ALLANTOIN
Allantoin is a versatile ingredient used to improve the appearance and feel of the skin, with keratolytic, moisturizing, soothing, and anti-irritant properties, and it promotes the renewal of epidermal cells and accelerates wound healing.
Allantoin is a naturally occurring chemical compound found in plants like comfrey, horse chestnut, and bearberry, and is also synthesized to meet market demands, making it widely used in cosmetic and personal care products.
Allantoin is a safe, non-irritant compound that helps to shed dead skin cells, improve skin hydration, and provide a soothing effect, making it ideal for anti-aging and sensitive skin formulations.
CAS Number: 97-59-6
EC Number: 202-592-8
Molecular Formula: C4H6N4O3
Molecular Weight: 158.12 g/mol
Synonyms: Allantoin, Herpecin L, Herpecin-L, HerpecinL, Sebical, Woun'dres, allantoin, 97-59-6, 5-Ureidohydantoin, Glyoxyldiureide, 1-(2,5-dioxoimidazolidin-4-yl)urea, Cordianine, Glyoxyldiureid, Allantol, Sebical, Alantan, AVC/Dienestrolcream, Urea, (2,5-dioxo-4-imidazolidinyl)-, Psoralon, Septalan, Hydantoin, 5-ureido-, Cutemol emollient, Uniderm A, (2,5-Dioxo-4-imidazolidinyl)urea, (2,5-dioxoimidazolidin-4-yl)urea, Glyoxylic(acid) diureide, DL-Allantoin, Caswell No. 024, Glyoxylic diureide, NSC 7606, 5-Ureido-2,4-imidazolidindion, Alwextin, Herpecin L, CCRIS 1958, 2,5-Dioxo-4-imidazolidinyl-urea, (+/-)-Allantoin, N-(2,5-Dioxo-4-imidazolidinyl)urea, C4H6N4O3, EPA Pesticide Chemical Code 085701, Allantoin [USAN:BAN], 4-ureido-2,5-Imidazolidinedione, Idelalisib metabolite m1a, AI3-15281, NSC-7606, Fancol TOIN, 5-Ureidohydrantoin, EINECS 202-592-8, BRN 0102364, 5-Ureido-2,4-imidazolidindione, DTXSID3020043, UNII-344S277G0Z, CHEBI:15676, HSDB 7490, NSC7606, Allantoin (JAN/USP), N-(2,5-dioxoimidazolidin-4-yl)urea, 344S277G0Z, allantion, 97-59-6 (racemic), DTXCID0043, MLS000737882, 5377-33-3, Sd 101, Allantoin [USAN:USP:BAN:JAN], EC 202-592-8, 5-25-15-00338 (Beilstein Handbook Reference), DL-ALLANTOIN-5-13C; 1-15N, urea, N-(2,5-dioxo-4-imidazolidinyl)-, ALLANTOIN (II), ALLANTOIN [II], ALLANTOIN (MART.), ALLANTOIN [MART.], D00121, ALLANTOIN (USP-RS), ALLANTOIN [USP-RS], ALLANTOIN (EP MONOGRAPH), ALLANTOIN [EP MONOGRAPH], ALLANTOIN (USP MONOGRAPH), ALLANTOIN [USP MONOGRAPH], Ureidohydantoin, N-[2,5-dioxoimidazolidin-4-yl]urea, SMR000528073, SR-01000766252, MFCD00005260, Alantoina, Hemocane, CAS-97-59-6, Prestwick_11, NCGC00016358-01, Allation,(S), 5-ureido-Hydantoin, Allantoin (8CI), Spectrum_001078, ALLANTOIN [JAN], ALLANTOIN [MI], ALLANTOIN [HSDB], ALLANTOIN [INCI], ALLANTOIN [USAN], Allantoin, (.+.)-, Prestwick0_000002, Prestwick1_000002, Prestwick2_000002, Prestwick3_000002, Spectrum2_000219, Spectrum3_000876, Spectrum4_000716, Spectrum5_001526, ALLANTOIN [VANDF], bmse000437, D01HNL, ALLANTOIN [WHO-DD], SCHEMBL3208, Oprea1_621175, BSPBio_000003, BSPBio_002551, KBioGR_001271, KBioSS_001558, MLS002473300, Allantoin, analytical standard, DivK1c_000281, SPECTRUM1500801, SPBio_000237, SPBio_001924, BPBio1_000005, CHEMBL593429, SD 101 [WHO-DD], 5-Ureidohydantoin;Glyoxyldiureide, HMS500O03, KBio1_000281, KBio2_001558, KBio2_004126, KBio2_006694, KBio3_002051, Allantoin, >=98.0% (N), NINDS_000281, Urea,5-dioxo-4-imidazolidinyl)-, HMS1568A05, HMS1921I10, HMS2092K16, HMS2095A05, HMS2268N08, HMS3712A05, HMS3885M08, Pharmakon1600-01500801, AMY13912, BCP31832, component of Skin-balm (Salt/Mix), HY-N0543, 2,5-Imidazolidinedione, 4-ureido-, Tox21_110395, Tox21_202087, Tox21_302912, BBL027508, CCG-39781, NSC757792, s3856, STL373778, AKOS000120642, AKOS016038547, Tox21_110395_1, CS-7741, DB11100, LS-7181, NSC-757792, SDCCGMLS-0066595.P001, IDI1_000281, USEPA/OPP Pesticide Code: 085701, Allantoin, p.a., 98.5-101.0%, N-(2,5-Dioxo-4-imidazolidinyl)urea #, NCGC00094854-01, NCGC00094854-02, NCGC00094854-03, NCGC00094854-04, NCGC00094854-05, NCGC00094854-06, NCGC00094854-07, NCGC00256403-01, NCGC00259636-01, AC-11040, AS-13865, NCI60_041675, Sodium Methanethiolate (~20% in Water), Urea, n-(2,5-dioxo-4-imidazolidinil)-, N-(2,5-Dioxo-4(1h)-imidazolidinyl)urea, SBI-0051759.P002, A0211, AB00052307, FT-0604592, EN300-21043, C01551, D85069, Urea, (2,5-dioxo-4-imidazolidinyl)- (9CI), AB00052307_11, 3-Hydroxy-2-propyl-4-pentenoic Acid Ethyl Ester, Q409804, Urea, (2,5-dioxo-4-imidazolidinyl)-, (.+.)-, J-522839, SR-01000766252-2, SR-01000766252-3, SR-01000766252-4, W-100104, Z104486690, Allantoin, European Pharmacopoeia (EP) Reference Standard, A999F0D6-0285-41D9-A6BA-B705987B663C, Allantoin, United States Pharmacopeia (USP) Reference Standard, Allantoin, Pharmaceutical Secondary Standard; Certified Reference Material, 5-Ureidohydantoin; Glyoxyldiureide; Glyoxylic diureide; Cordianine; Glyoxyldiureid; (2,5-Dioxo-4-imidazolidinyl)urea
Allantoin is a naturally-occurring chemical compound.
In its pure form, Allantoin is a white, odorless powder.
Many plants contain allantoin, such as comfrey, horse chestnut, and bearberry.
Allantoin is a substance that is endogenous to the human body and also found as a normal component of human diets.
Allantoin is a major metabolic intermediate in most organisms.
Allantoin is found in OTC cosmetic products and other commercial products such as oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions.
Allantoin has also demonstrated to ameliorate the wound healing process in some studies.
Allantoin is a moisturizing and healing agent that has the ability to shed dead skin cells and leave the skin fresh and glowy.
Allantoin is used in a variety of cosmetic and personal care products because of its many benefits.
Allantoin is one of the latest trending ingredients that can be found in shampoos, scar creams, acne products and lotions.
Allantoin is a versatile ingredient used to improve the appearance and feel of the skin.
Allantoin is a natural derivative of the comfrey plant highly effective at exfoliating dead skin cells, increasing skin hydration and softness, and causing calming and soothing effects.
Allantoin improves the skin's moisture retention providing a smoothening effect.
Allantoin is used in cosmetic products as an ideal addition to anti-aging products to help to minimize the appearance aging and skin damage.
In addition to its moisturizing properties, Allantoin is an effective anti-irritant, protecting the skin.
Due to this multifunctionality Allantoin is broadly used in a wide range of beauty care application, including skin care, toiletries, and sun and hair care products.
Allantoin is a white to off-white, practically odorless crystalline powder.
Allantoin occurs naturally in the roots & leaves of the comfrey plant, but to satisfy market needs allantoin is produced synthetically but nature identical.
Allantoin improves skin irritation and hydration levels while also reducing the impacts of aging on the skin.
The chemical formula of Allantoin is C4H6N4O3.
Allantoin is a skin active ingredient with keratolytic, moisturizing, soothing, anti-irritant properties, promotes the renewal of epidermal cell and accelerates wounds healing.
Allantoin is safe and non-irritant, highly compatible with the skin and with cosmetic raw materials.
Allantoin enjoys a long history of use in cosmetics and topical pharmaceuticals with no findings of toxicity or adverse reactions.
Allantoin is a chemical compound with formula C4H6N4O3.
Allantoin is also called 5-ureidohydantoin or glyoxyldiureide.
Allantoin is a diureide of glyoxylic acid.
Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria.
Allantoin is produced from uric acid, which itself is a degradation product of nucleic acids, by action of urate oxidase (uricase).
The occurs as a natural mineral compound (IMA symbol Aan).
Allantoin is a moisturizing and healing agent that has the ability to shed dead skin cells and leave the skin fresh and glowy.
The chemical formula of Allantoin is C4H6N4O3.
Allantoin is one of those magical cosmetic and personal care ingredients that isn't hyped enough in the world of overhyped ingredients.
Allantoin serves many purposes such as moisturization and healing of scars and is added to a variety of products such as lotions, mascaras and shampoos.
Allantoin is a naturally occurring ingredient that appears as a white powder in its raw form.
Allantoin is derived from plants like chestnut, bearberry, and comfrey.
However, Allantoin can also be made from urea and glyoxylic acid.
Lastly, Allantoin can be synthetically made as well.
Allantoin is renowned for its softening and soothing properties.
Allantoin is an ingredient of choice for your "homemade" repairing treatments and your preparations for sensitive or blemished skin.
Allantoin, as I-1R agonist, has the potential to develop as a new therapeutic agent for hypertension.
Allantoin has memory-enhancing, anti-oxidative and anti-inflammatory activities.
Allantoin can enhance the antifungal activity of Nanoencapsulation.
Allantoin is a skin conditioning agent that promotes healthy skin, stimulates new and healthy tissue growth.
Allantoin mediates PI3K-Akt-GSK-3β signal pathway.
Allantoin is a chemical compound with formula C4H6N4O3.
Allantoin is also called 5-ureidohydantoin or glyoxyldiureide.
Allantoin is a diureide of glyoxylic acid.
Named after the allantois, an amniote embryonic excretory organ in which Allantoin concentrates during development in most mammals except humans and higher apes, it is a product of oxidation of uric acid by purine catabolism.
After birth, Allantoin is the predominant means by which nitrogenous waste is excreted in the urine of these animals.
In humans and higher apes, the metabolic pathway for conversion of uric acid to Allantoin is not present, so the former is excreted.
Recombinant rasburicase is sometimes used as a drug to catalyze this metabolic conversion in patients.
In fish, Allantoin is broken down further (into ammonia) before excretion.
Allantoin is a major metabolic intermediate in many other organisms including plants and bacteria.
Allantoin, in its organic form, is a compound that is found and extracted from certain plants like sugar beets, chamomile and wheat sprouts.
Allantoin's also known as aluminum dihydroxy allantoinate, but we’ll just call it Allantoin to keep things simple.
Most notably, Allantoin can be extracted from the comfrey plant, which is native to parts of Asia and Europe.
In skincare, Allantoin that is mainly used is recreated in labs to be chemically equivalent to its natural form.
This lab-created version, such as allantoin glycyrrhetinic acid, mimics the effects of natural Allantoin and has been proven to be safe enough to work in many different beauty products.
Allantoin’s core function is to be a non-toxic moisturising agent, so it’s a great ingredient to look out for if you’re in need of deep hydration or anti-ageing.
Allantoin’s a mild keratolytic, which means that it has the ability to increase the water content within cells and also helps to shed the outer layers of skin (desquamation).
Along with these major factors, Allantoin also has tons of other bonuses!
Allantoin is one of the main active principles of comfrey roots (regenerative and very healing plant).
Allantoin is a hygroscopic white powder.
Allantoin is stored away from moisture.
The cosmetics industry extracts Allantoin from the mucus of certain gastropods.
In plants, Allantoin is found in the roots of comfrey and in cereal seeds.
Recognized for Allantoin's moisturizing, anti-irritant properties and its cellular trophic action (beneficial on cell growth), Allantoin is very effective even at low concentration (from 0.1%).
While Allantoin is present in botanical extracts from comfrey, it is usually synthesized chemically to meet global demand. Allantoin is a synthesized nature-identical product manufactured to USP specifications.
Allantoin is non-toxic, non-irritant and non-allergenic.
Allantoin is an ingredient for your restorative, soothing and anti-inflammatory preparations.
Allantoin is a powerful ingredient, which makes it a must-have for sensitive, damaged or irritated skin.
Allantoin can be of organic or plant origin, it is found in one of the active ingredients of comfrey, roots of a plant known as "donkey's ears", but also in cereal seeds.
Allantoin is used anti-wrinkle, regenerate new tissues, an antioxidant that fights free radicals that destroy skin and accelerate the ageing process.
Allantoin is used dissolve in water.
Allantoin is made from glycolic acid and urea.
The white odourless powder, Allantoin, is well soluble in water and not sensitive to heat.
Allantoin comes in the form of a white crystalline powder.
Allantoin is a nitrogenous compound that is found both in the plant environment (Comfrey root for example) or animal (in the urine of calves).
Allantoin can also be obtained synthetically from uric acid.
Allantoin is a moisturizing agent, almost as effective as urea in binding moisture.
Originally Allantoin is a plant metabolite, but today it is also made synthetically.
Ideal in care for oily or impure skin, Allantoin eliminates dead skin cells and excessive sebum.
Allantoin also has a healing, smoothing and regenerating action on skin cells.
Allantoin is an ideal cosmetic active ingredient to help regenerate and heal the skin.
Allantoin softens and soothes the skin.
Allantoin is useful for the preparation of moisturizing and soothing cosmetics.
Allantoin is an active substance present in, among other things, Comfrey (Symphytum officinale) and Horse chestnut (Aesculus hippocastanum).
Allantoin has a wound healing and skin regenerating effect.
Allantoin makes the skin smoother and softer by removing dead skin cells.
The skin can therefore also be better hydrated and the production of new skin cells is stimulated.
Allantoin is made biotechnologically from urea and glycolic acid.
Allantoin is suitable for all skin types, including sensitive (baby) skin.
Allantoin is a chemical compound with formula C4H6N4O3.
Allantoin is also called 5-ureidohydantoin or glyoxyldiureide.
Allantoin is a diureide of glyoxylic acid.
Allantoin is a major metabolic intermediate in most organisms including animals, plants and bacteria.
Allantoin is produced from uric acid, which itself is a degradation product of nucleic acids, by action of urate oxidase (uricase).
The occurs as a natural mineral compound (IMA symbol Aan).
Allantoin is a skin active ingredient with keratolytic, moisturizing, soothing, anti-irritant properties, promotes the renewal of epidermal cell and accelerates wounds healing.
Allantoin is safe and non-irritant, highly compatible with the skin and with cosmetic raw materials.
Allantoin enjoys a long history of use in cosmetics and topical pharmaceuticals with no findings of toxicity or adverse reactions.
Uses of Allantoin:
Allantoin is used in a variety of cosmetic and personal care products because of its many benefits.
Allantoin is one of the latest trending ingredients that can be found in shampoos, scar creams, acne products and lotions.
Allantoin improves skin irritation and hydration levels while also reducing the impacts of ageing on the skin.
Allantoin has healing, soothing and regenerating properties for the skin, it tightens the pores, so it will be widely used in the event of wounds or burns.
Allantoin regulates the secretion of sebum,
Allantoin has a very gentle keratolytic action, it eliminates dead cells and stimulates cell regeneration.
Allantoin is also a moisturizing and softening ingredient, removes lesions, irritations and roughness of the skin.
Allantoin is a cosmetic active ingredient known for its regenerating and healing properties.
Moisturizing, Allantoin maintains the cutaneous hydrolipidic film and makes the skin supple and soft.
Also soothing and anti-inflammatory, Allantoin is ideal for fighting skin irritations.
Allantoin is used all skin types, especially sensitive, damaged, irritated skin, skin damaged by the sun, oily skin and prone to imperfections.
Allantoin is used cream, balm, repairing milk or after-sun, shaving balm for men, face care for irritated skin.
Allantoin is frequently used in the treatment of wounds, burns and skin ulcers.
Allantoin helps in the regeneration of damaged tissues and acts as a healing accelerator.
Allantoin's many benefits make its use very beneficial for after-shave balms, for sensitive skin or for babies and children.
Allantoin has a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and improving the desquamation of the upper layers of dead skin cells, increasing the smoothness of the skin; promote cell proliferation and wound healing; and a soothing, anti-irritant and protective effect on the skin by forming complexes with irritating and sensitizing agents.
Free-flowing synthetic hygroscopic powder, Allantoin, widely used in cosmetic, dermatological and pharmaceutical formulations for its soothing and anti-irritant properties.
Allantoin stimulates the formation of healthy, normal tissue, even at low concentrations.
Allantoin is used in cosmetic formulation in body care, after shave lotion, antiperspirants.
The hand cream with Allantoin intensively repairs damaged hands.
Allantoin is used regularly, it's Repairing Hand Cream soothes and repairs damaged hands and restores their suppleness and softness
Allantoin is the star ingredient for promoting healthy skin.
Thanks to Allantoin's restorative, soothing and moisturizing action.
Allantoin stimulates skin renewal, regulates the inflammatory process, improves the skin's ability to retain water.
Thanks to its keratolytic effect, Allantoin helps eliminate dead cells, which regenerates the skin, restoring its radiance and softness.
Finally, thanks to its softening effect, Allantoin leaves the skin soft and supple.
Allantoin has traditionally been used to stimulate wound healing because of its stimulating effect on the production of new cells.
Allantoin is is now known for its exfoliating and keratolytic action.
Allantoin has a light exfoliating effect by removing dead skin cells and creating soft, smooth skin.
Allantoin has a keratolytic effect by softening and softening the cornea, making it better able to retain water.
Allantoin makes the skin moister, softer and more supple.
Allantoin is suitable for all skin types, including sensitive (baby) skin.
Allantoin can be used in creams and lotions especially for sensitive, dry and irritated skin.
In addition, Allantoin can be processed in acne creams and after-sun products.
In cosmetics, Allantoin is used for its astringent, anti-irritant, anti-inflammatory, healing and moisturizing properties.
Allantoin is also used in the treatment of dentin hypersensitivity.
Allantoin is traditionally used for its healing, regenerating and soothing properties.
In cosmetics, Allantoin is frequently obtained from snail slime.
Here we use a synthetic Allantoin, equivalent to natural in terms of non-toxicity and safety.
Allantoin has moisturizing and keratolytic properties.
By increasing the amount of water in the extracellular matrix and enhancing the elimination of dead cells , Allantoin softens the skin, stimulates tissue regeneration and brightens the complexion.
In addition, Allantoin reacts with irritants and sensitizers present on the skin and deactivates them.
Allantoin is also suitable as a moisturizing active ingredient in shampoos for an irritated scalp and eczema.
Allantoin is used in creams and lotions for sensitive, dry, irritated and acne-prone skin.
Allantoin is one of those magical cosmetic and personal care ingredients that isn't hyped enough in the world of overhyped ingredients.
Allantoin serves many purposes such as moisturization and healing of scars and is added to a variety of products such as lotions, mascaras and shampoos.
Skin care (irritations, sunburn, burning, dry skin, chapped lips, etc.), bath and shower products.
Allantoin promotes the cleansing of dead skin and the production of new cells.
Skin care:
Allantoin is great for the skin as it helps in moisturizing and healing damaged surfaces.
Allantoin also reduces skin irritation and inflammation.
Further, Allantoin is helpful in treating scars.
Allantoin makes the cosmetic products more hydrating and better textured.
Allantoin is also an anti-aging ingredient that is a rage among Korean cosmetics.
Allantoin helps reduce the appearance of fine lines and wrinkles.
Skincare use for:
Creams, lotions and cleansers for the face, hands and body
Lip balms
Shave and Aftershave products
Serums, toners and masks
Sunscreens
Bath and shower products
Makeup and cosmetics
Haircare
Infant products
Hair care:
Allantoin is added to hair care products as it is beneficial in treating itchy and dry scalp by providing deep nourishment.
Allantoin can soothe the scalp and make it feel refreshed.
Allantoin has been used in a wide variety of personal care products and cosmetics for decades due to its gentleness and effectiveness including:
Cosmetics:
Manufacturers may use Allantoin as an ingredient in over-the-counter cosmetics.
Pharmaceuticals:
Allantoin is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products.
Biomarker of oxidative stress:
Since uric acid is the end product of the purine metabolism in humans, only non-enzymatic processes with reactive oxygen species will give rise to Allantoin, which is thus a suitable biomarker to measure oxidative stress in chronic illnesses and senescence.
Applications of Allantoin:
Allantoin is present in botanical extracts of the comfrey plant and in the urine of most mammals.
Chemically synthesized bulk allantoin, which is chemically equivalent to natural allantoin, is safe, non-toxic, compatible with cosmetic raw materials and meets CTFA and JSCI requirements.
Over 10,000 patents reference allantoin.
Cosmetics:
Manufacturers may use allantoin as an ingredient in over-the-counter cosmetics.
Pharmaceuticals:
Allantoin is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products.
Biomarker of oxidative stress:
Since uric acid is the end product of the purine metabolism in humans, only non-enzymatic processes with reactive oxygen species will give rise to allantoin, which is thus a suitable biomarker to measure oxidative stress in chronic illnesses and senescence
Allantoin is suitable for any personal care application.
Allantoin's use notably increases the performance of every cosmetic preparation:
Allantoin is used at low levels on intact skin gives a smooth and healthy appearance; used on irritated, chapped and cracked skin provide relief from pain and promote healing.
Allantoin is also useful as only active ingredient.
The many cosmetic applications include:
Body and face care: tonics, gels, creams, lotions, wipes.
Hand-care: gels, lotions, creams.
Shaving-care: shaving soaps, aftershaves, gels, lotions, creams.
Baby-care: diaper rash, bath products, gels, lotions, creams, powders, wipes.
Lips-care: sticks, creams.
Sun-care: sunscreens, aftersuns, suntans, gels, lotions, creams.
Hair products: shampoos, tonics.
Bath products: shower gels, bubble baths, intimate, powders, wipes.
Oral preparations: toothpastes, mouthwashes.
Benefits and Uses of Allantoin:
Allantoin has USP grade.
Allantoin Soothes and alleviates skin-irritations.
Allantoin Has moisturizing and hydrating effects.
Allantoin Recognized as skin protectant by the FDA
Allantoin is Often used to minimize pore size.
Allantoin Has anti-aging properties making the skin look younger and rejuvenated.
Allantoin has many skin care benefits, including:
Reducing irritation:
One 2015 studyTrusted Source compared the anti-irritant effects of pure allantoin and comfrey extract, which also contains naturally-occurring allantoin.
The researchers found that both substances reduced irritation.
However, the comfrey extract was more effective than pure allantoin.
This suggests that a combination of compounds in comfrey root has a beneficial effect on irritation.
Child eczema:
Atopic dermatitis, or atopic eczema, causes inflamed, itchy, and dry skin.
Allantoin is especially important to soothe these symptoms in young children to prevent them from scratching and breaking the skin.
Allantoin, aloe vera, and oatmeal all have anti-inflammatory properties, which may make them useful additions to a treatment regimen for child eczema alongside medications.
Acne:
Benzoyl peroxide is a first-line acne treatment.
However, Allantoin's drying effect on the skin may accelerate aging and discourage people from using it.
This may lead to worsened symptoms and more acne scarring.
In a small 2020 study of 31 women, participants responded well to a new acne regimen containing allantoin and a blend of ceramides.
Overall, they noticed a reduction in acne symptoms and improved skin barrier function.
Scars:
A combination of allantoin and onion extract has been available as a scar-treatment gel for several decades.
Proponents claim onion extract has anti-inflammatory properties, whereas allantoin is hydrating and epithelizing.
This means Allantoin helps to grow new skin cells.
A 2018 study including 125 participants found that their scars were less noticeable after wearing an allantoin and onion extract patch after skin surgery.
This supports the theory that allantoin has scar healing properties.
Wound healing:
Pectin and allantoin already have many uses in the pharmaceutical and beauty industry.
However, both show promise for aiding wound healing.
A 2020 study found that pectin-allantoin films sped up healing time by 25% in rats with skin wounds.
Studies that investigate the wound healing properties of allantoin tend to use animals, so the results may not apply to humans.
The results of this study are promising and suggest that pectin and allantoin could have uses in wound care.
Moisturizes:
Allantoin acts as an emollient that keeps your skin moisturized and prevents dryness and irritation.
Soothes skin:
Allantoin has the additional functionality of being a calming agent.
Allantoin soothes and protects the skin by forming complexes with irritant and sensitizing agents, according to Herrmann.
Improves skin-healing:
Allantoin has been noted to help soothe injured skin and promote wound healing and is often used to treat skin irritation and rashes.
Exfoliates:
Allantoin is also keratolytic, which means it exfoliates dead skin cells.
Allantoin helps desquamation, the shedding of the outermost membrane or layer of tissue from the inside out.
Hydrates:
Allantoin's keratolytic property can increase the water contents of cells, therefore, fighting against the damage of transepidermal water loss (TEWL) in the dermis, which keeps the skin looking plump and youthful.
Think of Allantoin as almost the expansion of a sponge when wet, holding the maximum amount of liquid.
Improves skin dullness:
Allantoin promotes cell proliferation and supports overall remodeling.
If the skin is stressed by the usual and customary list of offenders, then the skin is going to try to repair itself as opposed to having more cells turn over.
What we want to do with the epidermis is to have Allantoin constantly exfoliating itself and having more cells be produced because that’s how you get a faster transit time of the epidermal cells.
As people get older, then that transit time from the base layer of the epidermis to the top layer takes longer, and also the skin is stressed, and those are some of the causes of dull, dry skin, too.
This is going to help with that cell proliferation.
Smoothes skin:
Removing surface dead skin cells (stratum corneum), also helps keep the skin smooth and soft.
Rejuvenates the cells:
Although it's gentle, Allantoin can still be an effective anti-aging ingredient.
Allantoin is highly beneficial in facilitating collagen synthesis.
As Allantoin stimulates the fibroblasts (cells responsible for producing collagen), it also boosts extracellular matrix synthesis, which is why it is a strong rejuvenator.
Functions of Allantoin:
Skin conditioning agent:
Allantoin keeps the skin in good condition.
Skin protection agent:
Allantoin helps to avoid the harmful effects of external factors on the skin.
Soothing Agent:
Allantoin helps alleviate skin or scalp discomfort.
Allantoin is present in 6.12% of cosmetics.
Main Functions:
Restorative
Soothing
Keratolytic
Action Mode of Allantoin:
The beneficial effects on the skin of Allantoin were well documented.
Allantoin is a mild keratolytic agent that dissolves the intercellular cement that holds the cornified cells together, helping the natural desquamation of stratum corneum and increasing skin smoothness.
The moisturizing effect results from Allantoin's ability to increase the water bounded to the intercellular matrix and keratin, thereby softening skin and making the skin look healthier.
The soothing, anti-irritant and skin protectant effect is due to the ability of Allantoin to form complexes and neutralize many irritant and sensitizing agents.
Allantoin enhances epidermal cell-proliferation, promotes the regeneration of damaged epitelium and accelerates wound healing.
Experimetal Properties of Allantoin:
Allantoin is a heterocyclic compound derived from purine.
Allantoin is an odourless white powder, soluble in water to 0.5%, very slightly soluble in alcohols, insoluble in oils and apolar solvents.
Allantoin is stable in the pH range 3-8 and to 80°C prolonged heating.
Allantoin is fully compatible with cosmetic ingredients and with anionic, non-ionic, cationic systems.
As a cosmetic ingredient, the cosmetic active ingredient Allantoin is recognized for these properties:
Restorative:
Allantoin stimulates skin renewal.
Soothing:
Allantoin regulates the inflammatory process.
Allantoin maintains good skin hydration:
Allantoin improves the skin's ability to retain water.
Keratolytic:
Allantoin helps eliminate dead cells, which regenerates the skin, restoring its radiance and softness.
Softening:
Allantoin makes the skin softer and more supple.
History of Allantoin:
Allantoin was first isolated in 1800 by the Italian physician Michele Francesco Buniva (1761–1834) and the French chemist Louis Nicolas Vauquelin, who mistakenly believed it to be present in the amniotic fluid.
In 1821, the French chemist Jean Louis Lassaigne found it in the fluid of the allantois; he called it "l'acide allantoique".
In 1837, the German chemists Friedrich Wöhler and Justus Liebig synthesized it from uric acid and renamed it "allantoïn".
Animals:
Named after the allantoin (an amniote embryonic excretory organ in which it concentrates during development in most mammals except humans and other hominids), Allantoin is a product of oxidation of uric acid by purine catabolism.
After birth, Allantoin is the predominant means by which nitrogenous waste is excreted in the urine of these animals.
In humans and other higher apes, the metabolic pathway for conversion of uric acid to allantoin is not present, so the former is excreted.
Recombinant rasburicase is sometimes used as a drug to catalyze this metabolic conversion in patients.
In fish, allantoin is broken down further (into ammonia) before excretion.
Allantoin has been shown to improve insulin resistance when administered to rats and to increase lifespan when administered to the nematode worm Caenorhabditis elegans.
Bacteria:
In bacteria, purines and their derivatives (such as allantoin) are used as secondary sources of nitrogen under nutrient-limiting conditions.
Their degradation yields ammonia, which can then be utilized.
For instance, Bacillus subtilis is able to utilize allantoin as its sole nitrogen source.
Origin of Allantoin:
Allantoin is a metabolic intermediate of a wide variety of organisms: from bacteria, to vegetals and animals.
Allantoin was found in many plants, and particularly in the leaves and roots of comfrey (Symphytum officinale), an herb of family Boraginacee.
The roots and leaves of this herb contain from 0.6 to 1% Allantoin and have a long history of use in the treatment of wounds in form of poultices and decoctions.
Allantoin is the end product of purine degradation in Mammalians (except Primates) and derives from the oxidation of uric acid.
Allantoin can’t be extracted from animals with industrial advantages, thus all internet alerts on the animal origin of Allantoin are completely unsubstantiated.
Allantoin CTFA manufactured by Akema is the natural-identical compound fully obtained via a chemical process that make no use of substances of animal origin.
Handling and Storage of Allantoin:
Precautions for safe handling:
Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities:
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Storage class (TRGS 510):
8A: Combustible, corrosive hazardous materials
Stability and Reactivity of Allantoin:
Chemical stability:
Stable under recommended storage conditions.
Incompatible materials:
Strong oxidizing agents:
Hazardous decomposition products:
Hazardous decomposition products formed under fire conditions.
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas.
Disposal considerations:
Waste treatment methods:
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging:
Dispose of as unused product.
First Aid Measures of Allantoin:
General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
Move out of dangerous area.
If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact:
Take off contaminated clothing and shoes immediately.
Wash off with soap and plenty of water.
Consult a physician.
In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
Continue rinsing eyes during transport to hospital.
If swallowed:
Do NOT induce vomiting.
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.
Firefighting Measures of Allantoin:
Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture:
Carbon oxides, Nitrogen oxides (NOx), Hydrogen chloride gas
Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
Accidental Release Measures of Allantoin:
Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid breathing vapours, mist or gas.
Evacuate personnel to safe areas.
Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up:
Soak up with inert absorbent material and dispose of as hazardous waste.
Keep in suitable, closed containers for disposal.
Exposure Controls/Personal Protection of Allantoin:
Components with workplace control parameters:
Contains no substances with occupational exposure limit values.
Exposure controls:
Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
Personal protective equipment:
Eye/face protection:
Tightly fitting safety goggles.
Faceshield (8-inch minimum).
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection:
Handle with gloves.
Gloves must be inspected prior to use.
Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product.
Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:Dermatril (KCL 740 / Aldrich Z677272, Size M)
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested: Dermatril (KCL 740 / Aldrich Z677272, Size M)
Allantoin should not be construed as offering an approval for any specific use scenario.
Body Protection:
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection:
Where risk assessment shows air-purifying respirators are appropriate use a fullface respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls.
If the respirator is the sole means of protection, use a full-face supplied air respirator.
Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.
Identifiers of Allantoin:
CAS Number: 97-59-6
EC Number: 202-592-8
IUPAC Name: (2,5-dioxoimidazolidin-4-yl)urea
IUPAC Name: 5-(Hydroxymethyl)imidazolidine-2,4-dione
CAS Number: 97-59-6
Molecular Formula: C₄H₆N₄O₃
Molecular Weight: 158.12 g/mol
InChI Key: RGJGEJAFGSEVTK-UHFFFAOYSA-N
SMILES: C1(C(=O)NC(=O)N1)CO
PubChem CID: 204
EC Number: 202-592-8
UNII (Unique Ingredient Identifier): 344S277G0Z
Beilstein Registry Number: 102779
ChEBI ID: CHEBI:28262
ChemSpider ID: 198
KEGG Compound ID: C02754
ChEMBL ID: CHEMBL1154
RTECS Number: YN5080000
ECHA InfoCard: 100.002.680
Appearance: White crystalline powder
Melting Point: 230–234 °C (decomposes)
Solubility: Slightly soluble in water; soluble in alcohol and glycerol
pKa: 8.61 at 25 °C
CAS Number, 97-59-6
Chem/IUPAC Name:, Urea, (2,5-dioxo-4-imidazolidinyl)-
EINECS/ELINCS No:, 202-592-8
COSING REF No:, 31411
Properties of Allantoin:
Boiling Point: 478°C
Melting Point: 230°C
pH: 3.0-8.0
Solubility: Soluble in water
Purity: 99-100%. Melting point 230°C (446°F).
Item Form: Powder
Material Type Free: Odorless
Characteristic: White crystalline powder
Odor: Characteristically mild
Identification: Meets The Requirements
Angular Rotation: -0.10º~+0.10º
Acidity Or Alkalinity: Conform
Loss On Drying: ≤0.1%
Residue On Ignition: ≤0.1%
Reducing Substances: Complies
Related Compounds: ≤0.5%
Assay: 98.5 ~ 101.0%
Standard: USP32
Density: 1.7±0.1 g/cm3
General Description: White Powder
Odor: Characteristically mild
Appearance: White crystalline powder
Assay: 98.5%-101.0%
Identification: Infrared spectrum is march with the spectrum of allantoin CRSThin-Layer ChromatographicConform
Acidity or alkalinity: Conform
Angular rotation: -0.10º~+0.10º
Loss on drying %: 0.1 max
Residue on ignition %: 0.1 max
M.P ºC: 226-240
Heavy metals( pb) %: <0.001
Ph value: 4.5-6.5
Related substances %: 0.5 max
Physical state: solid
Color: white
Odor: No data available
Melting point/freezing point:
Melting point/range: 230 °C - dec.
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Chemical formula: C4H6N4O3
Molar mass: 158.117 g•mol−1
Appearance: colourless crystalline powder
Odor: odorless
Density: 1.45 g/cm3
Melting point: 230 °C (446 °F; 503 K) (decomposes)
Boiling point: 478 °C (892 °F; 751 K)
Solubility in water: 0.57 g/100 mL (25 °C)
4.0 g/100 mL (75 °C)
Solubility: soluble in alcohol, pyridine, NaOH, insoluble in ethyl ether
log P: −3.14
Acidity (pKa): 8.48
Specifications of Allantoin:
Appearance: White Powder
Odor: Orderless
Fineness: >500 Mesh
Assay %: 98.50-101.00%
PH(0.5%aq): 4.00-6.00
Nitroren%: 35.00-35.50
M.P ºC: >225
Heavy metals mg/kg: 10min
Loss on drying %: <0.20
Ash %: <0.10
Optical rotation: -0.1° - +0.1°
