Although many organic carbonates are produced using phosgene, propylene and ethylene carbonates are exceptions. They are mainly prepared by the carbonation of the epoxides[4] (epoxypropane, or propylene oxide here):
CH3CHCH2O + CO2 → CH3C2H3O2CO
The process is particularly attractive since the production of these epoxides consumes carbon dioxide. Thus this reaction is a good example of a green process. The corresponding reaction of 1,2-propanediol with phosgene is complex, yielding not only propylene carbonate but also oligomeric products.
Propylene carbonate can also be synthesized from urea and propylene glycol over zinc acetate.
Applications
As a solvent
Propylene carbonate is used as a polar, aprotic solvent. It has a high molecular dipole moment (4.9 D), considerably higher than those of acetone (2.91 D) and ethyl acetate (1.78 D). It is possible, for example, to obtain potassium, sodium, and other alkali metals by electrolysis of their chlorides and other salts dissolved in propylene carbonate.
Due to its high dielectric constant of 64, it is frequently used as a high-permittivity component of electrolytes in lithium batteries, usually together with a low-viscosity solvent (e.g. dimethoxyethane). Its high polarity allows it to create an effective solvation shell around lithium ions, thereby creating a conductive electrolyte. However, it is not used in lithium-ion batteries due to its destructive effect on graphite
Propylene carbonate can also be found in some adhesives, paint strippers, and in cosmetics.[9] It is also used as plasticizer. Propylene carbonate is also used as a solvent for removal of CO2 from natural gas and synthesis gas where H2S is not also present. This use was developed by El Paso Natural Gas Company and Fluor Corporation in the 1950s for use at the Terrell County Gas Plant in West Texas, now owned by Occidental Petroleum.
Other
Propylene carbonate product may be converted to other carbonate esters by transesterification as well (see Carbonate ester#Carbonate transesterification).
In electrospray ionization mass spectrometry, propylene carbonate is doped into low surface tension solutions to increase analyte charging.
In Grignard reaction propylene carbonate (or most other carbonate ester) might be used to create tertiary alcohols.
Safety
Clinical studies indicate that propylene carbonate does not cause skin irritation or sensitization when used in cosmetic preparations, whereas moderate skin irritation is observed when used undiluted. No significant toxic effects were observed in rats fed propylene carbonate, exposed to the vapor, or exposed to the undiluted liquid. In the US, propylene carbonate is not regulated as a volatile organic compound (VOC) because it does not contribute significantly to the formation of smog and because its vapor is not known or suspected to cause cancer or other toxic effects.
Properties
Related Categories Alternative Energy, Anhydrous Solvents, Electrolytes, Lithium-Ion Batteries, Materials Science,
Organic Solvents, Solvent Bottles, Solvent Packaging Options, Solvent by Application, Solvents, Solvents & Additives, Sure/Seal Bottles
Less...
Quality Level 100
grade anhydrous
vapor pressure 0.13 mmHg ( 20 °C)
0.98 mmHg ( 50 °C)
assay 99.7%
autoignition temp. 851 °F
expl. lim. 14.3 %
impurities <0.002% water
<0.005% water (100 mL pkg)
refractive index n20/D 1.421 (lit.)
bp 240 °C (lit.)
mp -55 °C (lit.)
density 1.204 g/mL at 25 °C (lit.)
SMILES string CC1COC(=O)O1
InChI 1S/C4H6O3/c1-3-2-6-4(5)7-3/h3H,2H2,1H3
InChI key RUOJZAUFBMNUDX-UHFFFAOYSA-N
Propylene carbonate can be synthesized from propylene oxide and CO2. Optically active form of propylene carbonate can be prepared from the reaction between CO2 and racemic epoxides. Decomposition of propylene carbonate on the graphite electrode in lithium batteries results in the formation of a lithium intercalated compound.
Propylene carbonate is a cyclic carbonate that is commonly used as a solvent and as a reactive intermediate in organic synthesis. It is being considered as a potential electrochemical solvent due to its low vapor pressure, high dielectric constant and high chemical stability.
Application
Propylene carbonate may be used as a solvent for the asymmetric hydrogenation of nonfunctionalized olefins.
Propylene carbonate (PC) is a VOC-exempt* clear polar solvent having high boiling and
flash points, a low order of toxicity and a mild ether-like odor. It is stable under most
conditions and is not hydroscopic or corrosive. is particularly well suited for applications
requiring a water white product or high purity. Examples would be cosmetics, electronics
or where recycling of spent material will occur.
Product
Identification
Chemical Name Dioxolanone
Chemical Family Organic Carbonate
Other Names 3-dioxolan-2-one 4-methyl-1
Chemical Formula C4H6O3
Propylene carbonate is a cyclic carbonate that reacts with amines to form carbamates,
undergoes hydroxy alkylation and transesterification. It can be used as an isocyanate and
unsaturated polyester resin cleanup solvent, viscosity reducer in coatings, CO2 extraction
solvent, electrolyte in lithium batteries, polar additive for clay gellants, foundry binder
catalyst, and textile dye carrier and cleaner.
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
is a PU-plasticizer. It is VOC-free clear polar solvent having high boiling and flashpoints.
Propylene Carbonate (PC) is a carbonate ester derived from propylene glycol with the peculiarity to have a low order of toxicity and a mild ether-like odor.
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000) is stable under most conditions and it is not hydroscopic or corrosive.
It is particularly well suited for applications requiring a water-white product or high purity.
It can be used in cosmetics and personal care products; mainly in the formulation of make-up, primarily lipstick, eye shadow, and mascara, as well as in skin cleansing products.
Propylene Carbonate (PC) being a cyclic carbonate reacts with amines to form carbamates, undergoes hydroxy alkylation and transesterification can be used as an isocyanate and unsaturated polyester resin cleanup solvent, viscosity reducer in coatings, CO2 extraction solvent, electrolyte in lithium batteries, polar additive for clay gellants, foundry binder catalyst, and textile dye carrier and cleaner.
Under proper storage conditions the shelf life is 12 months.
Positive control:
Negative controls
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000) for the matrix blood, inactivated controls (=negative controls) were included to demonstrate that hydrolysis of the test item was due to specific in vitro metabolism instead of general chemical instability. In the respective negative controls, test item concentration was 1 mM (n=3). The reference item ethylene carbonate was tested at 1 mM (n=3). Negative control samples were prepared using inactive matrix. For blood, the negative controls were inactivated by addition of TCA containing precipitation reagent before the addition of test item to the incubate. After 0 and 30 minutes, respectively, the corresponding samples
were processed for LC-MS analysis.
Buffer control
In addition, potassium phosphate buffer was used as control matrix to exclude non-metabolic degradation processes; i.e. the finding that the concentrations remained stable over the investigated time suggests that the decrease of the parent compound wase mainly due to specific/enzymatic in vitro metabolism. Potassium buffer samples were generated by spiking 198 μl potassium phosphate buffer (100 mM, pH 7.4) with 2 μl test item/reference item working solutions. The resulting start concentrations were 1 mM. After 0 and 30 minutes, the samples were processed for LC-MS analysis.
Details on study design:
The Wistar rat blood applied in the in vitro experiments reported herein is intended to represent the central compartiment of an organism which contains significant amounts of metabolizing enzymes, i.e. hydrolases. These are proposed to metabolize ester compounds such as the test item propylene carbonate and the reference ethylene carbonate.
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
and the reference ethylene carbonate were tested at a concentration of 1 mM in blood. Sampling time points were selected in order to allow the calculation of an in vitro half-life value, i.e. 0 min, 0.5 min, 1 min, 5 min and 30 min. The incubation solutions (n=3 per test condition) were prepared by adding 2 μl of the 100-fold concentrated working solution to 198 μl of pre-incubated assay matrix (15 min preincubation at 37 °C) resulting in an incubation concentration of 1 mM (test and reference items) with a final solvent concentration of 0.75% solvent. Incubations were conducted at 37°C on a horizontal shaker at 650 rpm. After the respective incubation time the corresponding samples were chemically inactivated by addition of TCA containing protein precipitation reagent (+ internal standard).
The precipitation reagent consisted of water supplemented with trichloro acetic acid and internal standard. (The precipitation reagent for PG/EG with 400 μM ISTD PC-d6/EC-d4 was prepared as follows: TCA (8%) in water: e.g. 20 ml water + 1600 mg trichloro acetic acid (TCA) + 800 μl internal standard stock solution (10 mM). The precipitation reagent for blank samples was TCA (8%) in water: 10 ml water + 800 mg trichloro acetic acid (TCA)). The complete in vitro sample volume (200 μl) containing the test item /reference item after incubation with blood or phosphate buffer were mixed with 200 μl precipitation reagent supplemented with ISTD, vortexmixed for 10 second. After a centrifugation step (e.g. 4000 rpm in centrifuge Eppendorf 5417C or equivalent, for 10 minutes) the supernatant was transferred to a 96 well plate for LC-MS analysis.
In a second step the amount of hydrolysis products propylene glycol and ethylene glycol, respectively, were quantified.
Details on dosing and sampling:
Preparation of calibration standards and quality control samples for glycol analysis
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
Stock solutions of PG and EG are prepared in water (each 15 mM). Separate stocks are prepared for calibrators and QCs, respectively. The working solutions for spiking the matrix were prepared in water at the concentrations 15 mM, 10 mM, 8 mM, 5.33 mM, 4 mM, 2.67 mM, 1.33 mM (for calibrators) and 8mM, 5.33 and 4mM (for quality control samples). The resulting nominal concentrations of the calibrators were 1800, 1200, 960, 640, 480, 320 and 160 nM, the nominal concentrations of the QC samples were 960, 640 and 480 nM. For the preparation of the sample 88 μl matrix was precipitated with 100 μl precipitation reagent with ISTD and immediately vortexed for 10 seconds. Afterwards 12 μl of the corresponding working solution was added and the samples briefly shaken. After a centrifugation step (e.g. 4000 rpm in centrifuge Eppendorf 5417C or equivalent, for 10 minutes) the supernatant was transferred to a 96 well plate for LC-MS analysis. (The precipitation reagent for PG/EG with 400 μM ISTD PC-d6/EC-d4 was prepared as follows: TCA (8%) in water: e.g. 20 ml water + 1600 mg trichloro acetic acid (TCA) + 800 μl internal standard stock solution (10 mM). The precipitation reagent for blank samples was TCA (8%) in water: 10 ml water + 800 mg trichloro acetic acid (TCA)).
LC-MS for glycol analysis (for both PG and EG)
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
The analysis was performed under isocratic HPLC conditions using 10 % buffer 1 and 90 % buffer 2. Chromatographic run time is 4 min per injection.
The HPLC column was a Luna (Phenomenex), 150 x 4.6 mm, 3 μm. The HPLC flow rate was 900 μl/min. The column is operated at room temperature. Buffer 1 (organic) was acetonitrile, buffer 2 (aqueous) was water + NaCl (10 mg/l). Autosampler wash solvent 1 was Ethanol /Water (5+95, v/v), autosampler wash solvent 2 was Isopropanol / Water (1+1, v/v). The sample injection volume was 20 μl.
In addition, negative control incubates were performed to exclude non-metabolic degradation processes; i.e. the finding that the concentrations remained stable over the investigated time suggests that the decrease of the parent compound is mainly due to hydrolytically active ingredients of blood. Negative controls were blood samples that were chemically inactivated blood samples (using trichloroacetic acid containing reagent) before
the incubation with the test item propylene carbonate and the reference item ethylene carbonate. Potassium phosphate buffer served as additional control matrix to show that any hydrolysis observed with the biorelevant test matrix blood is due to metabolic hydrolytic activity.
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
A positive control known for hydrolysis in Wistar rat blood was included in the assay set up in order to demonstrate the suitability of the test systems. As positive control for blood incubations ethylene carbonate was tested at 1 mM, respectively.
Statistics:
-The statistical parameters comprised:
Mean: Calculated with MS Excel 2007, function MITTELWERT
SD: Calculated with MS Excel 2007, function STANDARDABWEICHUNG
The numbers displayed in the result tables are rounded.
%CV: Mean of SD x 100 / Mean (coefficient of variation)
Intraday precision: %CV calculated from the 4-fold samples of each QC level
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
Current research efforts in the field of poly(propylene carbonate) prepared from carbon dioxide and propylene oxide are reviewed. Interest in the polymer has been revived in light of the current discussion on sustainability and biodegradability. The progress in understanding and increasing the activity of heterogeneous zinc catalysts is steadily increasing, but without a quantum leap. The microstructure, the properties of the melt, and the solid material are given. The material property profile can be expanded through the synthesis of terpolymers based on propylene oxide, carbon dioxide and other epoxides, lactones or anhydrides etc. with the same catalyst; or the preparation of poly(propylene carbonate) blends with biodegradable or biocompatible components like calcium carbonate, wood flour, fibers, or other biodegradable polymers.
Propylene Carbonate is a nonviscous, clear liquid that is used in cosmetic
products at concentrations ranging from 5 0.1 */o to 5%. Undiluted Propylene
Carbonate produced minimal to moderate ocular irritation and slight erythema in rabbits. The dermal LO," in rabbits of the undiluted ingredient was
>20 mllkg. Undiluted Propylene Carbonate was nontoxic by inhalation to
dogs and guinea pigs in a 21-day study. Propylene Carbonate was negative for
mutagenicity in the Ames Assay, and negative for genotoxicity in the Rat Hepatocyte Primary Culture/DNA Repair Test. In clinical studies, undiluted
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000) caused moderate skin irritation, whereas 5 and 10% Propylene Carbonate in aqueous solution produced no skin irritation or sensitization. Cosmetic products containing up to 20% Propylene Carbonate were essentially nonsensitizing and, at most, moderately irritating to human skin, nonphototoxic, and nonphotosensitizing. It is concluded that Propylene Carbonate is safe as a cosmetic ingredient in the present practices of use and concentration.
The invention relates to a process for the preparation of propylene carbonate, which process involves contacting propylene oxide with carbon dioxide at a temperature of from 150° C. to 250° C. in the presence of a recycled tetraalkylphosphonium bromide catalyst.
Propylene carbonate eş anlamlıları: 108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
İzosiyanatlar ile uyumlu, yapıştırıcı, üretan kaplama ve elastomerlerde uygulama özelliklerini iyileştirmek için kullanılır.
Kaynama Noktası, °C 242
Parlama Noktası, °C 135
Yoğunluk (Kg/Litre) 1,198.Propilen Karbonat (PC) CAS NO: 108-32-7
Propilen Karbonat renksiz şeffaf bir sıvıdır. Suda ve karbon tetraklorürde kayganlaştırılabilir ve iyi karıştırılmış ve çözülmüş olabilir. Propilen karbonat, petro-gaz, petrol sahası gazı ve petrol piroliz gazında ve aynı zamanda sentez besleme gazında dekarbonasyonu kaldırmak için bir çözücü olarak yaygın şekilde kullanılabilir.Propilen Karbonat (PC)
Açıklama: Propilen Karbonat
Fiziksel ve Kimyasal Özellik: Uçucu olmayan madde içermeyen şeffaf sıvı.
Moleküler Formül: C4H6O3
CAS Numarası: 108-32-7
ÖZELLİKLER
SAFLIK %99,5 MIN
NEM %0.2 MAX
RENK APHA-30 MAX
250KG / Yeni Demir Tamburda Paketlenmiştir; 20'FCL = 20MT
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
Uygulama: 1) Elektronik Sanayi: Propilen Karbonat, yüksek enerji hücrelerinde ve kondenserlerde iyi dielektrik olarak kullanılabilir.
2) Macromolekül Endüstrisi: Propilen Karbonat, polimerler için çözücü ve plastikleştirici olarak kullanılabilir.
3) Kimya Endüstrisi: Propilen Karbonat, Dimetil Karbonat'ın ana maddesi olarak kullanılabilir ve doğal gazdan, petrol gazı çatlayan gazından CO2 ve H2S'nin uzaklaştırılmasında yaygın olarak kullanılır.
4) Diğer alanlar: Propilen Karbonat tekstil ve baskı ve boya endüstrisinde de kullanılabilir.
Depolama ve taşıma: Propilen Karbonat yanıcıdır. Oksidasyona maruz kalırsa yanacaktır. Serin ve rüzgarlı, özel bir depoda yangından uzakta depolanmalı ve yanıcı bir kimyasal ürün olarak taşınmalıdır.
Propilen karbonat (genellikle kısaltılan PC ) bir bir organik bileşiğin , formül CH 3 Cı- 2 , H 3 O 2 CO. Bu a, karbonat esteri elde edilen propilen glikol . Bu, renksiz ve kokusuz sıvı olarak faydalıdır polar , aprotik çözücü . Propilen karbonat kiral ama özel olarak kullanılan rasemik bir karışım.
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
Hazırlık
Birçok organik karbonatlar kullanılarak üretilir, ancak fosgen , propilen ve etilen karbonatlar istisnalar vardır. Bunlar ağırlıklı olarak hazırlanır gazlı epoksitleri (epoksipropan, ya da propilen oksit var):
CH 3 CHCH 2 O + CO 2 CH → 3 C 2 H 3 O 2 CO
Bu epoksitler üretimi karbondioksit kullandığı için yöntem özellikle çekicidir. Bu nedenle, bu reaksiyon, bir yeşil işleminin iyi bir örnektir. Karşılık gelen reaksiyon 1,2-propandiol fosgen ile propilen karbonat değil, aynı zamanda oligomerik ürünleri sadece elde karmaşıktır.
Propilen karbonat da sentezlenebilir üre ve propilen glikol üzerinde çinko asetat .
Bir çözücü olarak
Propilen karbonat polar olarak kullanıldığında, aprotik çözücü. Bu yüksek olan bir moleküler dipol momenti (4.9 D göre daha önemli ölçüde daha yüksek), aseton (2.91 D ) ve etil asetat (1.78 D ). Bu elde etmek üzere, örneğin, mümkün olan potasyum , sodyum , ve diğer alkali metaller ile elektroliz bunların arasında klorürler ve propilen karbonat içinde çözülmüştür diğer tuzlar.
64, yüksek dielektrik sabiti nedeniyle, sık sık, bir yüksek olarak kullanılan geçirgenlik bileşeni elektrolit içinde lityum pilleri (örneğin, düşük viskoziteli bir çözücü ile genellikle birlikte, dimetoksietan ). Bu yüksek polariteye sahip bir etkin oluşturmak için olanak çözme ve böylece iletken oluşturma, lityum iyonları çevresinde bir kabuk elektrolit . Bununla birlikte, bu kullanılmaz lityum iyon pil nedeniyle üzerindeki yıkıcı etkisinden grafit .
Propilen karbonat bazı bulunabilir yapıştırıcı , boya sökücü , ve kozmetik . Ayrıca olarak kullanılır plastikleştirici . Propilen karbonat, aynı zamanda CO çıkarılması için bir çözücü olarak kullanılan 2 H, doğal gaz ve sentez gazından 2 S aynı zamanda mevcut değildir. Bu kullanım El Paso Doğalgaz Şirketi tarafından geliştirilen Fluor Corporation, şimdi Occidental Petroleum ait Batı Teksas Terrell İlçe Gaz Santrali, kullanılmak üzere 1950'li yıllarda.
Diğer
Propilen karbonat ürünü, diğer karbonat esterler dönüştürülebilir transesterifikasyon (bakınız ayrıca karbonat esteri # Karbonat edilmiş transesterleştirme ).
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
Gelen elektrosprey iyonizasyon kütle spektrometresi, propilen karbonat analit şarj artırmak için düşük yüzey gerilmeli eriyikler halinde sertleştirilmektedir.
Emniyet
Klinik çalışmalar, kozmetik preparasyonlar kullanıldığında seyreltilmemiş kullanıldığında orta cilt iritasyonu gözlemlenmektedir propilen karbonat, cilt tahrişine veya hassasiyete neden olmadığını göstermektedir. Önemli bir toksik etki buharına maruz kalan, propilen karbonat beslenen sıçanlarda, veya seyreltilmemiş sıvı maruz bırakılmıştır. ABD'de, propilen karbonat olarak düzenlenmemiştir uçucu organik bileşik bu oluşumuna önemli ölçüde katkıda bulunmaz, çünkü (VOC) sis ve buhar bilinen ya da kanser ya da diğer toksik etkilere neden olduğundan şüphelenilen değildir.
Propylene carbonate (108-32-7; 4-Methyl-1,3-dioxolan-2-one; 1,2-Propylene carbonate; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl-; Cyclic propylene carbonate; Texacar PC; Arconate 5000; 1,2-Propanediol carbonate; 1-Methylethylene carbonate; Cyclic 1,2-propylene carbonate; Dipropylene carbonate; 1,2-Propanediyl carbonate; 4-Methyldioxalone-2; Propylene glycol cyclic carbonate; Cyclic methylethylene carbonate; 4-Methyl-2-oxo-1,3-dioxolane; Carbonic acid, propylene ester; Carbonic acid, cyclic propylene ester; NSC 11784; Propylenester kyseliny uhlicite; Carbonic acid cyclic methylethylene ester; HSDB 6806; EINECS 203-572-1; Propylene carbonate [NF]; Carbonic acid, cyclic propylene ether; propylenester kyseliny uhlicite [Czech]; BRN 0107913; AI3-19724; 4-methyl-1,3-dioxolane-2-one; Propylene carbonate (NF); WLN: T5OVOTJ D; DSSTox_CID_6789; DSSTox_RID_78214; DSSTox_GSID_26789; Propylene carbonate, 99.5%; CAS-108-32-7; PC-HP; Propylene carbonate, 99.5%, anhydrous, AcroSeal(R); Propylene carbonate [USAN]; Solvenon PC; propylen carbonate; MFCD00005385; Carbonic acid propylene; ACMC-209dtm; ACMC-20aj2f; Arconate propylene carbonate; EC 203-572-1; ACMC-1C29L; SCHEMBL15309; 5-19-04-00021 (Beilstein Handbook Reference); KSC492E8H; CHEMBL1733973; DTXSID2026789; 2-Oxo-4-methyl-1,3-dioxolane; CTK3J2283; 1,2-PDC; 4-methyl-[1,3]dioxolan-2-one; NSC1913; NSC-1913; NSC11784; Tox21_202047; Tox21_303214; ANW-15928; BBL027518; MFCD00798265; NSC-11784; STL373011; AKOS009158417; MCULE-9055336051; Propylene Carbonate (Industrial Grade); VC30366; Propylene carbonate, anhydrous, 99.7%; NCGC00165974-01; NCGC00165974-02; NCGC00256995-01; NCGC00259596-01; Propylene carbonate, for HPLC, 99.7%; AK109386; AK688454; BP-30108; LS-51953; O433; SC-65189; SY008770; DB-018081; Propylene carbonate, ReagentPlus(R), 99%; CS-0076373; FT-0602265; FT-0639979; FT-0660009; FT-0674103; NS00004305; P0525; D05633; 23262-EP2269986A1; 23262-EP2274983A1; 23262-EP2284165A1; 23262-EP2292593A2; 23262-EP2295399A2; 23262-EP2308858A1; PROPYLENE CARBONATE;Cyclic propylene carbonate; Propylene carbonate, Selectophore(TM), >=99.0%; Propylene carbonate, Vetec(TM) reagent grade, 98%; F0001-0165; Propylene carbonate, >=99%, acid <10 ppm, H2O <10 ppm; Propylene carbonate, United States Pharmacopeia (USP) Reference Standard; carbonate de propylène; 1, 3-Dioxolan-2-one, 4-methyl-; 1,2-Propanediol cyclic carbonate; 1,3-Dioxolan-2-one, 4-methyl- [ACD/Index Name]; 4-Methyl-1,3-dioxol-2-one [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-on [German] [ACD/IUPAC Name]; 4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; 4-Méthyl-1,3-dioxolan-2-one [French] [ACD/IUPAC Name]; 4-Methyl-2-oxo-1,3-dioxolane; 8D08K3S51; Arconate 1000; Carbonic acid cyclic 1,2-propylene ester; Carbonic acid, cyclic propylene ether; Cyclic propylene carbonate; FF9650000; Jeffsol PC; MFCD00005385 [MDL number]; PC; PC-HP; Propylene glycol cyclic carbonate; UNII:8D08K3S51E; (4S)-4-Methyl-1,3-dioxolan-2-one [ACD/IUPAC Name]; (R)-4-Methyl-1,3-dioxolan-2-one; (S)-4-Methyl-1,3-dioxolan-2-one; 1,2-PDC; 1,2-PROPANEDIOL CARBONATE; 1,2-Propanediyl carbonate; 1,2-PROPYLENE CARBONATE; 1,2-Propylene glycol carbonate; 1,2-Propylene-d6 Carbonate; 1-Methylethylene carbonate; 2-Oxo-4-methyl-1,3-dioxolane; 4-METHYL-1,3-DIOXOLANE-2-ONE; Arconate 5000; Arconate propylene carbonate; Carbonic acid cyclic methylethylene ester; Carbonic acid, cyclic propylene ester; Carbonic acid, propylene ester; CYCLIC 1,2-PROPYLENE CARBONATE; Cyclic methylethylene carbonate; Dipropylene carbonate; MFCD00798264 [MDL number]; MFCD00798265 [MDL number]; Propylene Carbonate (Industrial Grade); propylene carbonate [pc]; propylene carbonate 99%; propylene carbonate 99.5%; propylene carbonate, 99%; propylene carbonate, 99%,; propylene carbonate, 99.5%; propylene carbonate, 99.5%, anhydrous, acroseal??; propylene carbonate, reagent; propylene carbonate 99%, hydry, water 50 ppm (by k.f.); propylenecarbonate; Propylenester kyseliny uhlicite [Czech]; Propylenester kyseliny uhlicite; Solvenon PC; Texacar PC; WLN: T5OVOTJ D, propilen karbonat, propilen ester, propilenester, propandil karbonat, propilen glikol, 4-metil-1,4-dioksolan, diogzolan, diokzolan, arkonat 5000)
