EC / List no.: 205-286-2

CAS no.: 137-26-8

Mol. formula: C6H12N2S4

Molecular Formula: C6H12N2S4

(CH3)2N-CS-S-S-CS-N(CH3)2

Synonym(s) of TMTD: Tetramethylthiuram disulfide, Bis(dimethylthiocarbamoyl) disulfide, Bis(dimethylthiocarbamyl) disulfide, Thiram

Preferred IUPAC name: Dimethylcarbamothioic dithioperoxyanhydride

Chemical formula: C6H12N2S4

Molar mass: 240.42 g·mol−1

Appearance: White to yellow crystalline powder or flake

Odor: Characteristic[vague]

Melting point: 155 to 156 °C (311 to 313 °F; 428 to 429 K)

Boiling point: decomposes

Solubility in water: 30 mg/L

Vapor pressure: 0.000008 mmHg (20 °C)

Chemical properties of TMTD:

Tetramethylthiuram disulfide is a type of sulfur fungicide. 

Tetramethylthiuram disulfide has been found to dissolve entirely in chloroform, acetone, and ether. 

Tetramethylthiuram disulfide is available as dust, flowable, wettable powder, water-dispersible granules, and water suspension formulations and in mixtures with other fungicides.

TMTD is of low to moderate persistence. 

TMTD: Formula, C6H12N2S4; MW, 240.44; MP, 155–156°C; BP, 129°C (at 20 mm Hg); log P, 1.73; VP, 1.73E-05 mm Hg; solubility in H2O, 30 mg/l; other solubilities (g/l at 25°C): ethanol < 10, acetone 80, chloroform 230, and hexane 0.04; (g/l at 20°C) dichloromethane 170, toluene 18, and isopropanol 0.7

TMTD is only slightly soluble in water (30 mg l−1) and has a strong tendency to adsorb to soil particles, and thus is not expected to contaminate groundwater. 

The soil half-life for TMTD is reported to be 15 days. TMTD degrades more readily in acidic soils and soils high in organic matter. 

TMTD has been shown to persist for up to 2 months in sandy soil but disappeared within 1 week from compost soil. 

The significant metabolites of TMTD in soil are copper dimethyldithiocarbamates, dithiocarbamate, dimethylamine, and carbon disulfide. 

TMTD can be degraded in soil by microbial action or hydrolysis under acidic conditions. 

TMTD is rapidly broken down in water by hydrolysis and photodegradation, especially under acidic conditions.

Uses of TMTD:

1. TMTD belongs to protective fungicides of broad spectrum, with a residual effect period of up to 7d or so. 

It is mainly used for dealing with seeds and soil and preventing powdery mildew, smut, and rice seedlings damping off of cereal crops. 

It can also be used for some fruit trees and vegetable diseases. 

For example, dressing seed with 500g of 50% wettable powder can control rice blast, leaf spot, barley, and wheat smut.

2. As a pesticide, Tetramethylthiuram Disulfide is often called TMTD. 

TMTD is mainly used to treat seeds and soil and to prevent and control cereal powdery mildew, smut, and vegetable diseases. 

As the super accelerator of natural rubber, synthetic rubber, and latex, this product is often called accelerator TMTD. 

Thiram (TMTD) represents a thiuram vulcanization accelerator, accounting for 85% of the total amount of similar products. 

Thiram (TMTD) is also the super accelerator of natural rubber, diene synthetic rubber, Ⅱ, R, and EPDM, with the highest utilization rate. 

The vulcanization-promoting force of Tetramethylthiuram Disulfide (TMTD) is powerful but not vulcanized without zinc oxide.

3. TMTD is used to manufacture cables, wires, tires, and other rubber products.

4. TMTD is the super accelerator of natural, synthetic, and latex rubber.

5. TMTD is used as the late effect promoter of natural rubber, butadiene rubber, styrene-butadiene rubber, and polyisoprene rubber.

6. TMTD is used for the pest control of rice, wheat, tobacco, sugar beet, grapes, and other crops, as well as for seed dressing and soil treatment.

7. TMTD is suitable for manufacturing natural rubber, synthetic rubber, and latex and can be used as a curing agent. 

TMTD is the second accelerator of thiazole accelerators, which can be used as the continuous vulcanization accelerator with other accelerators.

8. TMTD (Tetramethylthiuram Disulfide) can be used as the super-vulcanization accelerator in the rubber industry and is often used with a thiazole accelerator. 

TMTD can also be combined with other accelerators as the continuous rubber accelerator. 

TMTD can also be used as a curing agent for slowly decomposing out of free sulfur at more than 100 ℃. 

Its products have excellent resistance to aging and heat, so it applies to natural and synthetic rubber. 

TMTD mainly manufactures tires, tubes, shoes, cables, and other industrial products. 

In agriculture, TMTD can be used as a fungicide and insecticide, and it can also be used as a lubricant additive.

9.  Production methods from dimethylamine, carbon disulfide, ammonia condensation reaction was dimethyl dithiocarbamate and then the oxidation of hydrogen peroxide to the finished product.

IUPAC names

[disulfanediylbis(carbonothioylnitrilo)]tetramethan

[disulfanediylbis(carbonothioylnitrilo)]tetramethane

Bis(dimethylthiocarbamoyl) disulfide

bis(dimethylthiocarbamoyl) disulfide

Bis(dimethylthiocarbamoyl)disulfide

dimethylcarbamothioylsulfanyl N,N-dimethylcarbamodithioate

N,N,N',N'-tetramethyl-Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2)

N,N-diethylcarbamodithioate

N,N-dimethyl[(dimethylcarbamothioyl)disulfanyl]carbothioamide

Tetramethylthiuram Disulfide

tetramethylthiuram disulfide

Tetramethylthiuram disulphide

tetramethylthiuram disulphide

Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetramethyl-

Thioperoxydicarbonic diamide, tetramethyl-

Thiram

thiram

Thiram

thiram (ISO)

UPV

Trade names

MAT77 B

Thiram P

Registration dossier