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Chlorhexidine gluconate

Synonyms: Chlorhexidine gluconate, Chlorhexidine digluconate, CHX, CHG, CHDG, Chlorhexidine, Spectradyne, Chlorohexidine gluconate, Chlorohexidine digluconate
Chlorhexidine gluconate is a antiseptic skin cleanser for surgical scrubs, wounds, preoperative skin preparation, and germicidal hand rinses.
Chlorhexidine gluconate is a chemical that has been shown to decrease microbial flora on the skin and prevent infection risk in various settings, including as a skin preparatory agent for surgical procedures and insertion of vascular access devices, as a surgical hand scrub, and for oral hygiene.

Chlorhexidine Gluconate is a low-foaming, effective cationic cosmetic preservative. 

Chlorhexidine Gluconate is suitable for hand and body washes, cosmetics, and other personal care applications to provide antibacterial solid protection. 

Chlorhexidine Gluconate, wipes, rinse-off, leave-on, and oral products are used in baby care.

EC / List no.: 242-354-0

CAS no.: 18472-51-0

Chlorhexidine Gluconate is a potent bactericide that can be used in various personal care applications. 

Chlorhexidine Gluconate is extremely mild to the skin and is non-sensitizing. 

Chlorhexidine Gluconate is a broad-spectrum antimicrobial biguanide used as a topical antiseptic in dental practice to treat inflammatory dental conditions caused by microorganisms.

Chlorhexidine Gluconate is one of the most common skin and mucous membrane antiseptic agents today.

Topical Chlorhexidine Gluconate for disinfection and oral rinses for dental use carries activity against many pathogens, including bacteria, yeasts, and viruses.

Chlorhexidine gluconate oral rinse treats gingivitis (swelling, redness, bleeding gums).

Chlorhexidine gluconate oral rinse is not for treating all types of gingivitis. 

Chlorhexidine Gluconate, 20% Solution, is a broad-spectrum bacteriostatic antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative.

Chlorhexidine Gluconate 20% is effective against plaque oral flora, including Candida, and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. 

Chlorhexidine Gluconate can be used in antiseptic soap, a mouthwash that fights plaque, disinfect wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.

Chlorhexidine Gluconate is mainly available in OTC products to clean and prepare the skin before surgery and before injections to help reduce bacteria that potentially can cause skin infections. 

Surgical hand scrub: Chlorhexidine Gluconate significantly reduces the number of microorganisms on the hands and forearms before surgery or patient care
Healthcare personnel handwash: Chlorhexidine Gluconate  helps reduce bacteria that potentially can cause infection
Patient preoperative skin preparation: Chlorhexidine Gluconate is used for the preparation of the patient’s skin before surgery
Chlorhexidine Gluconate is applied for Skin wounds and general skin cleansing

These products are available as solutions, washes, sponges, swabs, and under many different brand names.

Chlorhexidine Gluconate Antiseptic Mouthwash is an antimicrobial solution that inhibits the formation of dental plaque. 

Chlorhexidine Gluconate Antiseptic Mouthwash is indicated as an aid in the treatment and prevention of gingivitis and in maintaining oral hygiene, particularly in situations where toothbrushing cannot be adequately employed (e.g., following oral surgery or in physically handicapped patients). 

Chlorhexidine Gluconate Antiseptic Mouthwash promotes gingival healing following periodontal surgery or manages recurrent oral ulceration. 

Additionally, Chlorhexidine Gluconate Antiseptic Mouthwash is helpful in the treatment of denture stomatitis and thrush.

Chlorhexidine gluconate is used to treat gingivitis, another name for mild gum disease. 

Chlorhexidine’s broad-spectrum antimicrobial effects are due to its ability to disrupt microbial cell membranes. 

The positively charged chlorhexidine gluconate molecule reacts with negatively charged phosphate groups on microbial cell surfaces. 
This reaction destroys the cell's integrity, allowing leakage of intracellular material, and provides chlorhexidine to enter the cell, causing precipitation of cytoplasmic components and, ultimately, cell death.

The specific means of cell death depends on chlorhexidine gluconate concentration - lower concentrations are bacteriostatic and result in leakage of intracellular substances such as potassium and phosphorous. 

In contrast, higher concentrations are bactericidal and cause cytoplasmic precipitation.7

How Does It Work?
When you rinse with chlorhexidine gluconate mouthwash, chlorhexidine destroys harmful mouth bacteria, even after you spit.

Are There Any Side Effects?
Chlorhexidine gluconate mouthwash has a few possible side effects, like a change in taste, increased tartar build-up, and staining of the teeth, gums, and dental appliances. Not to worry, though. 
These side effects are usually very minor.

While severe side effects of using medicated mouthwash are rare, some people can experience swollen neck glands and irritation in the mouth and tip of the tongue. Notify your dentist immediately if you experience any of these symptoms or believe you might be experiencing an allergic reaction to the mouthwash.

Is It Safe?
Only use chlorhexidine gluconate mouthwash if your physician or dentist prescribes it. Under the guidance of a healthcare professional, the product is safe when used as directed. 
According to C. S. Mott Children's Hospital, medicated mouthwash is not meant for anyone under 18 without your physician's clinical judgment, so keep it out of reach from young children.

Though chlorhexidine gluconate mouthwash effectively kills mouth bacteria in mild cases of gum disease, it's not a substitute for regular brushing and flossing for total oral health.

Regulatory process names
Chlorhexidine gluconate

D-gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

D-gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

D-gluconic acid, compound with N,N′′-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine(2:1) (CHDG)

N,N''-bis(4-Chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine digluconate

Translated names of Chlorhexidine gluconate:
5,5′-bis(4-chlorfenyl)-1,1′-(hexan-1,6-diyl)bis(biguanid)-bis(d-glukonát) (CHDG) (cs)

Acid D-gluconic, compus cu N,N′′-bis(4-clorofenil)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidină (2:1) (CHDG) (ro)

Acide D-gluconique, composé avec N,N″-bis(4-chlorophényl)-3,12-diimino-2,4,11,13-tétraazatétradécanediamidine (2:1) (CHDG) (fr)

Acido D-gluconico, composto con N,N′′- bis(4-clorofenil)-3,12-diimmino-2,4,11,13-tetraazatetradecanodiammidina (2:1) (CHDG) (it)

Aċidu D-glukonik ma' N,N′′-bis(4-klorofenil)-3,12-diimino-2,4,11,13-tetraażatetradekanediammidin (2:1) (CHDG) (mt)

D-glikonskābe, savienojums ar N,N′′-bis(4-hlorfenil)-3,12-diimino-2,4,11,13-tetraazatetradekāndiamidīnu (2:1) (CHDG) (lv)

D-gliukono rūgšties ir N,N′′-bis(4-chlorfenil)-3,12-diimino-2,4,11,13- tetraazatetradekandiamidino junginys (2:1) (CHDG) (lt)

D-gluconic acid, compound with N,N′′-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1) (CHDG) (no)

D-gluconsyre, forbindelse med N,N″-bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1) (CHDG) (da)

D-Gluconsäure, Verbindung mit N,N′′-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1) (CHDG)) (de)

D-gluconzuur, verbinding met N,N′′-bis(4-chloorfenyl)-3,12-diimino-2,4,11,13-tetraazatetradecaandiamidine (2:1) (CHDG) (nl)

D-glukonihappo, yhdiste N,N′′-bis(4-kloorifenyyli)-3,12-di-imino-2,4,11,13-tetra-atsatetradekaanidiamidiinin kanssa (2:1) (CHDG) (fi)

D-glukonsav reakcióterméke N,N′′-bisz(4-klórfenil)-3,12-diimino-2,4,11,13-tetraaza-tetradekán-diamidinnel (2:1) (CHDG) (hu)

D-glukonska kiselina, spoj s N,N′′-bis(4-klorofenil)-3,12-diimino-2,4,11,13-tetraazatetradekandiamidinom (2:1) (CHDG) (hr)

D-glukonska kislina, spojina z N,N''-bis(4-klorofenil)-3,12-diimino-2,4,11,13-tetraazatetradekandiamidinom (2:1) (CHDG) (sl)

D-glukonsyra, förening med N,N′′-bis(4-klorofenyl)-3,12-diimino-2,4,11,13-tetraazatetradekandiamidin (2:1) (CHDG) (sv)

D-glükoonhappe ja N,N′′-bis(4-klorofenüül)-3,12-diimino-2,4,11,13-tetraasatetradekaandiamidiini ühend (2:1) (CHDG) (et)

D-глюконова киселина, свързана с N,N′′-бис(4-хлорофенил)-3,12-диимино-2,4,11,13-тетраазатетрадекандиамидин (2:1) (CHDG) (bg)

Kwas d-glukonowy, związek z N,N″- bis(4-chlorofenylo)-3,12-diimino- 2,4,11,13-tetraazatetradekanodiamidyną (2:1) (CHDG) (pl)

kyselina D-glukónová, zlúčenina s N,N′′-bis(4-chlórfenyl)-3,12-diimino-2,4,11,13-tetraazatetradekánbis(amidimidom) (2:1) (CHDG) (sk)

Ácido D-glucónico, composto com N,N′′-bis(4-clorofenil)-3,12-diimino-2,4,11,13-tetrazatetradecanodiamidina (2:1) (CHDG) (pt)

Ácido D-glucónico, compuesto con N,N′′-bis(4-clorofenil)-3,12-diimino-2,4,11,13-tetraazatetradecanodiamidina (2:1) (CHDG) (es)

Ένωση D-γλυκονικού οξέος με N,N′′-δις(4-χλωροφαινυλο)-3,12-διιμινο-2,4,11,13-τετραζαδεκατετρανοδιαμιδίνη (2:1) (CHDG) (el)

IUPAC names

(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid

(1E)-2-[6-[[amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid

1,1′-(hexane-1,6-diyl)bis[5-(4-chlorophenyl)biguanide] di-d-gluconate

bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid); N-(4-chlorophenyl)-1-3-(6-{N-[3-(4-chlorophenyl)carbamimidamidomethanimidoyl]amino}hexyl)carbamimidamidomethanimidamide

Chlorhexidin digluconat

Chlorhexidine gluconate

Chlorhexidine gluconate solution

Chlorohexidine gluconate 20% (CHG)

Clariant product trade name: Vivhex-G

D-Gluconic acid, compd. with N1,N14-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)

D-Gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

D-gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

D-gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)

N',N'''''-hexane-1,6-diylbis[N-(4-chlorophenyl)(imidodicarbonimidic diamide)] - D-gluconic acid (1:2)

N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiimidamid compound with D-Gluconic acid (1:2)


Trade names

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