biguanid (Poliheksanid, PHMB) ciltte, gözlerde, burun kirpikli epitelinde ve yaralarda topikal olarak kullanıldığında iyi tolere edilir (Kaehn, 2010; Kramer ve diğerleri, 2004; Dissemond ve diğerleri, 2009; Kramer ve diğerleri, 2008). Artık sıvılar, jeller ve antimikrobiyal sargıları içeren Poliheksametilen biguanid (Poliheksanid, PHMB) içeren ürünler pazarı hızla genişlemektedir. Bu makale Poliheksametilen biguanid (Poliheksanid)in antimikrobiyal özelliklerine dair kanıtları özetlemektedir. PHMB ilk olarak Rose ve Swain (1954) tarafından sentezlendi. Poliheksametilen biguanid (Poliheksanid), çok çeşitli antibakteriyel uygulamalarda kullanılan katyonik bir biguanid polimeridir (O'Malley ve diğerleri, 2007). Poliheksametilen biguanid (Poliheksanid, PHMB) hazırlamak için çeşitli yöntemler geliştirilmiştir. Örneğin, mevcut yöntemlerden biri, iki aşamada sodyum disiyanamid ve heksametilendiaminin polikondensasyonu yoluyla Poliheksametilen biguanid (Poliheksanid, PHMB) elde etmektir (de Paula ve diğerleri, 2011). Poliheksametilen biguanid (Poliheksanid, PHMB) preparatları, ağırlıklı ortalama sayısı (n) 12 tekrarlayan heksametilen biguanid birimi olan polimerik biguanidlerin polidispers karışımlarıdır. Molekülün heterojenliği, her zincirin terminal pozisyonlarında herhangi bir kombinasyonda amin veya siyanoguanidin veya guanidin uç gruplarının varlığıyla daha da artar. Eşit miktarlarda (molar olarak) heksametilendiamin ve guanidin hidroklorür, mekanik bir karıştırıcı ve vakum sistemi ile donatılmış yuvarlak tabanlı, üç boyunlu bir şişede karıştırılır. Karışım 100 ° C'de 60 dakika ve ardından 170 ° C'de belirli bir süre reaksiyona girer. Reaksiyon sırasında, yan ürün amonyak, sulu HCl'den köpürtülerek nötralize edilir. Reaksiyonun sonunda, hafif sarı, viskoz sıvı, Poliheksametilen biguanid (Poliheksanid, PHMB) numunelerini vererek, soğuduktan sonra katılaşır (Wei ve diğerleri, 2009). Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca tıbbi / diş aletlerini ve tepsileri, çiftlik ekipmanlarını dezenfekte etmek için kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) de hayvan içme suyu olarak kullanılır ve Poliheksametilen biguanid (Poliheksanid, PHMB) de gıda işleme kurumları ve hastaneler için sert yüzeylerde kullanılır. Poliheksametilen biguanid (Poliheksanid, PHMB) antimikrobiyal el yıkamalarında, Poliheksametilen biguanid (Poliheksanid, PHMB) losyonlarda ve Poliheksametilen biguanid (Poliheksanid, PHMB) hava filtresi işlemlerinde ozona alternatif olarak kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca rekreasyonel su arıtımı için aktif bir bileşen olarak, çok çeşitli mikroorganizmalara karşı etkili bir klorsuz polimerik dezenfektan olarak kullanılır. Poliheksametilen biguanid (Poliheksanid), yüzme havuzu dezenfektanlarından kozmetik ve kontakt lens solüsyonlarındaki koruyuculara kadar çok çeşitli uygulamalarda kullanılmaktadır (Bucher, 2012). Klinik çalışmalar, Poliheksametilen biguanid (Poliheksanid)in insan immün yetmezlik virüsüne (HIV) karşı da dahil olmak üzere geniş bir aktivite spektrumuna sahip olduğunu göstermektedir (Wérthen ve diğerleri, 2004; Krebs ve diğerleri, 2005). Poliheksametilen biguanid (Poliheksanid), klinisyenlere çoğu klinik senaryo için etkili yara bakım modaliteleri sağlayan sunumlarda mevcut gibi görünmektedir ve ayrıca perioperatif temizlik ajanı olarak (Kramer, 1997), ağız yıkamada (Rosin, 2002) oftalmolojide (Kramer , 1997; Petrou-Binder, 2003). Petrou-Binder40, katarakt ameliyatından önce göz damlası olarak Poliheksametilen biguanid (Poliheksanid)in (Lavasept% 0.02) mikrop öldürücü etkilerini açıklamaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) yüzme havuzu dezenfektanlarında, Poliheksametilen biguanid (Poliheksanid, PHMB) kozmetikte, Poliheksametilen biguanid (Poliheksanid, PHMB) deri koruyucularda, Poliheksametilen biguanid (Poliheksanid, PHMB) kontakt lens dezenfektanlarında, Poliheksametilen biguanid (Poliheksanid, PHMB) tarımda temizleyici biguanide ve Poliheksametilen içinde bulunabilir. Gıda işlemede, Poliheksametilen biguanid (Poliheksanid)e, kuluçkalık yumurtaların tedavisinde bulunabilir, Poliheksametilen biguanid (Poliheksanid, PHMB) liflerde bulunabilir ve Poliheksametilen biguanid (Poliheksanid), tekstillerde ve kesme yağları ve yapıştırıcılar gibi teknik sıvılarda bulunabilir. Poliheksametilen biguanid (Poliheksanid), çevre dostu bir ürün olan ve kozmetik, deodorant, kontakt lens solüsyonları, kumaş yumuşatıcıları, su tedavileri gibi çok çeşitli ürünlerde değerli dezenfeksiyon, temizlik ve hijyen fonksiyonları sağlamak için gelecekte yaygın olarak kullanılması beklenen mükemmel bir biyosittir. , yara bakım ürünleri ve antimikrobiyal köpük örtüler. Poliheksametilen biguanid (Poliheksanid, PHMB) olması bekleniyor; havuz temizleyicilerinin bir bileşeni olan Poliheksametilen biguanid (Poliheksanid)'in cilt dezenfektanları ve idrar sondası yıkama solüsyonları olması beklenir; Poliheksametilen biguanid (Poliheksanid)'in farklı uygulamalarda dezenfektanlara ihtiyacı vardır; Poliheksametilen biguanid (Poliheksanid)in hastanelerde, gıda ve gıda ile temas eden ekipmanlarda dezenfektan olması beklenmektedir. Poliheksametilen biguanid (Poliheksanid)in bazı güncel özellikleri ve uygulamalarına genel bir bakış verildi ve tartışıldı. Poliheksametilen biguanid (Poliheksanid), çevre dostu bir biyosittir. Poliheksametilen biguanid (Poliheksanid), yaşamın her alanında geniş bir uygulama alanı olan yeni nesil bir dezenfektandır. Poliheksametilen biguanid (Poliheksanid), bakterilere, virüslere ve mantarlara karşı geniş bir aktivite yelpazesine sahip bir dezenfektandır. Poliheksametilen biguanid (Poliheksanid, PHMB) incelemesi, sentez yöntemlerinden, antimikrobiyal etkilerden ve hem insanlara hem de çevreye yönelik güvenlik hususlarından Poliheksametilen biguanid (Poliheksanid)in kapsamlı bir literatürünü sağlar. Poliheksametilen biguanid (Poliheksanid)in, çok çeşitli tüketici ve endüstriyel ürünlerde ve birçok pazar lideri şirket tarafından kullanılmaya devam ettiğine inanılmaktadır. Dezenfektan olarak Poliheksametilen biguanid (Poliheksanid), gıda dezenfeksiyonu da dahil olmak üzere gelişmiş çevresel işlemler için ümit verici olacak, dezenfektan olarak Poliheksametilen biguanid (Poliheksanid, PHMB) su dezenfeksiyonu için umut verici olacak, dezenfektan olarak Poliheksametilen biguanid (Poliheksanid, PHMB) yüzey dezenfeksiyonu için umut verici olacak ve ideal bir antimikrobiyal ajan kriterlerini karşılayacaktır. Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür, kısmen Poliheksametilen biguanid (Poliheksanid, PHMB) (2+) 'ye sahiptir Poliheksametilen biguanid (Poliheksanid), antibakteriyel ajan rolüne sahiptir. Poliheksametilen biguanid (Poliheksanid), antiseptik ilaç rolüne sahiptir. Poliheksametilen biguanid (Poliheksanid), dermatolojik ilaç rolüne sahiptir. Poliheksametilen biguanid (Poliheksanid), rol dezenfektanına sahiptir. Poliheksametilen biguanid (Poliheksanid), oftalmoloji ilacı rolüne sahiptir. Poliheksametilen biguanid (Poliheksanid), bir hidroklorürdür. Kozmetikte koruyucu olarak kullanılan Poliheksametilen biguanid (Poliheksanid)in güvenliği bu değerlendirmede gözden geçirilmiştir. Poliheksametilen biguanid (Poliheksanid), Uluslararası Kozmetik İçerikler Adlandırması (INCI) adıdır; Poliheksametilen biguanid (Poliheksanid), heksil biguanid tekrar birimleri (yani Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür (Poliheksametilen biguanid (Poliheksanid, PHMB) HCl)) içeren bir amino polimerin hidroklorür tuzunu ifade eder. Poliheksametilen biguanid (Poliheksanid), her bir monomerik tekrar biriminde 6 karbonlu bir zincire sahiptir ve her zaman hidroklorür tuzu olarak sağlanır. Poliaminopropil biguanid kimyasal adıyla tanımlanan Poliheksametilen biguanid (Poliheksanid), kozmetik bir bileşen değildir. Buna göre, bu rapor boyunca, büyük harfle yazılan INCI adı Poliheksametilen biguanid (Poliheksanid, PHMB) kullanıldığında, Poliheksametilen biguanid (Poliheksanid)in, Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür kimyasal adı olan kozmetik bileşene atıfta bulunduğu anlaşılmalıdır. Poliheksametilen biguanid (Poliheksanid, PHMB) de Poliheksametilen biguanid (Poliheksanid)in kozmetikte bildirilen kullanımları içeren bileşen olduğu anlaşılmalıdır. Ayrıca, bu raporda yer alan güvenlik testi verilerinin çoğu, INCI adının kullanımıyla belirtildiği gibi kimyasal Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür üzerinedir. Bu güvenlik değerlendirmesinde INCI adının Poliheksametilen biguanid (Poliheksanid)'in özel kullanımının tek istisnası, Poliheksametilen biguanid (Poliheksanid, PHMB) ve Poliheksametilen biguanid (Poliheksanid, PHMB) sonuçlarının karşılaştırıldığı bir sitoksisite çalışmasının özetiyle ilgilidir. Ek olarak,

Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca bebek losyonlarında, yağlarında veya kremlerinde% 0,1'e kadar maksimum kullanım konsantrasyonlarında kullanılmaktadır. Poliheksametilen biguanid (Poliheksanid, PHMB) içeren ürünler, günde birkaç kez sıklıkta uygulanabilir ve uygulamayı takiben değişken süreler boyunca deri veya saçla temas edebilir. Günlük veya ara sıra kullanım yıllarca uzayabilir. FDA VCRP'ye göre, Poliheksametilen biguanid (Poliheksanid, PHMB) bir koku preparasyonunda kullanılır ve bu da içeriğin tesadüfen solunmasına maruz kalmaya neden olabilir; bu kullanım için konsantrasyon verileri rapor edilmemiştir. SCCS başlangıçta Poliheksametilen biguanid (Poliheksanid)in maksimum% 0,3 konsantrasyona kadar koruyucu olarak kullanıldığında tüm kozmetik ürünlerde tüketiciler için güvenli olmadığı sonucuna varmıştır.12 2017 yılında SCCS, "Poliheksametilen biguanid (Poliheksanid)in bir koruyucu olarak kullanılması % 0.1'e kadar konsantrasyonlarda tüm kozmetik ürünlerde koruyucu güvenlidir ve püskürtülebilir formülasyonlarda kullanılması tavsiye edilmez ”. 2 Poliheksametilen biguanid (Poliheksanid, PHMB) şu anda Avrupa Komisyonu (EC) Düzenlemesi No. 1223/2009 (Kozmetik Yönetmelik) Ek V'te (giriş 28) tüm kozmetik ürünlerde maksimum% 0,3 konsantrasyonda kullanılacak bir koruyucu olarak listelenmiştir. 2,13 Ek olarak, Poliheksametilen biguanid (Poliheksanid, PHMB) 944/2013 sayılı Komisyon Tüzüğüne (AB) göre CMR 2 (Carc. 2) olarak sınıflandırılmıştır. CMR maddeleri kanserojen, mutajenik veya üreme için toksik olarak sınıflandırılır. Poliheksametilen biguanid (Poliheksanid), insan ve / veya hayvan çalışmalarından elde edilen kanıtlar, Poliheksametilen biguanid (Poliheksanid)in kozmetik bir bileşen olarak kullanımının yasak olduğu düşünüldüğünde, kanserojen Kategori 2'ye (Carc. 2, şüpheli insan kanserojenleri) yerleştirilir. bu tarihin. Poliheksametilen biguanid (Poliheksanid), Avrupa Komisyonu'nun bu bileşenin bir CMR maddesi olarak sınıflandırmasına göre, Ocak 2015'ten beri Danimarka'da kişisel bakım ürünlerinden yasaklanmıştır.13 Poliheksametilen biguanid (Poliheksanid), eğer bir risk değerlendirmesi gösteriyorsa, CMR maddelerinin kozmetik ürünlerde kullanılabileceği kaydedilmiştir. Maddenin kullanımı güvenlidir. SCCS'nin kozmetikte güvenli bir Poliheksametilen biguanid (Poliheksanid, PHMB) seviyesi belirleyen sonucuna atıfta bulunuldu. CIR güvenlik değerlendirmelerinde, Poliheksametilen biguanid (Poliheksanid), INCI adlarını büyük harfle yazmak için standart prosedürdür, ancak standart kimyasal adlar için küçük harf kullanmaktır. Buna göre, bu rapor boyunca, büyük harfle yazılmış INCI adı Poliheksametilen biguanid (Poliheksanid, PHMB) kullanıldığında, Poliheksametilen biguanid (Poliheksanid)in, Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür kimyasal ismine sahip kozmetik bileşene atıfta bulunduğu anlaşılmalıdır. Poliheksametilen biguanid (Poliheksanid, PHMB) de Poliheksametilen biguanid (Poliheksanid)in kozmetikte bildirilen kullanımları olan bileşen olduğu anlaşılmalıdır. Ayrıca, bu raporda yer alan güvenlik testi verilerinin çoğu, INCI adının kullanımıyla belirtildiği gibi kimyasal Poliheksametilen biguanid (Poliheksanid, PHMB) hidroklorür üzerinedir. Bu güvenlik değerlendirmesinde INCI adının Poliheksametilen biguanid (Poliheksanid)'in özel kullanımının tek istisnası, Poliheksametilen biguanid (Poliheksanid, PHMB) ve Poliheksametilen biguanid (Poliheksanid, PHMB) sonuçlarının karşılaştırıldığı bir sitoksisite çalışmasının özetiyle ilgilidir. 2017'de Tüketici Güvenliği Bilimsel Komitesi (SCCS), Poliheksametilen biguanid (Poliheksanid)'in tüm kozmetik ürünlerde koruyucu olarak% 0,1'e kadar konsantrasyonlarda kullanımının güvenli olduğunu ve püskürtülebilir formülasyonlarda kullanımının tavsiye edilmediğini belirten nihai bir görüş yayınladı.2 Ek olarak, Poliheksametilen biguanid (Poliheksanid), Amerika Birleşik Devletleri Çevre Koruma Ajansı (EPA) tarafından incelenmiştir. Bir kimyasal tedarikçiden Poliheksametilen biguanid (Poliheksanid, PHMB) kimliğine ilişkin yorumlar alındı, bu da etkili bir şekilde tüm Poliheksametilen biguanid (Poliheksanid)in Poliheksametilen biguanid (Poliheksanid, PHMB) HCl (yani, biguanid grupları ile birbirine bağlanmış C6 alkil zincirleri) olduğunu ve hiçbir propil biguanid grubunun mevcut olmadığını (INCI adı, Polyaminopropyl Biguanide, bileşenin polimer tekrar eden birimlerini tanımlamak için C6 alkil zincirlerinin ortasını rastgele seçmenin bir ürünüdür). Poliheksametilen biguanid (Poliheksanid), Poliheksametilen biguanid (Poliheksanid, PHMB) saf formunda,>% 94,2 saflığa sahip bir katı / toz olan ve genellikle yaklaşık% 20 sulu çözelti olarak pazarlanan bir polimerdir. . Poliheksametilen biguanid (Poliheksanid), çok çeşitli antibakteriyel uygulamalarda kullanılan katyonik bir biguanid polimeridir (O'Malley ve diğerleri, 2007). Poliheksametilen biguanid (Poliheksanid, PHMB) hazırlamak için çeşitli yöntemler geliştirilmiştir. Örneğin, mevcut yöntemlerden biri, iki aşamada sodyum disiyanamid ve heksametilendiaminin polikondensasyonu yoluyla Poliheksametilen biguanid (Poliheksanid, PHMB) elde etmektir (de Paula ve diğerleri, 2011). Poliheksametilen biguanid (Poliheksanid, PHMB) preparatları, ağırlıklı ortalama sayısı (n) 12 tekrarlayan heksametilen biguanid birimi olan polimerik biguanidlerin polidispers karışımlarıdır. Molekülün heterojenliği, her zincirin terminal pozisyonlarında herhangi bir kombinasyonda amin veya siyanoguanidin veya guanidin uç gruplarının varlığıyla daha da artar. Eşit miktarlarda (molar olarak) heksametilendiamin ve guanidin hidroklorür, mekanik bir karıştırıcı ve vakum sistemi ile donatılmış yuvarlak tabanlı, üç boyunlu bir şişede karıştırılır. Karışım 100 ° C'de 60 dakika ve ardından 170 ° C'de belirli bir süre reaksiyona girer. Reaksiyon sırasında, yan ürün amonyak, sulu HCl'den köpürtülerek nötralize edilir. Reaksiyonun sonunda, hafif sarı, viskoz sıvı, Poliheksametilen biguanid (Poliheksanid, PHMB) numunelerini vererek, soğuduktan sonra katılaşır (Wei ve diğerleri, 2009). PHMG, tarım ve gıda işleme tesisleri, lojistik, mutfaklar, nakliye araçlarında geniş bir uygulama alanına sahip yeni nesil bir dezenfektandır. Poliheksametilen biguanid (Poliheksanid), hücre zarı bütünlüğünü bozarak hücre ölümünü indükleyen, bakterilere, virüslere ve mantarlara karşı geniş bir aktivite yelpazesine sahip bir dezenfektandır (Ikeda ve diğerleri, 1983; Ikeda ve diğerleri, 1984; Moore ve Gray, 2007;). ve Poliheksametilen biguanid (Poliheksanid, PHMB) kozmetiklerde, kişisel bakım ürünlerinde, kumaş yumuşatıcılarda, kontakt lens solüsyonlarında, el yıkamalarında ve daha fazlasında koruyucu olarak kullanılır. Kozmetikte meyve ve sebzelerin korunması (KoffiNevry ve diğerleri, 2011; Kabara, 1984; Dugard ve Mawdsley, 1982). Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca ıslak mendilleri korumak için kullanılır; Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca tekstilde kokuyu kontrol etmek için kullanılır; Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca yara irigasyonunda mikrobiyal kontaminasyonu önlemek için kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) de steril pansumanlarda kullanılır; Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca vakum ve tuvaletlerin kokusunu gidermek için kullanılır (SCCS, 2005); Poliheksametilen biguanid (Poliheksanid, PHMB) ayrıca tıbbi / diş aletlerini ve tepsileri, çiftlik ekipmanlarını dezenfekte etmek için kullanılır, Poliheksametilen biguanid (Poliheksanid, PHMB) de hayvan içme suyu olarak kullanılır ve Poliheksametilen biguanid (Poliheksanid, PHMB) de gıda işleme kurumları ve hastaneler için sert yüzeylerde kullanılır. Poliheksametilen biguanid (Poliheksanid, PHMB) (PHMB) CAS 32289-58-0 Poliheksametilen biguanid (Poliheksanid, PHMB) bakterileri öldürmek için bir dezenfektan veya koruyucu olarak uygulanır. Poliheksametilen biguanid (Poliheksanid, PHMB) Gram-pozitif bakteriyi, gram-negatif bakteriyi, mantarı ve mayayı vb. Kısıtlar. Koruyucu olarak, Poliheksametilen biguanid (Poliheksanid, PHMB) (PHMB) CAS 32289-58-0 Poli (heksametilenbiguanid) Poliheksametilen biguanid (Poliheksanid, PHMB) kozmetik ürünler, Poliheksametilen biguanid (Poliheksanid, PHMB) kişisel bakım ürünleri, Poliheksametilen biguanid (Poliheksanid, PHMB) yumuşatıcılar, Poliheksametilen biguanid (Poliheksanid, PHMB) temas çözeltileri, Poliheksametilen biguanid (Poliheksanid, PHMB) el yıkama ürünleri vb. Poliheksametilen biguanid (Poliheksanid, PHMB) Kimyasal ürünlerden kullanılır. Poliheksametilen biguanid (Poliheksanid, PHMB) aynı zamanda hastaneler, Poliheksametilen biguanid (Poliheksanid, PHMB) okullar, Poliheksametilen biguanid (Poliheksanid, PHMB) oteller ve Poliheksametilen biguanid (Poliheksanid, PHMB) diğer birçok kamu alanı gibi yaygın olarak bulunan dezenfeksiyon alanında da uygulanmaktadır.

Molecular Formula of Polyhexamethylene Biguanide (Polihexanid, PHMB)(C8H17N5)n

Ph Level of Polyhexamethylene Biguanide (Polihexanid, PHMB)4~5

Taste of Polyhexamethylene Biguanide (Polihexanid, PHMB)Bitter

Purity of Polyhexamethylene Biguanide (Polihexanid, PHMB) 20%

Ingredients of Polyhexamethylene Biguanide (Polihexanid, PHMB) PHMB

Properties of Polyhexamethylene Biguanide (Polihexanid, PHMB) PHMB (polyhexamethylene biguanide) is a water-soluble cationic disinfectant with wide clinical, household, and industrial applications

Shelf Life of Polyhexamethylene Biguanide (Polihexanid, PHMB) 2 Years

Storage of Polyhexamethylene Biguanide (Polihexanid, PHMB)Room Temperature

Structural Formula of Polyhexamethylene Biguanide (Polihexanid, PHMB)(C8H17N5)n

Grade of Polyhexamethylene Biguanide (Polihexanid, PHMB)TECHNICAL

Product Type of Polyhexamethylene Biguanide (Polihexanid, PHMB) PHMB

Application of Polyhexamethylene Biguanide (Polihexanid, PHMB)Pharmaceutical

Physical Form of Polyhexamethylene Biguanide (Polihexanid, PHMB)Liquid

Appearance of Polyhexamethylene Biguanide (Polihexanid, PHMB)WATER WHITE

polyhexamethylene biguanide,is Available in colorless to pale yellow form, polyhexamethylene biguanide, PHMB is accessible in liquid form. polyhexamethylene biguanide,tastes bitter and its purity level is 20%. polyhexamethylene biguanide,can be stored for 24 months. polyhexamethylene biguanide,disinfecting chemical is water soluble and it is cationic by nature. polyhexamethylene biguanide,is suitable for household, industrial and clinical application purpose. Ph level of polyhexamethylene biguanide, liquid substance ranges between 4 to 5. polyhexamethylene biguanide, PHMB has been formulated under controlled temperature to preserve anti bacterial properties of polyhexamethylene biguanide. Standard of polyhexamethylene biguanide,liquid has been verified on the basis of composition of polyhexamethylene biguanide,, formulation method, effectiveness, shelf life, ph value, possible toxin content, etc. ppearance: white powder; colorless liquid; colorless translucent crystals

Assay of polyhexamethylene biguanide,: 95%;98%;20%; 25%;50%

Polyhexamethylene Biguanide (Polihexanid, PHMB)can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc.

Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in health care, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in chemicals, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in textiles, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in paper, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in wipes,Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in livestock, aquaculture, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in fisheries, plastics, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in agriculture, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in water treatment and Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in other fields.

Two equivalent CAS number of Polyhexamethylene Biguanide (Polihexanid, PHMB) can be allocated depending on how the polymer is described. CAS-No 27083-27-8 expresses the Polyhexamethylene Biguanide (Polihexanid, PHMB) in terms of its starting monomers (N,N’’’-1,6- hexanediylbis(N’-cyanoguanidine) and 1,6-hexanediamine). CAS-No 32289-58-0 expresses the Polyhexamethylene Biguanide (Polihexanid, PHMB) as the resultant polymer.

Polyhexamethylene Biguanide (Polihexanid, PHMB)(PHMB) is an antiseptic with antiviral and antibacterial properties used in several ways including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyhexamethylene Biguanide (Polihexanid, PHMB) (PHMB) is not safe for consumers when used as a preservative in all cosmetic products up to the maximum concentration of 0.3%. The safe Polyhexamethylene Biguanide (Polihexanid, PHMB) use could be based on a lower use concentration and/or restrictions with regard to cosmetic products' categories Polyhexamethylene Biguanide (Polihexanid, PHMB) hydrochloride (PHMB) (CAS 32289-58-0 / 27083-27-8 / 28757- 47-3 / 133029-32-0) with INCI name Polyaminopropyl Biguanide, is currently listed in Annex V (entry 28) of the Regulation (EC) No. 1223/20091 (Cosmetics Regulation) as preservative to be used in all cosmetic products up to a maximum concentration of 0.3%. Polyhexamethylene Biguanide (Polihexanid, PHMB)is classified as CMR 2 (Carc. 2) according to the Commission Regulation (EU) No. 944/20132 of 2 October 2013 amending for the purposes of Polyhexamethylene Biguanide (Polihexanid, PHMB)adaptation to technical and scientific progress the Regulation (EC) No. 1272/20083 . The classification applies from 1st January 2015 and according to Art. 15 (1) of the Cosmetics Regulation, Polyhexamethylene Biguanide (Polihexanid, PHMB)is considered prohibited as cosmetic ingredient from 1st January 2015. However, Polyhexamethylene Biguanide (Polihexanid, PHMB)Art. 15 (1) of the Cosmetics Regulation states that ‘a substance classified in category 2 may be used in cosmetic products where the substance has been evaluated by the SCCS and found safe for use in cosmetic products. To these ends the Commission shall adopt the necessary measures in accordance with the regulatory procedure with scrutiny referred to in Article 32(3) of this Regulation'. The SCCS published an opinion on the safety of Polyhexamethylene Biguanide (Polihexanid, PHMB)in June 2014 successively revised in July 2015 (SCCS/1535/14)4 in which they concluded that: " Polyhexamethylene Biguanide (Polihexanid, PHMB) is not safe for consumers when used as a preservative in all cosmetic products up to the maximum concentration of 0.3%. The safe Polyhexamethylene Biguanide (Polihexanid, PHMB)use could be based on a lower use concentration and/or restrictions with regard to cosmetic products' categories. Dermal absorption studies on additional representative cosmetic formulations are needed. On the basis of the data available, Polyhexamethylene Biguanide (Polihexanid, PHMB)the SCCS concludes that Polyhexamethylene Biguanide (Polihexanid, PHMB)is not safe for consumers when used as a preservative in cosmetic spray formulations up to concentration of 0.3%. Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in a variety of applications other than cosmetics. General exposure data from sources others than cosmetics should be submitted for the assessment of the aggregate exposure of polyhexamethylene biguanide.

The stability of Polyhexamethylene Biguanide (Polihexanid, PHMB)in deionised water has been established for at least 6 weeks. Polyhexamethylene Biguanide (Polihexanid, PHMB)was stated that nominal concentrations (expressed as Vantocil, i.e. 20 % polyhexamethylene biguanide) of 0.1, 35 and 80 mg/ml would be stable for the duration of the test. Stability analysis revealed that Polyhexamethylene Biguanide (Polihexanid, PHMB)over a concentration range of 0.02 to 7.0 mg/l was stable in drinking water for a period of 7 days. PHMB is supported under the Biocides Regulation No 528/2012, which distinguishes 22 product types (PT) Directive 98/8/EC for uses as a disinfectant. Polyhexamethylene Biguanide (Polihexanid, PHMB)is used as a preservative and as an antimicrobial agent. As a preservative, PHMB is used in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, Polyhexamethylene Biguanide (Polihexanid, PHMB)is used as a broad spectrum preservative. Polyhexamethylene Biguanide (Polihexanid, PHMB)is freely water soluble and therefore widely used in water-based products which are most susceptible to microorganism growth. Polyhexamethylene Biguanide (Polihexanid, PHMB)has an excellent activity against a wide range of Gram positive and Gram negative bacteria, fungi and yeasts and is particularly effective against microorganisms such as Pseudomanas species, which are difficult to control. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and SCCS/1581/16 Final Opinion on Polyhexamethylene Biguanide (Polihexanid, PHMB)Submission III 13 trays, farm equipment, animal drinking water, and hard surfaces for food handling institutions and hospitals; and to deodorize vacuums and toilets. Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in antimicrobial hand washes and Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in rubs and Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in air filter treatments as an alternative to ozone. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms. Further reported uses of Polyhexamethylene Biguanide (Polihexanid, PHMB)are purification of swimming pool water, beer glass sanitisation, solid surface disinfection in breweries and short-term preservation of hides and skins. Polyhexamethylene Biguanide (Polihexanid, PHMB)also known as PHMB, polyhexanide or polihexanide, is a highly water soluble and hydrolytically stable polymeric material. The presence of multiple hydrogen bond and chelation sites within Polyhexamethylene Biguanide (Polihexanid, PHMB)renders Polyhexamethylene Biguanide (Polihexanid, PHMB)of potential interest in the field of supramolecular chemistry.polyhexamethylene biguanide,is Available in colorless to pale yellow form, polyhexamethylene biguanide, PHMB is accessible in liquid form. polyhexamethylene biguanide,tastes bitter and its purity level is 20%. polyhexamethylene biguanide,can be stored for 24 months. polyhexamethylene biguanide,disinfecting chemical is water soluble and it is cationic by nature. polyhexamethylene biguanide,is suitable for household, industrial and clinical application purpose. Ph level of polyhexamethylene biguanide, liquid substance ranges between 4 to 5. polyhexamethylene biguanide, PHMB has been formulated under controlled temperature to preserve anti bacterial properties of polyhexamethylene biguanide. Standard of polyhexamethylene biguanide,liquid has been verified on the basis of composition of polyhexamethylene biguanide,, formulation method, effectiveness, shelf life, ph value, possible toxin content, etc. ppearance: white powder; colorless liquid; colorless translucent crystals

Assay of polyhexamethylene biguanide,: 95%;98%;20%; 25%;50%

Polyhexamethylene Biguanide (Polihexanid, PHMB)can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc.

Polyhexamethylene Biguanide (Polihexanid, PHMB)can be used directly after dilution with purified water or with other additive agent compound. Reference amount 1:125~1:1000 (w/w).

Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, Polyhexamethylene Biguanide (Polihexanid, PHMB)is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. Polyhexamethylene Biguanide (Polihexanid, PHMB)has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).

Polyhexamethylene Biguanide (Polihexanid, PHMB)containing Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for inter-operative irrigation, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for pre- and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for post-surgery skin and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for mucous membrane Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for post-operative dressings, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for surgical and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for non-surgical wound dressings, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for surgical bath/hydrotherapy,Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for chronic wounds like diabetic foot ulcer and burn wound management, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for routine antisepsis during minor incisions, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for catheterization, scopy, first aid, surface disinfection, and linen disinfection. Polyhexamethylene Biguanide (Polihexanid, PHMB)eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Branded as Baquacil, Polyhexamethylene Biguanide (Polihexanid, PHMB)also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. Polyhexamethylene Biguanide (Polihexanid, PHMB)is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Polyhexamethylene Biguanide (Polihexanid, PHMB)Leisure Time Free system.Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. The Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride salt (solution) is used in the majority of formulations. Polyhexamethylene Biguanide (Polihexanid, PHMB)a related biguanide disinfectant. Polyhexamethylene Biguanide (Polihexanid, PHMB)(is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyhexamethylene Biguanide (Polihexanid, PHMB) is an antiseptic with antiviral and antibacterial properties used in several ways including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyhexamethylene Biguanide (Polihexanid, PHMB) is also known as polyhexanide and polyaminopropyl biguanide, polymeric biguanide hydrochloride; polyhexanide biguanide. Polyhexamethylene Biguanide (Polihexanid, PHMB) is a commonly applied antiseptic, Polyhexamethylene Biguanide (Polihexanid, PHMB) often used as a preservative in cosmetics and Polyhexamethylene Biguanide (Polihexanid, PHMB) often used as a in personal care products. Polyhexamethylene Biguanide (Polihexanid, PHMB)shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.Polyhexamethylene Biguanide (Polihexanid, PHMB)is available also as a solid. Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride (PHMB) is a chemical biocide which is a polymer utilized in a wide variety of antimicrobial applications. This review provides a comprehensive literature of Polyhexamethylene Biguanide (Polihexanid, PHMB)features from synthesis methods,mode of action, antimicrobial effects and safety considerations to both humans and environments. Effectiveness against cellular organisms is due to the basic biguanide group attached to a flexible spacer, a hexamethylene group. Polyhexamethylene Biguanide (Polihexanid, PHMB)is a disinfectant with a broad spectrum of inducing cell death by disrupting cell membrane integrity. Polyhexamethylene Biguanide (Polihexanid, PHMB)is an environmentally friendly product noncorrosive and nontoxic to both humans and animals. Polyhexamethylene Biguanide (Polihexanid, PHMB)is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, Polyhexamethylene Biguanide (Polihexanid, PHMB)the preservation of fruit and vegetables. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to preserve wet wipes; Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to control odor in textiles;Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to prevent microbial contamination in wound irrigation and sterile dressings; to Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used disinfect medical/dental utensil and trays, Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used farm equipment, Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used animal drinking water, and hard surfaces for food handling institutions and hospitals; and to Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used deodorize vacuums and toilets. Polyhexamethylene Biguanide (Polihexanid, PHMB)can work at low concentrations with very fast action with a broad spectrum of action in addition of Polyhexamethylene Biguanide (Polihexanid, PHMB)wide acceptance and exploitation for potential multi-purpose functional use. Polyhexamethylene Biguanide (Polihexanid, PHMB)will be promising for advanced environmental treatments including food disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)will be promising for water disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)will be promising for surface disinfection, and meet the criteria for an ideal antimicrobial agent. Disinfecting agent is a substances used to control, prevent, or destroy harmful microorganisms (i.e., bacteria, viruses, or fungi) on inanimate objects and surfaces. Polyhexamethylene Biguanide (Polihexanid, PHMB)destroys or irreversibly inactivates most pathogenic microorganisms (Ewart,2001; EPA, 2004; Quinn and Markey, 2001; Kennedy et al., 2000). Chemical disinfectants were used scientifically around 150 years ago, but empiric practices can be found in ancient times . Since then several new biocides have been introduced and a significant amount of research on their activity against microorganisms has been performed. Biguanidines are an interesting class of compounds with many known or potential applications. It is bacteriostatic at lower concentrations, inhibiting membrane enzymes and promoting leakage of cellular constituents. Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride is a chemical biocide and a member of the polymeric guanidine family is used as a disinfectant and antiseptic and general disinfecting agents in the food industry and, very successfully, for the disinfection of swimming pools. Polyhexamethylene Biguanide (Polihexanid, PHMB)used biocide has been reviewed by US Environmental Protection Agency (EPA) and noted, with the exception of occupational users, as having very low aggregate risk of adverse health effects to the public or environment(EPA, 2005). Polyhexamethylene Biguanide (Polihexanid, PHMB)binds to the negatively charged phosphate head groups of phospholipids at bacteria cell wall, causing increased rigidity, sinking nonpolar British Journal of Environmental Sciences Vol.4, No.1, pp.49-55, February 2016 ___Published by European Centre for Research Training and Development UK (www.eajournals.org) 50 ISSN 2055-0219(Print), ISSN 2055-0227(online) segments into hydrophobic domains, disrupting the membrane with subsequent cytoplas- mic shedding culminating in cell death (Kaehn, 2010). There have been no reported instances of bacteria acquiring resistance to Polyhexamethylene Biguanide (Polihexanid, PHMB). Polyhexamethylene Biguanide (Polihexanid, PHMB)is well tolerated when used topically on skin, eyes, the ciliated epithelium of the nose, and wounds (Kaehn, 2010; Kramer et al., 2004; Dissemond et al., 2009; Kramer et al., 2008). The market for Polyhexamethylene Biguanide (Polihexanid, PHMB)-containing products, which now includes liquids, gels and antimicrobial dressings, is expanding rapidly. This article outlines the evidence on the antimicrobial properties of polyhexamethylene biguanide. PHMB was firstly synthesized by Rose and Swain (1954). Polyhexamethylene Biguanide (Polihexanid, PHMB)is a cationic biguanide polymer which is utilized in a wide variety of antibacterial applications (O’Malley et al., 2007). Several methods have been devised in order to prepare polyhexamethylene biguanide. For instance, one of the current methods is to obtain Polyhexamethylene Biguanide (Polihexanid, PHMB)by polycondensation of sodium dicyanamide and hexamethylenediamine in two steps (de Paula et al., 2011). Preparations of Polyhexamethylene Biguanide (Polihexanid, PHMB)are polydisperse mixtures of polymeric biguanides, with a weighted average number (n) of 12 repeating hexamethylene biguanide units. The heterogeneity of the molecule is increased further by the presence of either amine, or cyanoguanidine or guanidine end-groups in any combination at the terminal positions of each chain. Equal amounts (in molar) of hexamethylenediamine and guanidine hydrochloride to be mixed in a round-bottomed three-necked flask, which is equipped with a mechanical stirrer and vacuum system. The mixture reacts at 100 °C for 60 min, and then at 170 °C for a certain time. During the reaction, by-product ammonia is neutralized by bubbling through aqueous HCl. At the end of reaction, the slightly yellow, viscous liquid solidifies upon cooling giving Polyhexamethylene Biguanide (Polihexanid, PHMB)samples (Wei et al., 2009). PHMG is a new generation of disinfectant with a wide scope of applications in agriculture and food processing plants, logistics, kitchens, transport vehicles. Polyhexamethylene Biguanide (Polihexanid, PHMB)is a disinfectant with a broad spectrum of activity against bacteria, viruses and fungi, inducing cell death by disrupting cell membrane integrity (Ikeda et al, 1983; Ikeda et al, 1984; Moore and Gray, 2007;). and Polyhexamethylene Biguanide (Polihexanid, PHMB)shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics. Polyhexamethylene Biguanide (Polihexanid, PHMB)is available also as a solid. Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride (PHMB) is a chemical biocide which is a polymer utilized in a wide variety of antimicrobial applications. This review provides a comprehensive literature of Polyhexamethylene Biguanide (Polihexanid, PHMB)features from synthesis methods,mode of action, antimicrobial effects and safety considerations to both humans and environments. Effectiveness against cellular organisms is due to the basic biguanide group attached to a flexible spacer, a hexamethylene group. Polyhexamethylene Biguanide (Polihexanid, PHMB)is a disinfectant with a broad spectrum of inducing cell death by disrupting cell membrane integrity. Polyhexamethylene Biguanide (Polihexanid, PHMB)is an environmentally friendly product noncorrosive and nontoxic to both humans and animals. Polyhexamethylene Biguanide (Polihexanid, PHMB)is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, Polyhexamethylene Biguanide (Polihexanid, PHMB)the preservation of fruit and vegetables. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to preserve wet wipes; Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to control odor in textiles; Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to prevent microbial contamination in wound irrigation and sterile dressings; to Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used disinfect medical/dental utensil and trays, Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used farm equipment, Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used animal drinking water, and hard surfaces for food handling institutions and hospitals; and to Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used deodorize vacuums and toilets. Polyhexamethylene Biguanide (Polihexanid, PHMB)can work at low concentrations with very fast action with a broad spectrum of action in addition of Polyhexamethylene Biguanide (Polihexanid, PHMB)wide acceptance and exploitation for potential multi-purpose functional use. Polyhexamethylene Biguanide (Polihexanid, PHMB)will be promising for advanced environmental treatments including food disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)will be promising for water disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)will be promising for surface disinfection, and meet the criteria for an ideal antimicrobial agent. Disinfecting agent is a substances used to control, prevent, or destroy harmful microorganisms (i.e., bacteria, viruses, or fungi) on inanimate objects and surfaces. Polyhexamethylene Biguanide (Polihexanid, PHMB)is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, the preservation of fruit and vegetables (KoffiNevry et al., 2011; Kabara, 1984; Dugard and Mawdsley, 1982). Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to preserve wet wipes; Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to control odor in textiles; Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to prevent microbial contamination in wound irrigation, Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used sterile dressings; Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to deodorize vacuums and toilets (SCCS, 2005); Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to disinfect medical/dental utensil and trays, farm equipment, Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used animal drinking water and Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used hard surfaces for food handling institutions and hospitals. Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in antimicrobial hand washes and Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in rubs and Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in air filter treatments as an alternative to ozone. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used as an active ingredient for recreational water treatment, as a chlorine free polymeric sanitizer, which is effective against a wide variety of microorganisms. Polyhexamethylene Biguanide (Polihexanid, PHMB)has been used in a wide range of applications from swimming pool sanitisers to preservatives in cosmetics and contact lens solutions (Bucher,2012). Clinical studies indicate Polyhexamethylene Biguanide (Polihexanid, PHMB)has a broad spectrum of activity, including against human immunodeficiency virus (HIV) (Wérthen et al, 2004; Krebs et al, 2005). Polyhexamethylene Biguanide (Polihexanid, PHMB)appears to be available in presentations that provide clinicians with effective wound care modalities for most clinical scenarios and has also been used as a perioperative cleansing agent (Kramer, 1997), in mouth wash, (Rosin, 2002) in ophthalmology, (Kramer, 1997; Petrou-Binder, 2003). Petrou-Binder40 describes the germicidal effects of Polyhexamethylene Biguanide (Polihexanid, PHMB)(Lavasept 0.02%) as eye drops prior to cataract surgery. Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in swimming pool sanitizers, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in cosmetics, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in leather preservatives, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in contact lens disinfectants, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in cleanser in agriculture and Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in food handling, in Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in treatment of hatching eggs, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in fibers and Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in textiles and technical fluids like cutting oils and glues. Polyhexamethylene Biguanide (Polihexanid, PHMB)is an excellent biocide that is an environmentally friendly product and expected to be used widely in future to provide valuable disinfection, cleaning and hygiene functions in a wide type of products such as cosmetics, deodorant, contact lenses solutions, fabric softeners, water treatments, wound care products and antimicrobial foam dressings. Polyhexamethylene Biguanide (Polihexanid, PHMB)is expected to be; a component of pool cleaners, Polyhexamethylene Biguanide (Polihexanid, PHMB)is expected to skin disinfectants and urinary catheter flush solutions; Polyhexamethylene Biguanide (Polihexanid, PHMB)is expected to sanitizers in different applications; Polyhexamethylene Biguanide (Polihexanid, PHMB)is expected to disinfectant in hospitals and food and equipment in contact with food. An overview of some current features and applications of Polyhexamethylene Biguanide (Polihexanid, PHMB)was given and discussed. Polyhexamethylene Biguanide (Polihexanid, PHMB)is an environmentally friendly biocides. Polyhexamethylene Biguanide (Polihexanid, PHMB)is a new generation of disinfectant with a wide scope of applications in all aspects of life. Polyhexamethylene Biguanide (Polihexanid, PHMB)is a disinfectant with a broad spectrum of activity against bacteria, viruses and fungi. Polyhexamethylene Biguanide (Polihexanid, PHMB)review provides a comprehensive literature of Polyhexamethylene Biguanide (Polihexanid, PHMB)from synthesis methods, antimicrobial effects and safety considerations to both humans and environments. Polyhexamethylene Biguanide (Polihexanid, PHMB)is believed to continue to be used in wide ranging consumer and industrial products and by many market leading companies. Polyhexamethylene Biguanide (Polihexanid, PHMB)as a disinfectant will be promising for advanced environmental treatments including food disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)as a disinfectant will be promising for water disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)as a disinfectant will be promising for surface disinfection, and meet the criteria for an ideal antimicrobial agent. Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride has part polyhexamethylene biguanide(2+) Polyhexamethylene Biguanide (Polihexanid, PHMB)has role antibacterial agent .Polyhexamethylene Biguanide (Polihexanid, PHMB)has role antifungal agent. Polyhexamethylene Biguanide (Polihexanid, PHMB)has role antiseptic drug .Polyhexamethylene Biguanide (Polihexanid, PHMB)has role dermatologic drug .Polyhexamethylene Biguanide (Polihexanid, PHMB) has role disinfectant. Polyhexamethylene Biguanide (Polihexanid, PHMB)has role ophthalmology drug .Polyhexamethylene Biguanide (Polihexanid, PHMB) is a hydrochloride . The safety of Polyhexamethylene Biguanide (Polihexanid, PHMB)as used as a preservative in cosmetics is reviewed in this assessment. Polyhexamethylene Biguanide (Polihexanid, PHMB)is an International Nomenclature of Cosmetic Ingredients (INCI) name; Polyhexamethylene Biguanide (Polihexanid, PHMB)refers to the hydrochloride salt of an amino polymer comprising hexyl biguanide repeat units (i.e., Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride (Polyhexamethylene Biguanide (Polihexanid, PHMB)HCl)). Polyhexamethylene Biguanide (Polihexanid, PHMB)has a 6-carbon chain in each monomeric repeat unit, and is always supplied as the hydrochloride salt. Polyhexamethylene Biguanide (Polihexanid, PHMB)identified by the chemical name polyaminopropyl biguanide is not a cosmetic ingredient. Accordingly, throughout this report, when the capitalized INCI name Polyhexamethylene Biguanide (Polihexanid, PHMB)is used, Polyhexamethylene Biguanide (Polihexanid, PHMB)is to be understood that Polyhexamethylene Biguanide (Polihexanid, PHMB)is referring to the cosmetic ingredient that has the chemical name Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride. Polyhexamethylene Biguanide (Polihexanid, PHMB)should also be understood that Polyhexamethylene Biguanide (Polihexanid, PHMB)is the ingredient with reported uses in cosmetics. Furthermore, most of the safety test data included in this report are on the chemical Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride, as indicated by the use of the INCI name. The only exception to the exclusive use of the INCI name Polyhexamethylene Biguanide (Polihexanid, PHMB)in this safety assessment relates to the summary of a cytoxicity study, in which results for Polyhexamethylene Biguanide (Polihexanid, PHMB)and Polyhexamethylene Biguanide (Polihexanid, PHMB)are compared. Additionally, Polyhexamethylene Biguanide (Polihexanid, PHMB)has been reviewed by the United States Environmental Protection Agency (EPA). The EPA concluded that its use as a pesticide has very low aggregate risk of adverse health effects to the public or environment. According to 2017 VCRP data Polyhexamethylene Biguanide (Polihexanid, PHMB)is being used in 147 cosmetic products, mostly leave-on products.The results of a concentration of use survey provided in 2017 indicate that Polyhexamethylene Biguanide (Polihexanid, PHMB)is being used at concentrations up to 0.2% in leave-on products and concentrations up to 0.1% in rinse-off products (Table 3).7 Cosmetic products containing Polyhexamethylene Biguanide (Polihexanid, PHMB)may be applied to the skin and hair or may come in contact with the eyes (at maximum use concentrations up to 0.2 % in eye lotions) and mucous membranes (0.006% in other personal cleanliness products). Polyhexamethylene Biguanide (Polihexanid, PHMB)is being used in a lipstick product, the application of which may result in incidental ingestion; no concentration data were reported for this use. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also being used in baby lotions, oils, or creams at maximum use concentrations up to 0.1%. Products containing Polyhexamethylene Biguanide (Polihexanid, PHMB)may be applied as frequently as several times per day and may come in contact with the skin or hair for variable periods following application. Daily or occasional use may extend over many years. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to control odor in textiles; Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to prevent microbial contamination in wound irrigation, Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used sterile dressings; Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to deodorize vacuums and toilets (SCCS, 2005); Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to disinfect medical/dental utensil and trays, farm equipment, Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used animal drinking water and Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used hard surfaces for food handling institutions and hospitals. Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in antimicrobial hand washes and Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in rubs and Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in air filter treatments as an alternative to ozone. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used as an active ingredient for recreational water treatment, as a chlorine free polymeric sanitizer, which is effective against a wide variety of microorganisms. Polyhexamethylene Biguanide (Polihexanid, PHMB)has been used in a wide range of applications from swimming pool sanitisers to preservatives in cosmetics and contact lens solutions (Bucher,2012). Clinical studies indicate Polyhexamethylene Biguanide (Polihexanid, PHMB)has a broad spectrum of activity, including against human immunodeficiency virus (HIV) (Wérthen et al, 2004; Krebs et al, 2005). Polyhexamethylene Biguanide (Polihexanid, PHMB)appears to be available in presentations that provide clinicians with effective wound care modalities for most clinical scenarios and has also been used as a perioperative cleansing agent (Kramer, 1997), in mouth wash, (Rosin, 2002) in ophthalmology, (Kramer, 1997; Petrou-Binder, 2003). Petrou-Binder40 describes the germicidal effects of Polyhexamethylene Biguanide (Polihexanid, PHMB)(Lavasept 0.02%) as eye drops prior to cataract surgery. Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in swimming pool sanitizers, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in cosmetics, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in leather preservatives, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in contact lens disinfectants, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in cleanser in agriculture and Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in food handling, in Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in treatment of hatching eggs, Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in fibers and Polyhexamethylene Biguanide (Polihexanid, PHMB)can be found in textiles and technical fluids like cutting oils and glues. Polyhexamethylene Biguanide (Polihexanid, PHMB)is an excellent biocide that is an environmentally friendly product and expected to be used widely in future to provide valuable disinfection, cleaning and hygiene functions in a wide type of products such as cosmetics, deodorant, contact lenses solutions, fabric softeners, water treatments, wound care products and antimicrobial foam dressings. Polyhexamethylene Biguanide (Polihexanid, PHMB)is expected to be; a component of pool cleaners, Polyhexamethylene Biguanide (Polihexanid, PHMB)is expected to skin disinfectants and urinary catheter flush solutions; Polyhexamethylene Biguanide (Polihexanid, PHMB)is expected to sanitizers in different applications; Polyhexamethylene Biguanide (Polihexanid, PHMB)is expected to disinfectant in hospitals and food and equipment in contact with food. An overview of some current features and applications of Polyhexamethylene Biguanide (Polihexanid, PHMB)was given and discussed. Polyhexamethylene Biguanide (Polihexanid, PHMB)is an environmentally friendly biocides. Polyhexamethylene Biguanide (Polihexanid, PHMB)is a new generation of disinfectant with a wide scope of applications in all aspects of life. Polyhexamethylene Biguanide (Polihexanid, PHMB)is a disinfectant with a broad spectrum of activity against bacteria, viruses and fungi. Polyhexamethylene Biguanide (Polihexanid, PHMB)review provides a comprehensive literature of Polyhexamethylene Biguanide (Polihexanid, PHMB)from synthesis methods, antimicrobial effects and safety considerations to both humans and environments. According to the FDA VCRP, Polyhexamethylene Biguanide (Polihexanid, PHMB)is used in a fragrance preparation, which may result in incidental ingredient inhalation exposure; concentration data were not reported for this use. The SCCS originally concluded that Polyhexamethylene Biguanide (Polihexanid, PHMB)is not safe for consumers in all cosmetic products when used as a preservative up to the maximum concentration of 0.3%.12 In 2017, the SCCS issued a final opinion stating that “the use of Polyhexamethylene Biguanide (Polihexanid, PHMB)as a preservative in all cosmetic products at concentrations up to 0.1% is safe and that its use in sprayable formulations is not advised”. 2 Polyhexamethylene Biguanide (Polihexanid, PHMB)is currently listed in Annex V (entry 28) of the European Commission (EC) Regulation No. 1223/2009 (Cosmetic Regulation) as a preservative to be used in all cosmetic products at up to a maximum concentration of 0.3%.2,13 Additionally, Polyhexamethylene Biguanide (Polihexanid, PHMB)is classified as CMR 2 (Carc. 2) according to the Commission Regulation (EU) No. 944/2013. CMR substances are classified as carcinogenic, mutagenic, or toxic for reproduction. Polyhexamethylene Biguanide (Polihexanid, PHMB)is placed in carcinogen Category 2 (Carc. 2, suspected human carcinogens) when the evidence obtained from human and/or animal studies is not sufficiently convincing to place the the use of Polyhexamethylene Biguanide (Polihexanid, PHMB)as a cosmetic ingredient is considered to be prohibited as of this date. Polyhexamethylene Biguanide (Polihexanid, PHMB)has been banned from personal care products in Denmark since January of 2015, based on the European Commission’s classification of this ingredient as a CMR substance.13 Polyhexamethylene Biguanide (Polihexanid, PHMB)was noted that CMR substances may be used in cosmetic products if a risk assessment shows that the use of the substance is safe. Reference was made to the SCCS’s conclusion specifying a safe level of Polyhexamethylene Biguanide (Polihexanid, PHMB)in cosmetics. Polyhexanide (polyhexamethylene biguanide, Poliheksametilen biguanid (Poliheksanid)) is a polymer used as a disinfectant and antiseptic. In dermatological use,[1] it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide.[2] Poliheksametilen biguanid (Poliheksanid, PHMB) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae) (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Some products containing Poliheksametilen biguanid (Poliheksanid, PHMB) are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection.[4] Poliheksametilen biguanid (Poliheksanid, PHMB) eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis(Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Branded as Baquacil, it also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. It is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Leisure Time Free system. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Poliheksametilen biguanid (Poliheksanid, PHMB) is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. It is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)The Poliheksametilen biguanid (Poliheksanid, PHMB) hydrochloride salt (solution) is used in the majority of formulations. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride - 20% aqueous solutionPolyhexamethylene biguanidine, also known as Poliheksametilen biguanid (Poliheksanid), polyhexanide or polihexanide, is a highly water soluble and hydrolytically stable polymeric material. The presence of multiple hydrogen bond and chelation sites within Poliheksametilen biguanid (Poliheksanid, PHMB) renders it of potential interest in the field of supramolecular chemistry. Poliheksametilen biguanid (Poliheksanid, PHMB) shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics. Poliheksametilen biguanid (Poliheksanid, PHMB) is available also as a solid. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)The active ingredient (a.i.) Poly Hexa Methylene Biguanide (Poliheksametilen biguanid (Poliheksanid)) is a small size polymer obtained by the polycondensation of two monomers (1,6- hexanemethylenediamine and N,N```-1,6-hexanediylbis[N`-cyanoguanidine] (ie. HMBDA)). As Poliheksametilen biguanid (Poliheksanid, PHMB) is a small size polymer, some side reactions that occurred during the manufacturing process could modify significatively the structure of the polymer. The side reaction to obtain the unit guanidine occurred up to 10% in the process. Therefore, it can be considered that the structure of Poliheksametilen biguanid (Poliheksanid, PHMB) is not only composed by repetitive unit of guanidine but it is composed by repetitive unit of guanidine and biguanide. The active substance as manufactured (TK3 ) is a 20% w/w aqueous solution of Poliheksametilen biguanid (Poliheksanid). "Purity" is a difficult concept to apply to Poliheksametilen biguanid (Poliheksanid, PHMB) which is a mixture of polymers and related substances. Instead the applicant refers to the "strength" of the polymer which is defined as "% total solids" or "dried material". The typical Poliheksametilen biguanid (Poliheksanid, PHMB) strength is 20 %. However, eCA considers more appropriate to use the term "% of active substance (% a.s.)" or (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide) "active substance content" instead of "strength". The active substance content being defined as the sum of Poliheksametilen biguanid (Poliheksanid, PHMB) and its impurities contents, it can be considered identical to the % total solids and thus to the strength. However, the terms strength or dried Poliheksametilen biguanid (Poliheksanid, PHMB) are also used in identity and physico chemical sections and refer to the same thing. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide) As the technical material is the 20 % Poliheksametilen biguanid (Poliheksanid, PHMB) solution obtained directly from the manufacturing process (active substance as manufactured or TK), characterisation data were generated from the dried technical material (TC4 ) using the technique of freeze drying. The content of Poliheksametilen biguanid (Poliheksanid, PHMB) can be calculated by subtracting the total content of impurities in the dried technical material (without residual water) to 100. This value cannot be considered as a real purity but is the closest available data. The minimum content of Poliheksametilen biguanid (Poliheksanid, PHMB) TC was demonstrated > 95.6%. Since the active substance is a copolymer, identity characterisation criteria (based on % solid, content of Poliheksametilen biguanid (Poliheksanid, PHMB) in dried material, Mw, (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Mn and the biguanide/guanide ratio) as well as limits or range for each criterion are proposed by eCA in the confidential document IIA to characterise the source of Poliheksametilen biguanid (Poliheksanid, PHMB) in order to set reference specifications in case of approval of the active substance and future technical equivalence checks. eCA proposes to rename Poliheksametilen biguanid (Poliheksanid, PHMB) considered for approval in this dossier as "Poliheksametilen biguanid (Poliheksanid, PHMB) with a mean number-average molecular weight (Mn) of 1600 and a mean polydispersity (PDI) of 1.8" i.e. "Poliheksametilen biguanid (Poliheksanid, PHMB) (1600; 1.8)". For convenience, Poliheksametilen biguanid (Poliheksanid, PHMB) (1600; 1.8) is referred to hereafter as "Poliheksametilen biguanid (Poliheksanid)" or "a.s.". There is one relevant impurity, Hexamethylenediamine with a maximal content of 0.4%. All potential impurities have not been looked for and/or quantified. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Additional data about impurities and specifications for the active substance and the impurities should be submitted prior to approval. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Quality control data on structural characteristics (2003-2011) are reported in this confidential document to demonstrate that production of TK (liquid form) remained stable during this period of time from a structural point of view. It can be concluded that submitted characterisation data (2011) are representative of current production but also of older production and of active substance material used to perform the toxicological and ecotoxicological studies used to perform the risk assessment (See confidential doc IIA). This statement is only valid for structural data and not for evolution of impurity content in Poliheksametilen biguanid (Poliheksanid, PHMB) as no data was submitted to cover this point. The applicant also manufactures Poliheksametilen biguanid (Poliheksanid, PHMB) as a solid material ("Solid Poliheksametilen biguanid (Poliheksanid)"). Initially the applicant submitted both sources in the dossier. Comparison between liquid and Solid Poliheksametilen biguanid (Poliheksanid, PHMB) is discussed in confidential document IIA-02 "Comparison of liquid and solid Poliheksametilen biguanid (Poliheksanid)". (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide) eCA considers that liquid Poliheksametilen biguanid (Poliheksanid, PHMB) (VANTOCIL TG) and Solid Poliheksametilen biguanid (Poliheksanid, PHMB) are 2 different substances, based on structural considerations. Additional information to demonstrate technical equivalence will be required at product authorisation stage if Applicant claims solid Poliheksametilen biguanid (Poliheksanid, PHMB) as a new source. The active substance considered for approval in this dossier is the active substance as manufactured (TK): 20 % w/w aqueous solution of Poliheksametilen biguanid (Poliheksanid, PHMB) (VANTOCIL TG) also called liquid Poliheksametilen biguanid (Poliheksanid). TC (dried Poliheksametilen biguanid (Poliheksanid)) is a dusty solid/powder, off white with a strong ammonia smell. It has a glass transition temperature of 90-91°C (non crystalline polymer) and decomposes at 205-210°C before boiling. The TK (Poliheksametilen biguanid (Poliheksanid, PHMB) as manufactured, 20% in water) has a boiling point of 100.2°C. The table below present the efficacy data which support the efficacy of the Poliheksametilen biguanid (Poliheksanid, PHMB) in the frame of the active substance dossier. The data are generated from laboratory studies and have to be consolidated at the product authorisation stage related to the claims with data generated with real products. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)In particular, the concentration of 7,5 ppm of Poliheksametilen biguanid (Poliheksanid), which is in the order of magnitude of concentration found for swimming pool water desinfection, is shown subletal and thus susceptible to generate tolerance to E. Coli.Standard methods of measuring resistance brought about by biocide use are not available and should be developed for all type of biocides. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide) Oral absorption of Poliheksametilen biguanid (Poliheksanid, PHMB) ranges approximately from 0.3 to 8% but the value of 4% is retained based on the oral absorption of Poliheksametilen biguanid (Poliheksanid, PHMB) from diet at the lower dose tested. This value was selected as it corresponds to the closest conditions to the experimental conditions of the study in which the relevant oral NOAEL was determined. A dermal absorption of Poliheksametilen biguanid (Poliheksanid, PHMB) was determined to be 4% by default based on EFSA guidance on dermal absorption (2012), corresponding to the oral absorption value. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Since no information is available on absorption of Poliheksametilen biguanid (Poliheksanid, PHMB) by inhalation, an absorption of 100% is retained. A classification for acute oral or dermal toxicity is not justified for the active substance as manufactured, Poliheksametilen biguanid (Poliheksanid, PHMB) 20% in water. For respiratory route, a classification Xn; R20 or Acute Tox 4 - H332 is proposed based on the RAC opinion for Poliheksametilen biguanid (Poliheksanid). Poliheksametilen biguanid (Poliheksanid, PHMB) is not irritant by dermal contact. For eye irritation, classification is not justified based on the data of the Poliheksametilen biguanid (Poliheksanid, PHMB) 20% w/w. Poliheksametilen biguanid (Poliheksanid, PHMB) is considered as a moderate to strong potency skin sensitizer based on animal data. Human studies indicate that Poliheksametilen biguanid (Poliheksanid, PHMB) is a skin sensitizer in humans, although with a rare frequency of sensitisation in the current conditions of consumer uses. Classification Xi; R43 (may cause sensitisation by skin contact) or (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Skin sens 1 - H317 for CLP, is therefore warranted. Relatively low incidences from human data support classification as CLP Skin Sens 1B - H317 according to the 2nd ATP to CLP Regulation. On the basis of the severity of the effects caused by inhalation of Poliheksametilen biguanid (Poliheksanid, PHMB) (mortality and to a lesser extent histopathological changes in the respiratory tract and in the thymus), the absence of reversibility of inflammation in the respiratory tract and the very low doses causing these effects, classification T; R48/23 is warranted (CLP STOT RE 1 - H 372). By inhalation the primary target organ is the respiratory tract and no effect warranting classification are identified by oral and dermal route. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)The target organs are kidneys and liver via oral route. By dermal contact, local effects are expected. Poliheksametilen biguanid (Poliheksanid, PHMB) is not considered to be mutagenic or genotoxic, according to the results of the in vitro (Ames test and chromosomal aberration test) and in vivo studies (mouse bone marrow micronucleus test and UDS assay). Poliheksametilen biguanid (Poliheksanid, PHMB) increases the incidence of benign and malign vascular tumours in female rats by oral route and in male and female mice by oral and dermal route. The tumours are induced mainly in the liver, which is one of the target organ of Poliheksametilen biguanid (Poliheksanid, PHMB) and the increase is clearly seen at doses above the MTD. However, it is also observed more equivocally at doses below MTD (mouse oral study at mid-dose and rat oral study at high dose). These increases are not considered incidental when considering the clear induction of vascular tumours at higher doses and they are considered biologically significant and attributed to treatment. A classification as carcinogenic category 3; R40 or Carc 2 - H351 for CLP, is warranted. In absence of carcinogenicity data by inhalation, it is proposed to allocate the general hazard statement H351 without indication of the route of exposure. Poliheksametilen biguanid (Poliheksanid, PHMB) has no teratogenic effect and has no effect on fertility or reproductive performance at dose levels up to 2000 ppm. For non-professionals, Poliheksametilen biguanid (Poliheksanid, PHMB) concentration in BAQUACIL Poliheksametilen biguanid (Poliheksanid, PHMB) product is above classification limit for sensitisation properties. As a common practice, it is considered that non-professional users do not wear any personal protective equipment. However, according to the document "Authorisation of biocidal products classified as skin sensitizers requiring PPE for non-professional users" exposure assessment for nonprofessionals could be performed without and with the wearing of PPE as a Tier II assessment and the local risk characterisation should be performed considering potential exposure both with and without gloves. In this case, as explain above gloves will only reduce the quantity of product in contact with skin, not the concentration. So contact with the product could still occur. Only the combination of PPE, training to handle PPE and chemicals allow a safe use. As consumers are not trained to use PPE and chemicals, they can be exposed to the product when removing the gloves or they can use the gloves provided with the product for other uses. So providing PPE with the product is not sufficient to lead to a safe use for consumers against local effects. However, as BAQUACIL Poliheksametilen biguanid (Poliheksanid, PHMB) (Poliheksametilen biguanid (Poliheksanid, PHMB) 20%) is classified STOT RE 1, it shall not be authorised for making available on the market for use by the general public according to the BPR article 19.4.b). Polyhexanide (polyhexamethylene biguanide, Poliheksametilen biguanid (Poliheksanid)) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, and Omnicide. Poliheksametilen biguanid (Poliheksanid, PHMB) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae). Some products containing Poliheksametilen biguanid (Poliheksanid, PHMB) are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection. Poliheksametilen biguanid (Poliheksanid, PHMB) eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.

The Poliheksametilen biguanid (Poliheksanid, PHMB) hydrochloride salt (solution) is used in the majority of formulations.

The broad-spectrum antimicrobial biocide Polyhexamethylene Biguanide (Polihexanid, PHMB)(Poliheksametilen biguanid (Poliheksanid); polyhexanide) kills bacteria, fungi, parasites and certain viruses with a high therapeutic index; it is widely used in clinics, homes and industryIt is most commonly used as a biocide, but is also an important drug used in several topical applications. Poliheksametilen biguanid (Poliheksanid, PHMB) is composed of repeating basic biguanidine units connected by hexamethylene hydrocarbon chains, providing a cationic and amphipathic structure. Despite extensive use over several decades, and efforts to identify acquired resistant mutants, resistance to Poliheksametilen biguanid (Poliheksanid, PHMB) has not been reported. The evidence for a lack of acquired resistance is necessarily negative, and the possibility of mutation to resistance remains; nevertheless, it is striking that bacteria with acquired resistance have not been identified following extensive and varied usage. If the antibacterial activity of Poliheksametilen biguanid (Poliheksanid, PHMB) is due to membrane disruption, as widely reported, it would be expected to permeabilise bacterial cell barriers at growth inhibitory and sub growth inhibitory concentrations. To test this model, we first established the minimal inhibitory concentrations (MIC) and time kill properties for Poliheksametilen biguanid (Poliheksanid, PHMB) against (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Escherichia coli (strains K-12 and MG1655) and Salmonella enterica serovar Typhimurium (strain LT2).Polyhexamethylene Biguanide (Polihexanid, PHMB)can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc. Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in health care, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in chemicals, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in textiles, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in paper, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in wipes,Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in livestock, aquaculture, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in fisheries, plastics, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in agriculture, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in water treatment and Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in other fields. Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, Polyhexamethylene Biguanide (Polihexanid, PHMB)is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. Polyhexamethylene Biguanide (Polihexanid, PHMB)has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).Polyhexamethylene Biguanide (Polihexanid, PHMB)containing Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for inter-operative irrigation, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for pre- and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for post-surgery skin and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for mucous membrane Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for post-operative dressings, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for surgical and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for non-surgical wound dressings, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for surgical bath/hydrotherapy, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for chronic wounds like diabetic foot ulcer and burn wound management, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for routine antisepsis during minor incisions, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for catheterization, scopy, first aid, surface disinfection, and linen disinfection. Polyhexamethylene Biguanide (Polihexanid, PHMB)eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Branded as Baquacil, Polyhexamethylene Biguanide (Polihexanid, PHMB)also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. Polyhexamethylene Biguanide (Polihexanid, PHMB)is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Polyhexamethylene Biguanide (Polihexanid, PHMB)Leisure Time Free system.Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. The Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride salt (solution) is used in the majority of formulations. Polyhexamethylene Biguanide (Polihexanid, PHMB)a related biguanide disinfectant. Polyhexamethylene Biguanide (Polihexanid, PHMB)(is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. As reported previously, Poliheksametilen biguanid (Poliheksanid, PHMB) displayed potent growth inhibitory and cidal properties Also, following treatment, we examined cells using light microscopy. Unexpectedly, growth inhibitory concentrations of Poliheksametilen biguanid (Poliheksanid, PHMB) did not lyse cells, as monitored by bright-field microscopy. To assess cell barrier damage that could be invisible to microscopy, E. coli K-12 cultures were grown to mid-log phase, treated with Poliheksametilen biguanid (Poliheksanid, PHMB) in the presence of the fluorescent membrane integrity probe and then monitored using fluorimetry. This probe is useful as an indicator of membrane damage; because it is normally excluded from intact bacteria and its fluorescence quantum yield increases upon DNA binding. Therefore, intact bacteria are expected to display low fluorescence, and fluorescence is expected to increase following cell barrier damage As anticipated, freshly grown E. coli cultures displayed large increases in fluorescence following treatment with the known cell wall disruptor polymyxin B or heat treatment .Unexpectedly, Poliheksametilen biguanid (Poliheksanid, PHMB) treatment resulted in comparatively lower levels of fluorescence. Most strikingly, higher concentrations of Poliheksametilen biguanid (of Poliheksametilen biguanid (Poliheksanid), SYTOX®Green bound isolated E. coli DNA, as indicated by a large increase in fluorescence, relative to the addition of dye alone. However, prior addition of Poliheksametilen biguanid (Poliheksanid, PHMB) reduced fluorescence >80% . Therefore Poliheksametilen biguanid (Poliheksanid, PHMB) forms complexes with bacterial DNA in a way that retards electrophoretic mobility and masks DNA access to DNA ligands. The results of each of these experiments indicate that Poliheksametilen biguanid (Poliheksanid, PHMB) binds directly to DNA. Chronic wounds are often complex, difficult to heal, and may persist for months or years due to underlying disease processes or complications within the healing process. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Treating chronic wounds requires a multifaceted approach in order to address the underlying pathophysiology while promoting healing of the wound.1-4 Before a wound can close, the wound bed status needs to be addressed to assist in creating an environment conducive to tissue repair. This may require 1) removal of nonviable tissue, 2) maintenance of a moisture balance, 3) resolution of any bacterial imbalance, and 4) removal of impediments to healing at the epidermal margins.4 While each of these require attention, concern with bacterial imbalance in the wound bed has lead to the development and commercialization of a variety of antimicrobial (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide) products and therapies.

Bacterial imbalance. When wounds fail to heal or are classified as recalcitrant, one of the factors delaying healing that merits consideration is bacterial load in the wound bed and its effect on the tissue repair process.5,6 All chronic wounds are believed to have some level of bacterial bioburden. Depending on the number of organisms, the level of bacteria in the wound bed may be classified as contaminated, colonized, critically colonized, or infected.4,7 Contamination (the presence of organisms in a wound) and colonization (the proliferation of those organisms) are not routinely treated with oral or systemic antibiotics. Once a wound becomes critically colonized (a level of colonization affecting skin cell proliferation and tissue repair), it may progress to a "classic" infection, which may include erythema, cellulitis, edema, and increases in odor, pain, exudate, white blood cell count, and increased body temperature.(Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Delayed closure may suggest the formation of an extracellular polysaccharide matrix film or layer (sometimes called a glycocalyx) that shields the bacteria from attack while maintaining the moist environment in which they thrive. These colonies of bacteria are called biofilms and are produced by Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, and E coli, among others. The biofilm makes it difficult to eliminate pathogens by requiring as much as 50-1000 times the minimal inhibitory concentration (MIC) of an antibiotic or antiseptic.(Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Clinicians may attempt to address the bacterial imbalance by combining treatment modalities. To address infection in the wound bed systemic or oral antibiotics should be considered the first line of therapy, especially in complicated skin infections with clinical signs of cellulitis, leukocytosis, or fever. In conjunction with systemic therapy, there are a number of antimicrobial dressings currently on the market indicated for use on infected wounds. Antimicrobial dressings are comprised of a variety of different base materials to which antimicrobial agents are added. The major purported benefits of these dressings are that they may reduce the presence of pathogens and decrease the risk of infection while creating a wound bed that will readily support the normal sequence of wound repair. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide) The use of topical antimicrobial agents for wound care gained a wide acceptance in the 1960s once it was discovered that treating burns with silver nitrate decreased the number of deaths that were a result of sepsis from 60% to 28%. Antiseptic silver sulfadiazine (SSD) was associated with additional decreases in infection, eventually making a place for itself in general wound care. Silver sulfadiazine demonstrated improved outcomes and decreased infection rates. Antiseptics differ from antibiotics in that they have broad-spectrum activity and can be effective against many types of organisms including aerobic and anaerobic bacteria, yeasts, fungi, and molds. While there is concern that certain antiseptics may delay healing as a result of cytotoxicity to viable cells,14 current wound treatment products must demonstrate biocompatibility and effectiveness to reduce bioburden prior to approval for an antimicrobial indication. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Antiseptics used in current wound dressings include silver, iodine, and Polyhexamethylene Biguanide (Polihexanid, PHMB)(Poliheksametilen biguanid (Poliheksanid)).Bacterial resistance to antibiotics is extensively documented in medical literature. Resistance to antiseptics, however, has only been studied more recently. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Tambe and associates compared the ability of Staphylococcus epidermidis to develop resistance to various antibiotics and antiseptics after 20 S epidermidis cell culture passages. Results suggested that the bacteria developed resistance to the antibiotics minocycline and rifampicin, however no evidence of resistance was observed with chlorhexidine, silver sulfadiazine, and Poliheksametilen biguanid (Poliheksanid). Minor resistance was seen with Triclosan.

Silver. Silver has been used as an antimicrobial agent for thousands of years. Silver ions exert varying antimicrobial effects depending on their binding site. When binding occurs at the bacterial cell wall, ruptures can occur. When bound to proteins involved in respiration and nutrition of the organism, silver blocks these processes and the bacterium dies. When binding to DNA, silver can affect the replication and division of the organism.

The activity of silver lies in its ionic form.Elemental silver and silver salts demonstrate substantially less effectiveness against microbes. Previously, silver salt solutions, such as silver nitrate, were used to bathe the wound. These required large amounts of silver to achieve the desired effect. Silver sulfadiazine (SSD) creams enable much lower amounts of silver to be effective and act by discharging silver ions when in contact with wound exudate. Fox and Modak18 describe the mechanism by which sulfadiazine binds the silver and releases it into the wound over time at concentrations that are bactericidal. The silver ions, however, may be rapidly neutralized and require daily or more frequent application of SSD. The amount of silver released into the wound is not always clearly defined and can be a concern for toxicity in healthy tissue. More recent technological advancements have lead to methods of delivering silver to wounds over longer periods of time and at more predictable levels. (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)There are a variety of silver containing wound dressings available. Delivery systems vary and include polyethylene mesh (Acticoat®, Smith and Nephew, Largo, Fla), polyurethane foam (Contreet Ag®, Coloplast, Holtedam, Denmark), activated carbon (Actisorb 220®, Johnson and Johnson, Somerville, NJ), hydrocolloid (Contreet-H®, Coloplast), alginate with polymers (Arglaes®, Medline, Mundelein, Ill), alginate with carboxymethylcellulose (CMC) (SilverCel®, Johnson and Johnson), sodium carboxymethylcellulose (Aquacel Ag®, ConvaTec, Skillman, NJ), nylon (Silverlon®, Argentum Medical, Asheville, NC), and polyacrylate (Silvasorb®, Medline). (Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Thomas and McCubbin20,21 compared the in-vitro effectiveness of various silver containing products using 3 methods-zone of inhibition, challenge testing, and microbial transmission testing to demonstrate differences in the various dressings. Results against Staphylococcus aureus, Escherichia coli, and Candida albicans suggested that polyethylene mesh had the most rapid antimicrobial effect due to its rapid release of silver. Hydrocolloid was similar but had a slower onset. Activated carbon had little activity on the surface, but organisms that were absorbed into the dressing were inactivated by the silver. Jones et al22 found that some of the differences observed between polyethylene mesh and sodium CMC may be related to the conformability of the dressing. A greater wound bed conformability and contact correlated with an increased antimicrobial effect. Polyhexamethylene Biguanide (Polihexanid, PHMB)can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc. Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in health care, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in chemicals, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in textiles, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in paper, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in wipes,Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in livestock, aquaculture, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in fisheries, plastics, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in agriculture, Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in water treatment and Polyhexamethylene Biguanide (Polihexanid, PHMB)is widely used in other fields.Polyhexamethylene Biguanide (Polihexanid, PHMB)can be used directly after dilution with purified water or with other additive agent compound. Reference amount 1:125~1:1000 (w/w).

Since Polyhexamethylene Biguanide (Polihexanid, PHMB)in different areas of application, the product dosage are quite different, Polyhexamethylene Biguanide (Polihexanid, PHMB)is recommended to use under the guidance of our professional and technical persons.Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, Polyhexamethylene Biguanide (Polihexanid, PHMB)is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. Polyhexamethylene Biguanide (Polihexanid, PHMB)has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae). Polyhexamethylene Biguanide (Polihexanid, PHMB)containing Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for inter-operative irrigation, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for pre- and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for post-surgery skin and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for mucous membrane Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for disinfection, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for post-operative dressings, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for surgical and Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for non-surgical wound dressings, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for surgical bath/hydrotherapy,Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for chronic wounds like diabetic foot ulcer and burn wound management, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for routine antisepsis during minor incisions, Polyhexamethylene Biguanide (Polihexanid, PHMB)are used for catheterization, scopy, first aid, surface disinfection, and linen disinfection. Polyhexamethylene Biguanide (Polihexanid, PHMB)eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Branded as Baquacil, Polyhexamethylene Biguanide (Polihexanid, PHMB)also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. Polyhexamethylene Biguanide (Polihexanid, PHMB)is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Polyhexamethylene Biguanide (Polihexanid, PHMB)Leisure Time Free system.Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. Polyhexamethylene Biguanide (Polihexanid, PHMB)is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. The Polyhexamethylene Biguanide (Polihexanid, PHMB)hydrochloride salt (solution) is used in the majority of formulations. Polyhexamethylene Biguanide (Polihexanid, PHMB)a related biguanide disinfectant. Polyhexamethylene Biguanide (Polihexanid, PHMB)(is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyhexamethylene Biguanide (Polihexanid, PHMB) is an antiseptic with antiviral and antibacterial properties used in several ways including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyhexamethylene Biguanide (Polihexanid, PHMB) is also known as polyhexanide and polyaminopropyl biguanide, polymeric biguanide hydrochloride; polyhexanide biguanide. Studies suggest that iodine`s mechanism of action is through destabilization of the bacterial cell wall and disruption of the membrane that results in leakage of the intracellular components.Poliheksametilen biguanid (Poliheksanid)) (polihexametilenbiguanid) (polyhexamethylene biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Polyhexamethylene Biguanide (Polihexanid, PHMB)(Poliheksametilen biguanid (Poliheksanid)). Polyhexamethylene Biguanide (Polihexanid, PHMB)(Poliheksametilen biguanid (Poliheksanid)), also known as polyhexanide and polyaminopropyl biguanide, is a commonly used antiseptic. It is used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. A review of the literature demonstrates in-vivo and in-vitro safety and effectiveness of Poliheksametilen biguanid (Poliheksanid, PHMB) for a number of applications. For wound dressings, Wright and colleagues compared the effectiveness of a silver dressing to a dry gauze dressing containing Poliheksametilen biguanid (Poliheksanid, PHMB) (Kerlix AMD). Results demonstrated reduction in bioburden with both dressings when tested in an in-vitro bactericidal assay. Using a Kirby-Bauer zone of inhibition study, the gauze was not as effective.

POLYHEXAMETHYLENE BIGUANIDE (POLİHEGZAMETİLEN BİGUANİD)

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