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SORBITAN MONOPALMİTATE (SORBİTAN MONOPALMİTAT)

SORBITAN MONOPALMITATE (SORBİTAN MONOPALMİTAT)

CAS NO: 26266-57-9

 

SYNONYMS:
SORBITAN MONOPALMITATE;emülsiyonlaştırıcı S40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1,4-Anhydro-D-glucitol, 6-hexadecanoate; D-Glucitol, 1,4-anhydro-, 6-hexadecanoate; DSSTox_CID_9335; EC 247-568-; DSSTox_RID_7876; DSSTox_GSID_29335; CHEMBL3186294DTXSID6029335; SCHEMBL13700731; Sorbitan monopalmitate. (Compound usually contains also associated fatty acids.); 77K6Z421KU; ZINC8214459; Span 40 (=Sorbitan Monopalmitate); Tox21_112783; 1,4-anhydro-6-O-palmitoyl-D-glucitol; CAS-26266-57-9; S0061; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510;emülsiyonlaştırıcı S40; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1; SORBİTAN PALMITAT; sorbitan palmitate; sorbitane mono plmitate; palmitate; palmıtat; palmiyat; sorbitan mono palmıtat; sorbitan mono palmitat; sorbitane mono palmitat; sorbıtan mono palmıtat; sorbıtanmono palmıtat; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; E-495; Synonymscrill2;SPAN 40;sorgen70;glycomulp; liposorbp; montane40;ARLACEL 40; SPAN(R) 40; SPAN NO 40; emsorb2510; Sorbitan monopalnitateSpan #40 (=Sorbitan monopalmitate)Sorbitan Monopalmitate (Span-40)ARLACEL 40SORBITAN PALMITATESORBITAN MONOPALMITATESORBITANE MONOPALMITATESPAN(TM) 40SPAN NO 40SPAN(R) 40SPAN 40crill2 emsorb2510 EmulsifierS40 glycomulp liposorbp montane40 nikkolsp10 nissannonionpp40 nissannonionpp40r nonionpp40 protachemsmp rheodolsp-p10 Sorbitan,monohexadecanoate sorgen70 span(r)40hlb-value6.7 SORBITANMONOPALMITATE,NFSorbitanpalmitat26266-57-9C22H42O6C22H44O7Ester Type (Surfactants)Functional MaterialsNonionic SurfactantsSurfactantsCosmetic Ingredients & ChemicalsSorbitan monopalmitate, Span(R) 40Lonzest(R) SMP1,4-Anhydro-6-o-palmitoyl-D-glucitolSorbitan MonopalMitate, NF, EPSpan 40 Arlacel 40 Sorbitan MonopalmitatePalmitic acid compound with (2R,3R,4S)-2-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol (1:1)Palmitic acid compound with (2R,3R,4S)Nonionic SurfactantsEster Type (Surfactants)Surfactants; kaopan SP-P-10; E-495; SMP; Sorbitan Esters; emulsifiers; kaopan SP-P-10; liposorb P; lonzest SMP; monemul - 40; nikkol SP-10V; liposorb P; lonzest SMP; monemul - 40; sorbitan monohexadecanoate; sorbitan monohexadecanoate; rheodol SP-P10; sorbitan monopalmitate; sorbitan, esters, monohexadecanoate; [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate Liposorb P; emülsiyonlaştırıcı S40; SORBITAN MONOPALMITATE;emülsiyonlaştırıcı S40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1,4-Anhydro-D-glucitol, 6-hexadecanoate; D-Glucitol, 1,4-anhydro-, 6-hexadecanoate; DSSTox_CID_9335; EC 247-568-; DSSTox_RID_7876; DSSTox_GSID_29335; CHEMBL3186294DTXSID6029335; SCHEMBL13700731; Sorbitan monopalmitate. (Compound usually contains also associated fatty acids.); 77K6Z421KU; ZINC8214459; Span 40 (=Sorbitan Monopalmitate); Tox21_112783; 1,4-anhydro-6-O-palmitoyl-D-glucitol; CAS-26266-57-9; S0061; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510;emülsiyonlaştırıcı S40; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; CAS Number 26266-57-9; C22H42O6; sorbitan monohexadecanoate; sorbitan monopalmitate; sorbitan palmitate; Span 40; SORBITAN MONOPALMITATE; Sorbitan monohexadecanoate; Span 40; Sorbitan palmitate; Arlacel 40; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; Crill 2; Montane 40; Nikkol SP10; Nonion PP40; Sorgen 70;Nissan nonion PP40; Rheodol SP-P 10; Sorbitan, monopalmitate; Emsorb 2510; SORBITAN, MONOHEXADECANOATE;Nissan nonion PP 40RSorbitani palmitas [INN-Latin]; EINECS 247-568-8; Palmitate de sorbitan [INN-French];Palmitato de sorbitano [INN-Spanish]; Sorbitani palmitas; AI3-03901,Palmitate de sorbitan; Sorbitan palmitate [INN]; Palmitato de sorbitanoUNII-77K6Z421KU; Sorbitan monopalmitate [USAN:NF]; NCGC00181308-01; 1; SORBİTAN PALMITAT; sorbitan palmitate; sorbitane mono plmitate; palmitate; palmıtat; palmiyat; sorbitan mono palmıtat; sorbitan mono palmitat; sorbitane mono palmitat; sorbıtan mono palmıtat; sorbıtanmono palmıtat; Glycomul P; Liposorb P; Protachem SMP; Sorbitan palmitas; E-495; Synonymscrill2;SPAN 40;sorgen70;glycomulp; liposorbp; montane40;ARLACEL 40; SPAN(R) 40; SPAN NO 40; emsorb2510; Sorbitan monopalnitateSpan #40 (=Sorbitan monopalmitate)Sorbitan Monopalmitate (Span-40)ARLACEL 40SORBITAN PALMITATESORBITAN MONOPALMITATESORBITANE MONOPALMITATESPAN(TM) 40SPAN NO 40SPAN(R) 40SPAN 40crill2 emsorb2510 EmulsifierS40 glycomulp liposorbp montane40 nikkolsp10 nissannonionpp40 nissannonionpp40r nonionpp40 protachemsmp rheodolsp-p10 Sorbitan,monohexadecanoate sorgen70 span(r)40hlb-value6.7 SORBITANMONOPALMITATE,NFSorbitanpalmitat26266-57-9C22H42O6C22H44O7Ester Type (Surfactants)Functional MaterialsNonionic SurfactantsSurfactantsCosmetic Ingredients & ChemicalsSorbitan monopalmitate, Span(R) 40Lonzest(R) SMP1,4-Anhydro-6-o-palmitoyl-D-glucitolSorbitan MonopalMitate, NF, EPSpan 40 Arlacel 40 Sorbitan MonopalmitatePalmitic acid compound with (2R,3R,4S)-2-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol (1:1)Palmitic acid compound with (2R,3R,4S)Nonionic SurfactantsEster Type (Surfactants)Surfactants; kaopan SP-P-10; E-495; SMP; Sorbitan Esters; emulsifiers; kaopan SP-P-10; liposorb P; lonzest SMP; monemul - 40; nikkol SP-10V; liposorb P; lonzest SMP; monemul - 40; sorbitan monohexadecanoate; sorbitan monohexadecanoate; rheodol SP-P10; sorbitan monopalmitate; sorbitan, esters, monohexadecanoate; [2-[(2R,3S,4R)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] hexadecanoate Liposorb P; emülsiyonlaştırıcı S40; ; SORBITAN MONOPALMITATE; Sorbitan monopalmitate ; SORBiTAN MONOPALMiTATE; Sorbitan monopalmitat; Sorbıtane mono palmıtate; Sorbıtan mono palmıtate; Sorbitan mono palmitate;

 

 

 

Monopalmitate de sorbitane
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Monopalmitate de sorbitane
Sorbitan monopalmitate.svg
Des noms
Autres noms
Palmitate de sorbitane; Span 40; E495
Identifiants
Numero CAS
26266-57-9 ☑
ECHA InfoCard 100.043.229
Numéro E E495 (épaississants, ...)
PubChem CID
14927
UNII
77K6Z421KU ☑
Tableau de bord CompTox (EPA)
DTXSID6029335 Modifier cela sur Wikidata
Propriétés
Formule chimique
C22H42O6
Masse molaire 402,572 g · mol - 1
Point de fusion 46-47 ° C (115-117 ° F; 319-320 K) [1]
Dangers
Point d'éclair 113 ° C (235 ° F; 386 K) [1]
Sauf indication contraire, les données sont données pour les matériaux dans leur état standard (à 25 ° C [77 ° F], 100 kPa).
Références Infobox
Le monopalmitate de sorbitane (SMP) est un additif alimentaire [2] autorisé par l'UE. Il s'agit de l'entrée E495 dans la liste des numéros E des additifs alimentaires autorisés. [3] Il est également connu sous le nom commercial Span 40. [4]

 

 

Synopsis
Le monopalmitate de sorbitane est connu depuis au moins 1959. [5]

 

Vers 2000, le monopalmitate de sorbitan a été autorisé par l'UE dans les produits de boulangerie, les glaçages, les marmelades, les simulations de lait et de crème, les blanchissants pour boissons, les concentrés liquides de fruits et d'herbes, les sorbets, les sauces émulsionnées, les compléments alimentaires et les chewing-gums, entre autres. [3]

 


Le monopalmitate de sorbitane est un polysorbate dérivé du mélange d'esters partiels de sorbitol traités à l'acide palmitique. Le monopalmitate de sorbitane est un tensioactif lipophile. Il peut être trouvé en combinaison avec des polysorbates. Il est utilisé pour modifier la cristallisation des graisses. [3] Il est insoluble dans l'eau. [6] Jusqu'à 25 mg / kg de poids corporel peuvent être traités par l'homme. Le monopalmitate de sorbitan est métabolisé en sorbitol et en acide palmitique, sans aucun effet secondaire apparent. L'utilisation de graisses animales, comme le porc, dans la production de monopalmitate de sorbitane est possible. [4]

 

 

3.1 Aide sur les propriétés calculées Nouvelle fenêtre
Nom de la propriété Référence de la valeur de la propriété
Poids moléculaire 402,6 g / mol calculé par PubChem 2.1 (version PubChem 2019.06.18)
XLogP3-AA 5.8 Calculé par XLogP3 3.0 (version PubChem 2019.06.18)
Hydrogen Bond Donor Count 3 calculé par Cactvs 3.4.6.11 (version PubChem 2019.06.18)
Hydrogen Bond Acceptor Count 6 calculé par Cactvs 3.4.6.11 (version PubChem 2019.06.18)
Rotatable Bond Count 18 calculé par Cactvs 3.4.6.11 (version PubChem 2019.06.18)
Masse exacte 402,298139 g / mol calculée par PubChem 2.1 (version PubChem 2019.06.18)
Masse monoisotopique 402,298139 g / mol calculée par PubChem 2.1 (version PubChem 2019.06.18)
Surface polaire topologique 96,2 Ų calculée par Cactvs 3.4.6.11 (version PubChem 2019.06.18)
Nombre d'atomes lourds 28 calculé par PubChem
Charge formelle 0 calculée par PubChem
Complexité 389 calculée par Cactvs 3.4.6.11 (version PubChem 2019.06.18)
Nombre d'atomes d'isotopes 0 calculé par PubChem
Nombre défini de stéréocentres atomiques 4 calculés par PubChem
Undefined Atom Stereocenter Count 0 calculé par PubChem
Nombre de stéréocentres à liaisons définies 0 calculé par PubChem
Undefined Bond Stereocenter Count 0 calculé par PubChem
Nombre d'unités liées par liaison covalente 1 calculé par PubChem
Le composé est canonisé Oui

 

 


la description
Le monopalmitate de sorbitane (durée 40) est un émulsifiant non ionique, un tensioactif et un additif alimentaire. Le produit de Croda Inc. Span 40 est utilisé dans les soins de la peau, les cheveux et les cosmétiques décoratifs. Il est également utilisé comme effecteur dans des compositions capables de faciliter la pénétration à travers une barrière biologique. Ingrédient inactif de certains médicaments, il améliore l'administration transdermique de médicaments et est un vecteur potentiel de l'administration topique de médicaments. Dans la crème PLIAGLIS (lidocaïne et tétracaïne), le monopalmitate de sorbitan est utilisé comme ingrédient inactif. Le monopalmitate de sorbitane est un ester de sorbitane d'acide gras, de cire brun jaunâtre, légèrement soluble dans l'isopropanol, le xylène et la paraffine liquide, insoluble dans l'eau, non toxique.

 

 

Guide d'utilisation in vitro
Le monopalmitate de 10% de sorbitan ajouté à la pommade a augmenté significativement l'absorption percutanée du salicylate de sodium déterminée à partir des taux sanguins chez les lapins blancs de Nouvelle-Zélande à intervalles réguliers pendant 8 heures après l'application de la pommade.

 

 

Propriétés du monopalmitate de sorbitane
Point de fusion: 46-47 ° C (lit.)
Point d'ébullition: 444,68 ° C (estimation approximative)
Densité 1,0412 (estimation approximative)
indice de réfraction 1,4593 (estimation)
Point d'éclair:> 230 ° F
solubilité Pratiquement insoluble dans l'eau, soluble dans les huiles grasses, légèrement soluble dans l'alcool.
forme solide
couleur Flocons blancs
Hydrosolubilité insoluble dans l'eau
Équilibre hydrophile-lipophile (HLB) 6,7
InChIKeyDOCCLKYMPJSXGB-VCDGYCQFSA-N
Additifs indirects utilisés dans les substances en contact avec les aliments MONOPALMITATE SORBITAIN
Référence CAS DataBase26266-57-9 (Référence CAS DataBase)
Scores alimentaires d'EWG1
FDA UNII77K6Z421KU
Système de registre des substances de l'EPA Monopalmitate de sorbitane (26266-57-9)

 

 

Les usages
Le monopalmitate de sorbitane est un tensioactif non ionique de milieu de gamme HLB suggéré pour une utilisation en tant qu'émulsifiant sans ou sans huile pour les formulations cosmétiques, les produits ménagers et les produits chimiques textiles.
Les usages
le palmitate de sorbitan est un émulsifiant doté de capacités de liaison à l'humidité. Il sert également de solubilisant aux huiles essentielles dans l'eau. Il est dérivé du sorbitol.

 

 

SORBİTAN MONOPALMİTAT

 

Tanımlayıcılar
CAS numarası
26266-57-9 ☑
ECHA Bilgi Kartı 100.043.229
E numarası E495 (kıvam arttırıcılar, ...)
PubChem CID
14927
UNII
77K6Z421KU ☑
CompTox Kontrol Paneli (EPA)
DTXSID6029335 Bunu Wikidata'da düzenleyin
Özellikleri
Kimyasal formül
C22H42O6
Molar kütle 402.572 g · mol - 1
Erime noktası 46-47 ° C (115-117 ° F; 319-320 K) [1]
Tehlikeler
Parlama noktası 113 ° C (235 ° F; 386 K) [1]
Aksi belirtilmedikçe, standart halindeki malzemeler için veriler verilir (25 ° C [77 ° F], 100 kPa'da).
Bilgi kutusu referansları
Sorbitan monopalmitat (SMP), AB tarafından izin verilen bir gıda katkı maddesidir. İzin verilen gıda katkı maddelerinin E numarası listesine E495 girilir. [3] Span 40 ticari adı altında da bilinir. [4]

 

 

özet
Sorbitan monopalmitat en az 1959'dan beri bilinmektedir. [5]

 

2000 yılı civarında, Sorbitan monopalmitatın fırın ürünleri, kremalar, marmelatlar, süt ve krema simülasyonları, içecek beyazlatıcıları, meyve ve otların sıvı konsantreleri, sorbeler, emülsifiye soslar, gıda takviyeleri ve sakızlarda diğerlerine izin verilmiştir. [3]

 


Sorbitan monopalmitat, palmitik asit ile muamele edilmiş kısmi sorbitol esterlerinin karışımından türetilmiş bir polisorbattır. Sorbitan monopalmitat lipofilik bir yüzey aktif maddedir. Polisorbatlarla kombinasyon halinde bulunabilir. Yağların kristalleşmesini değiştirmek için kullanılır. [3] Suda çözünmez. [6] 25 mg / kg vücut ağırlığı insanlar tarafından işlenebilir. Sorbitan monopalmitat, belirgin bir yan etki olmaksızın sorbitol ve palmitik aside metabolize edilir. Sorbitan monopalmitat üretiminde domuz eti gibi hayvansal yağların kullanılması mümkündür. [4]

 

 


E495 (Sorbitan mono palmitat)
1 2

 

ÜRÜN ADI : Sorbitan Monopalmitat (E495)- SMP

SINIF : Emülgatör

TANIM VE İÇERİK : sorbitol ve anhidritlerinin kısmi esterleri ile bitkisel oleik asitin bir karışımıdır. Sorbitol,sorbitan, izosorbid esterleri ile serbest yağ asitleri içerebilir.

GÖRÜNÜM: Krem-sarımtrak boncuk katılar. Hafif karakteristik kokuya sahiptir.

ÇÖZÜNÜRLÜK : Suda çözünmez.

KULLANIM AMACI :

· Lipofilik yüzey aktif maddesidir. Genellikle polisorbatlarla bir arad emülgatör olarak kullanılır. Aynı zamanda yağların kristalizasyonunu değiştirmek için kullanılır

KULLANIM ALANI:

Ø Hafif pastacılık ürünlerinde

Ø Hafif pastacılık ürünleri,süsleme ve kaplama maddelerinde

Ø Ekmek mayasında

Ø Yağ emülsiyonlarında

Ø Süt ve krema karışımlarında

Ø Jöle marmelatlarda

Ø Tahin helvası çeşitlerinde

Ø Kakao bazlı şekerlemelerde

Ø Çikolatalarda

Ø Sıvı meyve ve bitki karışımlarında

Ø Tatlılarda

Ø Şeker bazlı şekerlemelerde

Ø Gıda takviyelerinde kulanılır

KULLANIM MİKTARI : Kullanım amacına ve istenilen ürüne göre uygulayıcı tarafından belirlenir.

AMBALAJ ÖZELLİĞİ : 25 kg Kraft Torba.

 

3.1 Hesaplanan Özellikler YardımıYeni Pencere
Özellik Adı Özellik Değeri Referansı
Moleküler Ağırlık 402.6 g / mol PubChem 2.1 tarafından hesaplanır (PubChem sürümü 2019.06.18)
XLogP3-AA 5.8 XLogP3 3.0 ile hesaplanır (PubChem sürümü 2019.06.18)
Cactvs 3.4.6.11 tarafından hesaplanan Hidrojen Bond Donör Sayısı 3 (PubChem sürümü 2019.06.18)
Cactvs 3.4.6.11 tarafından hesaplanan Hidrojen Bond Alıcı Sayısı 6 (PubChem sürümü 2019.06.18)
Cactvs 3.4.6.11 (PubChem sürümü 2019.06.18) ile hesaplanan Dönebilir Tahvil Sayısı 18
Tam Kütle 402.298139 g / mol PubChem 2.1 tarafından hesaplanır (PubChem sürümü 2019.06.18)
Monoizotop Kütlesi 402.298139 g / mol PubChem 2.1 tarafından hesaplandı (PubChem sürümü 2019.06.18)
Topolojik Polar Yüzey Alanı 96.2 Ų Cactvs 3.4.6.11 tarafından hesaplanmıştır (PubChem sürümü 2019.06.18)
PubChem tarafından hesaplanan Heavy Atom Sayısı 28
Resmi Ücret 0 PubChem tarafından hesaplanan
Karmaşıklık 389 Cactvs tarafından hesaplanmıştır 3.4.6.11 (PubChem sürümü 2019.06.18)
PubChem tarafından hesaplanan İzotop Atom Sayısı 0
PubChem tarafından tanımlanan Tanımlı Atom Stereo Merkezi 3
Tanımsız Atom Stereo Merkezi Sayı 0 PubChem tarafından hesaplandı
PubChem tarafından tanımlanan Bond Stereocenter Sayısı 0
Tanımsız Bond Stereocenter Sayısı 0 PubChem tarafından hesaplanan
Kovalent Bağlantılı Birim Sayısı 1 PubChem tarafından hesaplanır
Bileşik Kanonikleştirildi Evet

 

 


açıklama
Sorbitan monopalmitat (Span 40) noniyonik bir emülgatör, yüzey aktif madde ve gıda katkı maddesidir. Croda Inc. Span 40 ürünü cilt bakımı, saç bakımı ve dekoratif kozmetik ürünlerinde kullanılmaktadır. Ayrıca biyolojik bir bariyere nüfuz etmeyi kolaylaştırabilen kompozisyonlarda bir efektör olarak kullanılır. Bazı ilaçların aktif olmayan bileşeni, ilaçların transdermal iletimini geliştirir ve topikal ilaç iletimi için potansiyel bir taşıyıcıdır. PLIAGLIS kreminde (lidokain ve tetrakain) sorbitan monopalmitat, aktif olmayan bir bileşen olarak kullanılır. Sorbitan monopalmitat, izopropanol, ksilen ve sıvı parafin içinde az çözünür, suda çözünmeyen, toksik olmayan bir yağ asidi sorbitan ester, sarımsı kahverengi mumdur.

 

 

In Vitro Kullanım Kılavuzu
Merheme eklenen% 10 sorbitan monopalmitat, merhem uygulamasını takiben 8 saat boyunca düzenli aralıklarla Yeni Zelanda beyaz tavşanlarında kan seviyelerinden belirlenen sodyum salisilatın perkütanöz emilimini önemli ölçüde arttırdı.

 

 

Sorbitan monopalmitat Özellikleri
Erime noktası: 46-47 ° C (lit.)
Kaynama noktası: 444.68 ° C (kaba tahmin)
Yoğunluk 1.0412 (kaba tahmin)
kırılma indisi 1.4593 (tahmin)
Parlama noktası:> 230 ° F
çözünürlük Pratik olarak suda çözünmez, yağlı yağlarda çözünür, alkolde az çözünür.
form Katı
renk Beyaz pul
Suda Çözünürlük Suda çözünmez
Hidrofilik-Lipofilik Denge (HLB) 6.7
InChIKeyDOCCLKYMPJSXGB-VCDGYCQFSA-N-
Gıda ile Temas Eden Maddelerde Kullanılan Dolaylı Katkı Maddeleri SORBITAN MONOPALMITATE
CAS Veri Tabanı Referansı 26266-57-9 (CAS Veri Tabanı Referansı)
EWG'nin Gıda Puanları1
FDA UNII77K6Z421KU
EPA Madde Kayıt SistemiSorbitan monopalmitat (26266-57-9)

 

 

Kullanımları
Sorbitan monopalmitat, kozmetik formülasyonlar, ev ürünleri ve tekstil kimyasalları için w / o veya o / w emülsiyonlaştırıcı olarak kullanılması önerilen iyonik olmayan, orta aralıklı bir HLB yüzey aktif cismidir.
Kullanımları
sorbitan palmitat, nem bağlama kabiliyetlerine sahip bir emülgatördür. Aynı zamanda sudaki uçucu yağların çözünürleştiricisi olarak hizmet eder. Sorbitolden elde edilir.

 

 

E434: Polioksietilen (20) sorbitan monopalmitat
Tween 40, Polisorbat 40

 

 

Kaynağı:
E434; etilen oksit (sentetik bir bileşik), sorbitol (E420) ve palmitik asitten (doğal bir yağ asidi) üretilen sentetik bir bileşiktir.

 

 

Fonksiyon ve Özellikleri:
Emülgatör özelliktedir.

 

 

Ürünler:
Pastalarda kullanılır.

 

 

Kabul edilebilir günlük alım miktarı:
430-E436 sırası içindeki bileşiklerin bütün grupları için; 25 mg / kg vücut ağırlığı

 

 

Yan etkileri:
Kullanılan konsantrasyonlarında bilinen herhangi bir yan etkisi yoktur. Propilen glikolü tolere edemeyen insanlar, 430-E436 grubundan sakınmalıdır.

 

 

Kullanımındaki sınırlamalar:
Bu bileşikler (430-E436) içerisindeki yağ asitleri, çoğunlukla (neredeyse her zaman) bitkisel yağlardan elde edilmektedir. Fakat, hayvansal yağların (domuz yağı gibi) bu bileşikler içerisinde kullanımı tamamıyla dışlanamadığı için, buradaki yağ asitleri çok az da olsa hayvansal yağlardan da elde edilme ihtimalini taşır. Kimyasal olarak bu bileşiklerin kaynağı belirlenemez; sadece üreticiler bileşiğin kaynağı ile ilgili bilgi sağlayabilir.
Ürün adı:

 

Açıklık 40, Sorbitan Monopalmitate, emülsiyonlaştırıcı S40

Açıklık 60, Sorbitan Monostearat, Emülgatör S60

Eş anlamlı:

Sorbitan Mono palmitat

Sorbitan Mono stearat

Özellikleri:

Beyaz kremsi renk pulları.

Beyaz kremsi pullar.

CAS numarası:

26266-57-9

1338-41-6

Formül:

C22H42O6

 


C24H46O6

 

Yapısı:

image002.jpg

image003.jpg

Paket:

25/50 Kg HDPE Poşet

25/50 Kg HDPE Poşet

HSCode:

2932190090

34021300

Deri endüstrisinde metal işleme sıvısı, beyazlatıcı ve parlatıcı olarak kullanılır. Dağıtıcı ve ıslatma karakterleri ile tanınır. Span 60, Sorbitan Monostearat, Emulsifier S60 SMS, kozmetik ürünleri, gıdalar ve plastik endüstrilerinde geniş uygulamalara sahiptir. Küresel pazarda, Span 60, Sorbitan Monostearat, Emulsifier S60 SMS daha da "Spans" olarak bilinir. Bu arada, Avrupa ülkelerinde, bir gıda katkı maddesi olarak kabul edilmektedir.

Bu ürünün ambalajı 25 ila 50 Kg'lık HDPE Torbadadır, ayrıca paketi müşterilerin ihtiyaçlarına göre de yapabiliriz. Normalde, her zaman yeterli miktarda Span 60, Sorbitan Monostearat, Emulsifier S60 stokumuz var.

Bu maddenin serin ve gölgeli bir yerde tutulması, doğrudan güneş ışığından kaçınılması önerilmektedir. Üstün kaliteli ürün ve güvenli paketleme ile Span 60, Sorbitan Monostearate, Emulsifier S60 ürünlerimiz; Gıdalar, Kozmetik ürünler, Eczacılık, Hayvan Besleme, Emülgatörler ve diğer birçok sektörün gereksinimlerini karşılar.

Bu ürünün erime noktası 50-55'e kadar.

nem içeriği ikiye kadardır.

Span 60, Sorbitan Monostearat, Emülgatör S60 SMS, sorbitan (bir sorbitol türevi) ve stearik asit esteridir ve bazen sentetik bir balmumudur. Esas olarak nem ve sıvı yağların karıştırılması için bir emülgatör olarak kullanılır. Span 60, Sorbitan Monostearat, Emülgatör S60 SMS, gıda ve sağlık ürünlerinin üretiminde sıklıkla kullanılmaktadır. Emülsifiye edici, dağıtma ve ıslatma yeteneklerine sahip iyonik olmayan bir yüzey aktif maddedir. Ayrıca, deri endüstrisinde sentetik lifler, metal işleme sıvısı ve parlatıcıların oluşturulmasında da uygulama alanı bulmaktadır. Daha geniş olarak, Span 60, Sorbitan Monostearat, Emulsifier S60 plastik, gıda ve kozmetik endüstrilerinde kaplamalar, böcek ilaçları ve çeşitli uygulamalarda emülgatör olarak çalışır.

Avrupa ülkeleri tarafından bir gıda katkı maddesi olarak kullanım için onaylanmıştır (E numarası: E 491)

 

 

 

 


SORBITAN MONOPALMITATE
Sorbitan monopalmitate
rch
Sorbitan monopalmitate
Sorbitan monopalmitate.svg
Names
Other names
Sorbitan palmitate; Span 40; E495
Identifiers
CAS Number
26266-57-9 ☑
ECHA InfoCard 100.043.229
E number E495 (thickeners, ...)
PubChem CID
14927
UNII 
77K6Z421KU ☑
CompTox Dashboard (EPA)
DTXSID6029335 Edit this at Wikidata
Properties
Chemical formula
C22H42O6
Molar mass 402.572 g·mol-1
Melting point 46-47 °C (115-117 °F; 319-320 K)[1]
Hazards
Flash point 113 °C (235 °F; 386 K)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Sorbitan monopalmitate (SMP) is a food additive,[2] permitted by the EU. It is entry E495 in the E number list of permitted food additives.[3] It is also known under the trade name Span 40.[4]

 

 

Synopsis
Sorbitan monopalmitate has been known since at least 1959.[5]

 

Around 2000, Sorbitan monopalmitate was permitted by the EU in bakery products, icings, marmalades, simulations of milk and cream, beverage whiteners, liquid concentrates of fruit and herbs, sorbets, emulsified sauces, food supplements and chewing gum amongst others.[3]

 


Sorbitan monopalmitate is a polysorbate that is derived from the mixture of partial esters of sorbitol treated with palmitic acid. Sorbitan monopalmitate is a lipophilic surfactant. It may be found in combination with polysorbates. It is used to modify crystallisation of fats.[3] It is insoluble in water.[6] Up to 25 mg/kg bodyweight can be processed by humans. Sorbitan monopalmitate is metabolized to sorbitol and palmitic acid, without any apparent side effects. The use of animal fats, like pork, in the production of Sorbitan monopalmitate is possible.[4]

 

 

3.1Computed Properties HelpNew Window
Property Name Property Value Reference
Molecular Weight 402.6 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
XLogP3-AA 5.8 Computed by XLogP3 3.0 (PubChem release 2019.06.18)
Hydrogen Bond Donor Count 3 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Hydrogen Bond Acceptor Count 6 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Rotatable Bond Count 18 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Exact Mass 402.298139 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
Monoisotopic Mass 402.298139 g/mol Computed by PubChem 2.1 (PubChem release 2019.06.18)
Topological Polar Surface Area 96.2 Ų Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Heavy Atom Count 28 Computed by PubChem
Formal Charge 0 Computed by PubChem
Complexity 389 Computed by Cactvs 3.4.6.11 (PubChem release 2019.06.18)
Isotope Atom Count 0 Computed by PubChem
Defined Atom Stereocenter Count 4 Computed by PubChem
Undefined Atom Stereocenter Count 0 Computed by PubChem
Defined Bond Stereocenter Count 0 Computed by PubChem
Undefined Bond Stereocenter Count 0 Computed by PubChem
Covalently-Bonded Unit Count 1 Computed by PubChem
Compound Is Canonicalized Yes

 

 


description
Sorbitan monopalmitate (Span 40) is a nonionic emulsifier, surfactant and food additive. The product of Croda Inc. Span 40 is used in skin care, hair care and decorative cosmetics. It is also used as an effector in compositions capable of facilitating penetration across a biological barrier. Inactive ingredient of some medications it improves transdermal delivery of drugs and is a potential carrier for topical drug delivery. In PLIAGLIS cream (lidocaine and tetracaine) sorbitan monopalmitate is used as an inactive ingredient. Sorbitan monopalmitate is a fatty acid sorbitan ester, yellowish brown wax, slightly soluble in isopropanol, xylene and liquid paraffin, insoluble in water, non-toxic.

 

 

In Vitro Use Guide 
10% sorbitan monopalmitate added to the ointment significantly increased percutaneous absorption of sodium salicylate determined from blood levels in New Zealand white rabbits at regular intervals for 8 hr following application of the ointment.

 

 

Sorbitan monopalmitate Properties
Melting point:46-47 °C(lit.)
Boiling point:444.68°C (rough estimate)
Density 1.0412 (rough estimate)
refractive index 1.4593 (estimate)
Flash point:>230 °F
solubility Practically insoluble in water, soluble in fatty oils, slightly soluble in alcohol.
form Solid
color White flakes
Water Solubility Insoluble in water
Hydrophilic-Lipophilic Balance (HLB)6.7
InChIKeyDOCCLKYMPJSXGB-VCDGYCQFSA-N
Indirect Additives used in Food Contact SubstancesSORBITAN MONOPALMITATE
CAS DataBase Reference26266-57-9(CAS DataBase Reference)
EWG's Food Scores1
FDA UNII77K6Z421KU
EPA Substance Registry SystemSorbitan monopalmitate (26266-57-9)

 

 

Uses
Sorbitan monopalmitate is a nonionic, mid-range HLB surfactant suggested for use as a w/o or an o/w emulsifier for cosmetic formulations, household products and textile chemicals.
Uses
sorbitan palmitate is an emulsifier with moisture-binding abilities. It also serves as a solubilizer of essential oils in water. It is derived from sorbitol.
Sorbitan monopalmitate Preparation Products And Raw materials
Raw materials
Span 60 L-SORBITOL Hydrogen peroxide Sorbitol Palmitic acid
Preparation Products

 

 


E495 (Sorbitan Monopalmitate) (Sorbitan monopalmitate)
1 2

 

PRODUCT NAME : Sorbitan Mono Palmitate (E495)

SYNONYMOUS: Sorbitan monopalmitate; Sorbitan Esters

CLASS : Emulsifier

DESCRIPTION AND INGREDIENTS : It is a mixture of partial esters of sorbitol and anhydrides and vegetable palmitic acid. It may have free fatty acids and sorbitol, isosorbit esters.

APPEARANCE : Cream yellowish bead solid powders and characteristic smell.

SOLUBILITY : It cannot be decomposed in water.

INTENDED USAGE:

· It is lipophilic surfactant substance. It is generally used as an emulsifer together with polysorbates. It is used to change crystallization of the oils.

USAGE AREA :

Ø Fine bakery products

Ø Fine bakery products, decoration and coating materials

Ø Baker's yeasts

Ø Oil emulsions

Ø Milk and cream mixtures

Ø Gel marmelades

Ø Tahini halva varieties

Ø Cocoa based candies

Ø Chocolates

Ø Liquid mixtures of fruits and vegetables

Ø Sweets

Ø Sugar based candies

Ø Food supplements

QUANTITY OF USAGE : It is determined by the practitioner according to intended use and place of use.

PACKAGE FEATURES : 25 kg Kraft Bag.

 

Products
123456789
E495 (Sorbitan Monopalmitate) (SMP)
E495 (Sorbitan Monopalmitate) (SMP)
PRODUCT NAME : Sorbitan Mono Palmitate (E495) SYNONYMOUS: Sorbitan monopalmitate; Sorbitan Esters CLASS : Emulsifier DESCRIPTION AND INGREDIENTS : It is...

 

 

E494 (Sorbitan Monooleate) (SMO)
E494 (Sorbitan Monooleate) (SMO)
PRODUCT NAME : Sorbitan Monooleate (E494) SYNONYMOUS: SMO; Sorbitan Esters CLASS : Emulsifier DESCRIPTION AND INGREDIENTS : It is a...

 

 


Sorbitan monopalmitate (Span 40) is a nonionic emulsifier, surfactant and food additive. The product of Croda Inc. Span 40 is used in skin care, hair care and decorative cosmetics. It is also used as an effector in compositions capable of facilitating penetration across a biological barrier. Inactive ingredient of some medications it improves transdermal delivery of drugs and is a potential carrier for topical drug delivery. In PLIAGLIS cream (lidocaine and tetracaine) sorbitan monopalmitate is used as an inactive ingredient. Sorbitan monopalmitate is a fatty acid sorbitan ester, yellowish brown wax, slightly soluble in isopropanol, xylene and liquid paraffin, insoluble in water, non-toxic.
Sorbitan monopalmitate (SMP) is a food additive,permitted by the EU. It is entry E495 in the E number list of permitted food additives.[3] It is also known under the trade name Span 40. Synopsis Sorbitan monopalmitate has been known since at least 1959. Around 2000, SMP was permitted by the EU in bakery products, icings, marmalades, simulations of milk and cream, beverage whiteners, liquid concentrates of fruit and herbs, sorbets, emulsified sauces, food supplements and chewing gum amongst others.SMP is a polysorbate that is derived from the mixture of partial esters of sorbitol treated with palmitic acid. SMP is a lipophilic surfactant. It may be found in combination with polysorbates. It is used to modify crystallisation of fats.It is insoluble in water.Up to 25 mg/kg bodyweight can be processed by humans. SMP is metabolised to sorbitol and palmitic acid, without any apparent side effects. The use of animal fats, like pork, in the production of SMP is possible. 
Safety Information
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves RIDADR NONH for all modes of transport WGK Germany 1 Flash Point(F) 235.4 °F Flash Point(C) 113 °C

 

 

In Vitro Use Guide 
10% sorbitan monopalmitate added to the ointment significantly increased percutaneous absorption of sodium salicylate determined from blood levels in New Zealand white rabbits at regular intervals for 8 hr following application of the ointment.
Certificate of Analysis

 

 

Enter Lot No.
Certificate of Origin

 

 

Enter Lot No.
Bulk Quote-Order Product SDS Specification Sheet FT-IR Condensed Phase Structure Search

 

 

Sorbitan monopalmitate Properties
Melting point:46-47 °C(lit.)
Boiling point:444.68°C (rough estimate)
Density 1.0412 (rough estimate)
refractive index 1.4593 (estimate)
Flash point:>230 °F
solubility Practically insoluble in water, soluble in fatty oils, slightly soluble in alcohol.
Hydrophilic-Lipophilic Balance (HLB)6.7
InChIKeyDOCCLKYMPJSXGB-VCDGYCQFSA-N
CAS DataBase Reference26266-57-9(CAS DataBase Reference)
EPA Substance Registry SystemSorbitan, monohexadecanoate(26266-5)

 

CLASS : Emulsifier

DESCRIPTION AND INGREDIENTS : It is a mixture of partial esters of sorbitol and anhydrides and vegetable palmitic acid. It may have free fatty acids and sorbitol, isosorbit esters.

APPEARANCE : Cream yellowish bead solid powders and characteristic smell.

SOLUBILITY : It cannot be decomposed in water.

INTENDED USAGE:

It is lipophilic surfactant substance. It is generally used as an emulsifer together with polysorbates. It is used to change crystallization of the oils.

USAGE AREA :

Ø Fine bakery products

Ø Fine bakery products, decoration and coating materials

Ø Baker's yeasts

Ø Oil emulsions

Ø Milk and cream mixtures

Ø Gel marmelades

Ø Tahini halva varieties

Ø Cocoa based candies

Ø Chocolates

Ø Liquid mixtures of fruits and vegetables

Ø Sweets

Ø Sugar based candies

Ø Food supplements

QUANTITY OF USAGE : It is determined by the practitioner according to intended use and place of use.

PACKAGE FEATURES : 25 kg Kraft Bag.

 

A mixture of the partial esters of sorbitol and its mono- and dianhydrides
with edible commercial palmitic acid
C.A.S. number 26266-57-9

 

 

CHARACTERISTICS
IDENTIFICATION
Solubility (Vol. 4) Soluble at temperatures above its melting point in ethanol, methanol, ether,
ethylacetate, aniline, toluene, dioxane, petroleum ether and carbon
tetrachloride; insoluble in cold water but dispersible in warm water.
Congealing range (Vol. 4)45 - 47o

 

 

Infrared absorption The infrared spectrum of the sample is characteristic of a partial fatty acid
ester of a polyol 
PURITY
Water (Vol. 4) Not more than 1.5% (Karl Fischer Method)
Acid value (Vol. 4) Not less than 4.0 and not more than 7.5
Saponification value (Vol. 4)
Not less than 140 and not more than 150
Hydroxyl value (Vol. 4) Not less than 270 and not more than 305
Lead (Vol. 4) Not more than 2 mg/kg
Determine using an atomic absorption technique appropriate to the
specified level. The selection of sample size and method of sample
preparation may be based on the principles of the method described in
Volume 4, "Instrumental Methods."

 

We are a client centric organization and have come up with a premium quality range of Sorbitan Monopalmitate (Span 40). This is a nonionic, lipophilic (oil loving) surfactant that is prepared using high grade ingredients and in compliance with the industry standards.

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SORBITAN MONOESTERS OF PALMITIC, STEARIC, OLEIC AND LAURIC
ACIDS AND TRIESTERS OF STEARIC ACID

 

Explanation

 

Sorbitan monoesters of palmitic and stearic acids and triesters
of stearic acid have been evaluated for acceptable daily intake by the
Joint FAO/WHO Expert Committee on Food Additives in 1974 (see Annex I,
Ref. 32) and a toxicological monograph was prepared (see Annex I, Ref.
33). Sorbitan monoesters of oleic and lauric acids have not previously
been evaluated by JECFA. The previous published monograph has been
expanded to include sorbitan esters of oleic and lauric acids.

 

BIOLOGICAL DATA

BIOCHEMICAL ASPECTS

 

The fatty acid moiety of sorbitan monostearate has a coefficient
of digestibility of 53.3% (Oser & Oser, 1957b).

 

 

Experiments with 14C-labelled sorbitan monostearate showed that
at least 90% of the emulsifier, when fed to rats in oily solution, was
hydrolysed to stearic acid and anhydrides of sorbitol. A significant
fraction of the administered 14C was expired as CO2. When the
labelled material was administered in water, 16-25% was recovered in
the urine; when it was given in oil, 44-66% was recovered. Of the
ingested radioactivity, 3-7% was recovered in the tissues 48 hours
after feeding. Fractionation of the carcass fats showed that 14C was
incorporated into fatty acids, glycerol and a residue that did not
sublime (Wick & Joseph, 1953).

 

 

Sorbitan trioleate prepared with a 14C-label in the sorbitol
or the oleate moieties was administered orally to rats. After
administration of sorbitan 14C-trioleate, the appearance of 14C-CO2
in the expired air reached a peak at about 6 hours and amounted to
30-35% of administered label. The faeces and gastrointestinal tract
contained about 42% of the 14C-label, indicating that it was
incompletely absorbed, and 3% appeared in the urine; the liver
contained about 3% and the carcass about 22%. After administration of
the 14C-sorbitan-labelled ester, less than 2% of the label was
recovered as 14C-CO2; the proportions not absorbed were 24% from a
water emulsion and 37% from a solution in oil; the proportions
recovered of that absorbed were as follows: urine, 88%; expired air,
5%; liver, 1%; carcass, 6% (Treon et al., 1967).

 

TOXICOLOGICAL STUDIES

Acute toxicity

 

The physical properties and low toxicity of the partial esters of
sorbitan are such that formal acute toxicity tests are for the most
part impracticable.

 

 

Acute feeding tests on sorbitan monopalmitate have been conducted
in the rat. No toxic symptoms were observed in 10 male rats, weighing
100-175 g, using the ester as their sole ad libitum diet (except for
water) for 24 hours, during which they consumed an average of 1.5 g
per animal or approximately 10 g/kg bw (Krantz, 1947c).

 

 

For 10 rats, sorbitan monostearate was mixed with a diet at a
concentration of 50%. These animals weighed 175-250 g and, within 10
hours, had ingested about 3 g of the ester. They all appeared unharmed
after 3 days.

 

 

No toxic symptoms were observed in any of 10 female rats,
weighing 125-175 g, fed 10 ml/kg bw of sorbitan tristearate by stomach
tube, in the form of a 50% aqueous emulsion, and observed over a 6-day
period. Four of the 10 animals, all of which appeared normal, were
sacrificed and gave normal histological findings in the livers and
kidneys. In 10 female rats, weighing 125-175 g, intraperitoneal
injection of sorbitan tristearate in doses of 10 ml/kg (50% aqueous
emulsion form) produced 2 fatalities in 48 hours of observation; the
other animals appeared normal.

 

 

Sorbitan monopalmitate ("Span 40"), sorbitan monostearate ("Span
60") and sorbitan tristearate ("Span 65"), in the maximal orally
administerable doses (15.9 g/kg), produced no mortality in rats.
The LD50 of orally administered sorbitan (monooleate) and
sorbitan monolaurate in the rat was 39.8 and 37.5 g/kg, respectively
(Quigley, 1966). Diarrhoea occurred in all rats given either sorbitan
monooleate or laurate. Autopsy of the surviving animals 14 days after
treatment showed a high incidence of hydronephrosis.

 

Short-term studies

Hamster

 

Hamsters averaging 46 g in weight were segregated by sex into
groups varying in size from 14 to 22 and fed diets containing sorbitan
monolaurate at levels of 0, 5 and 15% for 68 days. Treated animals
developed mild diarrhoea and a depressed growth rate. The high-dose
group suffered 22% mortality compared to 8% in the control group.
Treatment-related effects were noted in the gastrointestinal tract,

 

 

including mucosal and intramural hyperaemia and oedema, with mild
infiltration by inflammatory cells. In the kidney of treated animals,
the cortical tubular epithelium exhibited fraying at the free edges of
cells, eosinophilic granularity and nuclear pyknosis. The kidney
alterations were regarded as reversible. Incomplete maturation in
testes and ovaries was more frequent in treated animals (Harris,
1951b).

 

Rat

 

Groups of 10 young rats were fed for 6 weeks diets containing 1%
or 4% of sorbitan monostearate. There was no effect on weight gain,
nor were there any significant changes histopathologically in the
liver, kidneys, intestine and bladder (Krantz, 1946).

 

 

Sodium monostearate was added to diets designed to induce hepatic
necrosis in rats. Levels up to 10% tended to prolong the survival time
and had no significant effect upon the hepatic changes over periods up
to 120 days (Gyorgy et al., 1958).

 

 

Rats in groups of 5 receiving sorbitan monostearate in their diet
for 6 weeks at levels of 5% or 15% showed no change in bile duct size
(Krantz, 1951).

 

 

Groups each of 30 Wistar rats (initial body weight 84-87 g)
equally divided by sex were fed sorbitan monolaurate at dietary levels
of 0, 2.5, 5.0 and 10%. Haematological and urinary analyses were
carried out at weeks 2, 6 and 13 and serum clinical chemistry at weeks
6 and 13. At weeks 2 and 6, 5 male and 5 female animals from each
group were sacrificed, and at the end of the thirteenth week all
surviving animals were sacrificed. Animals fed 5% and 10% test diet
showed statistically significant dose-related decreases in haemoglobin
levels, packed cell volumes (2, 6, 13 weeks) and total leucocyte count
(13 weeks, males only). No treatment-related effects were observed in
clinical chemistry values or urinalyses. At autopsy, organ weights
were determined, and a biological examination made of the brain,
pituitary, thyroid, heart, liver, spleen, kidneys, adrenal glands,
gonads, stomach, small intestine, caecum, lung, salivary gland, aortic
arch, thymus, various lymph glands, urinary bladder, colon, rectum,
pancreas, uterus and skeletal muscle. An increase in relative liver
weight occurred in the high-dose animals, and increased relative
kidney weight occurred in all test groups. These effects were first
observed in animals maintained on test diets for 2 weeks. No adverse
histological findings could be demonstrated in the kidney or other
tissues, except in the livers of animals in the high-dose groups where
there was an increased incidence of periportal vacuolation (Cater et
al., 1978).

 

 

Groups of 10 male and 10 female Osborne-Mendel rats, initial
weight 40-50 g, were fed diets containing 0, 15, 20 or 25% sorbitan
monolaurate for 23 weeks. Treated animals exhibited diarrhoea, an
unkempt appearance and severe growth retardation. At the 25% dose
level, only one animal of each sex survived the study. Upon gross
pathological examination, the livers of treated animals showed
paleness and enlargement, with a marked enlargement of the common bile
duct. Histological studies of the tissues showed marked liver damage
at all dose levels which consisted of fatty changes and fibrosis.
There was no bile duct proliferation but there was great common bile
duct enlargement. Focal nephritis was observed in the kidney and there
was a marked increase in the incidence of foamy alveolar macrophages
in the lungs of treated animals. No other tissues exhibited treatment-
related effects (Fitzhugh et al., 1960).

 

 

Weanling male Sprague-Dawley rats were distributed into groups of
14 and fed sorbitan monolaurate for 59 days at dietary levels of 0 and
25%. Treatment-related symptoms included reduced rate of growth,
reduced food consumption, diarrhoea, nasal haemorrhage and gangrenous
tails. Only 1 rat survived the treatment regimen, presenting a stunted
appearance resembling starvation (Harris et al., 1951a). In another
study, 14 male and 16 female rats were fed sorbitan monolaurate in
doses increasing to 25% by day 10 of the study, and continuing at that
level for 60 additional days. The toxic effects were similar to those
reported in the previous study. Results from pair-fed controls
indicate that the reduction in growth was not caused primarily by
reduced food consumption. Haematology at termination of the study
showed a treatment-related decrease in haemoglobin value. At autopsy,
increased relative organ-to-body weight was observed for brain,
kidney, heart, spleen, lung and liver. Histological studies of tissues
showed mild degenerative lesions in the kidney, necrosis of the liver,
and incomplete maturation of testes. No other effects were reported
(Harris et al., 1951a).

 

 

Groups of 6 female Holtzman rats, 21-24 days old, were fed diets
containing 0, 15 and 20% of sorbitan monolaurate for 21 days. All
animals on test diets suffered diarrhoea, alopecia, unthrifty
appearance, reduced rate of growth and increased mortality. No
pathological evaluation was made.

 

 

White male rats of unspecified strain, initial weight 60 g, were
distributed into groups of 4 or 5 and fed diets containing 0, 1 and 4%
sorbitan monolaurate for 6 weeks. A significant reduction in growth
rate occurred in the high-dose group. No significant histopathological
changes were reported in liver, intestine or bladder, but coagulated
fluid was present in the renal tubules.

 

 

Wistar rats, initial weight 89-94 g, were distributed into groups
of 15 males and 15 females and fed sorbitan monooleate at dietary
levels of 0, 2.5, 5.0 and 10% for 16 weeks. Animals on test diets

 

 

showed a decreased weight gain that was related to a reduction in food
intake. At weeks 2, 6 and 16, haematology, serum clinical chemistry
and urinalysis were carried out. Haematology studies showed lower
values for haemoglobin and packed cell volume in female rats fed 10%
sorbitan monooleate, with a significantly lower mean erythrocyte
count. Variations in clinical chemistry values did not appear to be
compound related. No compound-related effects were observed in the
urinalysis.

 

 

Autopsy of the test animals at the termination of the study
showed kidney enlargement in females in the 5% and 10% test groups.
Histological studies showed renal damage in these groups, as well as
periportal fatty changes in the liver of female rats in the 10% group.
No other compound-related histopathology was reported.
Groups of 10 male white rats of unspecified strain, initial
weight 100 g, were fed sorbitan monooleate at dietary levels of 0 and
10% for 6 weeks. Reductions in food consumption and in rate of growth,
and mild diarrhoea occurred in treated animals. Histological sections
from liver and kidney showed no differences between control and
treated animals. Haematological and serum clinical chemistry were
carried out at weeks 3 and 6 of the study. There were no significant
differences between test and control animals. At autopsy (3 weeks and
6 weeks), gross pathological and histological studies of selected
organs (liver and kidney) from 3 rats showed no compound-related
effects.

 

Dog

 

Dogs were fed sorbitan monostearate in a semi-synthetic diet at a
level of 5% for 19-20 months. There was no appreciable difference in
food intake, weight, maintenance and longevity between controls and
those fed sorbitan monostearate. The microscopic examination of the
tissues showed no changes attributable to the feeding of sorbitan
monostearate, with the exception of some haemosiderosis of the liver.
Thirty rats were fed on a diet containing 5% sorbitan
monostearate for up to 2 years. Growth rate and survival were similar
to those of the controls. There were no histological abnormalities
post mortem that could be attributed to the diet.

 

 

Experiments were conducted over a period of 2 years on 4
generations of rats (30 rats in each group). At levels of 5% and 10%
in the diet, no effects were observed on growth, food efficiency,
reproduction, lactation, metabolism, behaviour, mortality, or the
growth and histopathological appearance of the tissues. At a level of
20%, retardation of growth and impairment in lactation were noted, but
mortality was not increased. The weight of the liver and kidneys was
increased, but both appeared to be histologically normal.
Sorbitan monostearate was fed to groups of 24 rats at levels of
2, 5, 10 and 25% in the diet for 2 years. Levels of 2% and 5% did not
produce evidence of toxicity. The substance caused a significant
increase in mortality at the 10% and 25% levels, with growth
depression and enlargement of the liver and kidneys.

 

 


A life-span (2-year) chronic feeding study was conducted on 30
male rats, using 5% sorbitan tristearate in their diet. From this
experiment it was concluded that there was no alteration in the growth
pattern or survival of the test rats as compared to the controls, nor
were there any abnormalities that could be attributed to the
experimental diet.

 

 

A life-span (2-year) study was conducted with 30 white male rats
(strain unspecified, initial weights 54-63 g) that were given 5%
sorbitan monolaurate in their daily diet. No effect on growth or
mortality of the test rats, as compared with controls, could be
attributed to the test compound. Blood chemistry, haematology,
histopathological examinations and gross pathological examinations
of liver, kidney, spleen, brain, adrenals, urinary bladder,
gastrointestinal tract, pancreas, thyroid, heart, lung, testicle,
salivary gland, prostate, parathyroid, pituitary, striated muscle and
bone marrow were carried out both during the study, following interim
sacrifice at 6, 12 and 17 months, and at termination of the study. No
treatment-related changes were reported.

 

 

Groups of 10 male and 10 female weanling Sprague-Dawley rats were
fed diets containing 0, 5 and 10% sorbitan monolaurate for 2 years.
Animals consuming a 10% sorbitan monolaurate diet suffered diarrhoea
and a statistically significant reduction in growth, but animals fed
the 5% diet showed no adverse treatment-related effect. Because food
consumption data were inadequate, it could not be ascertained whether
the reduced growth was caused by reduced food consumption or by a
direct toxic effect. Liver, kidney, heart, aorta, spleen, pancreas and
body fat exhibited no treatment-related abnormalities when examined
grossly and histologically.

 

 

A group of 30 white male rats (strain unspecified, initial weight
54-63 g) were maintained on a diet containing 5% sorbitan monooleate
for a period of 2 years. There was a minor retardation of growth, and
no effect on mortality. Haematology and serum clinical chemistry tests
were carried out at months 6, 12 and 17 of the study. No compound-
related effects were reported. At months 6, 12 and 17, 1 control
and 1 test animal were sacrificed for histopathological examination of
liver, kidney and bone marrow, and at week 104, all surviving animals
were sacrificed. At autopsy, gross pathological and histopathological
examination of brain, spleen, pancreas, thyroid, parathyroid,
prostate, pituitary gland, salivary gland, adrenal, bladder, bone
marrow, heart, lymph node, lung, testicle and muscle did not show any
compound-related effects.

 

OBSERVATIONS IN MAN

 

Sorbitan monostearate given to 9 human subjects in doses of 
6 g/day for 28 days had no significant effect on the gastric activity 
or on the activity of the gastrointestinal tract.

 

 

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