IUPAC name: 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
Other names: Pantothenol, Pantothenyl alcohol, N-Pantoylpropanolamine, Bepanthen (trade name), Dexpanthenol (D form)
CAS Number: 16485-10-2
CAS Number: 81-13-0
D-Panthenol USP, cilt, saç ve tırnakların görünümünü iyileştiren sofistike kozmetik cilt bakımı ve saç bakım ürünleri için aktif bir bileşendir. İnsan ara metabolizmasında anahtar rol oynayan D-Pantotenik asidin (Vitamin B5) provitaminidir. Bu ürün, canlı dokuların yapısı ve işlevi için iyileştirici bir etki olarak uygulamalara sahiptir ve saçın büyümesi ve pigmentasyonu için derinlemesine nüfuz eden nemlendirme özelliklerine sahiptir.
Panthenol. ATAMAN'dan D-PANTHENOL 75 W, aktif, anti-inflamatuar bir ajandır. Bu provitamin, cilt kıllarının ve tırnakların daha iyi görünmesini sağlar. D-PANTHENOL 75 W terlemeyi önleyici ve deodorantlarda, sıvı sabunlarda, kişisel bakım bezlerinde, diş macunlarında / ağız gargaralarında ve güneş koruyucu formülasyonlarda uygulama alanı bulur. Ayrıca duş / banyo formüllerinde, şampuanlarda, kendi kendine bronzlaşmada, yüz temizliğinde, yumuşatmada, güneş sonrası, vücut, yüz ve bebek bakım ve temizlik ürünlerinde kullanılır.
pantotenik asidi oluşturmak üzere enzimatik olarak parçalanır. İyi penetrasyonu ve yüksek lokal konsantrasyonları nedeniyle dekspantanol, kaşıntıyı hafifletmek veya iyileşmeyi desteklemek için dermatolojik durumların tedavisi için merhemler ve losyonlar gibi birçok topikal üründe kullanılır. Dekspantenolün topikal kullanımının dermatolojik etkileri arasında artan fibroblast proliferasyonu ve yara iyileşmesinde hızlandırılmış yeniden epitelizasyon yer alır. Ayrıca, topikal bir koruyucu, nemlendirici görevi görür ve anti-inflamatuar özellikler göstermiştir. Dekspantenol ayrıca hem dekstrorotatör formu (dekspantenol) hem de levorotatuar formu (levopantenol) [DB11204] olarak içeren rasemik bir karışım olarak mevcuttur. Pantotenik asit optik olarak aktifken, sadece dekstrorotatör form (dekspantenol) biyolojik olarak aktiftir.
Pantotenol, 2 ve 4 pozisyonlarında hidroksi grupları ve karbomil nitrojende bir 3-hidroksipropil grubu ile ikame edilmiş 3,3-dimetilbutanamid olan bir monokarboksilik asit amittir. Kolinerjik bir ilaç ve provitamin olarak rol oynar. Bir amino alkol ve bir monokarboksilik asit amiddir.
Yan etkiler
Panthenol genellikle iyi tolere edilir. Nadir durumlarda, cilt tahrişi ve temas alerjileri bildirilmiştir.
Farmakoloji
Panthenol deriye ve mukoza zarlarına (bağırsak mukozası dahil) kolayca nüfuz eder ve burada hızla pantotenik aside oksitlenir. Pantotenik asit son derece higroskopiktir, yani suyu etkin bir şekilde bağlar. Ayrıca çok çeşitli enzimatik reaksiyonlarda ve dolayısıyla hücre büyümesinde rol oynayan koenzim A'nın biyosentezinde kullanılır.
Farmakoloji
Panthenol deriye ve mukoza zarlarına (bağırsak mukozası dahil) kolayca nüfuz eder ve burada hızla pantotenik asiye oksitlenir.
Pantenol, pantotenik asidin alkol analogudur ve bu nedenle B₅'nin provitaminidir. Organizmalarda hızla pantotenik aside oksitlenir. Oda sıcaklığında yapışkan, şeffaf bir sıvıdır. Pantenol, nemlendirici olarak ve farmasötik ve kozmetik ürünlerde yara iyileşmesini iyileştirmek için kullanılır.
D-Panthenol USP is an active ingredient for sophisticated cosmetic skin care and hair care products, improving the appearance of skin, hair and nails. It is the provitamin of D-Pantothenic acid (Vitamin B5), playing a key role in the human intermediary metabolism. This product has applications as a healing effect for the structure and function of living tissue, and has deep penetrating moisturizing properties for the growth and pigmentation of hair.
Panthenol. D-PANTHENOL 75 W by ATAMAN is an active, anti-inflammatory agent. This provitamin provides improved appearance of skin hair and nails. D-PANTHENOL 75 W finds application in antiperspirants & deodorants, liquid soaps, personal care wipe, toothpastes/mouthwashes and sun protection formulations. Also used in shower/bath formulas, shampoos, self-tanning, face cleansing, conditioning, after-sun, body-, face- & baby care & cleansing products.
chemical compound
D-(+)-Panthenol; D(+)-Panthenol; Bepantol; Pantol; Bepanthen; D-panthenol 50; Pantothenyl alcohol;D-Pantothenol; D-Pantothenyl alcohol;Provitamin B; Bepanthene;(2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide; (+)-Panthenol;D-panthenol
Panthenol (also called pantothenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus a provitamin of B5. In organisms it is quickly oxidized to pantothenic acid. It is a viscous transparent liquid at room temperature. Panthenol is used as a moisturizer and to improve wound healing in pharmaceutical and cosmetic products.
In pharmaceuticals, cosmetics and personal-care products, panthenol is a moisturizer and humectant, used in ointments, lotions, shampoos, nasal sprays, eye drops, lozenges, and cleaning solutions for contact lenses.
In ointments it is used for the treatment of sunburns, mild burns, minor skin injuries and disorders (in concentrations of up to 2–5%). It improves hydration, reduces itching and inflammation of the skin, improves skin elasticity, and accelerates epidermal wounds' rate of healing. For this purpose, it is sometimes combined with allantoin.
It binds to the hair shaft readily; so, it is a common component of commercial shampoos and hair conditioners (in concentrations of 0.1–1%). It coats the hair and seals its surface,[citation needed] lubricating the hair shaft and giving it a shiny appearance.
It is also recommended by tattoo artists as a post-tattooing moisturising cream.
Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.
Dexpanthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent. Dexpanthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of dexpanthenol is unclear, it may enhance the effect of acetylcholine. Dexpanthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.
Dexpanthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol is enzymatically cleaved to form pantothenic acid, which is an essential component of Coenzyme A, which acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium. Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties. Dexpanthenol is also available as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol) as [DB11204]. While pantothenic acid is optically active, only the dextrorotatory form (dexpanthenol) is biologically active.
Pantothenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. It has a role as a cholinergic drug and a provitamin. It is an amino alcohol and a monocarboxylic acid amide.
Adverse effects
Panthenol is generally well tolerated. In rare cases, skin irritation and contact allergies have been reported.
Pharmacology
Panthenol readily penetrates into the skin and mucous membranes (including the intestinal mucosa), where it is quickly oxidized to pantothenic acid. Pantothenic acid is extremely hygroscopic, that is, it binds water effectively. It is also used in the biosynthesis of coenzyme A, which plays a role in a wide range of enzymatic reactions and thus in cell growth.
Pharmacology
Panthenol readily penetrates into the skin and mucous membranes (including the intestinal mucosa), where it is quickly oxidized to pantothenic acid. Pantothenic acid is extremely hygroscopic, that is, it binds water effectively. It is also used in the biosynthesis of coenzyme A, which plays a role in a wide range of enzymatic reactions and thus in cell growth.
IUPAC name: 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
Other names: Pantothenol, Pantothenyl alcohol, N-Pantoylpropanolamine, Bepanthen (trade name), Dexpanthenol (D form)
CAS Number: 16485-10-2
CAS Number: 81-13-0
DL-Panthenol
panthenol
16485-10-2
DL-Pantothenol
DL-Pantothenyl alcohol
2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
Panthenolum
Pantenol
Pantenolo
Penthenol
Varitan
Panthenol , DL-form
(+-)-Pantothenyl alcohol
Pantenolo [DCIT]
Urupan
Alcool DL-pantotenilico
C9H19NO4
Pantenol [INN-Spanish]
Panthenolum [INN-Latin]
Pantothenylol
Intrapan
Pantenyl
D-(+)-Panthenol
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-
Provitamin B5
Alcool DL-pantotenilico [Italian]
Dextro pantothenyl alcohol
EINECS 240-540-6
MFCD00002944
Alcopan-250
D-(+)-Pantothenyl alcohol
Dexpantenol
Dexpanthenolum
2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
Pantothenol, D-
62507-76-0
AK-60852
(+-)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+)- (9CI)
Dexpantenol [INN-Spanish]
Dexpanthenolum [INN-Latin]
Q-201031
CCRIS 3947
HSDB 296
EINECS 201-327-3
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (+-)-
Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, DL-
component of Zentinic
Panthenol, (+)-
N-Pantoyl-3-propanolamine
(R)-2,4-Dihydroxy-N-(3-hydroxy-propyl)-3,3-dimethylbutanamide
Dexpanthenol [USAN:INN:BAN]
NSC302962
D(+)-alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide
d,l- panthenol
Fancol DL
alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide, D-(+)-
Panthenol [USAN:BAN:INN:JAN]
Panthenol, racemic
pantothenylol alcohol
ACMC-20ajzi
Dexpanthenol [USAN)
DL-Panthenol 99%
Panthenol [USAN:USP:INN:BAN:JAN]
2,3-dimethylbutyramide
DL-Panthenol, 99%
ACMC-209pkr
Panthenol (USP/INN)
Dexpanthenol (Panthenol)
ACMC-1AYN9
compnent of ilopan-Choline
EC 240-540-6
(R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (theta)-
CHEMBL1371937
D-(+)-2,3-dimethylbutyramide
Pharmakon1600-01505420
Pharmakon1600-01505656
DL-Pantothenol;DL-Pantothenyl alcohol
Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3
3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1-propanol
BRD-A59413292-001-04-1
Butanamide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-
3,3-dimethyl-2,4-bis(oxidanyl)-N-(3-oxidanylpropyl)butanamide
D-2,4-Dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)butyramide
Butanamide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-
Butyramide,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-
Panthenol, racemic, United States Pharmacopeia (USP)
Description: Provitamin B5 (synonyms: D-pantothenyl alcohol, pantothenol, dexpanthenol) is the alcohol analog of pantothenic acid (vitamin B5). Activity 75%. pH 8-9. Stabilized & preserved with 1% D-pantolactone. Clear viscous liquid, no or faint odor. Soluble in water & alcohol, not in oils.
CAS: 81-13-0, 7732-18-5
INCI Name: D-panthenol, water
Benefits:
Penetrates readily into skin & hair
Has good moisturizing and softening properties
Soothes irritated and blemished skin
Gives the hair moisture & shine and reduces split ends.
Use: Add to cold or hot formulas, usual final concentration 0.5-5%. For external use only.
Applications: Creams, lotions, shampoos, conditioners, body washes, makeup.
Raw material source: Propanolamine and beta-dimethylbutyrolactone
Manufacture: Panthenol is synthetically produced by combining propanolamine and beta-dimethylbutyrolactone.
Animal Testing: Not animal tested
GMO: GMO free (does not contain plant-derived components)
Vegan: Does not contain animal-derived components
Odor: characteristic
Use: D-Panthenol is an active for skin and hair care formulations that improves the appearance of skin and hair. It provides moisturization and anti-inflammatory benefits to skin and improves shine, prevents damage and moisturizes hair.
Panthenol [BAN] [INN] [JAN] [USAN] [USP] [Wiki]
(±)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide
(±)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
(±)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
(±)-Pantothenyl Alcohol
(±)-α,γ-Dihydroxy-N-(3-hydroxypropyl)-β,β-dimethylbutyramide
16485-10-2 [RN]
1724945
1744
2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamid [German] [ACD/IUPAC Name]
2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide [ACD/IUPAC Name]
2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-diméthylbutanamide [French] [ACD/IUPAC Name]
240-540-6 [EINECS]
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl- [ACD/Index Name]
DL-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
DL-Panthenol
DL-Pantothenyl alcohol
ES4316500
MFCD00002944 [MDL number]
pantenol [Spanish] [INN]
pantenol [Portuguese]
panthénol [French] [INN]
panthenol , DL-form
Panthenol DL-form
Panthenol, racemic
panthenolum [Latin] [INN]
UNII:WV9CM0O67Z
WV9CM0O67Z
пантенол [Russian] [INN]
بانثينول [Arabic] [INN]
泛醇 [Chinese] [INN]
Fancol DL
N-Pantoyl-3-propanolamine
N-Pantoyl-propanolamine
Pantenolo
(±)-Pantothenyl alcohol
(1S)-1-(2-pyridyl)ethanol
(R)-2-(1-HYDROXYETHYL)PYRIDINE
[16485-10-2]
1724947 [Beilstein]
1O6C93RI7Z
2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
6-Oxa-1-azaspiro[3.3]heptane [ACD/Index Name] [ACD/IUPAC Name]
6-Oxa-1-aza-spiro[3.3]heptane
Alcool DL-pantotenilico [Italian]
Alcopan-250
Bepanthen
Bepanthene
Bepantol
Butanamide, 2, 4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-
Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (θ)-
Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, DL-
D Panthenol
DB09357
Dexpantenol
Dexpanthenolum
dl-panthenol, 99%
DL-Pantothenol
DL-Pantothenol;DL-Pantothenyl alcohol
Ilopan [Trade name]
Intrapan [Trade name]
MFCD00065006 [MDL number]
Motilyn
Panadon
Pantenol
Pantenolo [DCIT]
Pantenyl
PANTHENOL [USAN:BAN:INN:JAN]
Panthenol Racemic
Panthenolum
PANTHODERM
Pantol
Pantothenol
Pantothenyl alcohol
Pantothenylol
pantothenylol alcohol
Penthenol
Pharmakon1600-01505420
Pharmakon1600-01505656
Propanolamine, N-pantoyl-
Provitamin B
Provitamin B5
Synapan
Thenalton
Urupan
Varitan
Zentinic
