Ethylhexylglycerin is a multifunctional cosmetic ingredient used as an active ingredient in deodorants, an emollient, and a moisturizer in skin care, improving the anti-microbial performance of other ingredients to keep products intact.

Ethylhexylglycerin can effectively prevent the growth of microorganisms while preserving beneficial skin flora, achieving antibacterial and deodorizing effects.

Ethylhexylglycerin can enhance the effects of traditional cosmetic preservatives, reducing the required amounts and enabling safer consumer us

CAS Number: 70445-33-9

EC Number: 274-273-0

Molecular Formula: C8H18O3

Molecular Weight: 174.23 g/mol

Synonyms: 70445-33-9, Ethylhexylglycerin, 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, Octoxyglycerin, 3-(2-ethylhexoxy)propane-1,2-diol, 3-(2-ethylhexyloxy)propane-1,2-diol, 3-((2-Ethylhexyl)oxy)propane-1,2-diol, 3-(2-ethylhexyloxy)-1,2-propanediol, UNII-147D247K3P, 147D247K3P, 3-[(2-ethylhexyl)oxy]propane-1,2-diol, 1,2-Propanediol, 3-((2-ethylhexyl)oxy)-, EC 408-080-2, MFCD03790878, ETHYLHEXYLGLYCERIN (MART.), ETHYLHEXYLGLYCERIN [MART.], Glycerol alpha-(2-Ethylhexyl) Ether, 3-[(2-Ethylhexyl)oxy]-1,2-propanediol, ethyl hexyl glycerine, LADY GOONG, SCHEMBL99276, DTXSID80990652, ETHYLHEXYLGLYCERIN [WHO-DD], 2-ethyl-1-hexyl monoglyceryl ether, BCP30328, C11H24O3, AKOS030240472, DB14557, AS-63022, SY055478, CS-0152371, E1044, NS00001816, D71207, A836886, Q5404486, Ethylhexyl Glycerin;Octoxyglycerin;3-(2-Ethylhexyloxy)propane-1,2-diol, 1,2-Propanediol,3-(2-ethylhexyl)oxy;2-propanediol,3-[(2-ethylhexyl)oxy]-1, Lexgard E;3-[2-(EthyL; OCTOXYGLYCERIN; ETHYLHEXYLGLYCERIN; Ethylhexyl Glecerine; Ethyl hexyl glycerol; Glycerol α-(2-Ethylhexyl) Ether; 1,2-Propanediol, 3-[(2-ethylhexyl)oxy]; 147D247K3P; 3-(2-ethylhexyloxy)propane-1,2-diol; 3-[(2-Ethylhexyl)oxy]-1,2-propandiol ; 3-[(2-Ethylhexyl)oxy]-1,2-propanediol; 3-[(2-Éthylhexyl)oxy]-1,2-propanediol; 3-[(2-ethylhexyl)oxy]propane-1,2-diol; 70445-33-9; UNII:147D247K3P; [70445-33-9]; 3-((2-Ethylhexyl)oxy)propane-1,2-diol; 3-(2-ethylhexoxy)propane-1,2-diol; 3-(2-ethylhexyloxy)-1,2-propanediol; 3-[2-(ethyl hexyl)oxyl]-1,2-propandiol; 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol; MFCD03790878; 70445-33-9; Ethylhexylglycerin

Ethylhexylglycerin is a glyceryl ether commonly used as part of a preservative system in cosmetic preparations.

Ethylhexylglycerin is a colorless transparent liquid.

Ethylhexylglycerin can not only have antibacterial and deodorizing capacity, but also Ethylhexylglycerin can enhance the effect of alcohol and Ethylhexylglycerin can increase the moisturizing properties of products.

Ethylhexylglycerin is a versatile moisturizer.

Ethylhexylglycerin can be a bacteriostatic in the formula.

Ethylhexylglycerin can be added to the aqueous phase and also Ethylhexylglycerin can be added to the oil phase.

When ethylhexylglycerin is added to water, it can exert a bacteriostatic protective effect on the environment, the entire formula.

Ethylhexylglycerin can be used to avoid adding preservatives and other components of Nipagin ester products.

Ethylhexylglycerin can be used as softener, moisturizing agent and wetting agent for all kinds of skin care emulsion systems, also can be used as shampoo, shower gel and other surfactant formulations.

Ethylhexylglycerin can effectively prevent the growth of microorganisms.

Adding moderate ethylhexylglycerin when making some cream products can resolve cream absorption, stickiness, and whitening skin imperfections.

Ethylhexylglycerin also has a deodorizing effect.

This is because ethylhexylglycerin can effectively prevent the growth and reproduction of bacteria that cause a distinctive odor without affecting the human body beneficial skin flora, thus achieving the effect of preventing unpleasant odor.

Once a certain amount of ethylhexylglycerin has been added, the effectiveness of the conventional preservative can also be suitably increased.

Nowadays, more and more attention has been paid to the application and safety of preservatives in cosmetics.

Ethylhexylglycerin can increase the effect of these substances and thus reduce the amount of these substances, thus enabling consumers to use them safely.

In the process of using ethylhexylglycerin, it is best if it is applied to the emulsification system firstly dispersed into the aqueous phase.

Also, mild polybasic alcohol can be added to ensure that the dispersion amount of ethylhexylglycerin in the aqueous phase is large.

In addition, ethylhexylglycerin can be dissolved in the oil phase as an anhydrous formula to achieve better results when used in combination with phenoxycetol.

Ethylhexylglycerin has excellent moisturizing properties, so Ethylhexylglycerin can be used as a multi-functional moisturizer and can play an antibacterial role in the formula.

When used, ethylhexylglycerin can be added to the water phase and also to the oil phase.

When ethylhexylglycerin is added to the aqueous phase, Ethylhexylglycerin can create an antibacterial environment and exert an antiseptic effect on the entire formulation, so Ethylhexylglycerin is a traditional preservative for synergistic effect.

As a result of repeated experiments, Ethylhexylglycerin can enhance the effects of traditional cosmetic preservatives such as ethylhexylglycerin, ethanol, phenoxy methyl lisothiazolinone and methyl paraben.

Ethylhexylglycerin mild moisturizer; has many benefits, such as acting as an emollient and can improve the skin feeling of cosmetic formulations.

Ethylhexylglycerin is a multifunctional cosmetic ingredient used as an active ingredient in deodorants.

Ethylhexylglycerin is used as an emollient and moisturizer in skin care, and Ethylhexylglycerin is used to improve the anti-microbial performance of other ingredients to keep products intact.

Ethylhexylglycerin is a colorless transparent liquid. Ethylhexylglycerin not only has antibacterial and deodorizing capacity.

Ethylhexylglycerin can also increase the effect of alcohol; can increase the moisturizing properties of products.

Ethylhexylglycerin is a synthetic compound that comes from grains and herbs.

Ethylhexylglycerin breaks down the cellular walls of microorganisms and kills them.

Ethylhexylglycerin is known to be a safe alternative to parabens.

Being an irritant to the skin is the disadvantage of Ethylhexylglycerin.

Ethylhexylglycerin; is used to ensure that the shampoo maintains its consistency.

Ethylhexylglycerin is a globally approved, versatile and multifunctional additive as well as a very effective deodorant active.

As an emollient and mild humectant Ethylhexylglycerin improves the skin feel of cosmetic formulations.

Ethylhexylglycerin reliably inhibits the growth and multiplication of odour-causing bacteria, while at the same time not affecting the beneficial skin flora.

Additionally, Ethylhexylglycerin can boost the efficacy of traditional preservatives and acts as an antimicrobial stabiliser in combination with other cosmetic ingredients. 

Ethylhexylglycerin is a natural preservative and skin conditioning agent made from glycerin.

Ethylhexylglycerin is derived from synthetic raw materials.

Ethylhexylglycerin has multiple benefits including acting as mild humectant, an emollient and can improve the skin feel of cosmetic formulations.

Ethylhexylglycerin is a multifunctional cosmetic ingredient used as an active component in deodorants, as an emollient and humectant in skin care, and boosting the anti-microbial performance of other ingredients to protect products from spoilage.

Ethylhexylglycerin is used in foundation, lipstick, moisturizers, make up, shampoo, conditioner, deodorant, antiperspirant, exfoliant, lotions, baby shampoo/lotion/soap, shaving cream, fragrance, makeup remover, tanning lotion, sunscreen.

Ethylhexylglycerin is a glyceryl ether that is commonly used as part of a preservative system in cosmetic preparations.

Ethylhexylglycerin is a relatively new cosmetic ingredient that is used for its surfactant, emollient, skin-conditioning and antimicrobial properties. 

Ethylhexylglycerin is an alkyl glyceryl ether.

This means that the ethylhexyl group is bound to glycerin at one end by an ether linkage. 

Despite the different types of names for these ingredients, they all consist of an alkyl group bound to glycerin by an ether linkage.

Ethylhexylglycerin and the other alkyl glyceryl ether ingredients may be used in bath products.

Ethylhexylglycerin may be used in body and hand products.

Ethylhexylglycerin may be used in cleansing products.

Ethylhexylglycerin is used in deodorants, eye makeup, foundations, hair care products and suntan products.

Ethylhexylglycerin is a colorless liquid.

As cosmetic system of no added preservatives, ethylhexylglycerin has bacteriostasis, moisturizing effect.

Due to a synergistic effect of ethylhexylglycerin, dosage of traditional preservatives in cosmetics are reduced, and the antibacterial effect of multi-functional cosmetic additives such as glycol and fatty acids are improved, and unpleasant odor caused by sebum is suppressed.

Ethylhexylglycerin is a clear liquid preservative derived from vegetable glycerin, often coconut or palm oil.

Ethylhexylglycerin has three jobs in our products: prevent the product from spoiling, keep the product from separating, and soften your skin.

Ethylhexylglycerin does this by breaking the surface tension in liquids allowing them to mix together and “soak in” better.

The emollient aspect of the ingredients vegetable glycerin source also makes our products feel creamier and softer on skin, and  Ethylhexylglycerin’s antimicrobial qualities help fight germs and bacteria.

Ethylhexylglycerin is a fantastic multitasker. For one thing, Ethylhexylglycerin is a much safer substitute for parabens, which are very controversial.

Ethylhexylglycerin also helps keep bacteria and germs off your skin and from forming inside the bottle, which in turn prevents body odor and other unfavorable scents from proliferating.

Ethylhexylglycerin also keeps our products perfectly blended and has an added bonus of making your skin feel soft and smooth.

Ethylhexylglycerin is rarely an allergen.

Uses of Ethylhexylglycerin:

Ethylhexylglycerin is a multifunctional ingredient commonly used in cosmetic and personal care products.

Ethylhexylglycerin's primary uses include:

Preservative:

Ethylhexylglycerin acts as a mild preservative, preventing the growth of bacteria and fungi in formulations, often used as a substitute or in combination with traditional preservatives.

Skin Conditioning:

Ethylhexylglycerin has emollient properties, which help to hydrate and soften the skin.

Antimicrobial:

Ethylhexylglycerin offers antimicrobial properties, which can help protect products from contamination and contribute to skin health.

Fragrance Enhancer:

Ethylhexylglycerin is used to boost the effectiveness of fragrances in cosmetics and toiletries.

Moisturizing:

Ethylhexylglycerin helps retain moisture in the skin, making it an ideal ingredient in moisturizing creams, lotions, and serums.

Emulsifier:

Ethylhexylglycerin helps stabilize emulsions (mixtures of oil and water), ensuring the even distribution of ingredients in formulations like creams and lotions.

Improves Product Texture:

Ethylhexylglycerin can enhance the texture of products, providing a smooth, non-greasy feel on the skin.

Haircare Benefits:

In haircare products, Ethylhexylglycerin helps improve hair texture and manageability while providing conditioning benefits.

Anti-inflammatory:

Some studies suggest that ethylhexylglycerin may have mild anti-inflammatory effects, benefiting sensitive or irritated skin.

Solvent:

Ethylhexylglycerin can also act as a solvent, helping other active ingredients dissolve or disperse more effectively in the formulation.

Applications of Ethylhexylglycerin:

Ethylhexylglycerin is a versatile ingredient widely used in the cosmetic and personal care industry due to its multifunctional properties.

As a mild preservative, Ethylhexylglycerin helps extend the shelf life of products by preventing the growth of bacteria, fungi, and other microorganisms, making it a popular alternative or complement to harsher preservatives.

Ethylhexylglycerin's skin-conditioning and emollient qualities allow it to hydrate and soften the skin, contributing to smooth, moisturized skin with a non-greasy feel.

In addition to Ethylhexylglycerin's antimicrobial properties, it enhances the effectiveness of fragrances, ensuring they last longer in products such as lotions, deodorants, and perfumes.

Ethylhexylglycerin also acts as an emulsifier, stabilizing the mixture of oil and water in creams and lotions, improving their texture and spreadability.

Ethylhexylglycerin is commonly found in haircare products as well, where it enhances hair texture, manageability, and shine.

Additionally, Ethylhexylglycerin's mild anti-inflammatory properties make it suitable for sensitive or irritated skin, adding to its appeal in skincare formulations.

With its broad range of applications, ethylhexylglycerin continues to be a key ingredient in clean beauty, anti-aging, and everyday skincare products.

Benefits of Ethylhexylglycerin:

Ethylhexylglycerin offers several benefits for both skin and product formulation:

Gentle Preservation:

Ethylhexylglycerin provides effective preservation without the harshness of traditional preservatives, reducing the risk of irritation, particularly for sensitive skin.

Moisturizing:

Ethylhexylglycerin's emollient properties help keep the skin hydrated, soft, and smooth, enhancing the overall skin texture and appearance.

Antimicrobial Protection:

By preventing microbial growth, Ethylhexylglycerin protects products from contamination and ensures safer, longer-lasting products.

Enhanced Skin Comfort:

Ethylhexylglycerin helps soothe and condition the skin, making it ideal for sensitive or irritated skin, contributing to a calming effect.

Improved Product Performance:

Ethylhexylglycerin boosts the effectiveness of other ingredients, including fragrances, making scents last longer and enhancing the overall performance of formulations.

Stabilizes Formulations:

Ethylhexylglycerin helps maintain the stability of emulsions, improving the texture, spreadability, and consistency of creams and lotions.

Non-Greasy Feel:

Ethylhexylglycerin adds a silky, smooth texture to products without leaving a greasy residue, ensuring a pleasant user experience.

Anti-Inflammatory:

Mild anti-inflammatory properties can benefit individuals with redness or inflammation, adding extra care for sensitive skin.

Haircare Benefits:

In hair products, Ethylhexylglycerin contributes to smoother, shinier, and more manageable hair, providing conditioning benefits.

Production of Ethylhexylglycerin:

Ethylhexylglycerin is produced through a chemical process known as esterification, where glycerin (glycerol) reacts with 2-ethylhexanol in the presence of a catalyst, usually an acid catalyst, under controlled temperature and pressure conditions.

During this reaction, the hydroxyl group (-OH) of the glycerin molecule bonds with the hydroxyl group of 2-ethylhexanol, forming an ester bond and producing ethylhexylglycerin.

The reaction is carefully monitored to ensure high purity and yield, and the final product is typically purified through distillation or other refining processes to remove any residual by-products or unreacted starting materials.

Synthesis of Ethylhexylglycerin:

The synthesis of ethylhexylglycerin begins with the esterification of glycerin, a compound commonly derived from plant oils or animal fats, with 2-ethylhexanol, a branched-chain alcohol that is itself typically synthesized from petroleum-based feedstocks. 

The esterification reaction is carried out under anhydrous conditions, often requiring elevated temperatures and the addition of a strong acid, such as sulfuric acid, to catalyze the reaction. 

Once the esterification is complete, the mixture undergoes separation and purification steps, including neutralization, distillation, and filtration, to isolate pure ethylhexylglycerin.

This process ensures the resulting compound meets the high standards required for use in personal care products, where purity and safety are critical.

Occurrence of Ethylhexylglycerin:

Ethylhexylglycerin is not commonly found in nature in its pure form, as it is a synthetic compound.

However, Ethylhexylglycerin's precursor components, glycerin and 2-ethylhexanol, can be derived from natural sources.

Glycerin is often obtained through the hydrolysis of fats and oils, both animal and plant-based, while 2-ethylhexanol is typically synthesized from petrochemical sources.

Though ethylhexylglycerin itself does not naturally occur in large quantities in plants or animals, the compound is synthesized and widely used in cosmetics, personal care products, and pharmaceuticals due to its beneficial properties, such as its ability to act as a mild preservative, emulsifier, and skin conditioning agent.

Handling and Storage of Ethylhexylglycerin:

Handling:

When handling ethylhexylglycerin, ensure good ventilation in the work environment to avoid inhalation of vapors.

Avoid direct contact with skin and eyes.

Wear appropriate protective equipment such as gloves and safety glasses.

Handle Ethylhexylglycerin with care to prevent spills or accidental release.

Storage:

Store ethylhexylglycerin in a cool, dry place, away from direct sunlight and sources of heat or ignition.

Keep containers tightly closed and store them in a well-ventilated area.

Avoid exposure to incompatible materials such as strong oxidizers.

Stability and Reactivity of Ethylhexylglycerin:

Stability:

Ethylhexylglycerin is generally stable under normal conditions of use and storage.

Ethylhexylglycerin should be kept away from extreme temperatures and sources of ignition to maintain its stability.

Reactivity:

Ethylhexylglycerin is not highly reactive but should be kept away from strong acids, bases, and oxidizing agents.

Ethylhexylglycerin does not undergo significant decomposition under typical storage conditions, but exposure to elevated temperatures or incompatible materials may lead to hazardous decomposition products.

First Aid Measures of Ethylhexylglycerin:

Inhalation:

If inhaled, remove the person from the area to fresh air immediately.

If symptoms such as coughing or difficulty breathing occur, seek medical attention.

Skin Contact:

In case of skin contact, wash the affected area with soap and water.

If irritation persists or if there is a significant reaction, seek medical advice.

Eye Contact:

If Ethylhexylglycerin comes into contact with the eyes, rinse immediately with plenty of water for at least 15 minutes.

Seek medical attention if irritation persists.

Ingestion:

If ingested, do not induce vomiting.

Rinse the mouth with water and seek medical attention immediately.

Do not give anything by mouth if the person is unconscious or convulsing.

Firefighting Measures of Ethylhexylglycerin:

Extinguishing Media:

Use water spray, foam, dry chemical, or carbon dioxide (CO2) to extinguish a fire involving ethylhexylglycerin.

Choose the extinguishing media based on the materials involved in the fire.

Special Firefighting Procedures:

Firefighters should wear self-contained breathing apparatus and full protective gear to prevent inhalation of harmful fumes.

Ethylhexylglycerin may emit hazardous fumes in case of a fire, so proper ventilation and protective measures are essential.

Hazardous Combustion Products:

During a fire, ethylhexylglycerin may decompose to release carbon monoxide, carbon dioxide, and other toxic gases.

These fumes can be hazardous to health, so appropriate safety precautions should be followed.

Accidental Release Measures of Ethylhexylglycerin:

Personal Precautions:

Wear appropriate protective equipment, including gloves, safety glasses, and respiratory protection if necessary.

Ensure adequate ventilation to avoid inhalation of vapors.

Environmental Precautions:

Prevent Ethylhexylglycerin from entering drains, sewers, or water systems.

Ethylhexylglycerin is not expected to be highly toxic to aquatic life, but spills should be contained and cleaned up to prevent environmental contamination.

Cleanup Methods:

Absorb the spilled material using inert absorbent materials like sand, earth, or vermiculite.

Collect the material into an appropriate container for disposal according to local regulations.

Clean the area thoroughly after the spill has been removed.

Exposure Controls/Personal Protective Measures of Ethylhexylglycerin:

Exposure Limits:

There are no specific exposure limits for ethylhexylglycerin established by regulatory bodies.

However, general workplace safety guidelines should be followed to minimize exposure.

Engineering Controls:

Ensure good ventilation in areas where ethylhexylglycerin is used or stored to prevent the buildup of vapors.

Personal Protective Equipment (PPE):

Eyes:

Wear safety glasses or goggles to protect against accidental splashes.

Skin:

Wear suitable gloves and protective clothing to prevent skin contact, particularly in cases of prolonged exposure.

Respiratory:

In situations where vapors or dust may be inhaled, use an appropriate respirator or dust mask.

Ensure the mask is suitable for the exposure levels.

Identifiers of Ethylhexylglycerin:

Chemical Name: 2-Ethylhexyl Glycerol

Common Name: Ethylhexylglycerin

CAS Number: 70445-33-9

EC Number: 274-273-0

Molecular Formula: C8H18O3

Molecular Weight: 174.23 g/mol

IUPAC Name: 2-ethylhexyl 2-hydroxypropyl ether

Synonyms: 2-Ethylhexyl glycerol, 2-Ethylhexanol glycerol ether, 2-Ethylhexylglyceryl ether

SMILES (Simplified Molecular Input Line Entry System): CCCCC(C)OCC(CO)O

InChI (International Chemical Identifier): InChI=1S/C8H18O3/c1-3-5-7(2)9-6-8(4)10/h7-8,9-10H,3-6H2,1-2H3

InChI Key: VZLFZWVYHBJGHY-UHFFFAOYSA-N

UNII (Unique Ingredient Identifier): L0R2B72Z7O

Properties of Ethylhexylglycerin:

Appearance: Clear, colorless to pale yellow liquid.

Solubility: Soluble in oils and alcohols, slightly soluble in water.

Boiling Point: Approximately 238°C (460°F).

Melting Point: Around -50°C (-58°F).

Density: Approximately 0.94 g/cm³ at 20°C.

Viscosity: Moderate, contributing to a smooth texture in formulations.

pH: Neutral, around 7, making it compatible with most products.

Odor: Mild, slightly sweet scent.

Molecular Weight: 204.31 g/mol

XLogP3-AA: 1.9

Hydrogen Bond Donor Count: 2

Hydrogen Bond Acceptor Count: 3

Rotatable Bond Count: 9

Exact Mass: 204.17254462 Da

Monoisotopic Mass: 204.17254462 Da

Topological Polar Surface Area: 49.7Ų

Heavy Atom Count: 14

Complexity: 117

Isotope Atom Count: 0

Defined Atom Stereocenter Count: 0

Undefined Atom Stereocenter Count: 2

Defined Bond Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Covalently-Bonded Unit Count: 1

Compound Is Canonicalized: Yes

Specifications of Ethylhexylglycerin:

Appearance: Clear, colorless to pale yellow liquid

Assay (Purity): ≥ 99% (by GC or HPLC)

pH (1% solution in water): 5.0 - 7.0

Refractive Index (20°C): 1.438 - 1.440

Density (20°C): 0.94 - 0.96 g/cm³

Boiling Point: ≥ 238°C (460°F)

Flash Point: ≥ 150°C (302°F)

Viscosity (at 25°C): 30 - 50 cP

Water Content: ≤ 0.5%

Odor: Mild, slightly sweet

Heavy Metals (as Pb): ≤ 10 ppm

Arsenic: ≤ 2 ppm

Microbial Limits: Total aerobic microbial count ≤ 100 cfu/g, Yeast & mold ≤ 10 cfu/g

Alternative Products of Ethylhexylglycerin:

Caprylyl Glycol

Hexylene Glycol

Pentylene Glycol

Glycerin

Propylene Glycol

Butylene Glycol