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Cyclohexasiloxane; decamethyl-; CYCLOHEXASILOXANE; siklohegzasiloksan; siklohekzasiloksan; siklohekzasilikon; SİKLO HEKZA SİLOKSAN; CYCLOHEXASILOXAN; Siklo Hekzasilikon; Cyclomethicone; Siklometikon; DodecaMethylhexacyclosiloxane; dodecamethyl-cyclohexasiloxan; DODECAMETHYLCYCLOHEXASILOXANE; 95098-26-3; ACMC-20lzer; CTK3F4195DODECAMETHYLCYCLOHEXASILOXANE; 540-97-6; Cyclohexasiloxane; dodecamethyl; UNII-XHK3U310BA; 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl 1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane; EINECS 208-762-8; XHK3U310BA; Cyclo hexa siloxane; 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-; HSDB 7723; ACMC-209ld0; DODEKANMETİLSİKLOHEKZASİLOKSAN; dodekametilsiklosiloksan; hegzasiloksan; hekzasiloksan; EC 208-762-8; AC1L1W7N; SCHEMBL93785; 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane; ANW-31954; MFCD00144215; AKOS015839990; ZINC169794506; FS-5671; LS-57370; SC-18515; DB-008587; TR-019128; D2040; FT-0625566; S08515; Dodecamethylcyclohexasiloxane analytical standard; C-56501; UNII-NMQ347994Z component IUMSDRXLFWAGNT-UHFFFAOYSA-N; Dodeka-metilsiklohekzasiloksan; Dodeka-metilsiklohegzasilokzan; 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane; Cyclohexasiloxane,2,2,4,4,6,6,8,8,10,10,12,12; 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane 95%; 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane, 95%; 2,2,4,4,6,6,8,8,10,10,12,12-Dodecamethylcyclohexasiloxane; AldrichCPR; Cyclomethicone 6, United States Pharmacopeia (USP) Reference Standard; 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexa; InChI=1/C12H36O6Si6/c1-19(2)13-20(3,4)15-22(7,8)17-24(11,12)18-23(9,10)16-21(5,6)14-19/h1-12H3



Primarily works as a skin conditioning agent and emollient. Like all other silicones, this ingredient has a unique fluidity that makes it easily spreadable. When applied to the skin, it gives a silky & slippery feeling to the touch and acts a mild water repellent by forming a protective barrier on the skin. It can also fill in fine lines/wrinkles, giving the face a temporary "plump" look.
Primarily works as a skin conditioning agent and emollient. Like all other silicones, this ingredient has a unique fluidity that makes it easily spreadable. When applied to the skin, it gives a silky & slippery feeling to the touch and acts a mild water repellent by forming a protective barrier on the skin. It can also fill in fine lines/wrinkles, giving the face a temporary "plump" look.
It is often used in conjunction with cyclopentasiloxane (INCL name Cyclomethicone) to work as a base liquid, carrying agent and wetting agent. It also helps reduce the amount of residue typically associated with deodorants & antiperspirants. You can mainly find it in personal care products such as facial moisturizer/lotion, foundation, anti-aging treatment, sunscreen, concealer and mascara.



Safety Measures/Side Effects:
While there's no evidence pointing to the adverse effects of this ingredient on human life, low concentrations have been shown to harm aquatic life. For this reason, Canada has restricted the use of this ingredient in cosmetic products and silicone breast implants, and includes it on its list of Accelerated Reduction/Elimination of Toxics (ARET).
CYCLOHEXASILOXANE is classified as :
Hair conditioning
Skin conditioning
CAS Number 540-97-6
EINECS/ELINCS No: 208-762-8
COSING REF No: 75406
Chem/IUPAC Name: Dodecamethylcyclohexasiloxane
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WHAT-IT-DOES: emollient, solvent
A light-feeling, volatile (meaning it does not absorb into the skin but evaporates from it) silicone that gives skin a unique, silky and non-greasy feel. It has excellent spreading properties and leaves no oily residue or build-up. XIAMETERTM PMX-0246 Cyclohexasiloxane
INCI Name:
Cyclohexasiloxane (and) Cyclopentasiloxane
XIAMETERTM PMX-0246 Cyclohexasiloxane Datasheet


Silicones Simplified: Xiameter - Home and Personal Care makes their documentation available in the regions indicated below:

XIAMETER® PMX-0246 Cyclohexasiloxane is a volatile polydimethylcyclosiloxane composed mainly of cyclohexasiloxane. This product is a base fluid in a number of personal care products, with excellent spreading and lubrication properties and unique volatility characteristics. It can be used in antiperspirants, skin creams, lotions and stick products, bath oils, makeup, suntan and shaving products.Description: Liquid silicone emollient useful for skin and hair care products. It is a blend of volatile polydimethylcyclosiloxane composed of cyclohexasiloxane (>95%) and cyclopentasiloxane (1-5%).

INCI Name: Cyclohexasiloxane, cyclopentasiloxane

CAS: 540-97-6, 541-02-6


Appearance: Colorless liquid
Specific gravity at 25°C: 0.96
Odor (Olfactory): Mild to odorless
Refractive index at 25°C: 1.402



Storage: Stable if kept in closed container at cool and dry place.cyclohexasiloxane
Rating: GOOD
Categories: Emollients
One of the numerous forms of synthetic silicone used in haircare and skincare products to improve texture, add shine (to hair) and impart emollience. Cyclohexasiloxane is a type of silicone that is used in cosmetics and personal care products as a solvent, carrier fluid, skin conditioning agent, and emollient.



Cyclohexasiloxane is a type of silicone. Silicones are synthetic polymers with a backbone composed of repeating units of siloxane (elemental silicon and oxygen), which is why silicones may also be referred to as polysiloxanes. Often, the terms "silicone" and "silicon" are mistakenly used interchangeably, when they are actually quite different. Silicon is the 14th element on the periodic table and the second most abundant element in the earth's crust, after oxygen. In contrast, silicones are always synthetically produced.


Cyclohexasiloxane can be further classified under the name cyclomethicone, which is the INCI (International Nomenclature for Cosmetic Ingredients) name for a category of cyclic silicones. In contrast with linear silicones, these molecules have a cyclic, or ring-like structure, comprised of only four to six repeat units of the dialkyl siloxane group. Cyclohexasiloxane is made up of six dialkyl siloxane groups, which is indicated by the "hexa" in the ingredient name. The group of cyclomethicone silicones are much smaller molecules than the polymeric silicones, such as polydimethylsiloxane (dimethicone), which may have hundreds of thousands of siloxane repeat units.


As a class, silicones improve the feel, appearance, and performance of cosmetic products. These ingredients act as silky moisturizers, conditioners, solvents, and delivery agents for other skin care ingredients. Silicones are able to help with skin redness and irritation due to their low surface tension, which enables them to spread easily across the surface of skin and form a protective covering.


Specifically, cyclohexasiloxane functions as a solvent for fragrance and essential oils, as well as a carrier fluid for higher molecular weight silicones such as dimethicone. This allows the formulator to prepare the oil phase of a cosmetic product by combining cyclohexasiloxane and the silicone and/or fragrance oil and add the emulsifier before adding the entire oil phase to the aqueous (water) phase. Overall, this improves the consistency of the final product.

Cyclohexasiloxane also functions as an emollient and skin/hair conditioning agent. Its fluidity allows it to spread easily on the skin and hair, forming a soft, invisible film. The film creates a lubricating, smooth, silky feel that does not feel greasy or sticky. It still allows oxygen, nitrogen, and other important nutrients to pass through, but blocks water from evaporating. Ultimately, this leads to skin that looks and feels hydrated and smooth. Additionally, the film formed by cyclohexasiloxane has mild water-repellency, which can be useful in the formulation of sun protection products.

Cyclohexasiloxane has a low vapor pressure, which means that is will evaporate easily from the skin or hair at room temperature. Due to this property, cyclohexasiloxane is not prone to build-up or an oily residue. The low vapor pressure of cyclohexasiloxane also enhances the delivery of active ingredients. While the structure of cyclohexasiloxane is too large to penetrate the skin or hair itself, it is small enough to dissolve the active ingredients and deposit these ingredients on the surface of skin or hair. Cyclohexasiloxane will then evaporate, leaving behind the active ingredients.


The safety of the group of cyclomethicone ingredients (including cyclohexasiloxane) has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The Panel noted that minimal percutaneous absorption was associated with these ingredients and the available data did not suggest skin irritation or sensitization potential. The Panel concluded that these ingredients are safe in the present practices of use and concentration.



Even though cyclohexasiloxane and other silicones have been proven both safe and effective for cosmetic purposes, there are claims that these ingredients are unsafe for topical use. However, since silicones are too large to penetrate the skin, they cannot cause allergic reactions or worsen skin conditions. Another claim is that the film formed by silicones somehow "suffocates" the skin. This claim is also false since the film still allows oxygen and other gases to pass through. Thus, the skin can still "breathe" after topical application of a product containing silicones.Siloxanes ( cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane and cyclomethicone) - Used to soften, smooth and moisten, these appear in a variety of cosmetics and are suspected endocrine disruptors and reproductive toxins.Physical Properties:
Appearance: colorless clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 0.96720 @ 25.00 °C.
Refractive Index: 1.40150 @ 20.00 °C.
Melting Point: -3.00 °C. @ 760.00 mm Hg
Boiling Point: 245.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.022500 mmHg @ 25.00 °C. (est)
Flash Point: 256.00 °F. TCC ( 124.40 °C. ) (est)
Soluble in:
water, 0.005007 mg/L @ 25 °C (est)
water, 0.0051 mg/L @ 25 °C (exp)

Organoleptic Properties:
Odor Strength:none
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).

Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: emollients
hair conditioning
skin conditioning

BOC Sciences
For experimental / research use only.
Odor: characteristic
Use: A cyclic volatile methylsiloxane (cVMS) used in cosmetic and personal care products. Used in dermal exposure
Sigma-Aldrich: Aldrich
For experimental / research use only.

Safety Information:
Preferred SDS: View 
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 50000 mg/kg
National Technical Information Service. Vol. OTS0572798



Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:
Category: cosmetic agents
Recommendation for cyclohexasiloxane usage levels up to:
not for fragrance use.

Recommendation for cyclohexasiloxane flavor usage levels up to:
not for flavor use.Cyclomethicone (mixture) and the specific chain length cyclic siloxanes (n = 4-7) reviewed in this safety assessment are cyclic dimethyl polysiloxane compounds. These ingredients have the skin/hair conditioning agent function in common. Minimal percutaneous absorption was associated with these ingredients and the available data do not suggest skin irritation or sensitization potential. Also, it is not likely that dermal exposure to these ingredients from cosmetics would cause significant systemic exposure. The Cosmetic Ingredient Review Expert Panel concluded that these ingredients are safe in the present practices of use and concentration.


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