CAS NUMBER; 107-15-3, 27308-78-7, 18299-54-2
EC NUMBER; 203-468-6, 242-181-0
SYNOYMS;Ethylenediamine; 1,2-diaminoethane; 1,2-ethanediamine; edamine; ethane-1,2-diamine; ethyl diamine; ethylenediamine; ethylenediamine (1:1) sulfate; ethylenediamine (1:1) sulfite; ethylenediamine conjugate acid; ethylenediamine dihydrobromide; ethylenediamine dihydrochloride; ethylenediamine dihydrogen iodide; ethylenediamine dihydroiodide; ethylenediamine dinitrate; ethylenediamine hydrochloride; ethylenediamine monohydrochloride; ethylenediamine phosphate; ethylenediamine sulfate; ethylenediamine, 3H-labeled cpd; ethylenediamine; Ethane-1,2-diamine; 1,2-Ethanediamine; 107-15-3; 1,2-Diaminoethane; Ethylene diamine; Ethylendiamine; Dimethylenediamine; 1,2-Ethylenediamine; edamine; Aethaldiamin; Aethylenediamin; Ethyleendiamine; Ethylene-diamine; beta-Aminoethylamine; 1,2-Diaminoaethan; Algicode 106L; Amerstat 274; 1,2-Diamino-ethaan; 1,2-Diamino-ethano; Aethaldiamin [German]; Caswell No. 437; Ethylenediamine [JAN]; Ethyleendiamine [Dutch]; Aethylenediamin [German]; Ethylene-diamine [French]; NCI-C60402; UNII-60V9STC53F; 1,2-Diaminoaethan [German]; 1,2-Diamino-ethaan [Dutch]; CCRIS 5224; ETHYLENEDIAMINE ANHYDROUS; HSDB 535; 1,2-Diamino-ethano [Italian]; 1,2-Ethanediamine, homopolymer; CHEBI:30347; Ethylenediamine, piperazine polymer; EINECS 203-468-6; UN1604; CHEMBL816; H2NCH2CH2NH2EPA Pesticide Chemical Code 004205; BRN 0605263; ETHANE,1,2-DIAMINO; Ethylendiamin; AI3-24231; 624-59-9 (di-hydrobromide); 333-18-6 (di-hydrochloride); 5700-49-2 (di-hydriodide); PIICEJLVQHRZGT-UHFFFAOYSA-N; 2-Aminoethylammonium chloride; MFCD00008204; 1, 2-Diaminoethane; Ethylenediamine [UN1604] [Corrosive]; NCGC00091527-01; DSSTox_CID_1881; DSSTox_RID_76382; DSSTox_GSID_21881; EN; 85404-18-8; CAS-107-15-3; Ethylenediamine, ReagentPlus(R), >=99%; 1,2-Ethanediamine, monohydrochloride; 1,2-Ethanediamine, hydrochloride (1:1); ethylenediarnine; 2-aminoethylamine; ethylene di amine; 1,4-diazabutane; 1,2-diaminoethan; ethylene - diamine; EDN; 1,2; ethylendiamine; 1,2-diamino-ethane; ethane 1,2-diamine; N,N'-ethylenediamine; Ethylenediamine, 8CI; QuadraPure® AEA; 1,2-ethylene diamine; 1,2-ethylene-diamine
Aminophylline Injection; .beta.-Aminoethylamine; ethane-1, 2-diamine; N,N'-ethylene diamine; ACMC-1BOEG; Ethylenediamine, BioXtra; AC1L1FMH; D0WT6A; Epitope ID:117724AC1Q54JY; 4-04-00-01166 (Beilstein Handbook Reference); KSC178S6D; Ethylenediamine (USP/JP15); Ethylenediamine (USP/JP17); 60V9STC53F; BDBM7972; NH2(CH2)2NH2; DTXSID5021881; Ethylenediamine, 99% 100ml; CTK0H8961; KS-00000UDI; 20829-66-7 (dinitrate); MolPort-001-783-384; LTBB001600; Ethylenediamine, analytical standard; Tox21_111145; Tox21_201202; LS-431; STL264241; ZINC37253587; 18299-54-2 (mono-hydrochloride); 25723-52-8 (unspecified sulfate); AKOS000118850; AN-4989; MCULE-4740333723; RP18257; RTR-033968; TRA0069196; UN 1604; 14852-17-6 (unspecified phosphate); Ethylenediamine, for synthesis, 99.0%; NCGC00091527-02; NCGC00258754-01; 22029-36-3 (sulfate[1:1]); 27308-78-7; AN-23406; BP-20367; Ethylenediamine [UN1604] [Corrosive]; SC-26825; 15467-15-9 (unspecified hydrochloride); KB-149152; TR-033968E0077; E0081; Ethylenediamine solution, technical, 75-80%; InChI=1/C2H8N2/c3-1-2-4/h1-4H; D01114; Ethylenediamine, SAJ special grade, >=99.0%; 25469-EP2289881A1; 25469-EP2295436A1; 25469-EP2298762A2; 25469-EP2298773A1; 25469-EP2305808A1; 25469-EP2308852A1; 25469-EP2314580A1; Ethylenediamine, meets USP testing specifications; 167669-EP2272813A2; 167669-EP2275395A2; 167669-EP2281563A1; Ethylenediamine, Vetec(TM) reagent grade, >=98%; QuadraPure® Aminoethyl aminobut-2-enoate ester; I14-2687; J-001723; Ethylenediamine, purified by redistillation, >=99.5%; F2191-0279; Ethylenediamine, puriss. p.a., absolute, >=99.5% (GC); Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester; 68845-05-6; 8030-24-8; QuadraPure(R) AEA, 100-400 mum particle size, extent of labeling: 1.3 mmol/g loading, 1 % cross-linked with divinylbenzene; ALPHA,OMEGA-ETHANEDIAMINE; BETA- AMINOETHYLAMINE; BETA-AMINOETHYLAMINE; 1,2-DIAMINOETHANE; 1,4-DIAZABUTANE; DIMETHYLENEDIAMINE; EDAMINE; 1,2-ETHANEDIAMINE; ETHYLENDIAMINE; ETHYLENEDIAMINE; ETHYLENEDIAMINE (ANHYDROUS); ETHYLENEDIAMINE MOD; 1,2-ETHYLENEDIAMINE; NCI-C60402; 1,2-DIAMINOETHANE (ETHYLENEDIAMINE); 210-810-8 [EINECS]; 623-73-4 [RN]; Acetic acid, 2-diazo-, ethyl ester [ACD/Index Name]; Diazoacétate d'éthyle [French] [ACD/IUPAC Name]; Diazoacetic acid ethyl ester
Diazoacetic Ester; EDA (ethylenediamine); Ethyl diazoacetate [ACD/IUPAC Name]; Ethyl Diazoethanoate; Ethyl-diazoacetat [German] [ACD/IUPAC Name]; N84B835FMR; (E)-2-diazonio-1-ethoxy-ethenolate; (E)-2-Diazonio-1-ethoxyethenolate [ACD/IUPAC Name]; 1154730-15-0 [RN]; 2-diazonio-1-ethoxy-ethenolate; 2-Diazonio-1-ethoxyethenolate; [ACD/IUPAC Name]; 333-18-6 [RN]; acetic acid, diazo-, ethyl ester; DAAE; Diazoacetic acid, ethyl ester; Diazoessigsaeure-aethylester [German]; EINECS 210-810-8; Ethoxycarbonyldiazomethane; ETHYL 2-DIAZOACETATE; Ethyl-2-diazoacetate; Ethyldiazoacetate; Ethyldiazoacetate, contains <15 wt. % dichloromethane; InChI=1/C4H6N2O2/c1-2-8-4(7)3-6-5/h3H,2H2,1H; MFCD00001989 [MDL number]; UNII:N84B835FMR; UNII-N84B835FMR; Ethylenediamine (EDA); i3-24231;NCIC60402;amerstat274;Aethaldiamin;algicode106l;caswellno437;H2NCH2CH2NH2;Diaminoethane;Ethylendia; Energy density analysis; chemical bond; dissociation process; excitation process; Mulliken population analysis; Ethylenediamine (EDA; 1,2-diaminoethane; CAS 107-15-3); 1,2-Diaminoethane; Ethylenediamine; 1,2-Ethanediamine; Ethylenediamine, >25% in a non hazardousdiluent; ETHYLENE DIAMINE; 1,2-Diaminoethane, hydrate; Ethylenediamine, EDA; 1,2-Diaminoethane; 1,2-Ethanediamine; 1,2-Diaminoethane; Dimethylenediamine ; 1,2-diaminoethane; 1,2-ethanediamine; edamine; ethane-1,2-diamine; ethyl diamine; ethylenediamine; ethylenediamine (1:1) sulfate; ethylenediamine (1:1) sulfite; ethylenediamine conjugate acid; ethylenediamine dihydrobromide; ethylenediamine dihydrochloride; ethylenediamine dihydrogen iodide; ethylenediamine dihydroiodide; ethylenediamine dinitrate; ethylenediamine hydrochloride; ethylenediamine monohydrochloride; ethylenediamine phosphate; ethylenediamine sulfate; ethylenediamine, 3H-labeled cpd; ethylenediamine; Ethane-1,2-diamine; 1,2-Ethanediamine; 107-15-3; 1,2-Diaminoethane; Ethylene diamine; Ethylendiamine; Dimethylenediamine; 1,2-Ethylenediamine; edamine; Aethaldiamin; Aethylenediamin; Ethyleendiamine; Ethylene-diamine; beta-Aminoethylamine; 1,2-Diaminoaethan; Algicode 106L; Amerstat 274; 1,2-Diamino-ethaan; 1,2-Diamino-ethano; Aethaldiamin [German]; Caswell No. 437; Ethylenediamine [JAN]; Ethyleendiamine [Dutch]; Aethylenediamin [German]; Ethylene-diamine [French]; NCI-C60402; UNII-60V9STC53F; 1,2-Diaminoaethan [German]; 1,2-Diamino-ethaan [Dutch]; CCRIS 5224; ETHYLENEDIAMINE ANHYDROUS; HSDB 535; 1,2-Diamino-ethano [Italian]; 1,2-Ethanediamine, homopolymer; CHEBI:30347; Ethylenediamine, piperazine polymer; EINECS 203-468-6; UN1604; CHEMBL816; H2NCH2CH2NH2; EPA Pesticide Chemical Code 004205; BRN 0605263; ETHANE,1,2-DIAMINO; Ethylendiamin; AI3-24231; 624-59-9 (di-hydrobromide); 333-18-6 (di-hydrochloride); 5700-49-2 (di-hydriodide); PIICEJLVQHRZGT-UHFFFAOYSA-N; 2-Aminoethylammonium chloride; MFCD00008204; 1, 2-Diaminoethane; Ethylenediamine [UN1604] [Corrosive]; NCGC00091527-01; DSSTox_CID_1881; DSSTox_RID_76382; DSSTox_GSID_21881; EN; 85404-18-8; CAS-107-15-3; Ethylenediamine, ReagentPlus(R), >=99%; 1,2-Ethanediamine, monohydrochloride; 1,2-Ethanediamine, hydrochloride (1:1); ethylenediarnine; 2-aminoethylamine; ethylene di amine; 1,4-diazabutane; 1,2-diaminoethan; ethylene - diamine; EDN; 1,2; ethylendiamine; 1,2-diamino-ethane; ethane 1,2-diamine; N,N'-ethylenediamine; Ethylenediamine, 8CI; QuadraPure® AEA; 1,2-ethylene diamine; 1,2-ethylene-diamine; Aminophylline Injection; .beta.-Aminoethylamine; ethane-1, 2-diamine; N,N'-ethylene diamine; ACMC-1BOEG; Ethylenediamine, BioXtra; AC1L1FMH; D0WT6A; Epitope ID:117724; AC1Q54JY; 4-04-00-01166 (Beilstein Handbook Reference); KSC178S6D; Ethylenediamine (USP/JP15); Ethylenediamine (USP/JP17); 60V9STC53F; BDBM7972; NH2(CH2)2NH2; DTXSID5021881; Ethylenediamine, 99% 100ml; CTK0H8961; KS-00000UDI; 20829-66-7 (dinitrate); MolPort-001-783-384; LTBB001600; Ethylenediamine, analytical standard; Tox21_111145; Tox21_201202; LS-431; STL264241; ZINC37253587; 18299-54-2 (mono-hydrochloride); 25723-52-8 (unspecified sulfate); AKOS000118850; AN-4989; MCULE-4740333723; RP18257; RTR-033968; TRA0069196; UN 1604; 14852-17-6 (unspecified phosphate); Ethylenediamine, for synthesis, 99.0%; NCGC00091527-02; NCGC00258754-01; 22029-36-3 (sulfate[1:1]); 27308-78-7; AN-23406; BP-20367; Ethylenediamine [UN1604] [Corrosive]; SC-26825; 15467-15-9 (unspecified hydrochloride); KB-149152; TR-033968; E0077; E0081; Ethylenediamine solution, technical, 75-80%; InChI=1/C2H8N2/c3-1-2-4/h1-4H; D01114; Ethylenediamine, SAJ special grade, >=99.0%; 25469-EP2289881A1; 25469-EP2295436A1; 25469-EP2298762A2; 25469-EP2298773A1; 25469-EP2305808A1; 25469-EP2308852A1; 25469-EP2314580A1; Ethylenediamine, meets USP testing specifications; 167669-EP2272813A2; 167669-EP2275395A2; 167669-EP2281563A1; Ethylenediamine, Vetec(TM) reagent grade, >=98%; QuadraPure® Aminoethyl aminobut-2-enoate ester; I14-2687; J-001723; Ethylenediamine, purified by redistillation, >=99.5%; F2191-0279; Ethylenediamine, puriss. p.a., absolute, >=99.5% (GC); Thiocyanic acid, C,C'-(2,6-diamino-3,5-pyridinediyl) ester; 68845-05-6; 8030-24-8; QuadraPure(R) AEA, 100-400 mum particle size, extent of labeling: 1.3 mmol/g loading, 1 % cross-linked with divinylbenzene; ALPHA,OMEGA-ETHANEDIAMINE; BETA- AMINOETHYLAMINE; BETA-AMINOETHYLAMINE; 1,2-DIAMINOETHANE; 1,4-DIAZABUTANE; DIMETHYLENEDIAMINE; EDAMINE; 1,2-ETHANEDIAMINE; ETHYLENDIAMINE; ETHYLENEDIAMINE; ETHYLENEDIAMINE (ANHYDROUS); ETHYLENEDIAMINE MOD; 1,2-ETHYLENEDIAMINE; NCI-C60402; 1,2-DIAMINOETHANE (ETHYLENEDIAMINE); 210-810-8 [EINECS]; 623-73-4 [RN]; Acetic acid, 2-diazo-, ethyl ester [ACD/Index Name]; Diazoacétate d'éthyle [French] [ACD/IUPAC Name]; Diazoacetic acid ethyl ester; Diazoacetic Ester; EDA (ethylenediamine); Ethyl diazoacetate [ACD/IUPAC Name]; Ethyl Diazoethanoate; Ethyl-diazoacetat [German] [ACD/IUPAC Name]; N84B835FMR; (E)-2-diazonio-1-ethoxy-ethenolate; (E)-2-Diazonio-1-ethoxyethenolate [ACD/IUPAC Name]; 1154730-15-0 [RN]; 2-diazonio-1-ethoxy-ethenolate; 2-Diazonio-1-ethoxyethenolate; [ACD/IUPAC Name]; 333-18-6 [RN]; acetic acid, diazo-, ethyl ester; DAAE; Diazoacetic acid, ethyl ester; Diazoessigsaeure-aethylester [German]; EINECS 210-810-8; Ethoxycarbonyldiazomethane; ETHYL 2-DIAZOACETATE; Ethyl-2-diazoacetate; Ethyldiazoacetate; Ethyldiazoacetate, contains <15 wt. % dichloromethane; InChI=1/C4H6N2O2/c1-2-8-4(7)3-6-5/h3H,2H2,1H; MFCD00001989 [MDL number]; UNII:N84B835FMR; (TETA); SynonymsEDA; C60402;amerstat274; Aethaldiamin;algicode106l;caswellno437;H2NCH2CH2NH2;Diaminoethane;Ethylendia; Energy density analysis; chemical bond; dissociation process; excitation process; Mulliken population analysis; Ethylenediamine (EDA; 1,2-diaminoethane; CAS 107-15-3); 1,2-Diaminoethane; Ethylenediamine; 1,2-Ethanediamine; Ethylenediamine, >25% in a non hazardousdiluent; ETHYLENE DIAMINE; 1,2-Diaminoethane, hydrate; Ethylenediamine, EDA; 1,2-Diaminoethane; 1,2-Ethanediamine; 1,2-Diaminoethane; Dimethylenediamine ; ETHYLENEDİAMİNE; ETHYLENEDIAMINE; ETHYLENE Dİ AMİNE; ETHYLENE DI AMINE; ETİLEN Dİ AMİN; ETILEN DI AMINE; ETİLEN DI AMIN; ETILEN Dİ AMIN; ETILEN DI AMİN; ETİLEN Dİ AMINE; ETHILEN Dİ AMİNE; ETILEN Dİ AMIN; etilen di amin; etılen dı amın; etılendıamıne; ethylenedıamıne; etilen di amine; etılen dı amın; etılen dı amıne; ethylenedıamıne; ethylenediamine; ethilendiamine; ethılendıamıne;
Chemical Formula: C2H8N2
Flash Point: 93 ° F (EPA, 1998)
Lower Explosive Limit (LEL): 4.2 % (EPA, 1998)
Upper Explosive Limit (UEL): 14.4 % (EPA, 1998)
Autoignition Temperature: 715 ° F (USCG, 1999)
Melting Point: 46 ° F (EPA, 1998)
Vapor Pressure: 10.7 mm Hg at 68 ° F (EPA, 1998)
Vapor Density (Relative to Air): 2.07 (EPA, 1998)
Specific Gravity: 0.898 at 77 ° F (EPA, 1998)
Boiling Point: 241 ° F at 760 mm Hg (EPA, 1998)
Molecular Weight: 60.12 (EPA, 1998)
Water Solubility: greater than or equal to 100 mg/mL at 63° F (NTP, 1992)
Ionization Potential: 8.60 eV (NIOSH, 2016)
IDLH: 1000 ppm (NIOSH, 2016)
Abstract;
Around three decades ago, environmental chemists developed a new technique to identify pollutants present in complex environmental mixtures: effect-directed analysis (EDA). EDA uses chemical tools (for the extraction, fractionation, and analysis of samples) together with biological tools (as bioassays) to find the cause of an observed effect. Such studies can be very powerful but the extensive material, the high number of fractions generated, and the expertise required by such intensive study can be an obstacle. This thesis tested different techniques for each EDA steps and several EDA studies have been performed. The aim of the thesis is to propose ways to increase EDA throughput and to facilitate the use of bioassays and chemical fractionations and analyses together. For the thesis, two bioassays were further developed and different fractionation and analytical techniques were performed and compared. In conclusion a «generic EDA» protocol was suggested as well as further development opportunities for EDA.
Chemical Properties
CLEAR liquid
General Description
A clear colorless liquid with an ammonia-like odor. Flash point of 91°F and a melting point of 47°F. Corrosive to tissue. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Density 7.5 lb / gal. Used to make other chemicals and as a fungicide.
Air & Water Reactions
Highly flammable. Hygroscopic. Fumes in the air. Water soluble. Biodegrades readily.
Reactivity Profile
A base. Highly reactive with many compounds. Can react violently with acetic acid, acetic anhydride, acrolein, acrylic acid, acrylonitrile, allyl chloride, carbon disulfide, chlorosulfonic acid, epichlorohydrin, ethylene chlorohydrin, hydrogen chloride, mesityl oxide, nitric acid, oleum, AgClO4, sulfuric acid, beta-propiolactone and vinyl acetate. Incompatible with strong acids, strong oxidizers (perchlorate salts), and chlorinated organic compounds. Ethylenediamine is also incompatible with halogenated organic compounds and metal halides. May react with nitromethane and diisopropyl peroxydicarbonate. May ignite on contact with cellulose nitrate. Readily absorbs carbon dioxide from the air to give crusty solid deposits. . Ethylenediamine reacts violently with ethylene chlorohydrin. (Lewis, R.J., Sr. 1992. Sax's Dangerous Properties of Industrial Materials, 8th Edition. New York: Van Nostrand Reinhold. pp. 1554.).
Health Hazard
Vapor inhalations at a concentration of 200 ppm for 5 to 10 minutes will lead to nasal irritation and produce a tingling sensation. Inhalation at concentrations of 400 ppm or greater leads to severe nasal irritation. Respiratory irritation may result. Many individuals are hypersensitive to Ethylenediamine exposure; therefore, safe threshold limits are difficult to set.
Fire Hazard
Burning rate: 2.2 mm/minute. When exposed to heat or flame, the material has a moderate fire potential. The material can react readily with oxidizing materials. Containers may explode in heat of fire. Material emits nitrogen oxides when burned. Avoid carbon disulfide, silver perchlorate, imines, oxidizing materials. Stable. Hazardous polymerization may not occur.
APPLICATIONS:
Agricultural Chemicals
Chelating Agents
Corrosion Inhibitors
Ethylene Urea Resins
Ion Exchange Resins
Lubricants for Thermoplastic Resin
Oil Additives
Polyamide Resins
Reforming Agents for Soils
Rubber Chemicals
Surface-active Agents
1,2-этандиамин, также известный как EDA или эдамин, относится к классу органических соединений, известных как моноалкиламины. 1,2-Этандиамин существует в виде жидкого, растворимого (в воде) и очень сильного основного соединения (на основе его pKa).
Ethane-1,2-diamine, Ethylenediamine (EDA); IUPAC name of substance: 1,2-Diaminoethane; synonyms and trade name: 1,2-ethanediamine, dimethylenediamine, beta-aminoethylamine, ethylenediamine (CAS: 107-15-3)
(EC: 203-468-6); ethylenediamine;EDA; Ethane-1,2-diamine; 1,2-Ethanediamine; Cas no:107-15-3; 1,2-Diaminoethane; Ethylene diamine; Ethylendiamine; edamine; Dimethylenediamine; 1,2-Ethylenediamine
1, 2-Ethanediamine, also known as en or edamine, belongs to the class of organic compounds known as monoalkylamines. These are organic compounds containing an primary aliphatic amine group. 1, 2-Ethanediamine exists as a liquid, soluble (in water), and a very strong basic compound (based on its pKa). 1, 2-Ethanediamine has been found in human liver and kidney tissues, and has also been detected in multiple biofluids, such as urine and blood. Within the cell, 1, 2-ethanediamine is primarily located in the cytoplasm. 1, 2-Ethanediamine participates in a number of enzymatic reactions. In particular, 1, 2-ethanediamine can be biosynthesized from ethane. 1, 2-Ethanediamine is also a parent compound for other transformation products, including but not limited to, ethylenebis(dithiocarbamic acid), ethylenediamine dihydrochloride, and ethylenediamine derivative.
Ethylenediamine (EDA - EDA) - (1,2-diaminoethane) is the lowest molecular weight homologue of ethyleneamines. It contains two primary amino groups and forms an azeotropic mixture with water with a maximum boiling point.
Ethylenediamine (abbreviated as en when a ligand) is the organic compound with the formula C2H4(NH2)2. This colorless liquid with an ammonia-like odor is a strongly basic amine.
It is a widely used building block in chemical synthesis, with approximately 500,000 tonnes produced in 1998. Ethylenediamine readily reacts with moisture in humid air to produce
a corrosive, toxic and irritating mist, to which even short exposures can cause serious damage to health (see safety). Ethylenediamine is the first member of the so-called polyethylene
amines.
Ethylenediamine is produced industrially by treating 1,2-dichloroethane with ammonia under pressure at 180 °C in an aqueous medium.
Ethylenediamine is used in large quantities for production of many industrial chemicals. It forms derivatives with carboxylic acids (including fatty acids), nitriles, alcohols (at elevated temperatures), alkylating agents, carbon disulfide, and aldehydes and ketones. Because of its bifunctional nature, having two amines, it readily forms heterocycles such as imidazolidines.
Precursor to chelation agents, drugs, and agrochemicals
A most prominent derivative of ethylenediamine is the chelating agent EDTA, which is derived from ethylenediamine via a Strecker synthesis involving cyanide and formaldehyde. Hydroxyethylethylenediamine is another commercially significant chelating agent. Numerous bio-active compounds and drugs contain the N-CH2-CH2-N linkage, including some antihistamines.[10] Salts of ethylenebisdithiocarbamate are commercially significant fungicides under the brand names Maneb, Mancozeb, Zineb, and Metiram. Some imidazoline-containing fungicides are derived from ethylenediamine.
Pharmaceutical ingredient
Ethylenediamine is an ingredient in the common bronchodilator drug aminophylline, where it serves to solubilize the active ingredient theophylline. Ethylenediamine has also been used in dermatologic preparations, but has been removed from some because of causing contact dermatitis. When used as a pharmaceutical excipient, after oral administration its bioavailability is about 0.34, due to a substantial first-pass effect. Less than 20% is eliminated by renal excretion.
Ethylenediamine-derived antihistamines are the oldest of the five classes of first-generation antihistamines, beginning with piperoxan aka benodain, discovered in 1933 at the Pasteur Institute in France, and also including mepyramine, tripelennamine, and antazoline. The other classes are derivatives of ethanolamine, alkylamine, piperazine, and others (primarily tricyclic and tetracyclic compounds related to phenothiazines, tricyclic antidepressants, as well as the cyproheptadine-phenindamine family)
Role in polymers
Ethylenediamine, because it contains two amine groups, is a widely used precursor to various polymers. Condensates derived from formaldehyde are plasticizers. It is widely used in the production of polyurethane fibers. The PAMAM class of dendrimers are derived from ethylenediamine.
Tetraacetylethylenediamine
The bleaching activator tetraacetylethylenediamine is generated from ethylenediamine. The derivative N,N-ethylenebis(stearamide) (EBS) is a commercially significant mold-release agent and a surfactant in gasoline and motor oil.
Other applications
as a solvent, it is miscible with polar solvents and is used to solubilize proteins such as albumins and casein. It is also used in certain electroplating baths.
as a corrosion inhibitor in paints and coolants.
ethylenediamine dihydroiodide (EDDI) is added to animal feeds as a source of iodide.
chemicals for color photography developing, binders, adhesives, fabric softeners, curing agents for epoxies, and dyes.
as a compound to sensitize nitromethane into an explosive. This mixture was used at Picatinny Arsenal during WWII, giving the nitromethane and ethylenediamine mixture the nickname PLX, or Picatinny Liquid Explosive.
Coordination chemistry
Ethylenediamine is a well-known bidentate chelating ligand for coordination compounds, with the two nitrogen atoms donating their lone pairs of electrons when ethylenediamine acts as a ligand. It is often abbreviated "en" in inorganic chemistry. The complex [Co(ethylenediamine)3]3+ is an archetypical chiral tris-chelate complex. The salen ligands, some of which are used in catalysis, are derived from the condensation of salicylaldehydes and ethylenediamine.
Related ligands
Related derivatives of ethylenediamine include ethylenediaminetetraacetic acid (EDTA), tetramethylethylenediamine (TMEDA), and tetraethylethylenediamine (TEEDA). Chiral analogs of ethylenediamine include 1,2-diaminopropane and trans-diaminocyclohexane.
Safety
Ethylenediamine, like ammonia and other low-molecular weight amines, is a skin and respiratory irritant. Unless tightly contained, liquid ethylenediamine will release toxic and irritating vapors into its surroundings, especially on heating. The vapors react with moisture in humid air to form a characteristic white mist, which is extremely irritating to skin, eyes, lungs and mucus membranes.
Areas of use:
Bleach activator
Chelating agents
Corrosion inhibitors
Elastomer fiber production
Fungicide production
Fuel additives
Additives used in the processing of mineral raw materials
Intermediate in the manufacture of pharmaceutical products
Lubricants for plastics
Polyamide resins
Rubber additives
Additives for the textile industry
Urethane reagents
Ethylenediamine (EDA)
Physical characteristics: Clear and Colorless Liquid
Molecular weight: 60.10 g / mol
Container type, Barrel
Flammable substances. Reacts strongly with aldehydes and acids. Absorbs carbon dioxide from the air. Ethylenediamine dissolves well in water (with heating of the solution), ethanol, worse - in ether, insoluble in benzene and other hydrocarbons. It is a strong foundation. Hygroscopic.
Areas of use:
- Used to create fibers, polyamide and rubber.
- The chelating agent is used as an inhibitor.
- As a lubricating agent in the plastics industry.
- Hardener for polyurethane foam and epoxy resins.
EDA; Ethane-1,2-diamine; 1,2-Ethanediamine; Cas no:107-15-3; 1,2-Diaminoethane; Ethylene diamine; Ethylendiamine; edamine; Dimethylenediamine; 1,2-Ethylenediamine
Aethaldiamin
Aethylenediamin
Ethyleendiamine
Ethylene-diamine
beta-Aminoethylamine
1,2-Diaminoaethan
Algicode 106L
Amerstat 274
1,2-Diamino-ethaan
1,2-Diamino-ethano
Aethaldiamin [German]
Caswell No. 437
Ethylenediamine [JAN]
Ethyleendiamine [Dutch]
1,2-Ethanediamine, homopolymer
Aethylenediamin [German]
Ethylene-diamine [French]
1,2-Diaminoaethan [German]
1,2-Diamino-ethaan [Dutch]
ETHYLENEDIAMINE ANHYDROUS
1,2-Diamino-ethano [Italian]
CHEBI:30347
Aminophylline Injection
Ethylenediamine, piperazine polymer
EINECS 203-468-6
ETHANE,1,2-DIAMINO
Ethylendiamin
2-Aminoethylammonium chloride
1, 2-Diaminoethane
27308-78-7
Ethylenediamine [UN1604] [Corrosive]
Ethylenediamine, 99%
Ethylenediamine, 99+%
1,2-diaminoethane phase II
1,2-diaminoethane phase I beta
1,2-diaminoethane phase I alpha
Polyamines
Ethylenediamine, 99+%, AcroSeal(R)
CAS-107-15-3
Ethylenediamine, ReagentPlus(R), >=99%
1,2-Ethanediamine, monohydrochloride
1,2-Ethanediamine, hydrochloride (1:1)
Ethylenediamine [USP:JAN]
ethylenediarnine
2-aminoethylamine
ethylene di amine
1,4-diazabutane
1,2-diaminoethan
ethylene - diamine
EDN
1,2-ethylendiamine
Edamine [INN]
1,2-diamino-ethane
ethane 1,2-diamine
N,N'-ethylenediamine
Ethylenediamine, 8CI
1,2-ethylene diamine
1,2-ethylene-diamine
.beta.-Aminoethylamine
ethane-1, 2-diamine
Ethylenediamine solution
N,N'-ethylene diamine
Ethylenediamine, BioXtra
Ethylenediamine (USP/JP15)
Ethylenediamine (USP/JP17)
1,2-Diamino-ethaan
1,2-Diamino-ethano
1,2-Diaminoaethan
1,2-Diaminoethane
1,2-Ethanediamine
1,2-Ethylenediamine
Aethaldiamin
EDA
Aethylenediamin
EDA
Algicode 106L
Amerstat 274
EDA
beta-Aminoethylamine
EDA
Dimethylenediamine
EDA
OtherEdamine
EDA
Ethylendiamine
Ethylenediamine
Kimyasal formül: C2H8N2
Parlama Noktası: 93 ° F (EPA, 1998)
Alt Patlama Sınırı (LEL):% 4.2 (EPA, 1998)
Üst Patlama Sınırı (UEL):% 14.4 (EPA, 1998)
Kendiliğinden Tutuşma Sıcaklığı: 715 ° F (USCG, 1999)
Erime Noktası: 46 ° F (EPA, 1998)
Buhar Basıncı: 68 ° F'de 10.7 mm Hg (EPA, 1998)
Buhar Yoğunluğu (Hava ile Bağıl): 2.07 (EPA, 1998)
Özgül Ağırlık: 77 ° F'da 0.898 (EPA, 1998)
Kaynama Noktası: 760 mm Hg'de 241 ° F (EPA, 1998)
Moleküler Ağırlık: 60.12 (EPA, 1998)
Suda Çözünürlük: 63 ° F'de 100 mg / mL'ye eşit veya daha büyük (NTP, 1992)
İyonizasyon Potansiyeli: 8.60 eV (NIOSH, 2016)
IDLH: 1000 ppm (NIOSH, 2016)
Özet;
Yaklaşık 30 yıl önce, çevre kimyacıları karmaşık çevresel karışımlarda bulunan kirleticileri tanımlamak için yeni bir teknik geliştirdiler: etki odaklı analiz (EDA). EDA, gözlenen bir etmenin nedenini bulmak için biyolojik aletler (biyo-tahliller) ile birlikte kimyasal aletler (numunelerin ekstraksiyonu, fraksiyonlanması ve analizi için) kullanır. Bu tür çalışmalar çok güçlü olabilir, ancak kapsamlı materyal, üretilen çok sayıda fraksiyon ve bu yoğun çalışmanın gerektirdiği uzmanlık bir engel olabilir. Bu tez, her EDA adımı için farklı teknikler test etti ve birkaç EDA çalışması yapıldı. Tezin amacı, EDA verimini arttırmak ve biyo-tahlil ve kimyasal parçalamaların kullanımını ve analizlerini birlikte kolaylaştırmak için yollar sunmaktır. Tez için iki biyoanaliz daha da geliştirildi ve farklı fraksiyonasyon ve analitik teknikler yapıldı ve karşılaştırıldı. Sonuç olarak, "genel bir EDA" protokolünün yanı sıra EDA için daha fazla gelişme fırsatları önerilmiştir.
Kimyasal özellikler
Temiz sıvı
Genel açıklama
Amonyak benzeri bir kokusu olan berrak renksiz bir sıvı. Parlama noktası 91 ° F ve erime noktası 47 ° F. Doku için aşındırıcı. Buharlar havadan ağırdır. Yanma sırasında zehirli azot oksitleri üretir. Yoğunluk 7,5 lb / gal. Diğer kimyasalları ve mantar ilacı olarak kullanılır.
Hava ve Su Reaksiyonları
Son derece yanıcı. Higroskopik. Havadaki dumanlar. Suda çözünür. Biyolojik olarak kolayca
Reaktivite Profili
Bir üs. Birçok bileşikle oldukça reaktiftir. Asetik asit, asetik anhidrit, akrolein, akrilik asit, akrilonitril, allil klorür, karbon disülfür, klorosülfonik asit, epiklorohidrin, etilen klorohidrin, hidrojen klorür, mezityum oksit, nitrik asit, oleum, AgClO4, sülfürik asit, beta-propiolakton ile reaksiyona girebilir. ve vinil asetat. Güçlü asitler, güçlü oksitleyiciler (perklorat tuzları) ve klorlu organik bileşikler ile uyumsuzdur. Etilendiamin ayrıca halojenli organik bileşikler ve metal halojenürlerle de uyumsuzdur. Nitrometan ve diizopropil peroksidikarbonat ile reaksiyona girebilir. Selüloz nitrat ile temasta tutuşabilir. Kabaca katı birikintiler elde etmek için karbondioksiti havadan emer. . Etilendiamin, etilen klorohidrin ile şiddetle reaksiyona girer. (Lewis, R.J., Sr. 1992. Sax'in Endüstriyel Malzemelerin Tehlikeli Özellikleri, 8. Baskı. New York: Van Nostrand Reinhold. S. 1554.).
Sağlık tehlikesi
5 ila 10 dakika boyunca 200 ppm'lik bir konsantrasyonda buhar inhalasyonları, burun tahrişine yol açacak ve bir karıncalanma hissi yaratacaktır. 400 ppm veya daha büyük konsantrasyonlarda inhalasyon, ciddi nazal irritasyona yol açar. Solunum tahrişine neden olabilir. Pek çok birey Ethylenediamine maruziyetine aşırı duyarlıdır; Bu nedenle, güvenli eşik limitleri ayarlamak zordur.
Yangın tehlikesi
Yanma oranı: 2.2 mm / dakika. Isıya veya aleve maruz kaldığında, malzemenin ılımlı bir yangın potansiyeli vardır. Malzeme oksitleyici malzemelerle kolayca reaksiyona girebilir. Kaplar ateşte patlayabilir. Malzeme yandığında azot oksitleri yayar. Karbon disülfid, gümüş perklorat, iminler, oksitleyici maddelerden kaçının. Kararlı. Tehlikeli polimerizasyon meydana gelmeyebilir.
UYGULAMALAR:
Tarımsal kimyasallar
Şelatlayıcılar
Korozyon önleyicileri
Etilen Üre Reçineleri
İyon Değişim Reçineleri
Termoplastik Reçine Yağları
Yağ Katkı Maddeleri
Polyamid Reçineleri
Topraklar için Reform Maddeleri
Kauçuk Kimyasalları
Yüzey aktif maddeler
