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MAGNESIUM DISTEARATE

Magnesium distearate is widely utilized in pharmaceuticals and cosmetics due to its properties as a lubricant, release agent, and its ability to delay dissolution, making it an essential ingredient in tablet production.
In addition to its role in pharmaceuticals, Magnesium distearate finds applications in various sectors such as cosmetics, food, polymer, rubber, and paint industries, where it serves multiple functions including gelling, stabilizing, antiadhesive, and plasticizing.
As a versatile additive, Magnesium distearate serves as a flow agent in capsules and tablets, enhancing consistency and quality control, while also finding utility in the food industry as an emulsifier, binder, thickener, and anticaking agent.

CAS Number: 557-04-0
EC Number: 209-150-3
Molecular Formula: C36H70MgO4
Molecular Weight (g/mol): 591.257

Synonyms: 209-150-3 [EINECS], 3919702 [Beilstein], 557-04-0 [RN], 70097M6I30, Dibasic magnesium stearate, Dioctadécanoate de magnésium [French] [ACD/IUPAC Name], Magnesium dioctadecanoate [ACD/IUPAC Name], MAGNESIUM OCTADECANOATE, Magnesium stearate [JAN] [JP15] [NF] [USP], Magnesiumdioctadecanoat [German] [ACD/IUPAC Name], MFCD00036391 [MDL number], OCTADECANOIC ACID MAGNESIUM SALT, Octadecanoic acid, magnesium salt, Octadecanoic acid, magnesium salt (2:1) [ACD/Index Name], stearic acid magnesium salt, Stearic acid, magnesium salt, synpro 90, Synpro Magnesium Stearate 90, WI4390000, (OCTADECANOYLOXY)MAGNESIO OCTADECANOATE, [557-04-0] [RN], 212132-26-8 [RN], EINECS 209-150-3, Magnesium [ACD/Index Name] [ACD/IUPAC Name], magnesium distearate, Magnesium stearate (contain palmitic acid), Magnesium stearate (JP17/NF), Magnesium Stearate NF, Magnesium Stearate NF EP FCC Kosher, MAGNESIUM(2+) DIOCTADECANOATE, MAGNESIUM(2+) ION BIS(N-OCTADECANOATE), magnesium(2+) ion bis(octadecanoate), Magnesium(II) Stearate, magnesiumstearate, octadecanoate, PARTECK LUB MST, Petrac MG 20NF, SM-P, UNII:70097M6I30, UNII-70097M6I30, 硬脂酸镁 [Chinese], MAGNESIUM STEARATE, 557-04-0, Magnesium octadecanoate, Magnesium distearate, Dibasic magnesium stearate, Octadecanoic acid, magnesium salt, magnesium(ii) stearate, Synpro 90, Petrac MG 20NF, Stearic acid, magnesium salt, NS-M (salt), SM-P, Magnesium stearate g, Synpro Magnesium Stearate 90, HSDB 713, Magnesii stearas, Magnesium distearate, pure, EINECS 209-150-3, NP 1500, SM 1000, CHEBI:9254, AI3-01638, magnesium dioctadecanoate, UNII-70097M6I30, Octadecanoic acid, magnesium salt (2:1), 70097M6I30, DTXSID2027208, MAGNESIUM STEARATE (II), MAGNESIUM STEARATE [II], Magnesium stearate [JAN], C36H70MgO4, Magnesium stearate [JAN:NF], DAYCLING, Magnesium stearate, tech, SCHEMBL935, DTXCID307208, Magnesium stearate (JP17/NF), MAGNESIUM STEARATE [MI], CHEMBL2106633, MAGNESIUM STEARATE [HSDB], MAGNESIUM STEARATE [INCI], Stearic Acid Magnesium(II) Salt, MAGNESIUM STEARATE [VANDF], HY-Y1054, MAGNESIUM STEARATE [WHO-DD], AKOS015915201, DB14077, MAGNESII STEARAS [WHO-IP LATIN], CS-0016049, NS00080495, S0238, D02189, A830764, Q416713

Magnesium distearate is the chemical compound with the formula Mg(C18H35O2)2.
Magnesium distearate is a soap, consisting of salt containing two equivalents of stearate (the anion of stearic acid) and one magnesium cation (Mg2+).

Magnesium distearate is a white, water-insoluble powder.
Magnesium distearate's applications exploit its softness, insolubility in many solvents, and low toxicity.
Magnesium distearate is used as a release agent and as a component or lubricant in the production of pharmaceuticals and cosmetics.

Magnesium distearate is the magnesium salt of stearic acid.
Magnesium distearates anhydrate, dihydrate and trihydrate forms have been prepared.

The tabletting of the blends of Magnesium distearate and lactose granules has been described.
The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined.

Magnesium distearate is widely used lubricant in pharmaceutical industry.
Magnesium distearate also plays a role in delaying the process of dissolution.
Magnesium distearates detection in tablets by laser-induced breakdown spectroscopy has been proposed.

Magnesium distearate, the salt of stearic acid, is widely employed as an inactive component in making pharmaceutical tablets.

Magnesium distearate is towards plastic applications.
Magnesium distearate is used as gelling agent, stabilizer, antiadhesive and plasticizer as a lot of different functions in primary sectors ;cosmetics, pharmacy, food, polymer, rubber and paint.
Magnesium distearate can be manufactured with demanded particular size and density, according to production process and industry.

Magnesium distearate is involved in the production of medical tablets, capsules, powders and polymer formulation.
Magnesium distearate is also used as a lubricant for tablets, anti-adherent, in dry coating and as a binding agent.
Magnesium distearate is an important ingredient in baby formulas.

Further, Magnesium distearate is used in the hydrogenation process.
In addition to this, Magnesium distearate is used to bind the sugar in hard candies like mints.

Magnesium distearate is a white, water-insoluble fine powder.
Magnesium distearate is a simple salt made up of two substances, a saturated fat called stearic acid and the mineral magnesium.

Magnesium distearate is the most common additive that is primarily used in capsules and tablets as it is considered a ‘flow agent’ so Magnesium distearate prevents the individual ingredients in a capsule from sticking together.

Magnesium distearate helps improves the consistency and quality control of capsules.
Magnesium distearate is used in the food industry as an emulsifier, binder and thickener, as well as an anticaking, lubricant, and antifoaming agent.

Magnesium distearate is the magnesium salt of stearic acid.
Magnesium distearates anhydrate, dihydrate and trihydrate forms have been prepared.

The tabletting of the blends of Magnesium distearate and lactose granules has been described.
The influence of mixing time on hardness, disintegration time and ejection force on the compressed tablets was examined.

Magnesium distearate is widely used lubricant in pharmaceutical industry.
Magnesium distearate also plays a role in delaying the process of dissolution.
Magnesium distearates detection in tablets by laser-induced breakdown spectroscopy has been proposed.

Magnesium distearate is a fine white powder that adds bulk to cosmetic and personal care products, while also providing them with a rich slippery feeling and adhesion.
Magnesium distearate makes products feel good to the touch and enhances the spreadability.
Magnesium distearate can also act as a lubricant and an anti-caking agent.

Magnesium distearate is generally found in products like creams, lotions, and powders where Magnesium distearate improves the overall performance and shelf life of the formulation.
Magnesium distearate is soluble in hot water and has the formula Mg(C18H35O2)2.

Magnesium distearate, a synthetic soap that consists of a mixture of magnesium salts of fatty acids, principally palmitic and stearic acid.
Magnesium distearate is one of the most commonly used excipients and corresponds to the chemical formula, C36H70MgO4.

Magnesium distearate is described in pharmacopoeia as a mixture of organic acids, chiefly Magnesium distearate, and magnesium palmitate.
Magnesium distearate is supplied as a very fine, light, white impalpable powder.
When touched, Magnesium distearate feels greasy and readily adheres to the skin.

Magnesium distearate is a solid, white powder at room temperature.
Magnesium distearate is a FDA-approved inactive ingredient commonly used in the pharmaceutical industry as a lubricant and release agent in the manufacture of tablet, capsule, and powder dosage forms.

Magnesium distearate is generally recognized as safe by the FDA.
Magnesium distearate exists as a salt form and is useful for it's lubricating properties for capsules and tablets in industry.

Magnesium distearate is used to help prevent pharmaceutical ingredients from adhering to industry equipment.
Magnesium distearate may be derived from both plant and animal sources.

Magnesium distearate is a common additive used in the pharmaceutical industry.
Magnesium distearate is a white, odorless, and tasteless powder that is highly insoluble in water, but soluble in organic solvents.
The chemical formula for Magnesium distearate is Mg(C18H35O2)2.

Have you ever wondered what that coating on your medications and vitamins is? It’s an additive made from Magnesium distearate.

Magnesium distearate is a fine white powder that sticks to your skin and is greasy to the touch.
Magnesium distearate’s a simple salt made up of two substances, a saturated fat called stearic acid and the mineral magnesium.

Stearic acid can also be found in many foods, such as:
chicken
eggs
cheese
chocolate
walnuts
salmon
cotton seed oil
palm oil
coconut oil

Magnesium distearate is commonly added to many foods, pharmaceuticals, and cosmetics.
In medications and vitamins, Magnesium distearate's primary purpose is to act as a lubricant.

Uses of Magnesium Distearate:
Magnesium distearate is often used as an anti-adherent in the manufacture of medical tablets, capsules and powders.
In this regard, the substance is also useful because Magnesium distearate has lubricating properties, preventing ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets; Magnesium distearate is the most commonly used lubricant for tablets.
However, Magnesium distearate might cause lower wettability and slower disintegration of the tablets and slower and even lower dissolution of the drug.

Magnesium distearate can also be used efficiently in dry coating processes.

In the production of pressed candies, Magnesium distearate serves as a release agent.
Magnesium distearate is also used to bind sugar in hard candies such as mints.

Magnesium distearate is a common ingredient in baby formulas.
In the EU and EFTA Magnesium distearate is listed as food additive E470b.

Uses of Magnesium distearate as excipient in pharmaceuticals:
Magnesium distearate is a widely used excipient in the pharmaceutical industry, serving a variety of purposes in drug formulation and manufacturing.

Here are some of the major uses of Magnesium distearate in pharmaceutical products:

Lubricant:
One of the most common uses of Magnesium distearate in pharmaceutical products is as a lubricant.
Magnesium distearate is added to drug formulations to reduce friction between particles and facilitate their movement through manufacturing equipment, such as tablet presses and capsule filling machines.

This helps to ensure consistent and efficient production of drug products.
Magnesium distearate is used as a lubricant for tablets and capsules in a range of 0.2 to 5%.

Anti-adherent:
Magnesium distearate can also serve as an anti-adherent in pharmaceutical products.
Magnesium distearate is added to prevent drug particles from sticking to the surfaces of manufacturing equipment, which can cause blockages or uneven dosing.

Flow agent:
In addition to lubrication, Magnesium distearate can also improve the flow properties of drug powders.
Magnesium distearate is added to reduce the cohesive forces between particles and improve their flowability, making Magnesium distearate easier to handle and process them during manufacturing.

Magnesium distearate has various uses in both cosmetics and skincare products.
Primarily, Magnesium distearate enhances the texture and performance of formulations within the cosmetic industry.

Cosmetic products:
Magnesium distearate is a good anti-caking agent that works wonders with cosmetic products.
Magnesium distearate promotes a slippery texture that enhances the blend and spreadability of products like blushes, eyeshadows, and foundations.
Magnesium distearate also aids with adherence to allow for long-lasting wear.

Skin care:
Magnesium distearate is often utilized as a thickening agent and emulsifier.
Magnesium distearate helps to stabilize and bind the ingredients in creams, lotions, and moisturizers, ensuring a consistent and smooth texture.
Magnesium distearate also aids in the absorption of oils and active ingredients, facilitating their delivery into the skin for improved efficacy.

Applications of Magnesium Distearate:
Magnesium distearate may be used as excipient in the formulations of diclofenac sodium tablets.
Magnesium distearate may be used for the preparation of tramadol HCl matrix tablets.

Manufacturing of Magnesium distearate:
Magnesium distearate can be derived from various sources such as animal, vegetable, and synthetic materials.
Animal-derived Magnesium distearate is usually sourced from beef or pork tallow, while vegetable-derived Magnesium distearate is obtained from hydrogenated cottonseed or palm oil.
Synthetic Magnesium distearate is produced by combining magnesium oxide or magnesium hydroxide with stearic acid.

Magnesium distearate is produced by the reaction of sodium stearate with magnesium salts or by treating magnesium oxide with stearic acid.

Occurrence of Magnesium Distearate:
Magnesium distearate is a major component of bathtub rings.
When produced by soap and hard water, Magnesium distearate and calcium stearate both form a white solid insoluble in water, and are collectively known as soap scum.

Origin of Magnesium Distearate:
Magnesium distearate is generally produced by the reaction between magnesium salts and stearic acid.
Stearic acid is neutralized with magnesium hydroxide or magnesium carbonate, resulting in the formation of Magnesium distearate.
Magnesium distearate is then purified, dried, and milled into a fine powder for use in cosmetics and other applications.

Handling and storage of Magnesium Distearate:

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Tightly closed.
Dry.

Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids

Stability and reactivity of Magnesium Distearate:

Reactivity:
No data available

Chemical stability:
Magnesium distearate is chemically stable under standard ambient conditions (room temperature).

Possibility of hazardous reactions:
No data available

Conditions to avoid:
no information available

Incompatible materials:
Strong oxidizing agents

Safety of Magnesium Distearate:
Magnesium distearate is generally considered safe for human consumption at levels below 2500 mg per kg of body weight per day and is classified in the United States as generally recognized as safe (GRAS).
In 1979, the FDA's Subcommittee on GRAS Substances (SCOGS) reported, "There is no evidence in the available information on Magnesium distearate that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current and in the manner now practiced, or which might reasonably be expected in the future."

Magnesium distearate is generally safe for use and has no reported side effects.
Magnesium distearate also does not clog pores or cause breakouts.

Patch testing of Magnesium distearate with Magnesium distearate can be done for sensitive skin, but is not typically required.
Depending on the source and manufacturing of this compound, Magnesium distearate can be vegan and halal.

First aid measures of Magnesium Distearate:

If inhaled:

After inhalation:
Fresh air.

In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.

In case of eye contact:

After eye contact:
Rinse out with plenty of water.
Remove contact lenses.

If swallowed:

After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.

Indication of any immediate medical attention and special treatment needed:
No data available

Firefighting measures of Magnesium Distearate:

Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture:
Carbon oxides
Magnesium oxide

Advice for firefighters:
In the event of fire, wear self-contained breathing apparatus.

Further information:
none

Accidental release measures of Magnesium Distearate:

Personal precautions, protective equipment and emergency procedures:

Advice for non-emergency personnel:
Avoid inhalation of dusts.
Evacuate the danger area, observe emergency procedures, consult an expert.

Environmental precautions:
No special precautionary measures necessary.

Methods and materials for containment and cleaning up:
Observe possible material restrictions.
Take up dry.

Dispose of properly.
Clean up affected area.
Avoid generation of dusts.

Identifiers of Magnesium Distearate:
CAS Number: 557-04-0
ChEBI: CHEBI:9254
ChemSpider: 10704
ECHA InfoCard: 100.008.320
E number: E572 (acidity regulators, ...)
PubChem CID: 11177
UNII: 70097M6I30
CompTox Dashboard (EPA): DTXSID2027208
InChI: InChI=1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
Key: HQKMJHAJHXVSDF-UHFFFAOYSA-L
InChI=1/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
Key: HQKMJHAJHXVSDF-NUQVWONBAM
SMILES: [Mg+2].[O-]C(=O)CCCCCCCCCCCCCCCCC.[O-]C(=O)CCCCCCCCCCCCCCCCC

CAS: 557-04-0
Molecular Formula: C36H70MgO4
Molecular Weight (g/mol): 591.257
MDL Number: MFCD00036391
InChI Key: HQKMJHAJHXVSDF-UHFFFAOYSA-L
PubChem CID: 11177
ChEBI: CHEBI:9254
IUPAC Name: magnesium;octadecanoate
SMILES: CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]

Synonym(s): Stearic acid magnesium salt
Linear Formula: [CH3(CH2)16CO2]2Mg
CAS Number: 557-04-0
Molecular Weight: 591.24
Beilstein: 3919702
EC Number: 209-150-3
MDL number: MFCD00036391
PubChem Substance ID: 24865972
NACRES: NA.22

Compound Formula: [CH3(CH2)16CO2]2Mg
Molecular Weight: 591.24
Appearance: White Powder
Melting Point: 200°C
Boiling Point: N/A
Density: N/A
Solubility in H2O: N/A
Exact Mass: 590.512452 g/mol
Monoisotopic Mass: 590.512452 g/mol

Linear Formula: [CH3(CH2)16CO2]2Mg
MDL Number: MFCD00036391
EC No.: 209-150-3
Beilstein/Reaxys No.: 3919702
Pubchem CID: 11177
IUPAC Name: magnesium; octadecanoate
SMILES: CCCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
InchI Identifier: InChI=1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
InchI Key: HQKMJHAJHXVSDF-UHFFFAOYSA-L

Properties of Magnesium Distearate:
Chemical formula: Mg(C18H35O2)2
Molar mass: 591.27 g/mol
Appearance: light white powder
Odor: slight
Density: 1.026 g/cm3
Melting point: 88.5 °C (191.3 °F; 361.6 K)
Solubility in water: 0.003 g/100 mL (15 °C)
0.004 g/100 mL (25 °C)
0.008 g/100 mL (50 °C)
Solubility: negligible in ether and alcohol slightly soluble in benzene

grade: technical grade
Quality Level: 100
form: powder

composition:
palmitate salt, 25%
stearate salt, 65%

mp: 200 °C (lit.)
SMILES string: CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC
InChI: 1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2
InChI key: HQKMJHAJHXVSDF-UHFFFAOYSA-L

Specifications of Magnesium Distearate:
Melting Point: 148°C to 152°C
Quantity: 250 g
Solubility Information: Slightly soluble in benzene. Insoluble in water,alcohol and ether.
Formula Weight: 591.27
Chemical Name or Material: Magnesium distearate

Names of Magnesium Distearate:

IUPAC name:
Magnesium octadecanoate

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