Corapan TQ is a dipeptide formed from L-threonine and L-glutamine residues, used as a photostabilizer and multifunctional oil-soluble emollient in cosmetic formulations.

Corapan TQ confers photostability to the UVA filter butyl methoxydibenzoylmethane (BMDBM) and is an excellent solvent for solid UV filters, improving the performance and longevity of sun care products.

Corapan TQ enhances skin hydration, repair, and soothing, making it a valuable ingredient in skincare products aimed at improving skin health and reducing the appearance of fine lines and wrinkles.

CAS Number: 96337-79-0

Molecular Formula: C9H17N3O5

Molecular Weight: 247.25

Synonyms: H-THR-GLN-OH, L-Threonyl-L-glutamine, THR-GLN, (S)-5-Amino-2-((2S,3R)-2-amino-3-hydroxybutanamido)-5-oxopentanoic acid, TQ, H-THR-GLN-OH, 96337-79-0, L-threonyl-L-glutamine, threonylglutamine, (S)-5-Amino-2-((2S,3R)-2-amino-3-hydroxybutanamido)-5-oxopentanoic acid, TQ dipeptide, threonyl-glutamine, T-Q Dipeptide, Threoninylglutamine, Threoninyl-Glutamine, L-Thr-L-Gln, L-Threoninyl-L-Glutamine, Threonine Glutamine dipeptide, Threonine-Glutamine dipeptide, SCHEMBL2492394, CHEBI:74855, MFCD00057941, CS-W012682, HY-W011966, DA-64290, Q27144965, (S)-5-Amino-2-((2S,3R)-2-amino-3-hydroxybutanamido)-5-oxopentanoic acid, (2S)-2-[(2S,3R)-2-AMINO-3-HYDROXYBUTANAMIDO]-4-CARBAMOYLBUTANOIC ACID, (2S)-5-amino-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-5-oxopentanoic acid

Corapan TQ is used as a photostabilizer for a widely-used UV-A absorber, butylmethoxydibenzoylmethane (BMDBM).

The photophysical properties of Corapan TQ have been studied through measurements of the transient absorption, fluorescence, phosphorescence and EPR spectra in ethanol.

The energy level of the lowest excited singlet state of Corapan TQ is higher than that of BMDBM (enol form).

The singlet-singlet energy transfer from BMDBM to Corapan TQ is energetically unfavourable.

The energy level of the lowest excited triplet (T1) state of Corapan TQ is lower than that of BMDBM.

Corapan TQ is probable that the mechanism of photostabilization of BMDBM by Corapan TQ is the triplet-triplet energy transfer from BMDBM to Corapan TQ.

The observed phosphorescence spectrum, T1 lifetime and zero-field splitting parameters indicate that the T1 state of Corapan TQ can be regarded mainly as a locally excited 3ππ* state within naphthalene. 

The sum of the quantum yields of fluorescence of Corapan TQ (0.59 ± 0.09) and singlet oxygen generation by DEHN (0.44 ± 0.04) is almost unity in ethanol.

About 60% of the UV energy absorbed by Corapan TQ is released as fluorescence, while about 40% is used to produce the excited triplet state.

The photoexcited states of 2-naphthoic acid have been studied for comparison.

Corapan TQ is a dipeptide formed from L-threonine and L-glutamine residues.

Corapan TQ has a role as a metabolite.

Corapan TQ is a photostabilizer and a multifunctional oil-soluble emollient.

Corapan TQ is a safe and effective cosmetic oil that confers photostability to sun care formulations.

By using 2 to 5% in a formulation that contains the UVA filter butyl methoxydibenzoylmethane Corapan TQ has been demonstrated there is a dramatic improvement in performance of the system.

Corapan TQ is an excellent solvent for solid UV filters.

Corapan TQ confers photostability to butyl methoxydibenzoylmethane (BMDM) in sun care formulations.

Corapan TQ is a genus of Gram-positive bacteria that includes many important human pathogens.

Corapan TQ is the most common cause of food poisoning, and can be fatal if not treated.

Corapan TQ causes necrotizing enteritis in infants, who have less resistance to the toxins produced by this bacterium.

The pathogenesis of C. perfringens has been shown to involve proteolytic activity, which breaks down proteins into smaller parts, and autocatalytic activity, which releases enzymes from within the cell to digest Corapan TQ's own peptidoglycan layer.

Proteolytic activity has also been shown to be involved in the development of cancer and other diseases such as atherosclerosis and Alzheimer's disease.

There are numerous interventions available for preventing or treating clostridium infections: chlorate, streptomycin, penicillin, erythromycin, tetracycline, metronidazole, fluoroquinolones such as

Corapan TQ is a dipeptide formed from L-threonine and L-glutamine residues. 

Corapan TQ has a role as a metabolite.

Corapan TQ is a clear colorless to pale yellow liquid used as a photostabilizer and multi-functional emollient. 

Corapan TQ confers photostability to the UVA-filter Butyl Methoxydibenzoylmethane (Neo Heliopan 357) and is an excellent solvent for oil soluble, solid UV-filters.

Corapan TQ adds gloss to finished formulations and is compatible with most commonly used cosmetic ingredients.

Corapan TQ is a photostabilizer and a multifunctional oil-soluble emollient. 

Corapan TQ is a safe and effective cosmetic oil that confers photostability to sun care formulations. 

By using 2 to 5% in a formulation that contains the UVA filter butyl methoxydibenzoylmethane Corapan TQ has been demonstrated there is a dramatic improvement in performance of the system. 

Corapan TQ is an excellent solvent for solid UV filters.

Corapan TQ confers photostability to butyl methoxydibenzoylmethane (BMDM) in sun care formulations.

Corapan TQ acts as a photostabilizer and multifunctional emollient. 

Corapan TQ is an excellent solvent for oil soluble, solid UV-filters and confers photostability to the UVA-filter Butyl Methoxydibenzoylmethane. 

Improves the SPF of suncare formulations and adds gloss to finished formulations. 

Corapan TQ is compatible with most commonly used cosmetic ingredients. 

Corapan TQ and homomenthyl salicylate (HMS, homosalate) are UV-B absorbers used in cosmetic sunscreens. 

Corapan TQ is a proprietary name for a specific formulation or product that contains the dipeptide Threonine-Glutamine (also known as Threonyl-Glutamine). 

This peptide is used in various applications, particularly in the cosmetic and pharmaceutical industries.

Often included in skincare products due to Corapan TQ's potential benefits for skin hydration, repair, and soothing properties. 

Corapan TQ may help improve the skin’s barrier function and reduce the appearance of fine lines and wrinkles.

Corapan TQ is used in formulations to enhance the delivery of active ingredients or as a component in therapeutic products aimed at improving skin health or other health benefits.

Helps in maintaining skin moisture and elasticity.

Corapan TQ aids in the repair and regeneration of the skin.

Provides a soothing effect to the skin, reducing irritation and sensitivity.

Corapan TQ available in various forms, including creams, serums, and other topical applications.

The dipeptide consists of the amino acids threonine and glutamine linked together.

Threonine and glutamine are known to support the skin’s moisture retention.

Corapan TQ helps to maintain and improve skin hydration levels.

Promotes repair and regeneration of damaged skin cells, which can help reduce signs of aging and improve skin texture.

The dipeptide has soothing properties that can reduce skin irritation and sensitivity, making Corapan TQ suitable for sensitive skin types.

Enhances skin elasticity and firmness, reducing the appearance of fine lines and wrinkles.

May be used in therapeutic formulations for skin conditions or other health-related benefits where skin hydration and repair are needed.

Corapan TQ can enhance the delivery and efficacy of active pharmaceutical ingredients by improving skin penetration.

Corapan TQ is used in formulations for wound healing products, aiding in the repair of damaged skin and promoting quicker recovery.

Included in products designed for sensitive or compromised skin, providing gentle hydration and protection.

Potentially used in dietary supplements for skin health, leveraging Corapan TQ's benefits for hydration and repair.

An essential amino acid that supports protein synthesis and tissue repair. 

Corapan TQ plays a role in maintaining the skin’s barrier function and hydration.

An amino acid that helps in cellular repair and regeneration. 

Corapan TQ is crucial for maintaining the health of the skin and mucous membranes.

Corapan TQ is a clear colorless to pale yellow liquid used as a photostabilizer and multi-functional emollient. 

Corapan TQ confers photostability to the UVA-filter Butyl Methoxydibenzoylmethane (Neo Heliopan® 357) and is an excellent solvent for oil soluble, solid UV-filters.

Corapan TQ adds gloss to finished formulations and is compatible with most commonly used cosmetic ingredients.

Commonly found in moisturizing creams and lotions aimed at improving skin hydration and elasticity.

Included in serums designed for targeted treatment of aging signs and skin repair.

Corapan TQ s used in facial masks to provide intensive hydration and soothing benefits.

Corapan TQ should comply with cosmetic and pharmaceutical regulations in different regions. 

Corapan TQ is important to check the product’s documentation for specific regulatory approvals.

Generally considered safe for use in cosmetics and dermatological products, but individual sensitivities should be monitored. 

Always refer to the product’s safety data and instructions for use.

Corapan TQ enhances the skin’s barrier function by improving hydration and reducing transepidermal water loss (TEWL). 

This helps protect the skin from external aggressors.

Cellular Regeneration: Supports cellular regeneration and repair by providing essential amino acids required for collagen and elastin production, leading to improved skin firmness and elasticity.

Often combined with other active ingredients such as hyaluronic acid, retinoids, and peptides to enhance overall efficacy. 

The synergistic effect can lead to more pronounced anti-aging and skin repair benefits.

Corapan TQ stability and Compatibility: Corapan TQ is generally stable in a wide range of cosmetic formulations, including those with varying pH levels and ingredient compositions.

Research and clinical studies may focus on the effectiveness of Corapan TQ in treating specific skin conditions, such as eczema, psoriasis, or dermatitis, by enhancing skin hydration and repair.

Corapan TQ is used in products designed for post-procedure care (e.g., after laser treatments or chemical peels) to soothe and accelerate skin healing.

Ideal for sensitive skin types due to Corapan TQ's gentle nature and ability to reduce irritation. 

Corapan TQ can be used in products specifically formulated for sensitive or reactive skin.

Particularly beneficial for aging skin as Corapan TQ helps improve skin elasticity, reduce fine lines, and enhance overall skin texture.

Corapan TQ effective in alleviating dryness and maintaining moisture levels, making Corapan TQ suitable for dry or dehydrated skin conditions.

Corapan TQ research may explore new formulations and applications of Corapan TQ in areas like regenerative medicine, advanced dermatology, and cosmetic science.

Potential for development in high-tech skincare products, including those targeting specific aging markers or skin repair processes.

Compliance with regulations in different markets (e.g., FDA in the U.S., EMA in Europe) is crucial. 

Check specific product documentation for regulatory approvals and usage guidelines.

Growing interest in peptides and amino acids in skincare has led to an increase in products featuring Corapan TQ, reflecting its importance in modern cosmetic formulations.

Ensuring that the ingredients are sourced ethically and sustainably can enhance the product’s appeal to environmentally conscious consumers.

Products containing Corapan TQ should be tested for safety and efficacy, including dermatological testing and consumer trials.

Uses of Corapan TQ:

Incorporated into creams, lotions, and serums to enhance skin hydration and reduce dryness.

Corapan TQ is used in anti-aging formulations to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and support skin regeneration.

Added to products designed for sensitive skin to soothe irritation and improve skin tolerance.

Featured in products aimed at repairing damaged skin and supporting the healing process, such as after dermatological procedures.

Included in firming creams and serums to improve skin firmness and reduce sagging.

Corapan TQ is used in topical formulations for treating skin conditions, such as eczema, psoriasis, and dermatitis, to enhance hydration and support skin repair.

Applied in wound healing products to promote skin regeneration and accelerate healing processes.

Corapan TQ utilized in products designed for use after cosmetic procedures (e.g., chemical peels, laser treatments) to soothe and support skin recovery.

Included in formulations targeting specific skin conditions where hydration and repair are critical.

Investigated for use in dietary supplements aimed at supporting skin health from within, enhancing overall hydration and repair.

Potentially used in body washes and shampoos for Corapan TQ's moisturizing and soothing properties, benefiting the skin and scalp.

Corapan TQ added to hand and foot creams to improve hydration and skin health, especially in dry or rough areas.

Corapan TQ included in facial masks designed for intensive anti-aging treatments, providing deep hydration and improving skin texture.

Research may explore Corapan TQ's potential use in injectable treatments for skin rejuvenation and repair.

Ongoing research into new formulations and applications for Corapan TQ, including high-tech skincare and pharmaceutical products.

Enhances the effectiveness of anti-wrinkle products by boosting skin hydration and elasticity.

Corapan TQ often included in formulations designed for the delicate eye area to reduce puffiness and fine lines.

Corapan TQ is used in lip balms to provide moisturizing benefits and improve lip texture and softness.

Incorporated into sunscreens and after-sun products to repair and soothe skin damaged by UV exposure.

Corapan TQ added to ointments for treating chronic skin conditions, improving skin hydration and barrier function.

Utilized in therapeutic creams and gels aimed at treating conditions characterized by dry or compromised skin.

Corapan TQ is used in post-surgical creams to promote faster healing of surgical wounds and reduce scarring.

Applied in burn treatment products to soothe and accelerate recovery of burned skin.

Incorporated into products designed to minimize the appearance of scars and improve skin texture.

Corapan TQ featured in high-potency serums that deliver concentrated doses of the peptide to target specific skin concerns.

Corapan TQ s used in conjunction with microneedling treatments to enhance the efficacy of the procedure and support skin repair.

Added to formulations for chemical peels to soothe the skin and aid in the recovery process.

Research into oral supplements containing Corapan TQ to support skin health from within and combat signs of aging.

Included in professional-grade treatments offered in dermatology clinics and spas for advanced skincare solutions.

Corapan TQ is used in men’s skincare lines, including shaving creams and aftershaves, to reduce irritation and improve skin comfort.

Added to body lotions and balms to provide all-over skin hydration and repair.

Potential exploration in new cosmetic procedures, such as injectables or topical applications aimed at enhancing skin health and appearance.

Ongoing research into novel formulations and delivery methods, including nanotechnology or encapsulation techniques for improved efficacy.

Common Uses:

Sunscreens:

Corapan TQ helps improve the texture and performance of the sunscreen, enhancing Corapan TQ's protection factor.

Moisturizers:

Corapan TQ is used for its non-greasy, lightweight feel, providing hydration and skin smoothness.

Cosmetic Formulations:

Found in makeup products like foundations or BB creams for smooth application.

Key Properties

Emollient:

Corapan TQ helps soften and smooth the skin, providing a silky texture.

Solvent:

Often used to dissolve other ingredients, improving the spreadability of products on the skin.

UV Filter Booster:

Corapan TQ enhances the effectiveness of UV filters, making it a valuable ingredient in sunscreens.

Analysis of Corapan TQ:

Synthesis Analysis:

The synthesis of Corapan TQ involves various enzymes and pathways.

For instance, a study on tea plants (Camellia sinensis) roots revealed that in the intermediate products of Lys, Thr, and Met synthesis from aspartate, the expression of ASA dehydrogenase (CsASADH) and aspartate kinase (CsAK) showed a trend of increasing first and then decreasing.

Another study showed that tRNAs can be sheared and fragmented into small non-coding RNAs, also known as tRNA-derived small RNAs (tDRs), which have been shown to be essential for regulating cell proliferation, apoptosis, metastasis, and immunity.

Chemical Reactions Analysis:

Corapan TQ undergoes various chemical reactions, particularly in biological systems.

For instance, in a bacterial cell surface adhesin, Corapan TQ ester bond cross-links are generated autocatalytically by a serine protease-like mechanism.

Production of Corapan TQ:

Production refers to the process of creating goods or services by combining various resources, including labor, materials, and equipment.

Corapan TQ involves transforming raw materials or components into finished products that are ready for consumption or distribution.

The production process can vary widely depending on the industry, but Corapan TQ generally follows several key stages, including planning, sourcing, manufacturing, quality control, and distribution.

Key Aspects of Production of Corapan TQ:

Input:

Resources such as raw materials, labor, capital, and energy are required to initiate the production process.

These inputs are transformed through different processes into outputs (finished goods or services).

Process:

The actual manufacturing or creation phase, where raw materials are converted into products.

This can involve physical or chemical changes, assembly, and finishing steps.

Output:

The final product or service that results from the production process, which can be sold to consumers or used in further production.

Quality Control:

Ensures that the products meet specified standards and are free from defects.

Quality control checks occur at various stages of production to ensure consistency and reliability.

Efficiency:

Production efficiency measures how well the inputs are utilized to minimize waste and reduce production costs while maximizing output.

Types of Production Systems:

Mass Production:

Involves producing large quantities of standardized products, often using assembly lines (e.g., automotive manufacturing).

Batch Production:

Involves producing goods in specific batches or groups, allowing for customization between batches (e.g., bakery goods, clothing).

Job Production:

Involves creating custom, one-off products that are tailor-made for specific clients (e.g., custom furniture, bespoke jewelry).

Automation:

In modern production, automation technologies such as robotics, artificial intelligence, and advanced machinery help increase productivity, reduce errors, and optimize the overall process.

Handling and Storage of Corapan TQ:

Handling:

Ensure proper ventilation in work areas.

Avoid contact with skin, eyes, and clothing.

Always handle Corapan TQ with appropriate personal protective equipment (PPE).

Follow standard safety protocols, including avoiding inhalation of vapors or dust.

Use caution when opening containers.

Wash hands thoroughly after handling and avoid eating, drinking, or smoking during use.

Storage:

Store in a cool, dry, well-ventilated area, away from incompatible materials (such as oxidizing agents or acids) and direct sunlight.

Keep containers tightly closed to prevent contamination or leakage.

Store at recommended temperatures to ensure product stability, and avoid conditions such as excessive heat or freezing that could degrade Corapan TQ.

Stability and Reactivity of Corapan TQ:

Stability:

Corapan TQ is generally stable under recommended storage conditions (temperature, pressure, and humidity).

No significant degradation occurs when stored correctly.

Reactivity:

Corapan TQ may react with incompatible substances, such as strong acids, bases, or oxidizing agents.

Avoid exposure to extreme heat or ignition sources, as this may cause decomposition or hazardous reactions.

Hazardous Decomposition Products:

Decomposition may release toxic fumes or gases, such as carbon oxides or other harmful compounds, depending on Corapan TQ’s composition.

Safety Profile Of Corapan TQ:

While generally safe, some individuals may experience skin sensitivity or allergic reactions. 

Corapan TQ’s important to conduct a patch test before using products containing Corapan TQ on larger areas of skin.

In rare cases, products containing Corapan TQ could cause mild irritation, redness, or discomfort, especially if used in high concentrations or on sensitive skin.

Ensure that Corapan TQ and products containing it comply with relevant cosmetic and pharmaceutical regulations in region (e.g., FDA, EMA). 

Check for specific guidelines regarding concentration limits and usage.

The safety of Corapan TQ depends on its purity and the quality of manufacturing. 

Impurities or contaminants could pose additional risks.

As with any ingredient, there is a potential risk of allergic reactions. 

Symptoms may include rash, itching, swelling, or difficulty breathing. 

Discontinue use and seek medical advice if any adverse reactions occur.

In formulations, Corapan TQ should be tested for compatibility with other active ingredients to avoid potential interactions that could affect Corapan TQ's safety or efficacy.

First Aid Measures of Corapan TQ:

Inhalation:

If inhaled, move the person to fresh air immediately.

Seek medical attention if breathing difficulties or respiratory symptoms persist.

Administer oxygen if necessary.

Skin Contact:

Wash affected skin thoroughly with soap and water.

Remove contaminated clothing and shoes.

If irritation persists, seek medical advice.

Eye Contact:

Rinse eyes immediately with plenty of water for at least 15 minutes.

If irritation continues, seek medical attention.

Ingestion:

Do not induce vomiting unless instructed by medical personnel.

Rinse mouth with water and seek medical help immediately.

Firefighting Measures of Corapan TQ:

Suitable Extinguishing Media:

Use water spray, foam, dry chemical, or carbon dioxide (CO₂) to extinguish the fire, depending on the specific material.

Specific Hazards Arising from the Chemical:

In the event of a fire, toxic gases such as carbon monoxide, carbon dioxide, or other harmful vapors may be released.

Corapan TQ may produce irritating or corrosive fumes upon combustion.

Protective Equipment for Firefighters:

Firefighters should wear full protective gear, including self-contained breathing apparatus (SCBA) to prevent inhalation of hazardous decomposition products.

Accidental Release Measures of Corapan TQ:

Personal Precautions, Protective Equipment, and Emergency Procedures:

For All Personnel:

Evacuate the area if needed and avoid contact with the spill.

Keep untrained individuals away and avoid inhaling fumes.

For Responders:

Wear appropriate PPE, including gloves, goggles, and respirators.

Ensure good ventilation and stay upwind.

Environmental Precautions:

Prevent Corapan TQ from reaching water sources, drains, or soil.

Use barriers to contain the spill and alert environmental authorities if necessary.

Methods for Containment and Cleanup:

Small Spills:

Use absorbents (like sand or absorbent pads) to contain and clean up.

Place waste in labeled containers.

Large Spills:

Contain the spill with barriers, use vacuum systems or absorbents for cleanup, and dispose of Corapan TQ properly.

Exposure Controls/Personal Protective Equipment of Corapan TQ:

Engineering Controls:

Ensure good ventilation and use local exhaust systems where applicable to maintain airborne concentrations below permissible exposure limits (PEL).

Use closed systems or proper ventilation when working with volatile materials.

Personal Protective Equipment:

Eye/Face Protection:

Wear safety goggles or face shields to prevent eye exposure.

Skin Protection:

Wear appropriate protective gloves and clothing to avoid skin contact.

Respiratory Protection:

In cases where ventilation is insufficient, use a properly fitted NIOSH-approved respirator.

General Hygiene Considerations:

Wash hands after handling Corapan TQ, and remove any contaminated clothing to avoid prolonged exposure.

Dispose of contaminated items according to local regulations.

Identifiers of Corapan TQ:

CAS Number: 96337-79-0

Molecular Formula: C9H17N3O5

Molecular Weight: 247.25

Properties of Corapan TQ:

Melting point: >208°C (subl.)

storage temp.: −20°C

solubility: Water (Slightly)

form: Solid

color: White to Off-White

Assay: 95.00 to 100.00

Food Chemicals Codex Listed: No

Boiling Point: 537.96 °C. @ 760.00 mm Hg (est)

Flash Point: 501.00 °F. TCC ( 260.30 °C. ) (est)

logP (o/w): 10.475 (est)

Soluble in: water, 1.152e-005 mg/L @ 25 °C (est)