Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. 

Climbazole has shown a high in vitro and in vivo efficacy against Malassezia spp. that appear to play an important role in the pathogenesis of dandruff.

Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole.

Indications and formulations

Climbazole is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. 

Climbazole may be accompanied by other active ingredients such as zinc pyrithione or triclosan.

CAS Number: 38083-17-9 

EINECS : 253-775-4

Formula: C15H17ClN2O2

Molar mass: 292.76 g·mol−1

Melting point: 94 – 98 °C

Vapour pressure: 0.001 Pa (50°) < 0.1 mbar (80 °)

Density: 580 kg/m3

Explositivity/ Flammability properties: no information

UV spectrum λ = 276 nm: E(1/1) approx. 35.5

λ = 283 nm: E(1/1) approx. 28 

Climbazole is an additive and antifungal agent used in over-the-counter shampoos, conditioners, lotions, and face washes to treat human fungal skin infections like eczema and dandruff. 

Dandruff is suffered by as much as half of the population and about one in every ten individuals in the world will develop eczema during their lifetime. 

This agent helps to treat these moderate to severe fungal infections and their symptoms such as redness, and dry, itchy, and flakey skin without causing irritation to the affected area when used properly.

Climbazole is soluble and can be dissolved in a small amount of rubbing alcohol, glycols, surfactants, and perfume oils, but it is insoluble in water. 

Climbazole  also dissolves faster at elevated temperatures so using a warm solvent is recommended.

Is Dandruff a Fungus?

Most dandruff problems are a result of fungus known as Malassezia that live on your scalp causing skin cells to multiply more quickly than usual. 

The most effective treatment is dandruff shampoo that delivers the anti-fungal agent directly to the scalp.

Is Eczema a Fungus?

Eczema, also known as eczematous dermatitis, has many causes such as predetermined genetic allergens, but the most common is a bacterium know as Staphylococcus aureus. 

This is found on the skin of almost everyone who suffers from eczema since it thrives on the weepy, broken skin caused by this condition. 

It can also provide entry points for infection making treatment even more difficult. 

Though eczema is normally not a fungus itself, inhibiting infection using an anti-fungal agent such as Climbazole can be the key to successful treatment of eczema.

Climbazole is a broad-spectrum imidazole antifungal agent that can provide anti-dandruff benefits.

Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff. Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole. For climbazole, the range of MICs is between < 0.06 and 1 μg/mL with an empirical median of 0.06 μg/mL. [1]

Climbazole is not mutagenic in the Salmonella typhimurium or Escherichia coli Ames assay and does not induce micronuclei in human lymphocytes. 

An in vivo mouse micronucleus test also shows it is non-mutagenic up to a maximum tolerated dose (MTD) of 150 mg/kg administered orally. In the in vivo/in vitro unscheduled DNA synthesis assay, climbazole shows no evidence of DNA damage in the livers of rats at doses up to the MTD of 200 mg/kg orally. A toxicokinetic study is performed in mice with oral administration of [14C]-climbazole (150 mg/kg). Radioactivity (20.42 μg-equiv./g plasma) is detected 15 min after oral administration of [14C]-climbazole, and the peak concentration is 62.96 μg-equiv./g plasma at 8 h after dosing.

Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. 

Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role

(±)-Climbazole

1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone [ACD/IUPAC Name]

1-(4-Chlorophénoxy)-1-(1H-imidazol-1-yl)-3,3-diméthyl-2-butanone [French] [ACD/IUPAC Name]

1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

1-(4-Chlorphenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanon [German] [ACD/IUPAC Name]

1-(4-Chlorphenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-on

253-775-4 [EINECS]

2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl- [ACD/Index Name]

38083-17-9 [RN]

4374

618020

9N42CW7I54

Climbazole [BAN] [INN] [Wiki]

CLIMBAZOLE, (R)-

CLIMBAZOLE, (S)-

Climbazolum [Latin] [INN]

EL7085000

MFCD00055505 [MDL number]

UNII:9N42CW7I54

(±)-Climbazole

[38083-17-9]

1-(4-Chlorophenoxy)-1-(1H-imidazolyl)-3,3-dimethyl-2-butanone

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone

1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one

1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-butan-2-one

1-(4-chlorophenoxy)-1-imidazolyl-3,3-dimethylbutan-2-one

1-(4-Chlorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone

1-(4-clorophenoxy)-3,3-dimethyl-1-(IMIDAZOLE-1-yl)-2-butanone

1-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone

1-(p-Chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone

1185117-79-6 [RN]

2-Butanone, 1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-

BAY e-6975

BAY-E 6975

BAY-e 6975;Baypival

Baypival

BAYSAN [Wiki]

Climbazol

Climbazol 10 ?g/mL in Cyclohexane

Climbazol 10 µg/mL in Cyclohexane

Climbazol 10 �g/mL in Cyclohexane

Climbazole 10 µg/mL in Cyclohexane

Climbazole 10 µg/mL in Cyclohexane

Climbazole 10 �g/mL in Cyclohexane

CLIMBAZOLE-D4

climbazolum

https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:83719

KS-5112

Pharmakon1600-01504833

QA-2612

TL8002789

климбазол

كليمبازول

氯咪巴唑

Climbazole

38083-17-9

Climbazol

BAY-E 6975

1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one

2-Butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-

1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one

Baypival

CHEBI:83719

MFCD00055505

NCGC00166153-01

Baysan

DSSTox_CID_26555

DSSTox_RID_81715

DSSTox_GSID_46555

Climbazolum

1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanone

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl-2-butanone

1-(4-Chlorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone

Climbazol [INN-Spanish]

Climbazolum [INN-Latin]

CAS-38083-17-9

Climbazole [INN:BAN]

EINECS 253-775-4

BRN 0618020

Bay e 6975

CCRIS 8169

MEB 6401

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone

1-(p-Chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone

1-(p-Chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone

1-(4-Clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone

(+/-)-Climbazole-d4

1-(4-Chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone

EC 253-775-4

SCHEMBL39729

US9138393, Climbazole

US9144538, Climbazole

5-23-04-00209 (Beilstein Handbook Reference)

MLS004773943

1-NAPHTHYLACETICANHYDRIDE

BAY e-6975

CHEMBL1437764

DTXSID6046555

OWEGWHBOCFMBLP-UHFFFAOYSA-

BDBM181112

HMS2090O13

HMS3652P05

HMS3744O15

Pharmakon1600-01504833

HY-B1151

MEB-6401

Tox21 112343

Tox21_112343

AC-272

DL-358

NSC759808

s4178

2-BUTANONE, 1-(p-CHLOROPHENOXY)-3,3-DIMETHYL-1-(1-IMIDAZOLYL)-

AKOS015895513

Tox21_112343_1

CCG-213958

CS-4675

DB15580

KS-5112

NSC 759808

NSC-759808

Climbazole 10 microg/mL in Cyclohexane

NCGC00166153-02

NCGC00166153-03

SMR001550495

AB0012194

DB-049235

FT-0624097

FT-0655760

FT-0665095

SW219213-1

Climbazole, PESTANAL(R), analytical standard

H10384

AB01275501-01

AB01275501_02

AB01275501_03

083C179

A824009

AO-295/40848554

Q629373

SR-05000001501

Q-100974

SR-05000001501-1

BRD-A61676498-001-01-7

Climbazole, United States Pharmacopeia (USP) Reference Standard

1-(4-chloranylphenoxy)-1-imidazol-1-yl-3,3-dimethyl-butan-2-one

1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one

1-(4-chlorophenoxy)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one

Trade name: 

Baypival

Crinipan AD

Synonyms:

  baypival

  baysan

2- butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-

2- butanone, 1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-

1-(4- chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone

1-(4- chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one

1-(4- chlorophenoxy)-1-(1H-imidazolyl)-3,3-dimethyl-2-butanone

1-(4- chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl butanone

1-(4- chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone

1-(p- chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone

1-(4- chlorophenoxy)-1-imidazolyl-3,3-dimethylbutan-2-one

1-(p- chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone

1-(4- clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone

  crinipan AD (Symrise)