Chlorphenesin is a synthetic preservative used in cosmetics and personal care products to prevent bacterial growth and contamination, thereby extending the product's shelf life.

Chlorphenesin has antifungal and antibacterial properties, making it effective against various microorganisms, though it is often combined with other preservatives to enhance its efficacy.

Chlorphenesin is used in a variety of products including aftershave lotions, bath products, deodorants, hair conditioners, and skin care items, and is typically included at concentrations up to 0.32%.

CAS Number: 104-29-0

EC Number: 203-192-6

Molecular Formula: C9H11ClO3

Molecular Weight: 202.63

Synonyms: 3-(4-CHLOROPHENOXY)-1,2-PROPANEDIOL;GLYCEROL A-P-CHLOROPHENYL ETHER;LABOTEST-BB LT01147791;CHLORPHENESIN;CHLORPHENESINE;CHLORPHENSIN;3-(PARA-CHLOROPHENOXY)-1,2-PROPANEDIOL;Chlorophenesin (CHP);chlorphenesin;104-29-0;3-(4-Chlorophenoxy)-1,2-propanediol;3-(4-chlorophenoxy)propane-1,2-diol;Chlorophenesin;Gecophen;Demykon;Mycil;Chlorphenesinum;Adermykon;p-Chlorophenyl glyceryl ether;Chlorphenesine;Clorfenesina;2-Chlorphenesin;1,2-Propanediol, 3-(4-chlorophenoxy)-;3-(p-Chlorophenoxy)-1,2-propanediol;Clorfenesina [INN-Spanish];Chlorphenesine [INN-French];Chlorphenesinum [INN-Latin];Glycerol alpha-p-chlorophenyl ether;p-Chlorophenyl-alpha-glyceryl ether;3-(p-Chlorophenoxy)propane-1,2-diol;NSC 6401;UNII-I670DAL4SZ;EINECS 203-192-6;I670DAL4SZ;1,2-PROPANEDIOL, 3-(p-CHLOROPHENOXY)-;BRN 2210845;CHEBI:3642;DTXSID0049028;AI3-24623;NSC-6401;DTXCID5028954;4-06-00-00831 (Beilstein Handbook Reference);MFCD00021990;Glycerol .alpha.-p-chlorophenyl ether;p-Chlorophenyl-.alpha.-glyceryl ether;NCGC00160584-01;Clorfenesina (INN-Spanish);1,2-Propanediol, 3-(4-chlorophenoxy)- (9CI);Chlorphenesine (INN-French);Chlorphenesinum (INN-Latin);CHLORPHENESIN (MART.);CHLORPHENESIN [MART.];Gechophen;p-Chlorophenyl;Chlorphenesin [INN:BAN];3-(4-Chlorophenoxy)propane-1,2-diol;3-(4-Chlorophenoxy)propane-1,2-diol;alpha-Glyceryl ether;3-?(4-?Chlorophenoxy)?-?1,?2-?propanediol(Chlorphenesin);(+/-)-Chlorphenesin;Wet Wipes AT8039;Maybridge1_000170;CHLORPHENESIN [MI];WLN: Q1YQ1OR DG;CHLORPHENESIN [INN];MixCom1_000324;1, 3-(p-chlorophenoxy)-;Oprea1_755443;SCHEMBL93836;CHLORPHENESIN [VANDF];1, 3-(4-chlorophenoxy)-;CHLORPHENESIN [WHO-DD];CHEMBL388751;NSC6401;HMS3604N15;3-p-Chlorophenoxy-1,2-propanediol;ALBB-025796;HY-A0133;Tox21_113554;AC-266;s6442;1-(p-chlorophenoxy)-2,3-propanediol;AKOS005203039;DB00856;HS-0080;3-(p-chlorophenoxy)-propane-1,2 diol;BP-20218;CAS-104-29-0;DA-51861;SY058281;C3659;Chlorphenesin 100 microg/mL in Acetonitrile;CS-0017448;NS00008320;C07928;D71194;EN300-122624;SR-01000944964;J-001139;Q5103226;SR-01000944964-1;BRD-A92262698-001-01-7;BRD-A92262698-001-02-5;Z995094004

Chlorphenesin is a synthetic ingredient that acts as a preservative for cosmetic and beauty products.

Chlorphenesin prevents bacterial growth and contamination, thus improving the quality and shelf lives of the products.

However, Chlorphenesin is a weak ingredient and is often combined with other preservatives when used in the cosmetic industry.

In its raw form, Chlorphenesin appears as a crystalline powder that is white to off-white in color.

The chemical formula of Chlorphenesin is C9H11ClO3.

Chlorphenesin is glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group.

Chlorphenesin has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections.

Chlorphenesin's 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm.

As a skin care ingredient, Chlorpenesin is used as a water- and glycerin-soluble preservative to inhibit contamination.

Since Chlorpenesin’s considered weak against some types of bacteria, it’s always combined with other preservatives, such as phenoxyethanol and caprylyl glycol, to boost stability and increase the product’s shelf life.

Chlorpenesin is also considered a “cosmetic biocide” to help prevent unwanted odors on skin.

Chlorphenesin has a role as a muscle relaxant, an antibacterial drug and an antifungal drug.

Chlorphenesin is a glycol, a member of propane-1,2-diols and a member of monochlorobenzenes.

Chlorphenesin is diol with a 4-chlorophenyl group, a fine white to pale-cream-colored crystal with a slightly phenolic odor and bitter taste.

The high-purity chlorphenesin is ideal for blending with existing preservation systems to enhance their performance.

The preservative performance is clearly enhanced by the addition of chlorphenesin as demonstrated in kill-rate studies using organisms.

Chlorphenesin is an effective and universal anti-bacterial and anti-fungal agent that boosts preservative effectiveness to a higher level.

Chlorphenesin is used for the preservation and stabilization of cosmetics and medicines.

Chlorphenesin works well in composition with other preservatives.

Blended with potassium sorbate, sodium benzoate and/or parabens Chlorphenesin boosts their performance, improving the shelf-life and usage period.

Chlorphenesin is another synthetic preservative found in cosmetics and personal care products. As far as synthetic preservatives go, Chlorphenesin’s one of the milder ones.

Chlorphenesin’s not considered as toxic as parabens or iodopropynyl butylcarbamate—though it can cause dermatitis in adults—but like benzyl alcohol, it’s not safe for infants.

Chlorphenesin is a reversible antigen-associated immunosuppressant.

Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics.

Chlorphenesin is a preservative that is used as an analytical agent in vivo to determine chemical stability and to maintain the pH of a solution.

Chlorphenesin has been shown to be stable in human serum at a concentration of 0.1% (w/v).

Chlorphenesin is also a carbamate, which reacts with acidic compounds, such as benzalkonium chloride, to form chlorhexidine.

In vitro assays have shown that chlorphenesin inhibits the enzyme acetylcholinesterase, which breaks down acetylcholine.

This effect may be due to Chlorphenesin's ability to bind with serine hydroxyl groups on the protein.

Chlorphenesin also has been shown to inhibit the activity of isoxsuprine hydrochloride, an inhibitor of cyclooxygenase-2 (COX-2), through competitive inhibition.

Chlorphenesin is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.

Chlorphenesin is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Chlorphenesin is a phenol ether used to treat painful muscular conditions.

Chlorphenesin works by blocking nerve impulses (or pain sensations) that are sent to your brain.

Chlorphenesin is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions.

Chlorphenesin is not commercially available in the United States.

Chlorpenesin is a synthetic ingredient that acts as a preservative for cosmetic and beauty products.

Chlorpenesin prevents bacterial growth and contamination, thus improving the quality and shelf lives of the products.

However, Chlorpenesin is a weak ingredient and is often combined with other preservatives when used in the cosmetic industry.

In its raw form, Chlorpenesin appears as a crystalline powder that is white to off-white in color.

The chemical formula of Chlorpenesin is C9H11ClO3.

Chlorpenesin is glycerol in which the hydrogen of one of the primary hydroxy groups is substituted by a 4-chlorophenyl group.

Chlorpenesin has antifungal and antibacterial properties, and is used for treatment of cutaneous and vaginal infections.

Chlorpenesin's 1-carbamate is used as a skeletal muscle relaxant for the treatment of painful muscle spasm.

Chlorpenesin has a role as a muscle relaxant, an antibacterial drug and an antifungal drug.

Chlorpenesin is a glycol, a member of propane-1,2-diols and a member of monochlorobenzenes.

Chlorpenesin is a preservative and cosmetic biocide that helps prevent the growth of microorganisms.

In cosmetics and personal care products, Chlorpenesin is used in the formulation of aftershave lotions, bath products, cleansing products, deodorants, hair conditioners, makeup, skin care products, personal cleanliness products, and shampoos.

Uses of Chlorpenesin:

Chlorphenesin is an antigen-associated immunosuppressant that inhibits IgE-mediated histamine release.

Chlorphenesin is also used as an antimycotic agent.

Chlorophenesin is a preservative with fungistatic and bactericidal properties.

Chlorphenesin is used for relieving skeletal muscle pain.

Chlorphenesin is a useful ingredient that is commonly used as a preservative in skincare formulations owing to its antifungal and antibacterial properties.

Chlorphenesin prevents microbial growth and contamination, thus extending the shelf life of products and maintain their safety and efficacy.

Chlorphenesin is however thought to be ineffective against some kinds of bacteria and is hence used in combination with with other preservatives, such as phenoxyethanol and caprylyl glycol, to boost stability and increase Chlorphenesin’s shelf life.

Chlorphenesin is also considered a “cosmetic biocide” for its ability to prevent unpleasant skin odors.

Chlorphenesin is used in cosmetic products such as aftershave lotions, bath products, deodorants, hair conditioners, makeup, skin care products, eye care cosmetics, personal cleanliness products, and shampoos.

Chlorpenesin is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions.

Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain.

Was investigated as a modulator of histamine release.

The mechanism of action of Chlorpenesin is not well defined, and its effects are measured mainly by subjective responses.

Chlorpenesin is known that Chlorpenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle.

Chlorpenesin is active against harmful bacteria, fungi, and yeasts.

Chlorpenesin is also considered a multivalent preservative, which carries a significance in terms of being used in any formulation since Chlorphenesin can stabilize other chemical groups in the same formulation.

Chlorpenesin is also known as a cosmetic biocide, meaning it can cleanse the skin as well as deodorize skin by eliminating odor-causing bacteria.

Chlorpenesin stabilizes the preparation with the antimicrobial point of view plus it also has weak emulsifier properties.

Chlorpenesin can be called as a multipurpose ingredient of any formulation since when it is used in a product apart from serving the main purpose of Chlorphenesin.

Chlorpenesin also protects skin from other harmful bacteria, fungi or yeasts and at the same time stabilizes the main product as well.

Chlorpenesin is used in creams, lotions, gels, sticks serums, shampoos, conditioners, alcohol absolutes, makeup products, personal cleansing products, and foams.

Chlorpenesin is used in leave-on products in concentration 0.3% and in rinse off product up to 0.32% concentration.

Chlorpenesin is a useful ingredient in the world of cosmetics and personal care.

Chlorpenesin can be found in products such as sunscreens and toners.

Skin care:

Chlorpenesin is a great preservative that helps skin care products to last longer and thus have better quality.

The addition of Chlorpenesin also eliminates bad odor from the product.

Hair care:

Chlorpenesin is also added to hair care products because of its antimicrobial properties.

Chlorpenesin saves the products from negative side effects due to contact with oxygen and prevents the growth of bacteria and molds.

Consumer Uses:

Chlorphenesin is used in the following products: cosmetics and personal care products and perfumes and fragrances.

Other release to the environment of Chlorphenesin is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Widespread uses by professional workers:

Chlorphenesin is used in the following products: cosmetics and personal care products and pharmaceuticals.

Chlorphenesin is used in the following areas: health services.

Other release to the environment of Chlorphenesin is likely to occur from: indoor use as processing aid.

Uses at industrial sites:

Chlorphenesin is used in the following products: cosmetics and personal care products and perfumes and fragrances.

Chlorphenesin is used in the following areas: health services.

Chlorphenesin is used for the manufacture of: food products, textile, leather or fur.

Release to the environment of Chlorphenesin can occur from industrial use: in processing aids at industrial sites.

Origin of Chlorpenesin:

Chlorphenesin is made by the condensation of glycidol and p-chlorophenol in the presence of a catalyst such as a quaternary ammonium salt or a tertiary amine.

Handling and Storage of Chlorpenesin:

Handling:

Handle with care to avoid dust formation and inhalation.

Use appropriate equipment to minimize exposure.

Avoid contact with skin and eyes.

Ensure adequate ventilation in the workplace.

Storage:

Store in a cool, dry place away from direct sunlight and sources of ignition.

Keep containers tightly closed when not in use.

Store away from incompatible materials.

Stability and Reactivity of Chlorpenesin:

Stability:

Chlorphenesin is generally stable under recommended storage conditions.

Reactivity:

Avoid contact with strong acids or bases.

Chlorphenesin may react with strong oxidizing agents.

Decomposition may produce harmful fumes.

Safety profile of Chlorpenesin:

Chlorphenesin is safe for skin and hair when used within the prescribed percentages.

In both rinse-off and leave-on products, Chlorphenesin should not be used more than the concentration of 0.3% - Chlorphenesin can be harmful otherwise.

Chlorphenesin can have negative side effects such as irritation and allergic reactions on certain skin types.

A patch test before full application is highly recommended.

Further, limited data suggests no risks for application during pregnancy and breastfeeding.

First Aid Measures of Chlorpenesin:

Inhalation:

Move to fresh air immediately.

Seek medical attention if symptoms persist.

Skin Contact:

Wash affected area with plenty of soap and water.

Remove contaminated clothing.

Seek medical advice if irritation occurs.

Eye Contact:

Rinse eyes with water for at least 15 minutes.

Remove contact lenses if present.

Seek medical attention immediately.

Ingestion:

Do not induce vomiting.

Rinse mouth with water and seek medical attention immediately.

Fire-Fighting Measures of Chlorpenesin:

Extinguishing Media:

Use water spray, foam, dry chemical, or carbon dioxide (CO2) for extinguishing fires.

Fire Fighting Instructions:

Wear self-contained breathing apparatus and protective clothing to prevent exposure to toxic fumes.

Cool containers with water to prevent rupture in case of fire.

Accidental Release Measures of Chlorpenesin:

Personal Precautions:

Wear appropriate PPE including gloves and safety goggles.

Ensure adequate ventilation.

Environmental Precautions:

Avoid release into the environment.

Prevent further spillage if safe to do so.

Cleanup Methods:

Sweep up and place in a suitable container for disposal.

Clean affected area with appropriate cleaning agents.

Exposure Controls/Personal Protective Equipment of Chlorpenesin:

Exposure Limits:

Follow occupational exposure limits as specified by relevant regulations and guidelines.

Engineering Controls:

Use adequate ventilation systems to minimize exposure.

Ensure proper handling procedures are in place.

Personal Protective Equipment:

Respiratory Protection:

Use if airborne concentrations exceed exposure limits.

Hand Protection:

Wear appropriate gloves.

Eye Protection:

Use safety goggles or face shields.

Skin Protection:

Wear suitable protective clothing to prevent skin contact.

Identifiers of Chlorpenesin:

CAS Number: 104-29-0

Chem/IUPAC Name: 1,2-Propanediol, 3-(4-chlorophenoxy)-

EINECS/ELINCS No: 203-192-6

COSING REF No: 32667

Chemical Formula: C9H11ClO3

IUPAC Name: 4-chloro-2-hydroxyphenyl methyl ether

CAS Number: 104-29-0

EC / List no.: 203-192-6

CAS no.: 104-29-0

Mol. formula: C9H11ClO3

Properties of Chlorpenesin:

Melting point: 77-79°C

Boiling point: 290.96°C (rough estimate)

Density: 1.2411 (rough estimate)

Vapor pressure: 0Pa at 25℃

Refractive index: 1.5470 (estimate)

RTECS: TY4260000

Storage temp.: Sealed in dry,Room Temperature

Solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated)

Form: Solid

pka: 13.44±0.20(Predicted)

Color: White to Off-White

Water Solubility: Slightly soluble in water.

LogP: 1.23 at 23℃

CAS DataBase Reference: 104-29-0(CAS DataBase Reference)

NIST Chemistry Reference: 1,2-Propanediol, 3-(4-chlorophenoxy)-(104-29-0)

Physical State: Solid (usually found as a white to off-white crystalline powder)

Melting Point: Around 77-79°C (171-174°F)

Solubility: Slightly soluble in water, but soluble in organic solvents like alcohol and acetone

pH: Chlorphenesin's solutions are typically slightly acidic

Specifications of Chlorpenesin:

Appearance: White to off-white crystalline powder

Assay (Purity): Typically, 98-102% pure

Melting Point: 77-79°C

Loss on Drying: Generally ≤ 0.5%

Heavy Metals: Should meet standard limits, often ≤ 10 ppm

Identification: Should match the characteristics of Chlorphenesin as determined by methods like IR spectroscopy or HPLC

Names of Chlorpenesin:

Regulatory process names:

1,2-Propanediol, 3-(4-chlorophenoxy)-

1,2-Propanediol, 3-(4-chlorophenoxy)- (9CI)

1,2-Propanediol, 3-(p-chlorophenoxy)-

2-Chlorphenesin

3-(4-Chlorophenoxy)-1,2-propanediol

3-(p-Chlorophenoxy)-1,2-propanediol

3-(p-Chlorophenoxy)-propane-1,2-diol

Adermykon

Chlorophenesin

Chlorphenesin

Chlorphenesin

chlorphenesin

Chlorphenesine

Chlorphenesinum

Clorfenesina

Demykon

Gecophen

Glycerol alpha-p-chlorophenyl ether

Mycil

p-Chlorophenyl glyceryl ether

p-Chlorophenyl-alpha-glyceryl ether

IUPAC names:

1,2-propanediol, 3-(4-chlorophenoxy)-

3-(4-Chlorophenoxy)-1,2-propanediol

3-(4-Chlorophenoxy)-1,2-propanediole

3-(4-Chlorophenoxy)propane-1,2-diol

3-(4-chlorophenoxy)propane-1,2-diol

Chlorphenesin

chlorphenesin

Chlorphenesin

Trade names:

Cosvat

DEKABEN CP

Saliphenesin

Other identifiers:

104-29-0