1-9 A-D E-G H-M N-P Q-S T-Z

PLURONIC FT L 61

PLURONIC FT L 61

CAS No.: 9003-11-6
EC No.: 618-355-0

Synonyms:
PLURONIC FT L 61; Poloxamer; Poloksamer; 9003-11-6;Poloxamer;Poloksamer; Poloksamer;  Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Pluronic; Pluronıc; Poloksamer-pluronıc; Poloksamer-pluronic; Poloxamer;pluronic; poloxamer;pluronıc; poloxamer-pluronic; poloxamer-pluronıc; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene) block copolymer; Oxirane; methyl-; polymer with oxirane; Oxirane; methyl-; polymer with; oxirane; block; Pluronic F 38; Pluronic F108; Pluronic F127; Pluronic F68; Pluronic F77; Pluronic L44; Pluronic L62; Pluronic L64; Pluronic P103; Pluronic P104; Pluronic P105; Poloksamer-101;  poloksamer- 105;  Poloksamer- 108;  Poloxamer- 122; Poloksamer- 123; Poloksamer- 124; Poloksamer-181; Poloksamer-182; Poloksamer-183; PLURONIC FT L 61; Poloxamer- 184; Poloksamer-185; Poloksamer- 188; Poloxamer- 212; Poloksamer-215; Poloksamer-; PLURONIC FT L 61; Poloksamer-217 Poloksamer- 234; Poloksamer- 235; Poloksamer- 237; Poloksamer-238; Poloksamer-282; Poloksamer-284; PPoloksamer-r 288; Poloxamer- 331; Poloxamer- 333; Poloxamer- 334; Poloksamer-335; Poloxamer- 338; Poloksamer-401; Poloksamer-402; Poloksamer- 402; Poloxamer-s Poloxamer- 101; Poloxamer- 105; Poloxamer- 108; Poloxamer- 122; Poloxamer- 123; Poloxamer- 124; PLURONIC FT L 61; Poloxamer- 181; Poloxamer- 182; Poloxamer- 183; Poloxamer- 184; Poloxamer- 185; Poloxamer- 188; Poloxamer- 212; Poloxamer; Poloksamer; 9003-11-6;Poloxamer;Poloksamer; Poloksamer;  Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Pluronic; Pluronıc; Poloksamer-pluronıc; PLURONIC FT L 61; Poloksamer-pluronic; Poloxamer;pluronic; poloxamer;pluronıc; poloxamer-pluronic; poloxamer-pluronıc; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene) block copolymer Poloxamer- 215; Poloxamer- 217; Poloxamer- 231; Ethylene glycol-propylene glycol block ; PLURONIC FT L 61; PLURONIC FT L 61; Ethylene oxide-propylene oxide block copolymer dipropylene glycol ;  oxide block copolymer ether with ethylene glycol; Ethylene oxide-propylene oxide block polymer; Poloxamer- 234; Poloxamer- 235; Poloxamer- 237; Poloxamer- 238; Poloxamer- 282; Poloxamer- 284; Poloxamer- 288; PLURONIC FT L 61; PLURONIC FT L 61; Poloxamer- 331; Poloxamer- 333; Poloxamer- 334; Poloxamer- 335; Poloxamer- 338; Ethylene glycol-propylene glycol block; Ethylene oxide-propylene oxide block copolymer dipropylene glycol; oxide block copolymer ether with ethylene glycol; Ethylene oxide-propylene oxide block polymer; Poloxamer- 401; Poloxamer- 402; Poloxamer- 403; Poloxamer- 407; Poloxamer- 105; Pluronic P123; Pluronic P65; Pluronic P84; Pluronic P85; Poloxamer-188; Tergitol XH; PLURONIC FT L 61; PLURONIC FT L 61; Ethylene glycol-propylene glycol block; Ethylene oxide-propylene oxide block copolymer dipropylene glycol;  oxide block copolymer ether with ethylene glycol; Ethylene oxide-propylene oxide block polymer; F 108; F 127; F 77; F 87; F 88; Lutrol F; Methyloxirane polymer with oxirane block; P 103; P 104; P 105; P 123; P 65; P 84; P 85; Pluracare; Pluronic; Pluronic L 61; Poloxamer; Poloxamer 188; Polyoxamer 108; Polyoxypropylene-polyoxyethylene block copolymer; Propylene oxide ethylene oxide block polymer; Slovanik M-640; Tergitol nonionic XH; (Poloksamer(Pluronic)101;  poloksamer(Pluronic) 105;  PLURONIC FT L 61; PLURONIC FT L 61; Poloksamer(Pluronic) 108;  Poloxamer(Pluronic) 122; Poloksamer(Pluronic) 123; Poloksamer(Pluronic) 124; Poloksamer(Pluronic)181; Poloksamer(Pluronic)182; Poloksamer(Pluronic)183; Poloxamer(Pluronic) 184; Poloksamer(Pluronic)185; Poloksamer(Pluronic) 188; PLURONIC FT L 61; PLURONIC FT L 61; Poloxamer(Pluronic) 212; Poloksamer(Pluronic)215; Poloksamer(Pluronic); Poloksamer(Pluronic)217 Poloksamer(Pluronic) 234; Poloksamer(Pluronic) 235; Poloksamer(Pluronic) 237; Poloksamer(Pluronic)238; Poloksamer(Pluronic)282; Poloksamer(Pluronic)284; PPoloksamer(Pluronic)r 288; PLURONIC FT L 61; PLURONIC FT L 61; Poloxamer(Pluronic) 331; Poloxamer(Pluronic) 333; Poloxamer(Pluronic) 334; Poloksamer(Pluronic)335; Poloxamer(Pluronic) 338; Poloksamer(Pluronic)401; Poloksamer(Pluronic)402; Poloksamer(Pluronic) 402; Poloxamer(Pluronic)s Poloxamer(Pluronic) 101; Poloxamer; Poloksamer; 9003-11-6;Poloxamer;Poloksamer; Poloksamer;  Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Pluronic; Pluronıc; Poloksamer-pluronıc; Poloksamer-pluronic; Poloxamer;pluronic; poloxamer;pluronıc; PLURONIC FT L 61; PLURONIC FT L 61; poloxamer-pluronic; poloxamer-pluronıc; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene) block copolymer; Oxirane; methyl-; polymer with oxirane; Oxirane; methyl-; polymer with; oxirane; block; Pluronic F 38; Pluronic F108; Pluronic F127; Pluronic F68; Pluronic F77; Pluronic L44; Pluronic L62; Pluronic L64; Pluronic P103; Pluronic P104; Pluronic P105; Poloxamer(Pluronic) 105; Poloxamer(Pluronic) 108; Ethylene glycol-propylene glycol block ; Ethylene oxide-propylene oxide block copolymer dipropylene glycol ;  oxide block copolymer ether with ethylene glycol; PLURONIC FT L 61; PLURONIC FT L 61; Poloxamer; Poloksamer; 9003-11-6;Poloxamer;Poloksamer; Poloksamer;  Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Pluronic; Pluronıc; Poloksamer-pluronıc; Poloksamer-pluronic; Poloxamer;pluronic; poloxamer;pluronıc; poloxamer-pluronic; poloxamer-pluronıc; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene) block copolymerEthylene oxide-propylene oxide block polymer; Poloxamer(Pluronic) 122; Poloxamer(Pluronic) 123; Poloxamer(Pluronic) 124; Poloxamer(Pluronic) 181; Poloxamer(Pluronic) 182; Poloxamer(Pluronic) 183; PLURONIC FT L 61; PLURONIC FT L 61; Ethylene glycol-propylene glycol block ; Ethylene oxide-propylene oxide block copolymer dipropylene glycol ;  oxide block copolymer ether with ethylene glycol; Ethylene oxide-propylene oxide block polymer; Poloxamer(Pluronic) 184; Poloxamer(Pluronic) 185; Poloxamer(Pluronic) 188; Poloxamer(Pluronic) 212; Poloxamer(Pluronic) 215; Poloxamer(Pluronic) 217; Poloxamer; Poloksamer; 9003-11-6;Poloxamer;Poloksamer; Poloksamer;  Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Pluronic; Pluronıc; Poloksamer-pluronıc; Poloxamer; Poloksamer; 9003-11-6;Poloxamer;Poloksamer; Poloksamer;  Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Pluronic; Pluronıc; Poloksamer-pluronıc; Poloksamer-pluronic; Poloxamer;pluronic; poloxamer;pluronıc; poloxamer-pluronic; poloxamer-pluronıc; PLURONIC FT L 61; PLURONIC FT L 61; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene) block copolymerPoloksamer-pluronic; Poloxamer;pluronic; poloxamer;pluronıc; poloxamer-pluronic; poloxamer-pluronıc; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene) block copolymer Poloxamer(Pluronic) 231; Poloxamer(Pluronic) 234; Poloxamer(Pluronic) 235; Poloxamer(Pluronic) 237; Poloxamer(Pluronic) 238; Poloxamer; Poloksamer; 9003-11-6;Poloxamer;Poloksamer; Poloksamer;  Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Pluronic; Pluronıc; Poloksamer-pluronıc; Poloksamer-pluronic; Poloxamer;pluronic; poloxamer;pluronıc; poloxamer-pluronic; poloxamer-pluronıc; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene) block copolymerPoloxamer(Pluronic) 282; Poloxamer(Pluronic) 284; Poloxamer(Pluronic) 288; Poloxamer(Pluronic) 331; Ethylene glycol-propylene glycol block ; Ethylene oxide-propylene oxide block copolymer dipropylene glycol ;  oxide block copolymer ether with ethylene glycol; Ethylene oxide-propylene oxide block polymer;  Poloxamer(Pluronic) 333; Poloxamer(Pluronic) 334; Poloxamer(Pluronic) 335; Poloxamer(Pluronic) 338; PLURONIC FT L 61; PLURONIC FT L 61; Poloxamer(Pluronic) 401; Poloxamer(Pluronic) 402; Poloxamer(Pluronic) 403; and Poloxamer(Pluronic) 407; Poloxamer(Pluronic) 105; Poloxamer; Poloksamer; 9003-11-6;Poloxamer;Poloksamer; Poloksamer;  Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol); Pluronic; Pluronıc; Poloksamer-pluronıc; Poloksamer-pluronic; Poloxamer;pluronic; PLURONIC FT L 61; PLURONIC FT L 61; poloxamer;pluronıc; poloxamer-pluronic; poloxamer-pluronıc; alpha-Hydro-omega-hydroxypoly(oxyethylene)a-poly(oxopropylene)b-poly(oxyethylene) block copolymer; PLURONIC FT L 61


PLURONIC FT L 61

PLURONIC FT L 61ler, iki hidrofilik polioksietilen (poli (etilen oksit)) zinciriyle çevrili merkezi bir hidrofobik polioksipropilen (poli (propilen oksit)) zincirinden oluşan kopolimerlerdir. PLURONIC FT L 61ler noniyonik triblok kopolimerlerdir. PLURONIC FT L 61 kelimesi, 1973 yılında bu malzemeler için patent alan mucit Irving Schmolka tarafından icat edildi. PLURONIC FT L 61ler ayrıca Synperonics, PLURONIC FT L 61,  ve Kolliphor ticari isimleriyle de bilinir. Polimer blokların uzunlukları özelleştirilebildiğinden, biraz farklı özelliklere sahip birçok farklı PLURONIC FT L 61 mevcuttur. . PLURONIC FT L 61ler (PLURONIC FT L 61101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61181, PLURONIC FT L 61182, PLURONIC FT L 61183, PLURONIC FT L 61 184, PLURONIC FT L 61185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61215, PLURONIC FT L 61, PLURONIC FT L 61217 PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61238, PLURONIC FT L 61282, PLURONIC FT L 61284, PPLURONIC FT L 61r 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61401, PLURONIC FT L 61402, PLURONIC FT L 61 402 Benzoat, PLURONIC FT L 61 182 Dibenzoat), bir polioksietilen bloğundan, ardından bir polioksipropilen bloğundan, ardından bir polioksietilen bloğundan yapılmış polimerlerdir.  Genel terim PLURONIC FT L 61 için, bu kopolimerler genellikle P harfiyle (PLURONIC FT L 61 için) ve ardından üç rakamla adlandırılır: 100 ile çarpılan ilk iki rakam, polioksipropilen çekirdeğin yaklaşık moleküler kütlesini verir ve 10 ile çarpılan son rakam, yüzde polioksietilen içeriği (örneğin, P407 = 4000 g / mo'luk bir polioksipropilen moleküler kütlesi ve% 70 polioksietilen içeriği olan PLURONIC FT L 61). PLURONIC FT L 61 PLURONIC FT L 61 ve Synperonic ticari adları için, bu kopolimerlerin kodlanması, oda sıcaklığında fiziksel formunu tanımlayan bir harfle başlar (L = sıvı, P = macun, F = pul (katı)) ve ardından iki veya üç rakam, İlk rakam ( üç basamaklı bir sayıdaki iki basamak), 300 ile çarpılan sayısal atamada hidrofobun yaklaşık moleküler ağırlığını gösterir; ve son rakam x 10, polioksietilen içeriği yüzdesini verir (örneğin, L61, 1800 g / mol'lük bir polioksipropilen moleküler kütlesini ve% 10'luk bir polioksietilen içeriğini belirtir). Verilen örnekte, PLURONIC FT L 61 181 (P181) = PLURONIC FT L 61 L61 ve Synperonic PE / L 61. PLURONIC FT L 61 PLURONIC FT L 61101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61122, PLURONIC FT L 61123, PLURONIC FT L 61124, PLURONIC FT L 61181, PLURONIC FT L 61182, PLURONIC FT L 61183, PLURONIC FT L 61184, PLURONIC FT L 61 185, PLURONIC FT L 61188, PLURONIC FT L 61 212, PLURONIC FT L 61215, PLURONIC FT L 61217'nin değerlendirilmesi , PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61237, PLURONIC FT L 61238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61288, PLURONIC FT L 61331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 402 Kozmetiklerde Kullanılan PLURONIC FT L 61 105 Benzoate ve PLURONIC FT L 61 Dibenzoate. PLURONIC FT L 61 solüsyonlarının önemli bir özelliği, sıcaklığa bağlı kendiliğinden birleşme ve ısıyla jelleşme davranışlarıdır. PLURONIC FT L 61lerin konsantre sulu çözeltileri, düşük sıcaklıkta sıvıdır ve tersine çevrilebilir bir işlemde daha yüksek sıcaklıkta bir jel oluşturur. Bu sistemlerde meydana gelen geçişler, polimer bileşimine (moleküler ağırlık ve hidrofilik / hidrofobik molar oran) bağlıdır.
PLURONIC FT L 61ler, emülsiyon haline getirilecek maddelerin yüzey gerilimini azaltarak emülsiyonlar oluşturmaya yardımcı olur ve diğer bileşenlerin normalde çözünmeyecekleri bir çözücü içinde çözünmesine yardımcı olur. Suyun yağ ve kir ile karışmasına yardımcı olarak cildi ve saçı da temizler, böylece durulanabilir. PLURONIC FT L 61 188, mikroorganizmaları öldürür veya büyümelerini ve çoğalmalarını önler veya inhibe eder. PLURONIC FT L 61 182 Dibenzoat, cilt yüzeyinde kayganlaştırıcı görevi görerek cilde yumuşak ve pürüzsüz bir görünüm kazandırır.

. PLURONIC FT L 61ler (PLURONIC FT L 61101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61181, PLURONIC FT L 61182, PLURONIC FT L 61183, PLURONIC FT L 61 184, PLURONIC FT L 61185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61215, PLURONIC FT L 61, PLURONIC FT L 61217 PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61238, PLURONIC FT L 61282, PLURONIC FT L 61284, PPLURONIC FT L 61r 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61401, PLURONIC FT L 61402, PLURONIC FT L 61 402 Benzoat, PLURONIC FT L 61 182 Dibenzoat), bir polioksietilen bloğundan, ardından bir polioksipropilen bloğundan, ardından bir polioksietilen bloğundan yapılmış polimerlerdir. Düşük sıcaklıklarda ve konsantrasyonlarda (kritik misel sıcaklığının ve kritik misel konsantrasyonunun altında), çözelti içinde ayrı blok PLURONIC FT L 61 kopolimerler (unimerler) mevcuttur. Bu değerlerin üzerinde, miselleştirme adı verilen bir süreçte tek tek unimerlerin toplanması meydana gelir. Bu agregasyon, polimer konsantrasyonu veya sıcaklık arttıkça giderek daha az çözünür hale gelen hidrofobik polioksipropilen bloğunun dehidrasyonu tarafından yönlendirilir. PLURONIC FT L 61 PPO bloklarının çözücü ile etkileşimlerini en aza indirmek için birkaç unimerin toplanması gerçekleşir. Bu nedenle, agregaların çekirdeği çözünmez bloklardan (polioksipropilen) yapılırken, çözünür kısım (polioksietilen) misellerin kabuğunu oluşturur. Tükürük proteinlerinden Lizozim ve Laktoferrin içeren bir preparatın küçük çocuklarda diş çürüklerinin önlenmesi için bir çözüm getirebileceği düşünülmüş, PLURONIC FT L 61 taşıyıcı sistemler kullanılarak geliştirilen yeni bir formulasyonun topikal uygulamalarının ağız hastalıklarının tedavisinde etkili olduğu görülmüştür. Bu nedenle, Lizozim, Laktoferrin ve taşıyıcı sistem olarak PLURONIC FT L 61 F-127 isimli PLURONIC FT L 61 kullanılan, diş çürüğüne neden olduğu bilinen Streptococcus sobrinus, Streptococcus mutans ve Lactobacillus acidophilus bakteri suşları üzerindeki antibakteriyel etkileri kanıtlanmış farklı formulasyonlar geliştirilmiştir. Bu çalışmanın amacı, yeni geliştirilmiş bu formulasyonların biyouyumluluklarının klorheksidin jel ile karşılaştırmalı olarak in vitro koşullarda değerlendirilmesidir. PLURONIC FT L 61 PLURONIC FT L 61101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61122, PLURONIC FT L 61123, PLURONIC FT L 61124, PLURONIC FT L 61181, PLURONIC FT L 61182, PLURONIC FT L 61183, PLURONIC FT L 61184, PLURONIC FT L 61 185, PLURONIC FT L 61188, PLURONIC FT L 61 212, PLURONIC FT L 61215, PLURONIC FT L 61217'nin değerlendirilmesi , PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61237, PLURONIC FT L 61238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61288, PLURONIC FT L 61331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 402 Kozmetiklerde Kullanılan PLURONIC FT L 61 105 Benzoate ve PLURONIC FT L 61 Dibenzoate. Çalışmamızda kullanılan formulasyonlar: (1) pH:5.0 Sorensen's Tampon Çözeltisi, (2) %20 a/h PLURONIC FT L 61 407 jel, (3) %10 a/h PLURONIC FT L 61 407 jel, (4) Lizozim ve Laktoferrinin %20 konsantrasyondaki PLURONIC FT L 61 407 ile birleştirilmesiyle, (5) 4. grubun MİK değeri olacak şekilde Lizozim ve Laktoferrinin %10 konsantrasyondaki PLURONIC FT L 61 407 ile birleştirilmesiyle, (6) Sorensen's Çözeltisi (pH:7.0) negatif kontrol olarak, (7) Lizozim ve Laktoferrin tamponda (Sorensen's Çözeltisi pH:5.0) çözdürülerek yedi grup olarak hazırlanmıştır. Genel CAS No. 9003-11-6 tüm PLURONIC FT L 61ler için geçerlidir. PLURONIC FT L 61 105 Benzoate ve PLURONIC FT L 61 182 Dibenzoate CAS numarası yok. Bu polimerler sentetik bloktur etilen oksit ve propilen oksit kopolimerleri. Tıp ve araştırma uygulamalarında, genellikle bir PLURONIC FT L 61 ticari adı olan blok polimerler olarak anılırlar.

Daha çok polaksamer olarak adlandırılır. Orta blok hidrofobik olduğundan ve iki uç blok hidrofilik olduğundan, PLURONIC FT L 61, polimer yüzey aktif madde olarak davranır. Polaksamer noniyonik polimer yüzey aktif madde olarak kullanılır. Polaksamerler köpük önleyici maddeler, ıslatıcı maddeler, dağıtıcılar, koyulaştırıcılar ve emülgatörler olarak işlev görebilirler. PLURONIC FT L 61ler, iki hidrofilik polioksietilen (poli (etilen oksit)) zinciriyle çevrili merkezi bir hidrofobik polioksipropilen (poli (propilen oksit)) zincirinden oluşan kopolimerlerdir. PLURONIC FT L 61ler noniyonik triblok kopolimerlerdir. PLURONIC FT L 61 kelimesi, 1973 yılında bu malzemeler için patent alan mucit Irving Schmolka tarafından icat edildi. PLURONIC FT L 61ler ayrıca Synperonics, PLURONIC FT L 61,  ve Kolliphor ticari isimleriyle de bilinir. Polimer blokların uzunlukları özelleştirilebildiğinden, biraz farklı özelliklere sahip birçok farklı PLURONIC FT L 61 mevcuttur. Genel terim PLURONIC FT L 61 için, bu kopolimerler genellikle P harfiyle (PLURONIC FT L 61 için) ve ardından üç rakamla adlandırılır: 100 ile çarpılan ilk iki rakam, polioksipropilen çekirdeğin yaklaşık moleküler kütlesini verir ve 10 ile çarpılan son rakam, yüzde polioksietilen içeriği (örneğin, P407 = 4000 g / mo'luk bir polioksipropilen moleküler kütlesi ve% 70 polioksietilen içeriği olan PLURONIC FT L 61). PLURONIC FT L 61ler  (, PLURONIC FT L 61 212, PLURONIC FT L 61215, PLURONIC FT L 61, PLURONIC FT L 61217 PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61238, PLURONIC FT L 61282, PLURONIC FT L 61284, PPLURONIC FT L 61r 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61401, PLURONIC FT L 61402, PLURONIC FT L 61 402 Benzoat, PLURONIC FT L 61 182 Dibenzoat)PLURONIC FT L 61101PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61181, PLURONIC FT L 61182, PLURONIC FT L 61183, PLURONIC FT L 61 184, PLURONIC FT L 61185, PLURONIC FT L 61 188, bir polioksietilen bloğundan, ardından bir polioksipropilen bloğundan, ardından bir polioksietilen bloğundan yapılmış iki hidrofilik polioksietilen (poli (etilen oksit)) zinciriyle çevrili merkezi bir hidrofobik polioksipropilen (poli (propilen oksit)) zincirinden oluşan kopolimerlerdir.Polaksamer noniyonik polimer yüzey aktif madde olarak kullanılır. Polaksamerler köpük önleyici maddeler, ıslatıcı maddeler, dağıtıcılar, koyulaştırıcılar ve emülgatörler olarak işlev görebilirler. 

Faz geçişleri, tuzlar ve alkoller gibi katkı maddelerinin kullanımından da büyük ölçüde etkilenebilir. Tuzlarla etkileşimler, su yapısı yapıcıları (tuzlama) veya su yapısı kırıcıları (tuzlama) olarak hareket etme yetenekleriyle ilgilidir. Tuzsuz tuzlar, hidrojen bağı yoluyla suyun kendi kendine hidrasyonunu arttırır ve kopolimerlerin hidrasyonunu azaltır, böylece kritik misel sıcaklığını ve kritik misel konsantrasyonunu azaltır. Tuzlama elektrolitleri suyun kendi kendine hidrasyonunu azaltır ve polimer hidrasyonunu artırır, bu nedenle kritik misel sıcaklığını ve kritik misel konsantrasyonunu artırır. Farklı tuzlar, Hofmeister serisi tarafından 'tuzlama' güçlerine göre sınıflandırılmıştır. Tüm bu geçişleri karakterize eden farklı faz diyagramları, çok çeşitli deneysel teknikler (örneğin SAXS, Diferansiyel tarama kalorimetrisi, viskozite ölçümleri, ışık saçılımı) kullanılarak çoğu PLURONIC FT L 61 için oluşturulmuştur.
PLURONIC FT L 61lerin, membranların mikro viskozitesini etkileyen hücresel membranlara dahil oldukları gösterilmiştir. Polimerler, hücre tarafından bir miselden ziyade bir unimer olarak emildiğinde en büyük etkiye sahip gibi görünmektedir. "PLURONIC FT L 61ler, iki hidrofilik polioksietilen zinciri ile çevrili merkezi bir hidrofobik polioksipropilen zincirinden oluşan noniyonik triblok kopolimerlerdir. "PLURONIC FT L 61" kelimesi, 1973 yılında PLURONIC FT L 61ler için patent alan mucit Irving Schmolka tarafından icat edildi. PLURONIC FT L 61 61(PLURONIC FT L 61) 333, PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 402 Kozmetiklerde Kullanılan PLURONIC FT L 61 105 Benzoate ve PLURONIC FT L 61 Dibenzoate.PLURONIC FT L 61ler ayrıca PLURONIC FT L 61s ticari adlarıyla da bilinirler. Sudaki konsantre PLURONIC FT L 61 çözeltileri, misel mekanizma tarafından ısıyla tersine çevrilebilir sol-jel geçişine uğrar.115 Ticari PLURONIC FT L 61 407'nin ısıya duyarlı sol-jelleri, ağrı yönetimi, enfeksiyon tedavisi, doğurganlık gibi kısa süreli tedavilerde kullanım için önerilmiştir. PLURONIC FT L 61 PLURONIC FT L 61 407 çözeltileri (-% 25), 25 ° C'nin altındaki viskoz sıvılardır; vücut sıcaklığında yarı katı bir jel oluştururlar. PLURONIC FT L 61 Zayıf mekanik mukavemet, vücut sıvılarında nispeten yüksek çözünürlük ve biyolojik olarak parçalanmama, PLURONIC FT L 61 407'nin hücre iletim sistemlerinde kullanımının önündeki ana engellerdir. PLURONIC FT L 61 "blokları" arasındaki karbonat bağlantısının eklenmesi ve PLURONIC FT L 61lerin daha yüksek moleküler kütleli yapılara bağlanması118, bu dezavantajların üstesinden gelmek için denendi. PLURONIC FT L 61, poli (etilen oksit) -poli (propilen oksit) -poli (etiyelen oksit) triblok kopolimerden (PEO-PPO-PEO) oluşan amfifilik bir blok kopolimerdir.
 PLURONIC FT L 61lerin, kanser dışı hücrelere kıyasla bu hücrelerin zarlarındaki farklılıklar nedeniyle, tercihli olarak kanser hücrelerini hedeflediği gösterilmiştir. PLURONIC FT L 61lerin ayrıca MDR proteinlerini ve kanser hücrelerinin yüzeyindeki diğer ilaç dışa akış taşıyıcılarını inhibe ettiği gösterilmiştir; MDR proteinleri, ilaçların hücrelerden dışarı akışından sorumludur ve bu nedenle polaksemerler kanser hücrelerinin doksorubisin gibi kemoterapötik maddelere duyarlılığını arttırır.
PLURONIC FT L 61lerin ayrıca proto-apoptotik sinyali geliştirdiği, MDR hücrelerinde anti-apoptoik savunmayı azalttığı, glutatyon / glutatyon S-transferaz detoksifikasyon sistemini inhibe ettiği, sitokrom C'nin salınımını indüklediği, sitoplazmada reaktif oksijen türlerini artırdığı ve ortadan kaldırdığı gösterilmiştir. sitoplazmik veziküller içinde ilaç sekestrasyonu. 

P85 gibi belirli PLURONIC FT L 61lerin sadece hedef genleri hedef hücrelere taşıyabildikleri değil, aynı zamanda gen ekspresyonunu da arttırdıkları gösterilmiştir. P85 ve L61 gibi bazı PLURONIC FT L 61lerin de NF kappaB genlerinin transkripsiyonunu uyardığı gösterilmiştir, ancak bunun gerçekleştirildiği mekanizma şu anda bilinmemekle birlikte, P85'in inhibe edici kappanın fosforilasyonunu indüklediği gösterilmiştir. PLURONIC FT L 61ler, etilen oksit bloğu (EO) ve propilen oksit (PO) (OEx – POy – OEx) zincirlerinin oluşturduğu büyük bir kopolimer yüzey aktif madde grubunu içeren noniyonik bileşiklerdir.PLURONIC FT L 61 PLURONIC FT L 61101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61122, PLURONIC FT L 61123, PLURONIC FT L 61124, PLURONIC FT L 61181, PLURONIC FT L 61182, PLURONIC FT L 61183, PLURONIC FT L 61184, PLURONIC FT L 61 185, PLURONIC FT L 61188, PLURONIC FT L 61 212, PLURONIC FT L 61215, PLURONIC FT L 61217'nin değerlendirilmesi , PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61237, PLURONIC FT L 61238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61288, PLURONIC FT L 61331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 402 Kozmetiklerde Kullanılan PLURONIC FT L 61 105 Benzoate ve PLURONIC FT L 61 Dibenzoate.
"PLURONIC FT L 61ler, iki hidrofilik polioksietilen zinciri ile çevrili merkezi bir hidrofobik polioksipropilen zincirinden oluşan noniyonik triblok kopolimerlerdir. "PLURONIC FT L 61" kelimesi, 1973 yılında PLURONIC FT L 61ler için patent alan mucit Irving Schmolka tarafından icat edildi. PLURONIC FT L 61ler ayrıca PLURONIC FT L 61s ticari adlarıyla da bilinirler. Sudaki konsantre PLURONIC FT L 61 çözeltileri, misel mekanizma tarafından ısıyla tersine çevrilebilir sol-jel geçişine uğrar.115 Ticari PLURONIC FT L 61 407'nin ısıya duyarlı sol-jelleri, ağrı yönetimi, enfeksiyon tedavisi, doğurganlık gibi kısa süreli tedavilerde kullanım için önerilmiştir.PLURONIC FT L 61 407 çözeltileri (-% 25), 25 ° C'nin altındaki viskoz sıvılardır; vücut sıcaklığında yarı katı bir jel oluştururlar. PLURONIC FT L 61 Zayıf mekanik mukavemet, vücut sıvılarında nispeten yüksek çözünürlük ve biyolojik olarak parçalanmama, PLURONIC FT L 61 407'nin hücre iletim sistemlerinde kullanımının önündeki ana engellerdir. PLURONIC FT L 61 "blokları" arasındaki karbonat bağlantısının eklenmesi ve PLURONIC FT L 61lerin daha yüksek moleküler kütleli yapılara bağlanması118, bu dezavantajların üstesinden gelmek için denendi. PLURONIC FT L 61, poli (etilen oksit) -poli (propilen oksit) -poli (etiyelen oksit) triblok kopolimerden (PEO-PPO-PEO) oluşan amfifilik bir blok kopolimerdir.
PLURONIC FT L 61ler, ABA tipi triblok yapıya sahip başka bir ısıya duyarlı hidrojel türüdür. PLURONIC FT L 61ler, toksik olmadığı bildirildiğinden ve 25 ° C'de ağırlıkça% 20'lik bir konsantrasyonda jeller oluşturabildiğinden ilaç dağıtımı için yaygın olarak kullanılmaktadır . Bununla birlikte, PLURONIC FT L 61 uygulamaları, tamamen fiziksel çapraz bağlanmadan kaynaklanan zayıf mekanik özellikleri nedeniyle büyük ölçüde sınırlıdır. Bu jeller, düşük viskozite ve çok yüksek geçirgenlikler ile karakterize edilir Dahası PLURONIC FT L 61ler vücutta sıcaklık LCST'nin üzerine çıktığında anında jelleşirken, sulu çözeltilerle karıştırıldıklarında yapısal bütünlüklerini kaybederler ve bu da onları ilaç verme amaçları için uygun hale getirmez PLURONIC FT L 61ler (PLURONIC FT L 61101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61181, PLURONIC FT L 61182, PLURONIC FT L 61183, PLURONIC FT L 61 184, PLURONIC FT L 61185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61215, PLURONIC FT L 61, PLURONIC FT L 61217 PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61238, PLURONIC FT L 61282, PLURONIC FT L 61284, PPLURONIC FT L 61r 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61401, PLURONIC FT L 61402, PLURONIC FT L 61 402 Benzoat, PLURONIC FT L 61 182  PNIPAAm polimerleri gibi, kimyasal olarak çapraz bağlanabilen PLURONIC FT L 61leri sentezleyerek bunları gelişmiş mekanik özelliklerle donatmak için çok çaba sarf edilmiştir. Bununla birlikte, PLURONIC FT L 61ler kimyasal yapıları nedeniyle, reaktif gruplar yalnızca zincir uçlarında bulunur, bu nedenle, kimyasal olarak çapraz bağlanabilen gruplar yalnızca üç blok zincirinin uçlarını kapatmak için kullanılabilir. PLURONIC FT L 61lerde iki ana tip çapraz bağlanabilir uç kapatma grubu vardır: metakrilat / akrilat ve etoksilsilan. Metakrilatlar / akrilatlar, metakriloil klorür / akriloil klorürün her iki uçtaki hidroksil gruplarıyla reaksiyona sokulmasıyla polimere bağlanabilir. Benzer şekilde, PLURONIC FT L 61ler (3-izosiyanato-propil) trietoksisilan, 2-etil-heksanoat katalizi altında hidroksil grupları ile reaksiyona girerek etoksisilan uç başlık gruplarını dahil etmek için kullanılabilir. PLURONIC FT L 61lerin bir diğer önemli özelliği, termojelleşme davranışlarıdır: aslında, bu polimerlerin bazılarının su dispersiyonları genellikle düşük sıcaklıklarda sıvı fazdadır, PLURONIC FT L 61ler ancak artan sıcaklıklarda güçlü bir jel haline gelir. PLURONIC FT L 61 ısıyla tersinir jelin formülasyonu ve karakterizasyonu, polimerik mikropartiküller ve hyaluronik asit içerirFiziksel olarak çapraz bağlanmış jeller 142.5 ± 29.7 KPa'lık bir sıkıştırma modülü sergilerken, termal başlatıcı olarak metakrilatlanmış PLURONIC FT L 61 ve amonyum persülfat (APS) kullanan radikal çapraz bağlı jeller üç kat daha serttir ve 415 ± 45.7 KPa'lık bir sıkıştırma modülü sergiler . Lizozim, daha yüksek mekanik özelliklere sahip diakrilatlı PLURONIC FT L 61 hidrojellerin protein salım profilini test etmek için bir model protein olarak kullanılmıştır. Bu PLURONIC FT L 61ler, sıcaklık LCST'nin üzerine çıkarıldığında anında yarı katılaşmış bir fiziksel jel oluşturdu. Daha sonra bu PLURONIC FT L 61ler, UV'ye maruz kalma ile önceden karıştırılmış (4-Benzoilbenzil) trimetilamonyum klorür ile başlatılan foto çapraz bağlanmaya tabi tutuldu. Foto çapraz bağlama ile jeller yapısal bütünlüklerini bir aya kadar korumuştur. 
PLURONIC FT L 61ler, farklı moleküler ağırlıklarda ve PPO / PEO oranlarında bulunan poli (etilen oksit) (PEO) ve poli (propilen oksit) (PPO) 'nun triblok kopolimerleridir. Tek bir polimer zincirinde PEO ve PPO bloklarının varlığı, kendiliğinden birleşme özellikleri geniş bir faz davranışı aralığı sergileyen esasen amfifilik moleküllere PLURONIC FT L 61ler yol açar. Bu miseller ve sıvı kristal fazlar oluşturma yeteneği, büyük ölçüde sıcaklığa bağlıdır çünkü sıcaklığın artması, kritik misel konsantrasyonunu (CMC) azaltan kendi kendine birleşmeye izin verir. PLURONIC FT L 61ler (PLURONIC FT L 61101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61181, PLURONIC FT L 61182, PLURONIC FT L 61183, PLURONIC FT L 61 184, PLURONIC FT L 61185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61215, PLURONIC FT L 61, PLURONIC FT L 61217 PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61238, PLURONIC FT L 61282, PLURONIC FT L 61284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333 PLURONIC FT L 61 334, PLURONIC FT L 61335, PLURONIC FT L 61 338, PLURONIC FT L 61401, PLURONIC FT L 61402, PLURONIC FT L 61 402 Benzoat, PLURONIC FT L 61 182 Dibenzoat), bir polioksietilen bloğundan, ardından bir polioksipropilen bloğundan, ardından bir polioksietilen bloğundan yapılmış polimerlerdir. Ortalama polioksietilen ve polioksipropilen birim sayısı, polimer ile ilişkili sayıya göre değişir. Örneğin, en küçük polimer olan PLURONIC FT L 61 101, ortalama 2 birim polioksietilen içeren bir blok, ortalama 16 birim polioksipropilen içeren bir blok ve ardından ortalama 2 birim polioksietilen içeren bir bloktan oluşur. PLURONIC FT L 61ler, renksiz sıvılar ve macunlardan beyaz katılara kadar çeşitlilik gösterir. Kozmetik ve kişisel bakım ürünlerinde PLURONIC FT L 61ler, cilt temizleyicileri, banyo ürünleri, şampuanlar, saç kremleri, gargaralar, göz makyajı temizleyicileri ve diğer cilt ve saç ürünlerinin formülasyonunda kullanılır. Ürün kategorisi Formülasyon sayısı Maksimum (Toplam formülasyon sayısı) İçerdiği bileşen konsantrasyonu (%) (FDA 2002) (FDA 2002) (CTFA 2004a) PLURONIC FT L 61 105 Saç kremleri (651) 5 - Tıraş kremi (134) 2 3 Toplam kullanım / PLURONIC FT L 61 105 7 için aralıklar 7 3 PLURONIC FT L 61 181 Nemlendiriciler (905) - 0,005 Diğer cilt bakımı müstahzarları (725) - 6 PLURONIC FT L 61 181 - 0,005–6 için toplam kullanımlar / aralıklar Diğer banyo preparatları (196) 1 Eyelinerler (548) 1 Rujlar (962) 1 Tıraş kremi (134) 1 Macun maskeleri / çamur paketleri (271) - 3 Diğer cilt bakımı müstahzarları (725) - 0.2 Güneş jeli, kremler ve sıvılar (131) - 6 PLURONIC FT L 61 için toplam kullanım / aralık 182 4 0.2 –6 PLURONIC FT L 61 184 Diğer banyo müstahzarları (196) 11 0,4 Göz makyajı temizleyici (100) 9 0,03–0,04 Saç kremleri (651) 6 - Renksiz şampuanlar (884) 5 10 Makyaj sabitleyicileri (20) - 3 Diğer makyaj müstahzarları (201) 1 0,9 Cilt temizleme kremleri, losyonları vb. (775) 27 3–6 Vücut ve el kremleri, losyonlar vb. (840) 1 0,4 Nemlendiriciler (905) - 0,3 Diğer s akraba bakımı müstahzarları (725) 1 3 Güneş jeli, kremler, sıvılar (131) - 2 Kapalı bronzlaşma müstahzarları (71) 1 - PLURONIC FT L 61 için toplam kullanım / aralıklar 184 62 0.03–10 PLURONIC FT L 61 185 Göz Losyonu (25) - 0.5–9 Göz makyaj temizleyici (100) - 2 Diğer Göz Makyajı Hazırlıkları (125) 1 - Macun Maskeleri (çamur paketleri) (271) 8 - Diğer cilt bakımı müstahzarları (725) - 0.5 PLURONIC FT L 61 185 9 0.5–9 PLURONIC FT L 61 188 Eye için toplam kullanım / aralıklar losyon (25) 1 - Kalıcı dalgalar (207) 6 - Cilt temizleme kremleri, losyonlar vb. (775) 3 1–2 Gece kremleri, losyonlar vb. (200) 1 - Diğer cilt bakımı müstahzarları (725) 1 2 İç mekan tabaklama preparatları (71) - 0.8 PLURONIC FT L 61 188 için toplam kullanımlar / aralıklar 12 0.8–2 (Tablo sonraki sayfada devam ediyor) 98 COMESTIC BİLEŞEN İNCELEME TABLOSU 4 PLURONIC FT L 61lerin kullanım sıklığı ve konsantrasyonu (Devamı). Ürün kategorisi Formülasyon sayısı Maksimum (Toplam formülasyon sayısı) içerik içeren kullanım konsantrasyonu (%) (FDA 2002) (FDA 2002) (CTFA 2004a) PLURONIC FT L 61 212 Diğer cilt bakımı preparatları (725) - 2 PLURONIC FT L 61 212 için toplam kullanımlar / aralıklar - 2 PLURONIC FT L 61 217 Diğer kişisel hijyen ürünleri (308) 2 - PLURONIC FT L 61 217 için toplam kullanım / aralıklar 2 - PLURONIC FT L 61 234 Renksiz şampuanlar (884) - 0,1 Saç toniği, pansumanlar vb. (598) - 0,3–2 Cilt temizleme kremleri, losyonları , vb. (775) - 0,5–10 Yüz ve boyun kremleri, losyonlar, vb. (310) - 0,5–1 Vücut ve el kremleri, losyonlar vb. (840) - 0,01 Nemlendiriciler (905) - 0,5 Diğer cilt bakımı müstahzarları (725) - 0.5 Diğer güneş müstahzarları (38) - 0.01 PLURONIC FT L 61 234 - 0.01–10 PLURONIC FT L 61 237 için toplam kullanım / aralıklar Göz makyajı temizleyici (100) 1 - Diş macunları (40) 1 - Ağız gargaraları ve nefes tazeleyiciler (46) 2 - Toplam PLURONIC FT L 61 237 için kullanımlar / aralıklar 4 - PLURONIC FT L 61 238 Diğer banyo müstahzarları (196) 1 - Vücut ve el kremleri, losyonlar, vb. (840) 2 - Ayak pudraları ve s dualar (35) 1 - PLURONIC FT L 61 238 için toplam kullanımlar / aralıklar 4 - PLURONIC FT L 61 333 Vücut ve el kremleri, losyonlar, vb. (840) - 1 PLURONIC FT L 61 333 - 1 PLURONIC FT L 61 334 Saç toniği, pansumanlar vb. için toplam kullanım / aralıklar ( 598) - 0.3 PLURONIC FT L 61 334 için toplam kullanımlar / aralıklar - 0.3 PLURONIC FT L 61 335 Ağız gargaraları ve nefes tazeleyiciler (46) 2 - PLURONIC FT L 61 335 2 - PLURONIC FT L 61 338 Ağız yıkama ve nefes tazeleyiciler için toplam kullanımlar / aralıklar (46) 2 - PLURONIC FT L 61 için toplam kullanımlar / aralıklar 338 2 - PLURONIC FT L 61 401 Vücut ve el kremleri, losyonlar, vb. (840) 2 - PLURONIC FT L 61 401 için toplam kullanım / aralıklar 2 - PLURONIC FT L 61 407 Göz makyajı temizleyici (100) - 2 Kalıcı dalgalar (207) 2 - Diğer manikür preparatları (55 ) - 5 Diş macunları (40) - 12–20 Ağız gargaraları ve nefes tazeleyiciler (46) 18 0,3–1 (Tablo sonraki sayfada devam ediyor) Poloksamer FT L 61(PLURONİC)S 99 TABLO 4 PLURONIC FT L 61lerin kullanım sıklığı ve konsantrasyonu (Devam). Ürün kategorisi Formülasyon sayısı Maksimum (Toplam formülasyon sayısı) içerik içeren kullanım konsantrasyonu (%) (FDA 2002) (FDA 2002) (CTFA 2004a) Diğer ağız hijyeni ürünleri (6) 1 - Koltuk altı deodorantları (247) 6 - Diğer kişisel hijyen ürünleri (308) 1 - Cilt temizleme kremleri, losyonlar vb. (775) - 9 Nemlendiriciler (905) - 1 Cilt tazeleyiciler (184) - 3 Diğer cilt bakımı müstahzarları (725) 3 - PLURONIC FT L 61 407 31 için toplam kullanım / aralıklar 0.3–20

PLURONIC FT L 61lerin bir diğer önemli özelliği, termojelleşme davranışlarıdır: aslında, bu polimerlerin bazılarının su dispersiyonları genellikle düşük sıcaklıklarda sıvı fazdadır, PLURONIC FT L 61ler ancak artan sıcaklıklarda güçlü bir jel haline gelir. PLURONIC FT L 61 ısıyla tersinir jelin formülasyonu ve karakterizasyonu, polimerik mikropartiküller ve hyaluronik asit içerir. Polietilen-propilen glikol kopolimeri ile eşanlamlı olan PLURONIC FT L 61 ve Supronic, PLURONIC FT L 61 veya Tetronic ticari isimleri, iyonik olmayan bir triblok kopolimer olarak 1950 yılında piyasaya sürülmüştür. [1] O zamandan beri çeşitli farmasötik uygulamalarda çok ünlü bir şekilde kullanıldılar. Kimyasal olarak PLURONIC FT L 61, a-Hidro-ω-hidroksipoli (oksietilen) bir poli (oksipropilen) b poli (oksietilen) bir blok kopolimerdir ve bir hidrofobik propilen oksit zincirini (PPO) sıkıştıran iki hidrofilik etilen oksit zincir zincirinden (PEO) oluşur bir kimyasal formül HO (C2H4O) a (C3H6O) b (C2H4O) aH verir, burada a ve b Tablo 1'de gösterilen değerlere sahiptir. PLURONIC FT L 61 124, PLURONIC FT L 61 188 olarak tanımlanan farklı polimerlere yol açan polimer blokların değişen uzunlukları PLURONIC FT L 61 237, PLURONIC FT L 61 338 ve PLURONIC FT L 61 407, özelliklerinde küçük bir fark gösterir.


PLURONIC FT L 61

PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor.

PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene.
Because the lengths of the polymer blocks can be customized, many different PLURONIC FT L 61s exist that have slightly different properties. For the generic term PLURONIC FT L 61, these copolymers are commonly named with the letter P (for PLURONIC FT L 61) followed by three digits: the first two digits multiplied by 100 give the approximate molecular mass of the polyoxypropylene core, and the last digit multiplied by 10 gives the percentage polyoxyethylene content (e.g. P407 = PLURONIC FT L 61 with a polyoxypropylene molecular mass of 4000 g/mo} PLURONIC FT L 61 and a 70% polyoxyethylene content). For the PLURONIC FT L 61 and Synperonic tradenames, coding of these copolymers starts with a letter to define PLURONIC FT L 61’s physical form at room temperature (L = liquid, P = paste, F = flake (solid)) followed by two or three digits, The first digit (two digits in a three-digit number) in the numerical designation, multiplied by 300, indicates the approximate molecular weight of the hydrophobe; and the last digit x 10 gives the percentage polyoxyethylene content (e.g., L61 indicates a polyoxypropylene molecular mass of 1800 g/mol and a 10% polyoxyethylene content). In the example given, PLURONIC FT L 61 181 (P181) = PLURONIC FT L 61 L61 and Synperonic PE/L 61. Work led by Kabanov has recently shown that some of these polymers, originally thought to be inert carrier molecules, have a very real effect on biological systems independently of the drug they are transporting. The PLURONIC FT L 61s have been shown to incorporate into cellular membranes affecting the microviscosity of the membranes. The polymers seem to have the greatest effect when absorbed by the cell as an unimer rather than as a micelle. ).  PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene.

PLURONIC FT L 61s are nonionic compounds that contains a large group of copolymers surfactants formed by chains of ethylene oxide block (EO) and propylene oxide (PO) (OEx–POy–OEx). PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor.

PLURONIC FT L 61s have been shown to preferentially target cancer cells, due to differences in the membrane of these cells when compared to noncancer cells. PLURONIC FT L 61s have also been shown to inhibit MDR proteins and other drug efflux transporters on the surface of cancer cells; the MDR proteins are responsible for the efflux of drugs from the cells and hence increase the susceptibility of cancer cells to chemotherapeutic agents such as doxorubicin. PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor.
The PLURONIC FT L 61s have also been shown to enhance proto-apoptotic signaling, decrease anti-apoptoic defense in MDR cells, inhibit the glutathione/glutathione S-transferase detoxification system, induce the release of cytochrome C, increase reactive oxygen species in the cytoplasm, and abolish drug sequestering within cytoplasmic vesicles.
An important characteristic of PLURONIC FT L 61 solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of PLURONIC FT L 61s are PLURONIC FT L 61s and poloxamines are also known as macromolecules, respectively. PLURONIC FT L 61s are a family of more than 50 different amphiphilic nonionic block polymers of hydrophobic propylene oxide (PO) and hydrophilic ethylene oxide (EO), covering a range of liquids, pastes and solids. PLURONIC FT L 61s consist of a central polyoxypropylene (POP) molecule, which is flanked on both sides by two hydrophilic chains of polyoxyethylene (POE). A slightly different structure is exhibited by the poloxamines, which are tetrafunctional block copolymers with four POE–POP blocks joined together by a central ethylene diamine bridgeliquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in PLURONIC FT L 61s depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. Assessment of PLURONIC FT L 61s PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, and PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, and PLURONIC FT L 61 182 Dibenzoate as Used in Cosmetics. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61 comes in many different forms and grades, including PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, and more. Spectrum Chemical has exactly the form and grade of PLURONIC FT L 61 for your lab needs. PLURONIC FT L 61 is a nonionic triblock copolymer. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene.
The phase transitions can also be largely influenced by the use of additives such as salts and alcohols. The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in). Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration. Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration. The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power. PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word PLURONIC FT L 61 was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.PLURONIC FT L 61s are also known by the trade names Synperonics, PLURONIC FT L 61, and Kolliphor. PLURONIC FT L 61s and poloxamines are also known as macromolecules, respectively. PLURONIC FT L 61s are a family of more than 50 different amphiphilic nonionic block polymers of hydrophobic propylene oxide (PO) and hydrophilic ethylene oxide (EO), covering a range of liquids, pastes and solids. PLURONIC FT L 61s consist of a central polyoxypropylene (POP) molecule, which is flanked on both sides by two hydrophilic chains of polyoxyethylene (POE). A slightly different structure is exhibited by the poloxamines, which are tetrafunctional block copolymers with four POE–POP blocks joined together by a central ethylene diamine bridgeliquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in PLURONIC FT L 61s depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. Different phase diagrams characterizing all these transitions have been constructed for most PLURONIC FT L 61s using a great variety of experimental techniques (e.g. SAXS, PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent  in which they would not normally dissolve. They also clean the skin and hair by helping water to mix with oil and dirt so that they can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance.Differential scanning calorimetry, viscosity measurements, light scattering). PLURONIC FT L 61s are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios. The presence of PEO and PPO blocks in a single polymer chain gives rise to essentially amphiphilic molecules whose self-assembling properties display a wide range of phase behavior. This ability to form micelles and liquid-crystalline phases is strongly temperature dependent since increasing the temperature allows self-association which decreases the critical micelle concentration (CMC). PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘PLURONIC FT L 61’ was coined by the inventor, Irving Schmolka, who received the patent for PLURONIC FT L 61s in 1973. PLURONIC FT L 61s are also known by their trade name PLURONIC FT L 61s. Concentrated PLURONIC FT L 61 solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial PLURONIC FT L 61 407 have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery. Solutions of PLURONIC FT L 61 407 (∼25%) are viscous liquids below 25 °C; at body temperature PLURONIC FT L 61s form a semisolid gel. Weak mechanic strength, relatively high solubility in body fluids, and nonbiodegradability are the main hurdles for the use of PLURONIC FT L 61 407 in cell delivery systems. Introduction of the carbonate linkage between PLURONIC FT L 61 ‘blocks’ and linking of PLURONIC FT L 61s into structures of a higher molecular mass118 PLURONIC FT L 61 were attempted to overcome these disadvantages. PLURONIC FT L 61 is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO). PLURONIC FT L 61s and poloxamine nonionic surfactants have diverse applications in various biomedical fields ranging from drug delivery and medical imaging to management of vascular diseases and disorders.

Another important property of PLURONIC FT L 61s is their thermogelling behaviour: in fact, water dispersions of some of these polymers are generally in the liquid phase at low temperatures but become a strong gel at increased temperatures.
Certain PLURONIC FT L 61s such as P85 have been shown not only to be able to transport target genes to target cells, but also to increase gene expression. Certain PLURONIC FT L 61s, such as P85 and L61, have also been shown to stimulate transcription of NF kappaB genes, although the mechanism by which this is achieved is currently unknown, bar that P85 has been shown to induce phosphorylation of the inhibitory kappa.
An important characteristic of PLURONIC FT L 61 solutions is their temperature dependent self-assembling and thermo-gelling behavior. Concentrated aqueous solutions of PLURONIC FT L 61s are liquid at low temperature and form a gel at higher temperature in a reversible process. The transitions that occur in these systems depend on the polymer composition (molecular weight and hydrophilic/hydrophobic molar ratio).
The phase transitions can also be largely influenced by the use of additives such as salts and alcohols. The interactions with salts are related to their ability to act as water structure makers (salting-out) or water structure breakers (salting-in). Salting-out salts increase the self-hydration of water through hydrogen bonding and reduce the hydration of the copolymers, thus reducing the critical micelle temperature and critical micelle concentration. Salting-in electrolytes reduce the water self-hydration and increase the polymer hydration, therefore increasing the critical micelle temperature and critical micelle concentration. The different salts have been categorized by the Hofmeister series according to their ‘salting-out’ power. Different phase diagrams characterizing all these transitions have been constructed for most PLURONIC FT L 61s using a great variety of experimental techniques. In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent  in which they would not normally dissolve. PLURONIC FT L 61s also clean the skin and hair by helping water to mix with oil and dirt so that PLURONIC FT L 61s can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. PLURONIC FT L 61s are polyoxyethlyene, polyoxypropylene block polymers. The impurities of commercial grade PLURONIC FT L 61 188, as an example, include low-molecular-weight substances (aldehydes and both formic and acetic acids), as well as 1,4-dioxane and residual ethylene oxide and propylene oxide. Most PLURONIC FT L 61s function in cosmetics as surfactants, emulsifying agents, cleansing agents, and/or solubilizing agents, and are used in 141 cosmetic products at concentrations from 0.005% to 20%. PLURONIC FT L 61s injected intravenously in animals are rapidly excreted in the urine, with some accumulation in lung, liver, brain, and kidney tissue. In humans, the plasma concentration of PLURONIC FT L 61 188 (given intravenously) reached a maximum at 1 h, then reached a steady state.

PLURONIC FT L 61s are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. The word ‘PLURONIC FT L 61’ was coined by the inventor, Irving Schmolka, who received the patent for PLURONIC FT L 61s in 1973. PLURONIC FT L 61s are also known by their trade name PLURONIC FT L 61s. Concentrated PLURONIC FT L 61 solutions in water undergo thermoreversible sol–gel transition by the micellar mechanism.115 Thermosensitive sol–gels of the commercial PLURONIC FT L 61 407 have been suggested for use in short-term treatments such as pain management, infection treatment, fertility control, and in topical drug delivery. Solutions of PLURONIC FT L 61 407 (∼25%) are viscous liquids below 25 °C; at body temperature PLURONIC FT L 61s form a semisolid gel. Weak mechanic strength, relatively high solubility in body fluids, and nonbiodegradability are the main hurdles for the use of PLURONIC FT L 61 407 in cell delivery systems. Introduction of the carbonate linkage between PLURONIC FT L 61 ‘blocks’ and linking of PLURONIC FT L 61s into structures of a higher molecular mass118 PLURONIC FT L 61 were attempted to overcome these disadvantages. PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products.PLURONIC FT L 61 is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO). Formulation and characterization of PLURONIC FT L 61 thermoreversible gel containing polymeric microparticles and hyaluronic acid. PLURONIC FT L 61s are triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) available in different molecular weights and PPO/PEO ratios. PLURONIC FT L 61 is composed of triblock copolymers of polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO). In recent years these hydrogels have been used as carriers for most routes of administration, the most interesting are discussed below. PLURONIC FT L 61s are polymers used for drug delivery as formulation excipients. PLURONIC FT L 61s are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. PLURONIC FT L 61s are also used in topical dosage forms and rectal suppositories. The common available grades are PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338, and PLURONIC FT L 61 407. PLURONIC FT L 61 as a nonionic surfactant, the synthetic polymer has been previously used in drug delivery and medical imaging applications PLURONIC FT L 61 sol-gel reversible hydrogels have attracted the attention for practical biomedical and pharmaceutical applications because of constituents solubility, biocompatibility with biological systems and easy administration of pharmaceutical formulations. The pharmaceutical and biomedical fields covered by the use of PLURONIC FT L 61s including solubilization of hydrophobic drugs, controlled release, biomacromolecule delivery (e.g., proteins and genes) and tissue engineering. PLURONIC FT L 61s help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent  in which they would not normally dissolve. PLURONIC FT L 61s also clean the skin and hair by helping water to mix with oil and dirt so that PLURONIC FT L 61s can be rinsed away. PLURONIC FT L 61 188 kills microorganisms, or prevents or inhibits their growth and reproduction. PLURONIC FT L 61 182 Dibenzoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance. PLURONIC FT L 61 with its synonym as polyethylene-propylene glycol copolymer and trade names as Supronic, PLURONIC FT L 61 or Tetronic have been introduced in 1950 as a non-ionic triblock copolymer. Assessment of PLURONIC FT L 61s PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, and PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, and PLURONIC FT L 61 182 Dibenzoate as Used in Cosmetics. They were since then very famously used in diverse pharmaceutical applications. Chemically PLURONIC FT L 61 is α-Hydro-ω-hydroxypoly (oxyethylene)a poly (oxypropylene)b poly (oxyethylene)a block copolymer and they consisted of two hydrophilic chains of ethylene oxide chains (PEO) that sandwiched one hydrophobic propylene oxide chain (PPO) giving a chemical formula HO(C2H4O)a(C3H6O)b(C2H4O)aH where a and b have the values as shown in the Table 1. The varying length of polymer blocks giving rise to different polymers identified as PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338 and PLURONIC FT L 61 407 showing a slight difference in their properties.

Most applications involve the use of PLURONIC FT L 61 P407 and include delivery of protein/peptide drugs [25], such as insulin [26], interleukin-2 [27], epidermal growth factor [28], bone morphogenic protein [29], fibroblastic growth factor, and endothelial cell growth factor [30]. Surfactants play an important role in stabilizing proteins in liquid formulations against aggregate/particle formation during processing, handling, storage, and transportation. Only 3 surfactants are currently used in marketed therapeutic protein formulations: polysorbate 20, polysorbate 80, and PLURONIC FT L 61 188. While polysorbates are the most widely used surfactants, their intrinsic oxidative and hydrolytic degradation issues highlights the importance of alternative surfactants such as PLURONIC FT L 61 188. Here, we compare polysorbates and PLURONIC FT L 61 188 with regards to their stabilizing properties under various stress and storage conditions for several monoclonal antibody formulations. Our data shows that PLURONIC FT L 61 188 can provide suitable protection of monoclonal antibodies against interfacial stress in liquid formulations in vials. However, visible protein-polydimethylsiloxane (PDMS; silicone oil) particles were observed in vials after long-term storage at 2-8°C for some protein formulations using PLURONIC FT L 61 188, which were not observed in polysorbate formulations. The occurrence of these protein-PDMS particles in PLURONIC FT L 61 188 formulations is a protein-specific phenomenon that may correlate with protein physico-chemical properties. In this study, the primary source of the PDMS in particles found in vials was considered to be from the primary packaging stoppers used. Our findings highlight benefits, but also risks associated with using PLURONIC FT L 61 188 in liquid biotherapeutic formulations. PLURONIC FT L 61s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) are polymers made of a block of polyoxyethylene, followed by a block of polyoxypropylene, followed by a block of polyoxyethylene. The average number of units of polyoxyethylene and polyoxypropylene varies based on the number associated with the polymer . For example, the smallest polymer, PLURONIC FT L 61 101, consists of a block with an average of 2 units of polyoxyethylene, a block with an average of 16 units of polyoxypropylene, followed by a block with an average of 2 units of polyoxyethylene. PLURONIC FT L 61s range from colorless liquids and pastes to white solids. In cosmetics and personal care products, PLURONIC FT L 61s are used in the formulation of skin cleansers, bath products, shampoos, hair conditioners, mouthwashes, eye makeup remover and other skin and hair products.


PLURONIC FT L 61

PLURONIC FT L 61 sont des copolymères triblocs non ioniques composés d'une chaîne hydrophobe centrale de polyoxypropylène (poly (oxyde de propylène)) flanquée de deux chaînes hydrophiles de polyoxyéthylène (poly (oxyde d'éthylène)). Le mot PLURONIC FT L 61 a été inventé par l'inventeur, Irving Schmolka, qui a reçu le brevet pour ces matériaux en 1973. PLURONIC FT L 61 sont également connus sous les noms commerciaux Synperonics, PLURONIC FT L 61, et Kolliphor.

Le poloxamère (PLURONIC FT L 61) se présente sous de nombreuses formes et qualités différentes, y compris le PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF , et plus. Spectrum Chemical a exactement la forme et le grade de PLURONIC FT L 61 pour les besoins de votre laboratoire. Le poloxamère (PLURONIC FT L 61) est un copolymère tribloc non ionique. Il est constitué d'une chaîne principale hydrophobe de polyoxypropylène bordée de chaque côté par deux chaînes hydrophiles de polyoxyéthylène.
Parce que les longueurs des blocs polymères peuvent être personnalisées, il existe de nombreux PLURONIC FT L 61 qui ont des propriétés légèrement différentes. Pour le terme générique PLURONIC FT L 61, ces copolymères sont communément nommés par la lettre P (pour PLURONIC FT L 61) suivie de trois chiffres: les deux premiers chiffres multipliés par 100 donnent la masse moléculaire approximative du noyau en polyoxypropylène, et le dernier chiffre multiplié par 10 donne le pourcentage de teneur en polyoxyéthylène (par exemple P407 = PLURONIC FT L 61 avec une masse moléculaire en polyoxypropylène de 4000 g / mois} PLURONIC FT L 61 et une teneur en polyoxyéthylène de 70% ). Pour les dénominations commerciales PLURONIC FT L 61 et Synperonic, le codage de ces copolymères commence par une lettre pour définir la forme physique du PLURONIC FT L 61 à température ambiante (L = liquide, P = pâte, F = flocon (solide)) suivi de deux ou trois chiffres, Le premier chiffre (deux chiffres dans un nombre à trois chiffres) dans la désignation numérique, multiplié par 300, indique le poids moléculaire approximatif de l'hydrophobe; et le dernier chiffre x 10 donne la teneur en pourcentage de polyoxyéthylène (par exemple, L61 indique une masse moléculaire de polyoxypropylène de 1800 g / mol et une teneur en polyoxyéthylène de 10%). Dans l'exemple donné, PLURONIC FT L 61 181 (P181) = PLURONIC FT L 61 L61 et Synperonic PE / L 61. Des travaux menés par Kabanov ont récemment montré que certains de ces polymères, à l'origine considérés comme des molécules porteuses inertes, ont un effet très réel sur les systèmes biologiques indépendamment du médicament qu'ils transportent. Il a été démontré que les PLURONIC FT L 61 s incorporent dans les membranes cellulaires affectant la microviscosité des membranes. Les polymères semblent avoir le plus grand effet lorsqu'ils sont absorbés par la cellule comme unimère plutôt que comme une micelle. ). Le poloxamère (PLURONIC FT L 61) se présente sous de nombreuses formes et qualités différentes, y compris le PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF , et plus. Spectrum Chemical a exactement la forme et le grade de PLURONIC FT L 61 pour les besoins de votre laboratoire. Le poloxamère (PLURONIC FT L 61) est un copolymère tribloc non ionique. Il est constitué d'une chaîne principale hydrophobe de polyoxypropylène bordée de chaque côté par deux chaînes hydrophiles de polyoxyéthylène.

PLURONIC FT L 61 sont des composés non ioniques qui contiennent un grand groupe de copolymères tensioactifs formés par des chaînes de blocs d'oxyde d'éthylène (OE) et d'oxyde de propylène (PO) (OEx – POy – OEx). PLURONIC FT L 61 sont des copolymères triblocs non ioniques composés d'une chaîne hydrophobe centrale de polyoxypropylène (poly (oxyde de propylène)) flanquée de deux chaînes hydrophiles de polyoxyéthylène (poly (oxyde d'éthylène)). Le mot PLURONIC FT L 61 a été inventé par l'inventeur, Irving Schmolka, qui a reçu le brevet pour ces matériaux en 1973. PLURONIC FT L 61 sont également connus sous les noms commerciaux Synperonics, PLURONIC FT L 61, et Kolliphor.
Il a été démontré que PLURONIC FT L 61 ciblent préférentiellement les cellules cancéreuses, en raison des différences dans la membrane de ces cellules par rapport aux cellules non cancéreuses. Il a également été démontré que PLURONIC FT L 61 inhibent les protéines MDR et d'autres transporteurs d'efflux de médicaments à la surface des cellules cancéreuses; les protéines MDR sont responsables de l'efflux de médicaments des cellules et augmentent ainsi la sensibilité des cellules cancéreuses aux agents chimiothérapeutiques tels que la doxorubicine. PLURONIC FT L 61 sont des copolymères triblocs non ioniques composés d'une chaîne hydrophobe centrale de polyoxypropylène (poly (oxyde de propylène)) flanquée de deux chaînes hydrophiles de polyoxyéthylène (poly (oxyde d'éthylène)). Le mot PLURONIC FT L 61 a été inventé par l'inventeur, Irving Schmolka, qui a reçu le brevet pour ces matériaux en 1973. PLURONIC FT L 61 sont également connus sous les noms commerciaux Synperonics, PLURONIC FT L 61, et Kolliphor.
Il a également été démontré que PLURONIC FT L 61 améliorent la signalisation proto-apoptotique, diminuent la défense anti-apoptoïque dans les cellules MDR, inhibent le système de désintoxication de la glutathion / glutathion S-transférase, induisent la libération du cytochrome C, augmentent l'oxygène réactif espèces dans le cytoplasme et abolissent la séquestration des médicaments dans les vésicules cytoplasmiques.
Une caractéristique importante des solutions PLURONIC FT L 61 est leur comportement d'auto-assemblage et de thermogélification en fonction de la température. Les solutions aqueuses concentrées de PLURONIC FT L 61 sont du PLURONIC FT L 61 et les poloxamines sont également appelées macromolécules, respectivement. PLURONIC FT L 61 sont une famille de plus de 50 polymères blocs non ioniques amphiphiles différents d'oxyde de propylène hydrophobe (PO) et d'oxyde d'éthylène hydrophile (OE), couvrant une gamme de liquides, pâtes et solides. Le poloxamère (PLURONIC FT L 61) est constitué d'une molécule centrale de polyoxypropylène (POP), qui est flanquée des deux côtés par deux chaînes hydrophiles de polyoxyéthylène (POE). Une structure légèrement différente est présentée par les poloxamines, qui sont des copolymères séquencés tétrafonctionnels avec quatre blocs POE-POP réunis par un bridgeliquide central d'éthylène diamine à basse température et forment un gel à température plus élevée dans un processus réversible. Les transitions qui se produisent dans PLURONIC FT L 61 dépendent de la composition du polymère (poids moléculaire et rapport molaire hydrophile / hydrophobe). Ces dernières années, ces hydrogels ont été utilisés comme supports pour la plupart des voies d'administration, les plus intéressantes sont discutées ci-dessous. PLURONIC FT L 61 sont des polymères utilisés pour l'administration de médicaments comme excipients de formulation. Évaluation du PLURONIC FT L 61 s PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 ) 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403 et PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate et PLURONIC FT L 61 182 Dibenzoate comme utilisé dans les cosmétiques. PLURONIC FT L 61 sont utilisés dans des formulations pharmaceutiques en tant que tensioactifs, agents émulsifiants, agents solubilisants, agents dispersants et comme agents améliorant l'absorbance in vivo. PLURONIC FT L 61 sont également utilisés dans les formes posologiques topiques et les suppositoires rectaux. Les grades couramment disponibles sont le PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, Poloxamer ( PLURONIC FT L 61) 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338 et PLURONIC FT L 61 407. PLURONIC FT L 61 ) se présente sous de nombreuses formes et qualités différentes, y compris PLURONIC FT L 61 188 Surfactant, PLURONIC FT L 61 182, PLURONIC FT L 61 407 NF, 124 Grade, 338 NF, et plus. Spectrum Chemical a exactement la forme et le grade de PLURONIC FT L 61 pour les besoins de votre laboratoire.
Le poloxamère (PLURONIC FT L 61) est un copolymère tribloc non ionique. Il est constitué d'une chaîne principale hydrophobe de polyoxypropylène bordée de chaque côté par deux chaînes hydrophiles de polyoxyéthylène.
Les transitions de phase peuvent également être largement influencées par l'utilisation d'additifs tels que des sels et des alcools. Les interactions avec les sels sont liées à leur capacité à agir en tant que créateurs de structure de l'eau (relargage) ou casseurs de structure d'eau (relargage). Les sels de relargage augmentent l'auto-hydratation de l'eau par liaison hydrogène et réduisent l'hydratation des copolymères, réduisant ainsi la température micellaire critique et la concentration micellaire critique. Les électrolytes salés réduisent l'auto-hydratation de l'eau et augmentent l'hydratation du polymère, augmentant ainsi la température micellaire critique et la concentration micellaire critique. Les différents sels ont été classés par la série Hofmeister en fonction de leur pouvoir de «relargage». PLURONIC FT L 61 sont des copolymères triblocs non ioniques composés d'une chaîne hydrophobe centrale de polyoxypropylène (poly (oxyde de propylène)) flanquée de deux chaînes hydrophiles de polyoxyéthylène (poly (oxyde d'éthylène)). Le mot PLURONIC FT L 61 a été inventé par l'inventeur, Irving Schmolka, qui a reçu le brevet pour ces matériaux en 1973. PLURONIC FT L 61 sont également connus sous les noms commerciaux Synperonics, PLURONIC FT L 61, et Kolliphor. PLURONIC FT L 61 et les poloxamines sont également connus sous le nom de macromolécules, respectivement. PLURONIC FT L 61 sont une famille de plus de 50 polymères blocs non ioniques amphiphiles différents d'oxyde de propylène hydrophobe (PO) et d'oxyde d'éthylène hydrophile (OE), couvrant une gamme de liquides, pâtes et solides. Le poloxamère (PLURONIC FT L 61) est constitué d'une molécule centrale de polyoxypropylène (POP), qui est flanquée des deux côtés par deux chaînes hydrophiles de polyoxyéthylène (POE). Une structure légèrement différente est présentée par les poloxamines, qui sont des copolymères séquencés tétrafonctionnels avec quatre blocs POE-POP réunis par un bridgeliquide central d'éthylène diamine à basse température et forment un gel à température plus élevée dans un processus réversible. Les transitions qui se produisent dans PLURONIC FT L 61 dépendent de la composition du polymère (poids moléculaire et rapport molaire hydrophile / hydrophobe). Ces dernières années, ces hydrogels ont été utilisés comme supports pour la plupart des voies d'administration, les plus intéressantes sont discutées ci-dessous. Différents diagrammes de phase caractérisant toutes ces transitions ont été construits pour la plupart des PLURONIC FT L 61 en utilisant une grande variété de techniques expérimentales (ex: SAXS, PLURONIC FT L 61 s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 ) 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, Poloxamer ( PLURONIC FT L 61) 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) sont des polymères constitués d'un bloc de polyoxyéthylène, suivi d'un bloc de polyoxypropylène, suivi d'un bloc de polyoxyéthylène. Le nombre moyen d'unités de polyoxyéthylène et de polyoxypropylène varie en fonction du nombre associé au polymère.
Par exemple, le plus petit polymère, PLURONIC FT L 61 101, est constitué d'un bloc avec une moyenne de 2 unités de polyoxyéthylène, un bloc avec une moyenne de 16 unités de polyoxypropylène, suivi d'un bloc avec une moyenne de 2 unités de polyoxyéthylène. PLURONIC FT L 61 vont des liquides et pâtes incolores aux solides blancs. Dans les cosmétiques et les produits de soins personnels, le PLURONIC FT L 61 est utilisé dans la formulation de nettoyants pour la peau, de produits de bain, de shampooings, de revitalisants capillaires, de bains de bouche, de démaquillants pour les yeux et d'autres produits pour la peau et les cheveux. PLURONIC FT L 61 aident à former des émulsions en réduisant la tension superficielle des substances à émulsionner et aident d'autres ingrédients à se dissoudre dans un solvant dans lequel ils ne se dissoudraient normalement pas. Ils nettoient également la peau et les cheveux en aidant l'eau à se mélanger avec l'huile et la saleté afin qu'ils puissent être rincés. Le poloxamère (PLURONIC FT L 61) 188 tue les micro-organismes ou empêche ou inhibe leur croissance et leur reproduction. PLURONIC FT L 61 182 Le dibenzoate agit comme un lubrifiant à la surface de la peau, ce qui donne à la peau un aspect doux et lisse.Calorimétrie à balayage différentiel, mesures de viscosité, diffusion de la lumière). PLURONIC FT L 61 sont des copolymères triblocs de poly (oxyde d'éthylène) (PEO) et de poly (oxyde de propylène) (PPO) disponibles en différents poids moléculaires et rapports PPO / PEO. La présence de blocs PEO et PPO dans une seule chaîne polymère donne naissance à des molécules essentiellement amphiphiles dont les propriétés d'auto-assemblage présentent une large gamme de comportement de phase. Cette capacité à former des micelles et des phases cristallines liquides est fortement dépendante de la température car l'augmentation de la température permet une auto-association qui diminue la concentration micellaire critique (CMC). PLURONIC FT L 61 sont des copolymères triblocs non ioniques composés d'une chaîne hydrophobe centrale de polyoxypropylène flanquée de deux chaînes hydrophiles de polyoxyéthylène. Le mot «PLURONIC FT L 61» a été inventé par l'inventeur, Irving Schmolka, qui a reçu le brevet du PLURONIC FT L 61 en 1973. PLURONIC FT L 61 sont également connus par leur métier nom PLURONIC FT L 61s. Les solutions concentrées de PLURONIC FT L 61 dans l'eau subissent une transition sol-gel thermoréversible par le mécanisme micellaire.115 Des sol-gels thermosensibles du Poloxamer commercial (PLURONIC FT L 61) 407 ont été suggérés pour une utilisation dans des traitements à court terme tels que gestion de la douleur, traitement des infections, contrôle de la fertilité et administration de médicaments topiques. Les solutions de PLURONIC FT L 61 407 (∼25%) sont des liquides visqueux inférieurs à 25 ° C; à la température corporelle, le poloxamère (PLURONIC FT L 61) forme un gel semi-solide. Une faible résistance mécanique, une solubilité relativement élevée dans les fluides corporels et la non-biodégradabilité sont les principaux obstacles à l'utilisation du PLURONIC FT L 61 407 dans les systèmes de délivrance de cellules. L'introduction de la liaison carbonate entre les «blocs» de PLURONIC FT L 61 et la liaison de PLURONIC FT L 61 dans des structures de masse moléculaire plus élevée118 PLURONIC FT L 61 ont été tentées pour surmonter ces inconvénients. Le poloxamère (PLURONIC FT L 61) est un copolymère bloc amphiphile, constitué d'un copolymère tribloc poly (oxyde d'éthylène) -poly (oxyde de propylène) -poly (oxyde d'éthylène) (PEO-PPO-PEO). Le poloxamère (PLURONIC FT L 61) et les tensioactifs non ioniques poloxamine ont des applications diverses dans divers domaines biomédicaux allant de l'administration de médicaments et de l'imagerie médicale à la gestion des maladies et troubles vasculaires.
Une autre propriété importante des PLURONIC FT L 61 est leur comportement thermogélifiant: en effet, les dispersions dans l'eau de certains de ces polymères sont généralement en phase liquide à basses températures mais deviennent un gel résistant à des températures élevées.
Certains PLURONIC FT L 61 tels que P85 se sont avérés non seulement capables de transporter des gènes cibles vers des cellules cibles, mais également d'augmenter l'expression génique. Certains PLURONIC FT L 61, tels que P85 et L61, se sont également avérés stimuler la transcription des gènes NF kappaB, bien que le mécanisme par lequel cela est réalisé soit actuellement inconnu, sauf que P85 induit la phosphorylation de le kappa inhibiteur.
Une caractéristique importante des solutions PLURONIC FT L 61 est leur comportement d'auto-assemblage et de thermogélification en fonction de la température. Les solutions aqueuses concentrées de PLURONIC FT L 61 sont liquides à basse température et forment un gel à plus haute température dans un processus réversible. Les transitions qui se produisent dans ces systèmes dépendent de la composition du polymère (poids moléculaire et rapport molaire hydrophile / hydrophobe).
Les transitions de phase peuvent également être largement influencées par l'utilisation d'additifs tels que des sels et des alcools. Les interactions avec les sels sont liées à leur capacité à agir en tant que créateurs de structure de l'eau (relargage) ou casseurs de structure d'eau (relargage). Les sels de relargage augmentent l'auto-hydratation de l'eau par liaison hydrogène et réduisent l'hydratation des copolymères, réduisant ainsi la température micellaire critique et la concentration micellaire critique. Les électrolytes salés réduisent l'auto-hydratation de l'eau et augmentent l'hydratation du polymère, augmentant ainsi la température micellaire critique et la concentration micellaire critique. Les différents sels ont été classés par la série Hofmeister en fonction de leur pouvoir de «relargage». Différents diagrammes de phase caractérisant toutes ces transitions ont été construits pour la plupart des PLURONIC FT L 61 en utilisant une grande variété de techniques expérimentales. Ces dernières années, ces hydrogels ont été utilisés comme supports pour la plupart des voies d'administration, les plus intéressantes sont discutées ci-dessous. PLURONIC FT L 61 sont des polymères utilisés pour l'administration de médicaments comme excipients de formulation. PLURONIC FT L 61 sont utilisés dans des formulations pharmaceutiques en tant que tensioactifs, agents émulsifiants, agents solubilisants, agents dispersants et comme agents améliorant l'absorbance in vivo. PLURONIC FT L 61 sont également utilisés dans les formes posologiques topiques et les suppositoires rectaux. Les grades couramment disponibles sont le PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, Poloxamer ( PLURONIC FT L 61) 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338 et PLURONIC FT L 61 407. PLURONIC FT L 61 ) s aident à former des émulsions en réduisant la tension superficielle des substances à émulsionner et aident d'autres ingrédients à se dissoudre dans un solvant dans lequel ils ne se dissoudraient normalement pas. Le PLURONIC FT L 61 nettoie également la peau et les cheveux en aidant l'eau à se mélanger à l'huile et à la saleté afin que le PLURONIC FT L 61 puisse être rincé. Le poloxamère (PLURONIC FT L 61) 188 tue les micro-organismes ou empêche ou inhibe leur croissance et leur reproduction. PLURONIC FT L 61 182 Le dibenzoate agit comme un lubrifiant à la surface de la peau, ce qui donne à la peau une apparence douce et lisse. PLURONIC FT L 61 sont des polymères séquencés polyoxyéthylène, polyoxypropylène. Les impuretés du Poloxamer de qualité commerciale (PLURONIC FT L 61) 188, par exemple, comprennent des substances de bas poids moléculaire (aldéhydes et acides formique et acétique), ainsi que le 1,4-dioxane et l'oxyde d'éthylène résiduel et l'oxyde de propylène. . La plupart des PLURONIC FT L 61 fonctionnent en cosmétique comme tensioactifs, agents émulsifiants, agents nettoyants et / ou agents solubilisants, et sont utilisés dans 141 produits cosmétiques à des concentrations de 0,005% à 20%. PLURONIC FT L 61 injectés par voie intraveineuse chez les animaux sont rapidement excrétés dans l'urine, avec une certaine accumulation dans les tissus pulmonaires, hépatiques, cérébraux et rénaux. Chez l'homme, la concentration plasmatique de PLURONIC FT L 61 188 (administré par voie intraveineuse) a atteint un maximum à 1 h, puis a atteint un état d'équilibre.

PLURONIC FT L 61 sont des copolymères triblocs non ioniques composés d'une chaîne hydrophobe centrale de polyoxypropylène flanquée de deux chaînes hydrophiles de polyoxyéthylène. Le mot «PLURONIC FT L 61» a été inventé par l'inventeur, Irving Schmolka, qui a reçu le brevet du PLURONIC FT L 61 en 1973. PLURONIC FT L 61 sont également connus par leur métier nom PLURONIC FT L 61s. Les solutions concentrées de PLURONIC FT L 61 dans l'eau subissent une transition sol-gel thermoréversible par le mécanisme micellaire.115 Des sol-gels thermosensibles du Poloxamer commercial (PLURONIC FT L 61) 407 ont été suggérés pour une utilisation dans des traitements à court terme tels que gestion de la douleur, traitement des infections, contrôle de la fertilité et administration de médicaments topiques. Les solutions de PLURONIC FT L 61 407 (∼25%) sont des liquides visqueux inférieurs à 25 ° C; à la température corporelle, le poloxamère (PLURONIC FT L 61) forme un gel semi-solide. Une faible résistance mécanique, une solubilité relativement élevée dans les fluides corporels et la non-biodégradabilité sont les principaux obstacles à l'utilisation du PLURONIC FT L 61 407 dans les systèmes de délivrance de cellules. L'introduction de la liaison carbonate entre les «blocs» de PLURONIC FT L 61 et la liaison de PLURONIC FT L 61 dans des structures de masse moléculaire plus élevée118 PLURONIC FT L 61 ont été tentées pour surmonter ces inconvénients. PLURONIC FT L 61 s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 ) 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, Poloxamer ( PLURONIC FT L 61) 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, Poloxamer (PLU RONIC FT L 61) 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) sont des polymères constitués d'un bloc de polyoxyéthylène, suivi d'un bloc de polyoxypropylène, suivi d'un bloc de polyoxyéthylène. Le nombre moyen d'unités de polyoxyéthylène et de polyoxypropylène varie en fonction du nombre associé au polymère. Par exemple, le plus petit polymère, PLURONIC FT L 61 101, est constitué d'un bloc avec une moyenne de 2 unités de polyoxyéthylène, un bloc avec une moyenne de 16 unités de polyoxypropylène, suivi d'un bloc avec une moyenne de 2 unités de polyoxyéthylène. PLURONIC FT L 61 vont des liquides et pâtes incolores aux solides blancs. Dans les cosmétiques et les produits de soins personnels, le PLURONIC FT L 61 est utilisé dans la formulation de nettoyants pour la peau, de produits de bain, de shampooings, de revitalisants capillaires, de bains de bouche, de démaquillants pour les yeux et d'autres produits pour la peau et les cheveux. ) est un copolymère bloc amphiphile, constitué d'un copolymère tribloc poly (oxyde d'éthylène) -poly (oxyde de propylène) -poly (oxyde d'éthylène) (PEO-PPO-PEO). Formulation et caractérisation du gel thermoréversible PLURONIC FT L 61 contenant des microparticules polymériques et de l'acide hyaluronique. PLURONIC FT L 61 sont des copolymères triblocs de poly (oxyde d'éthylène) (PEO) et de poly (oxyde de propylène) (PPO) disponibles en différents poids moléculaires et rapports PPO / PEO. Le poloxamère (PLURONIC FT L 61) est composé de copolymères triblocs d'oxyde de polyéthylène (PEO) -oxyde de polypropylène (PPO) -oxyde de polyéthylène (PEO). Ces dernières années, ces hydrogels ont été utilisés comme supports pour la plupart des voies d'administration, les plus intéressantes sont discutées ci-dessous. PLURONIC FT L 61 sont des polymères utilisés pour l'administration de médicaments comme excipients de formulation. PLURONIC FT L 61 sont utilisés dans des formulations pharmaceutiques en tant que tensioactifs, agents émulsifiants, agents solubilisants, agents dispersants et comme agents améliorant l'absorbance in vivo. PLURONIC FT L 61 sont également utilisés dans les formes posologiques topiques et les suppositoires rectaux. Les grades couramment disponibles sont le PLURONIC FT L 61 PLURONIC FT L 61 68, PLURONIC FT L 61 88, PLURONIC FT L 61 98, PLURONIC FT L 61 108, Poloxamer ( PLURONIC FT L 61) 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338 et PLURONIC FT L 61 407.PLURONIC FT L 61 en tant que tensioactif non ionique, le polymère synthétique a déjà été utilisé dans l'administration de médicaments et les applications d'imagerie médicale Les hydrogels sol-gel réversibles de PLURONIC FT L 61 ont attiré l'attention pour des applications biomédicales et pharmaceutiques pratiques en raison de solubilité des constituants, biocompatibilité avec les systèmes biologiques et administration facile des formulations pharmaceutiques. Les domaines pharmaceutiques et biomédicaux couverts par l'utilisation de PLURONIC FT L 61, y compris la solubilisation de médicaments hydrophobes, la libération contrôlée, la délivrance de biomacromolécules (par exemple, protéines et gènes) et l'ingénierie tissulaire. PLURONIC FT L 61 aident à former des émulsions en réduisant la tension superficielle des substances à émulsionner et aident d'autres ingrédients à se dissoudre dans un solvant dans lequel ils ne se dissoudraient normalement pas. Le PLURONIC FT L 61 nettoie également la peau et les cheveux en aidant l'eau à se mélanger à l'huile et à la saleté afin que le PLURONIC FT L 61 puisse être rincé. Le poloxamère (PLURONIC FT L 61) 188 tue les micro-organismes ou empêche ou inhibe leur croissance et leur reproduction. PLURONIC FT L 61 182 Le dibenzoate agit comme un lubrifiant à la surface de la peau, ce qui donne à la peau une apparence douce et lisse. Le poloxamère (PLURONIC FT L 61) avec son synonyme de copolymère polyéthylène-propylène glycol et des noms commerciaux comme Supronic, PLURONIC FT L 61 ou Tetronic a été introduit en 1950 en tant que copolymère tribloc non ionique. Évaluation du PLURONIC FT L 61 s PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, PLURONIC FT L 61 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 ) 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, PLURONIC FT L 61 402, PLURONIC FT L 61 403 et PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate et PLURONIC FT L 61 182 Dibenzoate comme utilisé dans les cosmétiques. Ils ont été depuis lors très connus pour être utilisés dans diverses applications pharmaceutiques. Chimiquement PLURONIC FT L 61 est α-Hydro-ω-hydroxypoly (oxyéthylène) un poly (oxypropylène) b poly (oxyéthylène) un copolymère séquencé et ils se composaient de deux chaînes hydrophiles de chaînes d'oxyde d'éthylène (PEO) qui en sandwich un hydrophobe chaîne d'oxyde de propylène (PPO) donnant une formule chimique HO (C2H4O) a (C3H6O) b (C2H4O) aH où a et b ont les valeurs indiquées dans le tableau 1. La longueur variable des blocs polymères donnant naissance à différents polymères identifiés comme PLURONIC FT L 61 124, PLURONIC FT L 61 188, PLURONIC FT L 61 237, PLURONIC FT L 61 338 et PLURONIC FT L 61 407 montrant une légère différence dans leur Propriétés.
La plupart des applications impliquent l'utilisation de PLURONIC FT L 61 P407 et incluent l'administration de médicaments protéiques / peptidiques [25], tels que l'insuline [26], l'interleukine-2 [27], le facteur de croissance épidermique [28], la protéine morphogénique osseuse [29], facteur de croissance fibroblastique et facteur de croissance des cellules endothéliales [30]. Les surfactants jouent un rôle important dans la stabilisation des protéines dans les formulations liquides contre la formation d'agrégats / particules pendant le traitement, la manipulation, le stockage et le transport. Seuls 3 tensioactifs sont actuellement utilisés dans les formulations de protéines thérapeutiques commercialisées: le polysorbate 20, le polysorbate 80 et le poloxamère (PLURONIC FT L 61) 188. Alors que les polysorbates sont les tensioactifs les plus largement utilisés, leurs problèmes intrinsèques de dégradation oxydative et hydrolytique soulignent l'importance des tensioactifs alternatifs comme le PLURONIC FT L 61 188. Ici, nous comparons les polysorbates et le PLURONIC FT L 61 188 en ce qui concerne leurs propriétés stabilisantes dans diverses conditions de stress et de stockage pour plusieurs formulations d'anticorps monoclonaux. Nos données montrent que le PLURONIC FT L 61 188 peut fournir une protection appropriée des anticorps monoclonaux contre le stress interfacial dans des formulations liquides en flacons. Cependant, des particules visibles de protéine-polydiméthylsiloxane (PDMS; huile de silicone) ont été observées dans des flacons après un stockage à long terme à 2-8 ° C pour certaines formulations de protéines utilisant du PLURONIC FT L 61 188, qui n'ont pas été observées dans les formulations de polysorbate. La présence de ces particules protéine-PDMS dans les formulations de PLURONIC FT L 61 188 est un phénomène spécifique aux protéines qui peut être corrélé aux propriétés physico-chimiques des protéines. Dans cette étude, la principale source de PDMS dans les particules trouvées dans les flacons a été considérée comme étant les bouchons d'emballage primaire utilisés. Nos résultats mettent en évidence les avantages, mais également les risques associés à l'utilisation du PLURONIC FT L 61 188 dans des formulations biothérapeutiques liquides. PLURONIC FT L 61 s (PLURONIC FT L 61 101, PLURONIC FT L 61 105, PLURONIC FT L 61 108, PLURONIC FT L 61 122, PLURONIC FT L 61 123, PLURONIC FT L 61 124, PLURONIC FT L 61 181, PLURONIC FT L 61 182, PLURONIC FT L 61 183, PLURONIC FT L 61 184, PLURONIC FT L 61 185, PLURONIC FT L 61 188, PLURONIC FT L 61 212, PLURONIC FT L 61 215, PLURONIC FT L 61 217, PLURONIC FT L 61 ) 231, PLURONIC FT L 61 234, PLURONIC FT L 61 235, PLURONIC FT L 61 237, PLURONIC FT L 61 238, PLURONIC FT L 61 282, Poloxamer ( PLURONIC FT L 61) 284, PLURONIC FT L 61 288, PLURONIC FT L 61 331, PLURONIC FT L 61 333, PLURONIC FT L 61 334, PLURONIC FT L 61 335, PLURONIC FT L 61 338, PLURONIC FT L 61 401, Poloxamer (PLU RONIC FT L 61) 402, PLURONIC FT L 61 403, PLURONIC FT L 61 407, PLURONIC FT L 61 105 Benzoate, PLURONIC FT L 61 182 Dibenzoate) sont des polymères constitués d'un bloc de polyoxyéthylène, suivi d'un bloc de polyoxypropylène, suivi d'un bloc de polyoxyéthylène. Le nombre moyen d'unités de polyoxyéthylène et de polyoxypropylène varie en fonction du nombre associé au polymère. Par exemple, le plus petit polymère, PLURONIC FT L 61 101, est constitué d'un bloc avec une moyenne de 2 unités de polyoxyéthylène, un bloc avec une moyenne de 16 unités de polyoxypropylène, suivi d'un bloc avec une moyenne de 2 unités de polyoxyéthylène. PLURONIC FT L 61 vont des liquides et pâtes incolores aux solides blancs. Dans les cosmétiques et les produits de soins personnels, le PLURONIC FT L 61 est utilisé dans la formulation de nettoyants pour la peau, de produits de bain, de shampooings, de revitalisants capillaires, de bains de bouche, de démaquillants pour les yeux et d'autres produits pour la peau et les cheveux.
Ataman Kimya A.Ş. © 2015 Tüm Hakları Saklıdır.